Single-molecule bioimaging – using the properties of light to detect and understand biological particles a thousand times smaller than the width of a human hair – is revolutionizing our understanding of Alzheimer’s disease. By enabling interactions between single, and toxic, protein molecules to be studied with completely new levels of detail, this next generation technology is shining new light on the earliest stages of disease progression.
In this talk, I will showcase our cutting-edge suite of single-molecule bioimaging techniques, explain how they are being applied to investigate protein clustering implicated in Alzheimer’s disease, and highlight their key role in enabling researchers to more effectively and efficiently screen for next-generation therapeutics.