Somdatta Sinha

Activity: Hosting a visitorAcademic

Jon Pitchford - Host

Visit of Professor Somdatta Sinha (Indian Institute of Science, Education & Research Mohali, India)

Professor Sinha has a wide range of interests in the mathematical and statistical modelling of biological systems. She is a Fellow of all three Science Academies of India, and also holds the prestigious J C Bose Fellowship from the Government of India. Research Seminar 'Modelling Infectious Diseases: from genomes to populations' in Biology B/B/103 13:00-14:00 8 July 2016. Abstract: Development and spread of any Infectious disease in a population involve host-pathogen interactions at different levels of organization. At one end, this interaction can leave signatures of adaptation at the host and/or the pathogen's genomes. On the other end, interactions between hosts/ pathogens, through biological, environmental and social factors, finally decide the spread of infection at the population level. The overall temporal incidence pattern of a disease in a population is an outcome of the interaction of all the processes at these multiple scales. In this talk I will give two examples of modeling infectious diseases at two different scales. First, I will show, through statistical analysis of genomic signatures, what information can be obtained about the host-pathogen adaptation over time using the Human Immunodeficiency Virus-1 as the model system. At the population level, I will discuss a biologically realistic mathematical model of Malaria and show how only changes in environmental factors can explain the disease incidence pattern in different endemic regions in India.
8 Jul 2016

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