JOURNAL OF MEDICINAL CHEMISTRY

ISSNs: 0022-2623

American Chemical Society

Scopus rating (2021): CiteScore 11.2

Journal

Publications

  1. 2021
  2. An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)

    Al-Khawaldeh, I., Alyassiri, M., Aldred, G., Basmadjian, C., Bordoni, C., Harnor, S. J., Heptinstall, A. B., Hobson, S., Jennings, C., Khalifa, S., Lebraud, H., Martin, M. P., Miller, D. C., Shrives, H., De Souza, J., Stewart, H., Temple, M. J., Thomas, H., Totobenazara, J., Tucker, J. A. & 12 others, Tudhope, S., Wang, L-Z., Bronowska, A., Cano, C., Endicott, J. A., Golding, B., Hardcastle, I. R., Hickson, I., Wedge, S., Willmore, E., Noble, M. E. M. & Waring, M. J., 2 Jul 2021, (E-pub ahead of print)

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  3. 2020
  4. Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

    Bell, A. S., Yu, Z., Hutton, J. A., Wright, M. H., Brannigan, J. A., Paape, D., Roberts, S. M., Sutherell, C. L., Ritzefeld, M., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 23 Jul 2020

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  5. 2018
  6. Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides

    Waszkowycz, B., Smith, K. M., McGonagle, A. E., Jordan, A. M., Acton, B., Fairweather, E. E., Griffiths, L. A., Hamilton, N. M., Hamilton, N. S., Hitchin, J. R., Hutton, C. P., James, D. I., Jones, C. D., Jones, S., Mould, D. P., Small, H. F., Stowell, A. I. J., Tucker, J. A., Waddell, I. D. & Ogilvie, D. J., 13 Dec 2018

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  7. 2017
  8. Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.

    Rutaganira, F. U., Barks, J., Dhason, M. S., Wang, Q., Lopez, M. S., Long, S., Radke, J. B., Jones, N. G., Maddirala, A. R., Janetka, J. W., El Bakkouri, M., Hui, R., Shokat, K. M. & Sibley, L. D., 28 Dec 2017

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  9. Insulin-like Growth Factor 1 Analogs Clicked in the C Domain: Chemical Synthesis and Biological Activities

    Macháčková, K., Collinsová, M., Chrudinová, M., Selicharová, I., Pícha, J., Buděšínský, M., Vaněk, V., Žáková, L., Brzozowski, A. M. & Jiráček, J., 28 Dec 2017

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  10. Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1)

    Williamson, D. S., Smith, G. P., Acheson-Dossang, P., Bedford, S. T., Chell, V., Chen, I-J., Daechsel, J. C. A., Daniels, Z., David, L., Dokurno, P., Hentzer, M., Herzig, M. C., Hubbard, R. E., Moore, J. D., Murray, J. B., Newland, S., Ray, S. C., Shaw, T., Surgenor, A. E., Terry, L. & 3 others, Thirstrup, K., Wang, Y. & Christensen, K. V., 12 Oct 2017

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  11. 2014
  12. Structure-based design of potent and selective leishmania N-myristoyltransferase inhibitors

    Hutton, J. A., Goncalves, V., Brannigan, J. A., Paape, D., Wright, M. H., Waugh, T. M., Roberts, S. M., Bell, A. S., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 19 Sep 2014

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  13. 2013
  14. 2012
  15. Synthesis and evaluation of α-thymidine analogues as novel antimalarials

    Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H., 27 Dec 2012

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  16. 2011
  17. 2009
  18. Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone

    Brough, P. A., Barril, X., Borgognoni, J., Chene, P., Davies, N. G. M., Davis, B., Drysdale, M. J., Dymock, B., Eccles, S. A., Garcia-Echeverria, C., Fromont, C., Hayes, A., Hubbard, R. E., Jordan, A. M., Jensen, M. R., Massey, A., Merrett, A., Padfield, A., Parsons, R., Radimerski, T. & 13 others, Raynaud, F. I., Robertson, A., Roughley, S. D., Schoepfer, J., Simmonite, H., Sharp, S. Y., Surgenor, A., Valenti, M., Walls, S., Webb, P., Wood, M., Workman, P. & Wright, L., 13 Aug 2009

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  19. 2008
  20. 4,5-diarylisoxazole HSP90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer

    Brough, P. A., Aherne, W., Barril, X., Borgognoni, J., Boxall, K., Cansfield, J. E., Cheung, K-M. J., Collins, I., Davies, N. G. M., Drysdale, M. J., Dymock, B., Eccles, S. A., Finch, H., Fink, A., Hayes, A., Howes, R., Hubbard, R. E., James, K., Jordan, A. M., Lockie, A. & 17 others, Martins, V., Massey, A., Matthews, T. P., McDonald, E., Northfield, C. J., Pearl, L. H., Prodromou, C., Ray, S., Raynaud, F. I., Roughley, S. D., Sharp, S. Y., Surgenor, A., Walmsley, D. L., Webb, P., Wood, M., Workman, P. & Wrightt, L., 24 Jan 2008

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  21. 2005
  22. Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design

    Dymock, B. W., Barril, X., Brough, P. A., Cansfield, J. E., Massey, A., McDonald, E., Hubbard, R. E., Surgenor, A., Roughley, S. D., Webb, P., Workman, P., Wright, L. & Drysdale, M. J., 30 Jun 2005

    Article in JOURNAL OF MEDICINAL CHEMISTRY

  23. 1996
  24. 1987

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