Jack Birch Unit

Research output

Research output per year 1985 1999 2005 2006 2007 2008 2009 2011 2014 2024

• 177 Article
• 8 Literature review
• 5 Chapter
• 2 Conference contribution
• 5 More
  • 1 Chapter (peer-reviewed)
  • 1 Comment/debate
  • 1 Conference article
  • 1 Review article
  • 1 Patent

Research output per year

Research output per year

Search results

• 2023

  A pangenome graph reference of 30 chicken genomes allows genotyping of large and complex structural variants

  Mason, A. S., 22 Nov 2023, In: BMC Biology. 21, 17 p., 267.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  Barrier forming potential of epithelial cells from the exstrophic bladder

  Hinley, J. S., Duke, R., Jinks, J., Stahlschmidt, J., Keene, D., Cervellione, R. M., Mushtaq, I., De Coppi, P., Garriboli, M. & Southgate, J., 6 Jun 2022, In: The American Journal of Pathology. 192, 6, p. 943-955 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

  Baker, S. C., Mason, A. S., Slip, R., Skinner, K., Macdonald, A., Masood, O., Harris, R. S., Fenton, T. R., Periyasamy, M., Ali, S. & Southgate, J., 22 Feb 2022, In: Oncogene. 41, p. 2139-2151 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• LPCAT4 knockdown alters barrier integrity and cellular bioenergetics in human urothelium

  Mason, A. S., Varley, C. L., Foody, O. M., Li, X., Skinner, K., Walker, D., Larson, T. R., Wakamatsu, D., Baker, S. C. & Southgate, J., 6 Oct 2022, In: International Journal of Molecular Sciences. 23, 19, 19 p., 11871.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Surface Shave: Revealing the Apical-Restricted Uroglycome

  Wang, C. Y., Bergström, E., Southgate, J. & Thomas-Oates, J., 5 Jan 2022, (E-pub ahead of print) In: Journal of Proteome Research. 21, 2, p. 360–374 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The urothelial transcriptomic response to interferon gamma: implications for bladder cancer prognosis and immunotherapy

  Baker, S. C., Mason, A. S., Slip, R., Eriksson, P., Sjodahl, G., Trejdosiewicz, L. & Southgate, J., 27 Oct 2022, In: Cancers. 14, 21, 12 p., 5295.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  Augmentation of the insufficient tissue bed for surgical repair of hypospadias using acellular matrix grafts: A proof of concept study

  Morgante, D., Radford, A., Abbas, S. K., Ingham, E., Subramaniam, R. & Southgate, J., 20 Apr 2021, (E-pub ahead of print) In: Journal of Tissue Engineering. 12, 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Does a novel mutagenic process target KMT2D mutation in the most common first event on the path to bladder cancer

  Baker, S. C., Mason, A. S. & Southgate, J., 1 Mar 2021, In: European Urology. 79, 3, p. 435-436 2 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Intratumoural cytochrome P450 expression in breast cancer: impact on standard of care treatment and new efforts to develop tumour-selective therapies

  Sneha, S., Baker, S. C., Green, A., Storr, S., Aiyappa, R., Martin, S. & Pors, K., 12 Mar 2021, In: Biomedicines. 9, 3, 22 p., 290.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Translation of mechanical strain to a scalable biomanufacturing process for acellular matrix production from full thickness porcine bladder

  Ward, A., Morgante, D., Fisher, J., Ingham, E. & Southgate, J., 15 Oct 2021, In: Biomedical Materials. 16, 6, 14 p., 065023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  Pro-carcinogen activation and mutational signatures model the initiation of carcinogenesis in human urothelial tissues in vitro

  Baker, S. C., Mason, A. S. & Southgate, J., Aug 2020, In: European Urology. 78, 2, p. 143-147 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  Hypoxic changes to the urothelium as a bystander of end-stage bladder disease

  Radford, A. R., Hinley, J. S., Pilborough, A., Southgate, J. & Subramaniam, R., 15 Apr 2019, In: Journal of Pediatric Urology. 15, 2, p. 158.e1-158.e10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Loss of Janus Associated Kinase1 alters urothelial cell functionand facilitates the development of bladder cancer

  Daza-Cajigal, V., Albuquerque, A., Pearson, J. F., Hinley, J. S., Mason, A. S., Stahlschmidt, J., Thrasher, A. J., Mishra, V., Southgate, J. & Burns, S. O., 10 Sept 2019, In: Frontiers in immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Specificity of the Metallothionein-1 Response by Cadmium-Exposed Human Urothelial Cells

  McNeill, R. V., Mason, A. S., Hodson, M. E., Catto, J. W. F. & Southgate, J., 17 Mar 2019, In: International Journal of Molecular Sciences.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Differential transcription factor expression by human epithelial cells of buccal and urothelial derivation

  Southgate, J., Hustler, A., Eardley, I., Hinley, J. S., Pearson, J. F., Wezel, F., Radvanyi, F. & Baker, S. C., 15 Aug 2018, In: Experimental cell research. 369, 2, p. 284-294 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolising activity of “luminal” muscle-invasive bladder cancers

  Baker, S. C., Arlt, V., Indra, R., Joel, M., Stiborova, M., Eardley, I., Ahmad, N., Otto, W., Burger, M., Rubenwolf, P. C., Phillips, D. & Southgate, J., 1 May 2018, In: Molecular Carcinogenesis. 57, 5, p. 606-618 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Implications of TERT promoter mutations and telomerase activity for urothelial carcinogenesis

  Gunes, C., Wezel, F., Southgate, J. & Bolenz, C., 29 Mar 2018, (E-pub ahead of print) In: Nature reviews. Urology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  Genome-wide linkage and association study implicates the 10q26 region as a major genetic contributor to primary nonsyndromic vesicoureteric reflux

  Darlow, J. M., Darlay, R., Dobson, M. G., Stewart, A., Charoen, P., Southgate, J., Baker, S. C., Xu, Y., Hunziker, M., Lambert, H. J., Green, A. J., Santibanez-Koref, M., Sayer, J. A., Goodship, T. H. J., Puri, P., Woolf, A. S., Kenda, R. B., Barton, D. E. & Cordell, H. J., 6 Nov 2017, In: Scientific Reports. 7, 13 p., 14595 (2017).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Heterarchy of Transcription Factors Driving Basal and Luminal Cell Phenotypes in Human Urothelium

  Southgate, J., 10 Mar 2017, (E-pub ahead of print) In: Cell death and differentiation. p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Targeting deficiencies in the TLR5 mediated vaginal response to treat female recurrent urinary tract infection

  Ali, A. SM., Mowbray, C., Lanz, M., Stanton, A., Bowen, S., Varley, C. L., Hilton, P., Brown, K., Robson, W., Southgate, J., Aldridge, P., Tyson-Capper, A., Abraham, S., Pickard, R. & Hall, J., 8 Sept 2017, In: Scientific Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  A Rare Urachal Cyst in a Case of Ketamine-induced Cystitis Provides Mechanistic Insights

  Kidger, E., Stahlschmidt, J., Garthwaite, M., Fulford, S., Southgate, J. & Baker, S. C., Apr 2016, In: Urology. 90, p. 223.e1-223.e7

  Research output: Contribution to journal › Article › peer-review

• A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis

  Southgate, J., 21 Nov 2016, (E-pub ahead of print) In: Oncogene.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Characterization and Classification of Adherent Cells in Monolayer Culture using Automated Tracking and Evolutionary Algorithms

  Zhang, Z., Bedder, M., Smith, S. L., Walker, D., Shabir, S. & Southgate, J., Aug 2016, In: Biosystems. 146, p. 110-121 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Ketamine-Induced Apoptosis in Normal Human Urothelial Cells: A Direct, N-Methyl-d-Aspartate Receptor-Independent Pathway Characterized by Mitochondrial Stress

  Baker, S. C., Shabir, S., Georgopoulos, N. T. & Southgate, J., 18 Mar 2016, In: The American Journal of Pathology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  Sources of variability in cytosolic calcium transients triggered by stimulation of homogeneous uro-epithelial cell monolayers

  Appleby, P. A., Shabir, S., Southgate, J. & Walker, D., Apr 2015, In: Interface. 12, 105, 20141403.

  Research output: Contribution to journal › Article › peer-review

• The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch

  Smith, N. J., Hinley, J., Varley, C. L., Eardley, I., Trejdosiewicz, L. K. & Southgate, J., 14 Aug 2015, In: Bladder. 2, 1, 10 p., e9.

  Research output: Contribution to journal › Article › peer-review
• 2014

  A novel bidirectional positive-feedback loop between Wnt-β-catenin and EGFR-ERK plays a role in context-specific modulation of epithelial tissue regeneration

  Georgopoulos, N. T., Kirkwood, L. A. & Southgate, J., 1 Jul 2014, In: Journal of Cell Science. 127, 13, p. 2967-82 16 p.

  Research output: Contribution to journal › Article › peer-review

• Biomimetic urothelial tissue models for the in vitro evaluation of barrier physiology and bladder drug efficacy

  Baker, S. C., Shabir, S. & Southgate, J., 7 Jul 2014, In: MOLECULAR PHARMACEUTICS. 11, 7, p. 1964-70 7 p.

  Research output: Contribution to journal › Article › peer-review

• EGFR as a potential therapeutic target for a subset of muscle-invasive bladder cancers presenting a basal-like phenotype

  Rebouissou, S., Bernard-Pierrot, I., de Reyniès, A., Lepage, M-L., Krucker, C., Chapeaublanc, E., Hérault, A., Kamoun, A., Caillault, A., Letouzé, E., Elarouci, N., Neuzillet, Y., Denoux, Y., Molinié, V., Vordos, D., Laplanche, A., Maillé, P., Soyeux, P., Ofualuka, K., Reyal, F., & 8 othersBiton, A., Sibony, M., Paoletti, X., Southgate, J., Benhamou, S., Lebret, T., Allory, Y. & Radvanyi, F., 9 Jul 2014, In: Science Translational Medicine. 6, 244, 11 p., 244ra91.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Identification of ELF3 as an early transcriptional regulator of human urothelium

  Böck, M., Hinley, J., Schmitt, C., Wahlicht, T., Kramer, S. & Southgate, J., 15 Feb 2014, In: Developmental Biology. 386, 2, p. 321-30 10 p.

  Research output: Contribution to journal › Article › peer-review

• Independent Component Analysis Uncovers the Landscape of the Bladder Tumor Transcriptome and Reveals Insights into Luminal and Basal Subtypes

  Biton, A., Bernard-Pierrot, I., Lou, Y., Krucker, C., Chapeaublanc, E., Rubio-Pérez, C., López-Bigas, N., Kamoun, A., Neuzillet, Y., Gestraud, P., Grieco, L., Rebouissou, S., deReyniès, A., Benhamou, S., Lebret, T., Southgate, J., Barillot, E., Allory, Y., Zinovyev, A. & Radvanyi, F., 20 Nov 2014, In: Cell reports. 9, 4, p. 1235-1245 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Plasticity of in vitro-generated urothelial cells for functional tissue formation

  Wezel, F., Pearson, J. & Southgate, J., 1 May 2014, In: Tissue engineering. Part A. 20, 9-10, p. 1358-68 11 p.

  Research output: Contribution to journal › Article › peer-review

• Regenerative medicine in urology

  Garriboli, M., Radford, A. & Southgate, J., 2014, In: European Journal of Pediatric Surgery. 24, 3, p. 227-236 10 p.

  Research output: Contribution to journal › Article › peer-review

• The Human Tissue-Biomaterial Interface: A Role for PPARγ-Dependent Glucocorticoid Receptor Activation in Regulating the CD163(+) M2 Macrophage Phenotype

  Bullers, S. J., Baker, S. C., Ingham, E. & Southgate, J., 11 Sept 2014, In: Tissue engineering. Part A. 20, 17-18, p. 2390-2401 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Use of donor bladder tissues for in vitro research

  Garthwaite, M., Hinley, J., Cross, W., Warwick, R. M., Ambrose, A., Hardaker, H., Eardley, I. & Southgate, J., Jan 2014, In: BJU International. 113, 1, p. 160-166 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Cell-type-specific modelling of intracellular calcium signalling: A urothelial cell model

  Appleby, P. A., Shabir, S., Southgate, J. & Walker, D., 6 Sept 2013, In: Interface. 10, 86, 20130487.

  Research output: Contribution to journal › Article › peer-review

• Differential Expression of Oct4 Variants and Pseudogenes in Normal Urothelium and Urothelial Cancer

  Wezel, F., Pearson, J., Kirkwood, L. A. & Southgate, J., 7 Aug 2013, In: The American Journal of Pathology. Early Online, 4, p. n/a 9 p.

  Research output: Contribution to journal › Article › peer-review

• Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium

  Shabir, S., Cross, W., Kirkwood, L. A., Pearson, J. F., Appleby, P. A., Walker, D., Eardley, I. & Southgate, J., 1 Aug 2013, In: American journal of physiology-Renal physiology. 305, 3, p. F396-406

  Research output: Contribution to journal › Article › peer-review

• Nerve hyperplasia: a unique feature of ketamine cystitis

  Baker, S. C., Stahlschmidt, J., Oxley, J., Hinley, J., Eardley, I., Marsh, F., Gillatt, D., Fulford, S. & Southgate, J., 8 Oct 2013, In: Acta neuropathologica communications. 1, 64, 7 p., 20515960.

  Research output: Contribution to journal › Article › peer-review

• Reprogramming stromal cells from the urinary tract and prostate: a trip to pluripotency and back?

  Wezel, F. & Southgate, J., Nov 2013, In: European Urology. 64, 5, p. 762–764

  Research output: Contribution to journal › Article › peer-review

• The modulatory effect of cell-cell contact on the tumourigenic potential of pre-malignant epithelial cells: A computational exploration

  Walker, D. C. & Southgate, J., 6 Jan 2013, In: Journal of the Royal Society Interface. 10, 78, 20120703.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2012

  Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl

  Rubenwolf, P. C., Georgopoulos, N. T., Kirkwood, L. A., Baker, S. C. & Southgate, J., 24 Sept 2012, In: PLoS ONE. 7, 9, p. e45339 e45339.

  Research output: Contribution to journal › Article › peer-review

• Deregulation of Rab and Rab Effector Genes in Bladder Cancer

  Ho, J. R., Chapeaublanc, E., Kirkwood, L., Nicolle, R., Benhamou, S., Lebret, T., Allory, Y., Southgate, J., Radvanyi, F. & Goud, B., 19 Jun 2012, In: PLoS ONE. 7, 6, p. - 16 p., e39469.

  Research output: Contribution to journal › Article › peer-review

• Differentiation-Associated reprogramming of the transforming growth factor β receptor pathway establishes the circuitry for epithelial autocrine/paracrine repair

  Southgate, J., Fleming, J., Shabir, S., Varley, C., Kirkwood, L., White, A., Holder, J. & Tresdosiewicz, L., 19 Dec 2012, In: PLoS ONE. 7, 12, p. 1-12 e51404.

  Research output: Contribution to journal › Article › peer-review

• Seromuscular grafts for bladder reconstruction: extra-luminal demucosalisation of the bowel

  Subramaniam, R., Turner, A. M., Abbas, S. K., Thomas, D. F. M. & Southgate, J., Nov 2012, In: Urology. 80, 5, p. 1147-1150 4 p.

  Research output: Contribution to journal › Article › peer-review

• The modulatory effect of cell-cell contact on the tumorigenic potential of pre-malignant epithelial cells: a computational exploration

  Southgate, J. & Walker, D., 2012, (Accepted/In press) In: Interface. p. PMID 23097504

  Research output: Contribution to journal › Article › peer-review

• 2011

  A novel epigenetic phenotype associated with the most aggressive pathway of bladder tumor progression

  Vallot, C., Stransky, N., Bernard-Pierrot, I., Hérault, A., Zucman-Rossi, J., Chapeaublanc, E., Vordos, D., Laplanche, A., Benhamou, S., Lebret, T., Southgate, J., Allory, Y. & Radvanyi, F., 5 Jan 2011, In: Journal of the National Cancer Institute. 103, 1, p. 47-60 14 p.

  Research output: Contribution to journal › Article › peer-review

• Cellular integration and vascularisation promoted by a resorbable, particulate-leached, cross-linked poly(e-caprolactone) scaffold

  Baker, S. C., Rohman, G., Hinley, J., Stahlschmidt, J., Cameron, N. R. & Southgate, J., 12 May 2011, In: Macromolecular bioscience. 11, 5, p. 618-27 10 p.

  Research output: Contribution to journal › Article › peer-review

• Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells

  Munkley, J., Copeland, N. A., Moignard, V., Knight, J., Greaves, E., Ramsbottom, S. A., Pownall, B., Southgate, J., Ainscough, J. & Coverley, D. A., Apr 2011, In: Nucleic Acids Research. 39, 7, p. 2671-2677 7 p., PMID: 21109536.

  Research output: Contribution to journal › Article › peer-review

• Immortalisation of normal human urothelial cells compromises differentiation capacity

  Georgopoulos, N. T., Kirkwood, L. A., Varley, C. L., Maclaine, N. J., Aziz, N. & Southgate, J., Jul 2011, In: European Urology. 60, 1, p. 141-149 9 p.

  Research output: Contribution to journal › Article › peer-review