Alfred Aksel Antson

Search results

• 2025

  Penton blooming, a conserved mechanism of genome delivery used by disparate microviruses

  Bardy, P., MacDonald, C. I. W., Kirchberger, P. C., Jenkins, H. T., Botka, T., Byrom, L., Alim, N. T. B., Traore, D. A. K., Koenig, H. C., Nicholas, T. R., Chechik, M., Hart, S. J., Turkenburg, J. P., Blaza, J. N., Beatty, J. T., Fogg, P. C. M. & Antson, A. A., 19 Mar 2025, In: MBio. 16, 4, 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2024

  A stargate mechanism of Microviridae genome delivery unveiled by cryogenic electron tomography.

  Bardy, P., MacDonald, C. I. W., Kirchberger, P. C., Jenkins, H. T., Botka, T., Byrom, L., Alim, N. T. B., Traore, D. A. K., König, H. C., Nicholas, T. R., Chechik, M., Hart, S. J., Turkenburg, J. P., Blaza, J. N., Beatty, J. T., Fogg, P. C. M. & Antson, A. A., 11 Jun 2024, biorxiv.

  Research output: Working paper › Preprint

  Open Access

• Structural basis for DNA recognition by a viral genome-packaging machine

  Chechik, M., Greive, S. J. M., Antson, A. A. & Jenkins, H. T., 8 Aug 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 33, 10 p., e2406138121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Structure-based discovery of first inhibitors targeting the helicase activity of human PIF1

  Wever, M. J. A., Scommegna, F. R., Egea-Rodriguez, S., Dehghani-Tafti, S., Brandao-Neto, J., Poisson, J.-F., Helfrich, I., Antson, A. A., Rodeschini, V., Bax, B., Roche, D. & Sanders, C. M., 17 Oct 2024, (E-pub ahead of print) In: Nucleic Acids Research. 52, p. 12616–12632 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Surface microlayer-mediated virome dissemination in the Central Arctic

  Rahlff, J., Westmeijer, G., Weissenbach, J., Antson, A. & Holmfeldt, K., Dec 2024, In: Microbiome. 12, 1, 17 p., 218.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Viral Genomic DNA Packaging Machinery

  Hawkins, D. E. D. P., Godwin, O. C. & Antson, A. A., 5 Jul 2024, (E-pub ahead of print) Macromolecular Protein Complexes V: Structure and Function. Springer, Vol. 104. p. 181-205 25 p. (Sub-cellular biochemistry).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  File
• 2023

  Human 14-3-3 proteins site-selectively bind the mutational hotspot region of SARS-CoV-2 nucleoprotein modulating its phosphoregulation

  Tugaeva, K. V., Sysoev, A. A., Kapitonova, A. A., L R Smith, J., Zhu, P., Cooley, R. B., Antson, A. A. & Sluchanko, N. N., 30 Jan 2023, In: Journal of Molecular Biology. 435, 2, 17 p., 167891.

  Research output: Contribution to journal › Article › peer-review

• Insights into a viral motor: the structure of the HK97 packaging termination assembly

  Hawkins, D. E. D. P., Bayfield, O. W., Fung, H. K. H., Grba, D. N., Huet, A., Conway, J. F. & Antson, A. A., 21 Jul 2023, In: Nucleic Acids Research. 51, 13, p. 7025-7035 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Jorvik: a membrane-containing phage that will likely found a new family within Vinavirales

  Bardy, P., MacDonald, C., Pantucek, R., Antson, A. A. & Fogg, P. C. M., 17 Nov 2023, In: iScience. 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural atlas of a human gut crassvirus

  Bayfield, O. W., Shkoporov, A. N., Yutin, N., Khokhlova, E. V., Smith, J. L. R., Hawkins, D. E. D. P., Koonin, E. V., Hill, C. & Antson, A. A., 11 May 2023, In: Nature. 617, 7960, p. 409-416 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2022

  High-Voltage Biomolecular Sensing Using a Bacteriophage Portal Protein Covalently Immobilized within a Solid-State Nanopore

  Mojtabavi, M., Greive, S. J., Antson, A. A. & Wanunu, M., 14 Dec 2022, In: Journal of the American Chemical Society. 144, 49, p. 22540–22548 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural basis of DNA packaging by a ring-type ATPase from an archetypal viral system

  Fung, H. K. H., Grimes, S., Huet, A., Duda, R. L., Chechik, M., Gault, J., Robinson, C. V., Hendrix, R. W., Jardine, P. J., Conway, J. F., Baumann, C. G. & Antson, A. A., 10 Aug 2022, (E-pub ahead of print) In: Nucleic Acids Research. 14 p., gkac647.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  CryoEM structure of the Nipah virus nucleocapsid assembly

  Ker, D.-S., Jenkins, H. T., Greive, S. J. & Antson, A. A., 16 Jul 2021, In: PLOS PATHOGENS. 17, 7, e1009740.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Octahedral Trifluoromagnesate, an Anomalous Metal Fluoride Species, Stabilizes the Transition State in a Biological Motor

  Ge, M., Molt, R. W., Jenkins, H. T., Blackburn, G. M., Jin, Y. & Antson, A. A., 5 Mar 2021, In: ACS Catalysis. 11, 5, p. 2769-2773 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins

  Tugaeva, K. V., E D P Hawkins, D., L R Smith, J., Bayfield, O. W., Ker, D.-S., Sysoev, A. A., Klychnikov, O. I., Antson, A. A. & Sluchanko, N. N., 16 Apr 2021, In: Journal of Molecular Biology. 433, 8, 166875.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  An Unprecedented Octahedral Trifluoromagnesate MgF3(Wat)– Transition State Analog Reveals The Molecular Mechanism of ATP Hydrolysis by Zika Virus Helicase

  Ge, M., Molt. Jr., R. W., Jenkins, H. T., Blackburn, M., Jin, Y. & Antson, A. A., 27 Feb 2020, (ChemRxiv).

  Research output: Working paper

  Open Access

• Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

  Oxford Immunology Network Covid-19 Response T cell Consortium, Nov 2020, In: Nature immunology. 21, 11, p. 1336–1345

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss

  Bayfield, O. W., Steven, A. C. & Antson, A. A., 14 Apr 2020, (E-pub ahead of print) In: eLife. 9, 12 p., e55517.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• CryoEM structure of the Nipah virus nucleocapsid assembly

  Ker, D.-S., Jenkins, H. T., Greive, S. J. M. & Antson, A. A., 20 Jan 2020, (bioRxiv).

  Research output: Working paper

• Diversity and Host Interactions Among Virulent and Temperate Baltic Sea Flavobacterium Phages

  Nilsson, E., Bayfield, O. W., Lundin, D., Antson, A. A. & Holmfeldt, K., 30 Jan 2020, In: Viruses. 12, 2, 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family

  Tugaeva, K. V., Titterington, J., Sotnikov, D., Maksimov, E., Antson, A. A. & Sluchanko, N. N., 14 Apr 2020.

  Research output: Working paper

• Molecular basis for the recognition of steroidogenic acute regulatory protein by the 14-3-3 protein family

  Tugaeva, K. V., Titterington, J., Sotnikov, D. V., Maksimov, E. G., Antson, A. A. & Sluchanko, N. N., 6 Jul 2020, (E-pub ahead of print) In: FEBS Journal.

  Research output: Contribution to journal › Article › peer-review
• 2019

  Cryo-EM analysis of a viral portal protein in situ reveals a switch in the DNA tunnel

  Bayfield, O., Steven, A. & Antson, A. A., 25 Jul 2019, (bioRxiv).

  Research output: Working paper

  Open Access

• Cryo-EM structure and in vitro DNA packaging of a thermophilic virus with supersized T=7 capsids

  Bayfield, O. W., Klimuk, E., Winkler, D. C., Hesketh, E. L., Chechik, M., Cheng, N., Dykeman, E. C., Minakhin, L., Ranson, N. A., Severinov, K., Steven, A. C. & Antson, A. A., 26 Feb 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3556-3561 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase

  Dehghani-Tafti, S., Levdikov, V., Antson, A. A., Bax, B. & Sanders, C. M., 8 Apr 2019, In: Nucleic Acids Research. 47, 6, p. 3208-3222 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Thermostable virus portal proteins as reprogrammable adapters for solid-state nanopore sensors

  Cressiot, B., Greive, S. J. M., Mojtabavi, M., Antson, A. A. & Wanunu, M., 7 Nov 2018, In: Nature Communications. 9, 1, p. 1-7 7 p., 4652.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  Chimeric 14-3-3 proteins for unraveling interactions with intrinsically disordered partners

  Sluchanko, N. N., Tugaeva, K. V., Greive, S. J. & Antson, A. A., 20 Sept 2017, In: Scientific Reports. 7, 1, 12 p., 12014.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Porphyrin-Assisted Docking of a Thermophage Portal Protein into Lipid Bilayers: Nanopore Engineering and Characterization

  Cressiot, B., Greive, S. J., Si, W., Pascoa, T. C., Mojtabavi, M., Chechik, M., Jenkins, H. T., Lu, X., Zhang, K., Aksimentiev, A., Antson, A. A. & Wanunu, M., 9 Nov 2017, (E-pub ahead of print) In: ACS Nano. p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural basis for the interaction of a human small heat shock protein with the 14-3-3 universal signaling regulator

  Sluchanko, N. N., Beelen, S., Kulikova, A. A., Weeks, S. D., Antson, A. A., Gusev, N. B. & Strelkov, S. V., 7 Feb 2017, In: Structure. 25, 2, p. 305–316 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structure of the large terminase from a hyperthermophilic virus reveals a unique mechanism for oligomerization and ATP hydrolysis

  Xu, R.-G., Jenkins, H. T., Antson, A. A. & Greive, S. J., 24 Oct 2017, In: Nucleic Acids Research. 45, 22, p. 13029-13042 14 p., gkx947.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Viral genome packaging terminase cleaves DNA using the canonical RuvC-like two-metal catalysis mechanism

  Xu, R.-G., Jenkins, H. T., Chechik, M., Blagova, E. V., Lopatina, A., Klimuk, E., Minakhin, L., Severinov, K., Greive, S. J. & Antson, A. A., 7 Apr 2017, In: Nucleic Acids Research. 45, 6, p. 3580-3590 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  Human Lin28 forms a high-affinity 1:1 complex with the 106~363 cluster miRNA miR-363

  Peters, D. T., Fung, H. K., Levdikov, V. M., Irmscher, T., Warrander, F. C., Greive, S. J., Kovalevskiy, O., Isaacs, H. V., Coles, M. C. & Antson, A. A., 25 Aug 2016, In: Biochemistry. 55, p. 5021−5027 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• RNA protects a nucleoprotein complex against radiation damage

  Bury, C. S., McGeehan, J. E., Antson, A. A., Carmichael, I., Gerstel, M., Shevtsov, M. B. & Garman, E. F., 1 May 2016, In: Acta crystallographica. Section D, Structural biology. 72, Pt 5, p. 648-657 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  DNA recognition for virus assembly through multiple sequence-independent interactions with a helix-turn-helix motif

  Greive, S. J., Fung, H. K. H., Chechik, M., Jenkins, H. T., Weitzel, S. E., Aguiar, P. M., Brentnall, A. S., Glousieau, M., Gladyshev, G. V., Potts, J. R. & Antson, A. A., 15 Dec 2015, In: Nucleic Acids Research. p. 1-14 14 p.

  Research output: Contribution to journal › Article › peer-review

• From bacterial to human dihydrouridine synthase: automated structure determination

  Whelan, F., Jenkins, H. T., Griffiths, S. C., Byrne, R. T., Dodson, E. J. & Antson, A. A., 1 Jul 2015, In: Acta Crystallographica Section D: Biological Crystallography. 71, Pt 7, p. 1564-1571 8 p.

  Research output: Contribution to journal › Article › peer-review

• lin28 proteins promote expression of 17∼92 family miRNAs during amphibian development

  Warrander, F., Faas, L., Kovalevskiy, O., Peters, D., Coles, M., Antson, A. A., Genever, P. & Isaacs, H. V., 8 Oct 2015, In: Developmental Dynamics. 50 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases

  Byrne, R. T., Jenkins, H. T., Peters, D. T., Whelan, F., Stowell, J., Aziz, N., Kasatsky, P., Rodnina, M. V., Koonin, E. V., Konevega, A. L. & Antson, A. A., 12 May 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6033-6037 5 p.

  Research output: Contribution to journal › Article › peer-review

• Quantitative characterization of protein-protein complexes involved in base excision DNA repair

  Moor, N. A., Vasil'eva, I. A., Anarbaev, R. O., Antson, A. A. & Lavrik, O. I., 2015, In: Nucleic Acids Research.

  Research output: Contribution to journal › Article › peer-review

• Structural basis for DNA strand separation by a hexameric replicative helicase

  Chaban, Y., Stead, J. A., Ryzhenkova, K., Whelan, F., Lamber, E. P., Antson, A., Sanders, C. M. & Orlova, E. V., 3 Aug 2015, In: Nucleic Acids Research.

  Research output: Contribution to journal › Article › peer-review
• 2013

  12-Fold symmetry of the putative portal protein from the Thermus thermophilus bacteriophage G20C determined by X-ray analysis

  Williams, L. S., Levdikov, V. M., Minakhin, L., Severinov, K. & Antson, A. A., Nov 2013, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 11, p. 1239-1241 3 p.

  Research output: Contribution to journal › Article › peer-review

• S-Adenosyl-S-carboxymethyl-l-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA

  Byrne, R. T., Whelan, F., Aller, P., Bird, L. E., Dowle, A., Lobley, C. M. C., Reddivari, Y., Nettleship, J. E., Owens, R. J., Antson, A. A. & Waterman, D. G., 1 Jun 2013, In: Acta Crystallographica Section D: Biological Crystallography. 69, 6, p. 1090-1098 9 p.

  Research output: Contribution to journal › Article › peer-review

• The putative small terminase from the thermophilic dsDNA bacteriophage G20C is a nine-subunit oligomer

  Loredo-Varela, J., Chechik, M., Levdikov, V. M., Abd-El-Aziz, A., Minakhin, L., Severinov, K., Smits, C. & Antson, A. A., Aug 2013, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 8, p. 876-879 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding

  Whelan, F., Stead, J. A., Shkumatov, A. V., Svergun, D. I., Sanders, C. M. & Antson, A. A., Mar 2012, In: Nucleic Acids Research. 40, 5, p. 2271-2283 13 p.

  Research output: Contribution to journal › Article › peer-review

• Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase

  Griffiths, S., Byrne, R. T., Antson, A. A. & Whelan, F., 2012, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, Pt 3, p. 333-336 4 p.

  Research output: Contribution to journal › Article › peer-review

• Crystal structure of Citrobacter freundii Asp214Ala Tyrosine phenol-lyase reveals that Asp214 is critical for maintaining a strain in the internal aldimine

  Milić, D., Demidkina, T. V., Zakomirdina, L. N., Matković-Čalogović, D. & Antson, A. A., 2012, In: Croatica chemica acta. 85, 3, p. 283-288 6 p.

  Research output: Contribution to journal › Article › peer-review

• Monomeric 14-3-3ζ has a chaperone-like activity and is stabilized by phosphorylated HspB6

  Sluchanko, N. N., Artemova, N. V., Sudnitsyna, M. V., Safenkova, I. V., Antson, A. A., Levitsky, D. I. & Gusev, N. B., 7 Aug 2012, In: Biochemistry. 51, 31, p. 6127-6138 12 p.

  Research output: Contribution to journal › Article › peer-review

• Recombinant portal protein from Staphylococcus epidermidis bacteriophage CNPH82 is a 13-subunit oligomer

  Luan, W., Fesseler, J., Chechik, M., Buttner, C. R., Antson, A. A. & Smits, C., 1 Oct 2012, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 68, Pt 10, p. 1267-1270 4 p.

  Research output: Contribution to journal › Article › peer-review

• Structural basis for DNA recognition and loading into a viral packaging motor

  Buettner, C. R., Chechik, M., Ortiz-Lombardia, M., Smits, C., Ebong, I.-O., Chechik, V., Jeschke, G., Dykeman, E., Benini, S., Robinson, C. V., Alonso, J. C. & Antson, A. A., 17 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 811-816 6 p.

  Research output: Contribution to journal › Article › peer-review

• Trp RNA-binding attenuation protein: modifying symmetry and stability of a circular oligomer

  Bayfield, O. W., Chen, C.-S., Patterson, A. R., Luan, W., Smits, C., Gollnick, P. & Antson, A. A., 6 Sept 2012, In: PLoS ONE. 7, 9, e44309.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Crystallographic Snapshots of Tyrosine Phenol-lyase Show That Substrate Strain Plays a Role in C-C Bond Cleavage

  Milic, D., Demidkina, T. V., Faleev, N. G., Phillips, R. S., Matkovic-Calogovic, D. & Antson, A. A., 19 Oct 2011, In: Journal of the American Chemical Society. 133, 41, p. 16468-16476 9 p.

  Research output: Contribution to journal › Article › peer-review