Research output per year
Research output per year
Research output
- 19 Article
- 19 results
Search results
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2020
An epoxide intermediate in glycosidase catalysis
Sobala, L. F., Speciale, G., Zhu, S., Raich, L., Sannikova, N., Thompson, A. J., Hakki, Z., Lu, D., Abadi, S. S. K., Lewis, A. R., Rojas-Cervellera, V., Bernardo-Seisdedos, G., Zhang, Y., Millet, O., Jiménez-Barbero, J., Bennet, A. J., Sollogoub, M., Rovira, C., Davies, G. J. & Williams, S. J., 27 May 2020, In: ACS Central Science. 6, 5, p. 760-770Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Structure of human endo-a-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
Sobala, L. F., Fernandes, P. Z., Hakki, Z., Thompson, A. J., Howe, J. D., Hill, M., Zitzmann, N., Davies, S., Stamataki, Z., Butters, T. D., Alonzi, D. S., Williams, S. J. & Davies, G. J., 24 Nov 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 47, p. 29595-29601 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif
Thompson, A. J., Spears, R. J., Zhu, Y., Suits, M. D. L., Williams, S. J., Gilbert, H. J. & Davies, G. J., 1 May 2018, In: Acta crystallographica. Section D, Structural biology. 74, 5, p. 394-404 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Contribution of shape and charge to the inhibition of a family GH99 endo-α-1,2-mannanase
Petricevic, M., Sobala, L., Fernandes, P. Z., Raich, L., Thompson, A. J., Ganeko , B.-S., Millet, O., Zhu, S., Sollogoub, M., Jiménez-Barbero, J., Rovira, C., Davies, G. J. & Williams, S. J., 2017, In: Journal of the American Chemical Society. 139, 3, p. 1089–1097 jacs.6b10075.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Unloading shoes for intermittent claudication: a randomised crossover trial
Tew, G. A., Shalan, A., Jordan, A. R., Cook, L., Coleman, E. S., Fairhurst, C., Hewitt, C., Hutchins, S. W. & Thompson, A., 28 Nov 2017, In: BMC Cardiovascular Disorders. 17, 1, 10 p., 283.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2016
Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut
Hemsworth, G. R., Thompson, A. J., Stepper, J., Sobala, Ł. F., Coyle, T., Larsbrink, J., Spadiut, O., Goddard-Borger, E. D., Stubbs, K. A., Brumer, H. & Davies, G. J., 29 Jul 2016, In: Open Biology. 6, 7, 14 p., 160142.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2015
Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism
Thompson, A. J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R. J., Chandler, E., Temple, M. J., Stepper, J., Gilbert, H. J., Rovira, C., Williams, S. J. & Davies, G. J., 27 Apr 2015, In: Angewandte Chemie International Edition. 54, 18, p. 5378-5382 5 p.Research output: Contribution to journal › Article › peer-review
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Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E. A., Pudlo, N. A., Porter, N. T., Urs, K., Thompson, A. J., Cartmell, A., Rogowski, A., Hamilton, B. S., Chen, R., Tolbert, T. J., Piens, K., Bracke, D., Vervecken, W., Hakki, Z., Speciale, G. & Munōz-Munōz, J. L. & 12 others, , 8 Jan 2015, In: Nature. 517, 7533, p. 165-169 5 p.Research output: Contribution to journal › Article › peer-review
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Structural and kinetic dissection of the endo-α-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp
Hakki, Z., Thompson, A. J., Bellmaine, S., Speciale, G., Davies, G. J. & Williams, S. J., 26 Jan 2015, In: Chemistry : A European Journal. 21, 5, p. 1966-1977 12 p.Research output: Contribution to journal › Article › peer-review
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Structure of the GH76 -mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron
Thompson, A. J., Cuskin, F., Spears, R. J., Dabin, J., Turkenburg, J. P., Gilbert, H. J. & Davies, G. J., 1 Jan 2015, In: Acta Crystallographica. Section D, Biological Crystallography. D71, p. 408-415 8 p.Research output: Contribution to journal › Article › peer-review
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2014
A complex gene locus enables xyloglucan utilization in the model saprophyte Cellvibrio japonicus
Larsbrink, J., Thompson, A. J., Lundqvist, M., Gardner, J. G., Davies, G. J. & Brumer, H., 1 Oct 2014, In: Molecular Microbiology. 94, 2, p. 418-433 16 p.Research output: Contribution to journal › Article › peer-review
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Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate
Williams, R. J., Iglesias-Fernández, J., Stepper, J., Jackson, A., Thompson, A. J., Lowe, E. C., White, J. M., Gilbert, H. J., Rovira, C., Davies, G. J. & Williams, S. J., 20 Jan 2014, In: Angewandte Chemie International Edition. 53, 4, p. 1087-1091 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Dissecting conformational contributions to glycosidase catalysis and inhibition
Speciale, G., Thompson, A. J., Davies, G. J. & Williams, S. J., Oct 2014, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 28, 1, p. 1-13 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2012
Fleetamine (3-O-alpha-D-glucopyranosyl-swainsonine): the synthesis of a hypothetical inhibitor of endo-alpha-mannosidase
Quach, T., Tsegay, S., Thompson, A. J., Kukushkin, N. V., Alonzi, D. S., Butters, T. D., Davies, G. J. & Williams, S. J., 15 Jul 2012, In: TETRAHEDRON-ASYMMETRY. 23, 13, p. 992-997 6 p.Research output: Contribution to journal › Article › peer-review
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Structural and mechanistic insight into N-glycan processing by endo-alpha-mannosidase
Thompson, A. J., Williams, R. J., Hakki, Z., Alonzi, D. S., Wennekes, T., Gloster, T. M., Songsrirote, K., Thomas-Oates, J. E., Wrodnigg, T. M., Spreitz, J., Stuetz, A. E., Butters, T. D., Williams, S. J. & Davies, G. J., 17 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 781-786 6 p.Research output: Contribution to journal › Article › peer-review
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Structure of the catalytic core module of the Chaetomium thermophilum family GH6 cellobiohydrolase Cel6A
Thompson, A. J., Heu, T., Shaghasi, T., Benyamino, R., Jones, A., Friis, E. P., Wilson, K. S. & Davies, G. J., Aug 2012, In: Acta Crystallographica. Section D, Biological Crystallography. 68, 8, p. 875-882 8 p.Research output: Contribution to journal › Article › peer-review
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The Reaction Coordinate of a Bacterial GH47 α-Mannosidase: A Combined Quantum Mechanical and Structural Approach
Thompson, A. J., Dabin, J., Iglesias-Fernandez, J., Ardevol, A., Dinev, Z., Williams, S. J., Bande, O., Siriwardena, A., Moreland, C., Hu, T.-C., Smith, D. K., Gilbert, H. J., Rovira, C. & Davies, G. J., 29 Oct 2012, In: Angewandte Chemie International Edition. 51, 44, p. 10997-11001 5 p.Research output: Contribution to journal › Article › peer-review
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2010
Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont
Zhu, Y., Suits, M. D. L., Thompson, A. J., Chavan, S., Dinev, Z., Dumon, C., Smith, N., Moremen, K. W., Xiang, Y., Siriwardena, A., Williams, S. J., Gilbert, H. J. & Davies, G. J., Feb 2010, In: NATURE CHEMICAL BIOLOGY. 6, 2, p. 125-132 8 p.Research output: Contribution to journal › Article › peer-review
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2009
Metal-binding loop length and not sequence dictates structure
Sato, K., Li, C., Salard, I., Thompson, A. J., Banfield, M. J. & Dennison, C., 7 Apr 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 14, p. 5616-5621 6 p.Research output: Contribution to journal › Article › peer-review