Charles John Nash Lacey

Search results

• 2024

  Development of a Core Outcome Measure Instrument; "LeishCOM_LCL", for Localised Cutaneous Leishmaniasis

  Ranasinghe, S., Senarathne, S., Somaratne, V., Lacey, C. J. N., Jayakody, S., Wickramasinghe, A., Kahawita, I., Goto, H., Chatterjee, M., Lindoso, J. A. L., Parkash, V., Chaudhuri, S. J., Wickremasinghe, R., Das, N. K., Kaye, P. M. & Layton, A. M., 29 Aug 2024, In: PLOS NEGLECTED TROPICAL DISEASES. 18, 8, 18 p., e0012393.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis

  Parkash, V., Ashwin, H., Dey, S., Sadlova, J., Vojtkova, B., Van Bocxlaer, K., Wiggins, R., Thompson, D., Dey, N. S., Jaffe, C. L., Schwartz, E., Volf, P., Lacey, C. J. N., Layton, A. M. & Kaye, P. M., 2 Aug 2024, (E-pub ahead of print) In: Nature Medicine. 24 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  A clinical study to optimise a sand fly biting protocol for use in a controlled human infection model of cutaneous leishmaniasis (the FLYBITE study)

  Parkash, V., Ashwin, H., Sadlova, J., Vojtkova, B., Jones, G. L., Martin, N., Greensted, E., Allgar, V., Kamhawi, S., Valenzuela, J. G., Layton, A. M., Jaffe, C. L., Volf, P., Kaye, P. M. & Lacey, C. J. N., 30 Jun 2021, In: Wellcome Open Research. 6, 23 p., 168.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Assessing public perception of a sand fly biting study on the pathway to a controlled human infection model for cutaneous leishmaniasis

  Parkash, V., Jones, G., Martin, N., Steigmann, M., Greensted, E., Kaye, P., Layton, A. M. & Lacey, C. J., 30 May 2021, In: Research involvement and engagement. 7, 1, 12 p., 33.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Characterization of a new Leishmania major strain for use in a controlled human infection model

  Ashwin, H., Sadlova, J., Vojtkova, B., Becvar, T., Lypaczewski, P., Schwartz, E., Greensted, E., Van Bocxlaer, K., Pasin, M., Lipinski, K. S., Parkash, V., Matlashewski, G., Layton, A. M., Lacey, C. J. N., Jaffe, C. L., Volf, P. & Kaye, P., 11 Jan 2021, In: Nature Communications. 12, 1, p. 215 11 p., 215.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Overcoming roadblocks in the development of vaccines for leishmaniasis

  Kaye, P. M., Mohan, S., Mantel, C., Malhame, M., Revill, P., Le Rutte, E., Parkash, V., Layton, A. M., Lacey, C. J. N. & Malvolti, S., 2 Nov 2021, In: Expert Review of Vaccines. 20, 11, p. 1419-1430

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Safety and immunogenicity of ChAd63-KH vaccine in post-kala-azar dermal leishmaniasis patients in Sudan

  Younis, B. M., Osman, M., Khalil, E. A. G., Santoro, F., Furini, S., Wiggins, R., Keding, A., Carraro, M., Musa, A. E. A., Abdarahaman, M. A. A., Mandefield, L., Bland, M., Aebischer, T., Gabe, R., Layton, A. M., Lacey, C. J. N., Kaye, P. M. & Musa, A. M., 7 Jul 2021, In: Molecular therapy. 29, 7, p. 2366-2377 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Vaccines against leishmaniasis: using controlled human infection models to accelerate development

  Parkash, V., Kaye, P. M., Layton, A. M. & Lacey, C. J., 1 Nov 2021, In: Expert Review of Vaccines. 20, 11, p. 1407-1418 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  B-cell Zone Reticular Cell Microenvironments Shape CXCL13 Gradient Formation

  Coles, M. C., O'Toole, P. J., Lacey, C. J. N., Cosgrove, J., Novkovic, M., Albrecht, S., Zhou, Z., Pikor, N. B., Onder, L., Morbe, U., Cupovic, J., Miller, H., Alden, K. J., Thuery, A. L. M. I., Pinter, R., Jarrett, S., Taylor, E., Venetz, D., Heller, M., Uguccioni, M., & 11 othersLegler, D. F., Coatesworth, A., Polak, W. G., Cupedo, T., Manoury, B., Thelen, M., Stein, J. V., Wolf, M., Leake, M. C., Timmis, J. & Ludewig, B., 22 Jul 2020, In: Nature Communications. 11, 16 p., 3677.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• High incidence of Hepatitis C infection observed in the PROUD study of HIV pre-exposure prophylaxis

  Desai, M., White, E., Vora, N., Gilson, R., Lacey, C. J. N., Gafos, M., Clarke, A., Sullivan, A., White, D., Fox, J., Piontkowsky, D., McCormack, S. & Dunn, D. T., 3 Apr 2020, (E-pub ahead of print) In: Journal of Viral Hepatitis. 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  Chapter 10: Low-risk human papillomavirus: genital warts, cancer and respiratory papillomatosis

  Lacey, C. J. N., Guimera, N. & Garland, S. M., 15 Nov 2019, Human Papillomavirus: Proving and Using a Viral Cause for Cancer. Jenkins, D. & Bosch, F. X. (eds.). Academic Press, p. 165-178

  Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

• HPV vaccination in HIV infection

  Lacey, C. J. N., 24 Jun 2019, (Accepted/In press) In: Papillomavirus Reseacrh. 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Bioresource of Cervical Tissue Explants from Healthy Women

  Fox, J. M., Wiggins, R. & Lacey, C. J. N., 18 Sept 2018, In: Open Journal of Bioresources. 5, 4 p., 11.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Hepatitis B vaccination induces mucosal antibody responses in the female genital tract, indicating potential mechanisms of protection against infection

  Simpson, S. J., Wiggins, R., Fox, J. M., Mthethwa, J., Cai, C. & Lacey, C. J. N., 16 Nov 2018, (E-pub ahead of print) In: Sexually transmitted diseases.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Human papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in treatment and prevention of recurrence of anogenital warts (HIPvac trial)

  Murray, M. L., Meadows, J., Dore, C. J., Copas, A., Haddow, L. J., Lacey, C. J. N., Jit, M., Soldan, K., Bennett, K., Tetlow, M., Nathan, M. & Gilson, R., 6 Nov 2018, In: BMC Medical Research Methodology. 18, 125, 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

  Osman, M., Mistry, A., Keding, A., Gabe, R., Cook, E., Forrester, S., Wiggins, R., Di Marco, S., Colloca, S., Siani, L., Cortese, R., Smith, D. F., Aebischer, T., Kaye, P. M. & Lacey, C. J., 12 May 2017, In: PLOS NEGLECTED TROPICAL DISEASES. 11, 5, 24 p., e0005527.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  An analysis of baseline data from the PROUD study: an open-label randomised trial of pre-exposure prophylaxis

  PROUD Study Group, 24 Mar 2016, In: Trials. 17, 11 p., 163 (2016).

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study.

  Cosgrove, C. A., Lacey, C. J. N., Cope, A., Bartolf, A., Morris, G. C., Yan, C., Baden, S., Cole, T., Carter, D., Brodnicki, L., Shen, X., Joseph, S., DeRosa, S. C., Peng, L., Yu, X., Ferrari, G., Seaman, M., Montefiori, D. C., Frahm, N., Tomaras, G. D., & 3 othersStöhr, W., McCormack, S. & Shattock, R. J., 9 May 2016, In: PLosOne. 11, 5, 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial

  McCormack, S., Dunn, D. T., Desai, M., Dolling, D. I., Gafos, M., Gilson, R., Sullivan, A. K., Clarke, A., Reeves, I., Schembri, G., Mackie, N., Bowman, C., Lacey, C. J., Apea, V., Brady, M., Fox, J., Taylor, S., Antonucci, S., Khoo, S. H., Rooney, J., & 7 othersNardone, A., Fisher, M., McOwan, A., Phillips, A. N., Johnson, A. M., Gazzard, B. & Gill, O. N., 2 Jan 2016, In: The Lancet. 387, 10013, p. 53-60 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Recombinant polymorphic membrane protein D in combination with a novel, second-generation lipid adjuvant protects against intra-vaginal Chlamydia trachomatis infection in mice

  Kaye, P., Lacey, C. J. N., Paes, W. N. W., Brzozowski, A. M., Bland, J. M., Brown, N., Reed, S., Carter, D. & Cole, R., 29 Jul 2016, In: Vaccine. 34, 35, p. 4123-4131 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Two cases of possible transmitted drug-resistant HIV: likely HIV superinfection and unmasking of pre-existing resistance

  Martin, F., Lee, J., Thomson, E., Tarrant, N., Hale, A. & Lacey, C. J., 1 Jan 2016, In: International journal of STD & AIDS. 27, 1, p. 66-69 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2014

  Cervico-vaginal immunoglobulin g levels increase post-ovulation independently of neutrophils

  Schaefer, K., Brown, N., Kaye, P. M. & Lacey, C. J., 5 Dec 2014, In: PLoS ONE. 9, 12, 20 p., e114824.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• MABGEL 1: First Phase 1 Trial of the Anti-HIV-1 Monoclonal Antibodies 2F5, 4E10 and 2G12 as a Vaginal Microbicide

  Morris, G. C., Wiggins, R. C., Woodhall, S. C., Bland, J. M., Taylor, C. R., Jespers, V., Vcelar, B. A. & Lacey, C. J., 29 Dec 2014, In: PLoS ONE. 9, 12, 26 p., e116153.

  Research output: Contribution to journal › Article › peer-review
• 2012

  2012 European guideline for the management of anogenital warts

  Lacey, C. J. N., Woodhall, S. C., Wikstrom, A. & Ross, J., 2012, In: Journal of the European Academy of Dermatology and Venereology : JEADV.

  Research output: Contribution to journal › Article › peer-review

• EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease

  Arbyn, M., Sanjosé, S. D., Saraiya, M., Sideri, M., Palefsky, J., Lacey, C., Gillison, M., Bruni, L., Ronco, G., Wentzensen, N., Brotherton, J., Qiao, Y-L., Denny, L., Bornstein, J., Abramowitz, L., Giuliano, A., Tommasino, M. & Monsonego, J., 1 Nov 2012, In: International Journal of Cancer. 131, 9, p. 1969-1982 14 p.

  Research output: Contribution to journal › Article › peer-review

• Frequency and risk factors for prevalent, incident, and persistent genital carcinogenic human papillomavirus infection in sexually active women: community based cohort study

  Oakeshott, P., Aghaizu, A., Reid, F., Howell-Jones, R., Hay, P. E., Sadiq, S. T., Lacey, C. J., Beddows, S., Soldan, K. & Kerrigan, P., 2012, In: BMJ. 344, p. e4168

  Research output: Contribution to journal › Article › peer-review

• 2011

  National Research Networks and their relation to STI and HIV research

  Morris, G. C. & Lacey, C. J. N., Aug 2011, In: Sexually Transmitted Infections. 87, 5, p. 364-365 2 p.

  Research output: Contribution to journal › Editorial › peer-review

• Phase I randomised clinical trial of an HIV-1(CN54), clade C, trimeric envelope vaccine candidate delivered vaginally

  Lewis, D. J., Fraser, C. A., Mahmoud, A. N., Wiggins, R. C., Woodrow, M., Cope, A., Cai, C., Giemza, R., Jeffs, S. A., Manoussaka, M., Cole, T., Cranage, M. P., Shattock, R. J. & Lacey, C. J., 30 Sept 2011, In: PLoS ONE. 6, 9, p. e25165 e25165.

  Research output: Contribution to journal › Article › peer-review

• Promising control of genital warts: but is elimination possible?

  Lacey, C. J. N. & Garnett, G. P., Jan 2011, In: Lancet Infectious Diseases. 11, 1, p. 4-6 3 p.

  Research output: Contribution to journal › Article › peer-review

• The impact of genital warts: loss of quality of life and cost of treatment in eight sexual health clinics in the UK

  Woodhall, S. C., Jit, M., Soldan, K., Kinghorn, G., Gilson, R., Nathan, M., Ross, J. D., Lacey, C. J. N. & QOLIGEN Study Grp, Oct 2011, In: Sexually Transmitted Infections. 87, 6, p. 458-463 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  A randomised placebo-controlled safety and acceptability trial of PRO 2000 vaginal microbicide gel in sexually active women in Uganda

  Kamali, A., Byomire, H., Muwonge, C., Bakobaki, J., Rutterford, C., Okong, P., Profy, A., Byaruhanga, R., Namukwaya, S., McCormack, S., Grosskurth, H., Nunn, A. J. & Lacey, C. J. N., Jun 2010, In: Sexually Transmitted Infections. 86, 3, p. 222-226 5 p.

  Research output: Contribution to journal › Article › peer-review

• Microbicides and HIV prevention: lessons from the past, looking to the future

  Morris, G. C. & Lacey, C. J. N., Feb 2010, In: Current opinion in infectious diseases. 23, 1, p. 57-63 7 p.

  Research output: Contribution to journal › Article › peer-review

• PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial

  McCormack, S., Ramjee, G., Kamali, A., Rees, H., Crook, A. M., Gafos, M., Jentsch, U., Pool, R., Chisembele, M., Kapiga, S., Mutemwa, R., Vallely, A., Palanee, T., Sookrajh, Y., Lacey, C. J., Darbyshire, J., Grosskurth, H., Profy, A., Nunn, A., Hayes, R., & 1 othersWeber, J., 16 Oct 2010, In: Lancet. 376, 9749, p. 1329-1337 9 p.

  Research output: Contribution to journal › Article › peer-review

• Repeat infection with Chlamydia trachomatis after treatment: a systematic review

  Uddin, J., Woodhall, S. C., Peters, L., Wiggins, R., Hughes, G. & Lacey, C. J. N., Apr 2010, In: Hiv medicine. 11, p. 84-85 2 p.

  Research output: Contribution to journal › Article › peer-review

• Unacceptable side-effects associated with a hyperosmolar vaginal microbicide in a phase 1 trial

  Lacey, C. J., Woodhall, S., Qi, Z., Sawant, S., Cowen, M., McCormack, S. & Jiang, S., Oct 2010, In: International journal of STD & AIDS. 21, 10, p. 714-7 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  A multicentre, randomised, double-blind, placebo controlled study of cryotherapy versus cryotherapy and podophyllotoxin cream as treatment for external anogenital warts

  Gilson, R. J. C., Ross, J., Maw, R., Rowen, D., Sonnex, C. & Lacey, C. J. N., Dec 2009, In: Sexually Transmitted Infections. 85, 7, p. 514-519 6 p.

  Research output: Contribution to journal › Article › peer-review

• Cost of Treatment and QALYs Lost Due to Genital Warts: Data for the Economic Evaluation of HPV Vaccines in the United Kingdom

  Woodhall, S. C., Jit, M., Cai, C., Ramsey, T., Zia, S., Crouch, S., Birks, Y., Newton, R., Edmunds, W. J. & Lacey, C. J. N., Aug 2009, In: Sexually transmitted diseases. 36, 8, p. 515-521 7 p.

  Research output: Contribution to journal › Article › peer-review

• Phase I safety and immunogenicity randomised controlled trial of a vaginal gp140 vaccine

  Lewis, D. J., Lacey, C. J., Jeffs, S., Cole, T., Fraser, C., Wiggins, R., Woodrow, M., Cope, A., Cai, C., Giemza, E., Mahmhoud, A., Katinger, D., Cranage, M. & Shattock, R., 2009, In: Retrovirology. 6, p. - 1 p., P194.

  Research output: Contribution to journal › Article › peer-review

• Re: "Enhancement of HIV Infection by Cellulose Sulfate," by Tao et al.

  McCormack, S., Taylor, D., Richardson, B., Darbyshire, J., Sattentau, Q., Karim, Q. A., Karim, S. S. A., Kharsany, A., Lacey, C., Nunn, A. & Weber, J., 1 Mar 2009, In: AIDS research and human retroviruses. 25, 3, p. 373-373 1 p.

  Research output: Contribution to journal › Letter › peer-review

• Suitability of Simple Human Immunodeficiency Virus Rapid Tests in Clinical Trials in Community-Based Clinic Settings

  Everett, D. B., Baisley, K., Changalucha, J., Vallely, A., Watson-Jones, D., Cook, C., Knight, L., Ross, D. A., Mugeye, K., McCormack, S., Lacey, C. J., Jentsch, U. & Hayes, R. J., Apr 2009, In: Journal of clinical microbiology. 47, 4, p. 1058-1062 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  British HIV Association, BASHH and FSRH guidelines for the management of the sexual and reproductive health of people living with HIV infection 2008

  Fakoya, A., Lamba, H., Mackie, N., Nandwani, R., Brown, A., Bernard, E., Gilling-Smith, C., Lacey, C., Sherr, L., Claydon, P., Wallage, S. & Gazzard, B., 2008, In: Hiv medicine. 9, 9, p. 681-720 40 p.

  Research output: Contribution to journal › Article › peer-review

• Estimation of the impact of genital warts on health-related quality of life

  Woodhall, S., Ramsey, T., Cai, C., Crouch, S., Jit, M., Birks, Y., Edmunds, W. J., Newton, R. & Lacey, C. J. N., 1 Jun 2008, In: Sexually Transmitted Infections. 84, 3, p. 161-166 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Burden and management of non-cancerous HPV-related conditions: HPV-6/11 disease

  Lacey, C. J. N., Lowndes, C. M. & Shah, K. V., 31 Aug 2006, In: Vaccine. 24, p. 35-41 7 p.

  Research output: Contribution to journal › Article › peer-review

• Direct measurement of in-vivo vaginal microbicide levels of PRO 2000 achieved in a human safety study

  Lacey, C. J. N., Wright, A., Weber, J. N. & Profy, A. T., Apr 2006, In: Aids. 20, 7, p. 1027-1030 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers

  McCormack, S., Jespers, V., Low-Beer, N., Gabe, R., Kaganson, N., Chapman, A., Nunn, A., Lacey, C. & Van Damme, L., 2005, In: Sexually transmitted diseases. 32, 12, p. 765-70 6 p.

  Research output: Contribution to journal › Article › peer-review

• A randomized controlled safety and acceptability trial of dextrin sulphate vaginal microbicide gel in sexually active women in Uganda

  Bakobaki, J. M., Lacey, C. J., Bukenya, M. I., Nunn, A. J., McCormack, S., Byaruhanga, R. N., Okong, P., Namukwaya, S. W., Grosskurth, H. & Whitworth, J. A. G., 2 Dec 2005, In: Aids. 19, 18, p. 2149-2156 7 p.

  Research output: Contribution to journal › Article › peer-review

• Characteristics of autoimmune thyroid disease occurring as a late complication of immune reconstitution in patients with advanced human immunodeficiency virus (HIV) disease

  Chen, F., Day, S. L., Metcalfe, R. A., Sethi, G., Kapembwa, M. S., Brook, M. G., Churchill, D., de Ruiter, A., Robinson, S., Lacey, C. J. & Weetman, A. P., Mar 2005, In: Medicine. 84, 2, p. 98-106 9 p.

  Research output: Contribution to journal › Article › peer-review

• Randomized controlled trial of an adjuvanted human papillomavirus (HPV) type 6 L2E7 vaccine: infection of external anogenital warts with multiple HPV types and failure of therapeutic vaccination

  Vandepapeliere, P., Barrasso, R., Meijer, C. J. L. M., Walboomers, J. M. M., Wettendorff, M., Stanberry, L. R. & Lacey, C. J. N., 2005, In: The Journal of Infectious Diseases. 192, 12, p. 2099-2107 8 p.

  Research output: Contribution to journal › Article › peer-review

• The interrelation of demographic and geospatial risk factors between four common sexually transmitted diseases

  Monteiro, E. F., Lacey, C. J. N. & Merrick, D., 2005, In: Sexually Transmitted Infections. 81, 1, p. 41-6 6 p.

  Research output: Contribution to journal › Article › peer-review

• Therapy for genital human papillomavirus-related disease

  Lacey, C. J. N., Mar 2005, In: Journal of clinical virology. 32, p. S82-S90 9 p.

  Research output: Contribution to journal › Literature review › peer-review