Chris Elliott – Network — York Research Database

Accepting PhD Students

PhD projects

The most common genetic cause of Parkinson’s disease (PD) is a mutation in the LRRK2 gene, G2019S. We have developed a new fly model, which exploits the homology of between fly and human. The proboscis extension response (PER) shows a marked decline in performance with G2019S expression, but not with other mutations in LRRK2. This loss of function is most marked when G2019S is expressed in the dopaminergic neurons. It can be rescued by drug application. We will use the extensive fly genetic toolbox to test the function of G2019S as a dominant negative kinase mutation, and to screen candidate genes which slow degeneration. We will support this by using drug application (L-DOPA, kinase inhibitors, glycolytic upregulation). This will provide a new view of LRRK2 neurophysiology in the whole organism, in a way that has not been possible in mouse models.

Faculty of Sciences

University of York

Organisational unit: Faculty

68 shared research output

University of York

Organisational unit: University

68 shared research output

Psychology

Faculty of Sciences

Organisational unit: Academic Department

8 shared research output

York Neuroimaging Centre

Organisational unit: Research Group

4 shared research output

Physics

Faculty of Sciences

Organisational unit: Academic Department

1 shared research output

Electronic Engineering

Faculty of Sciences

Organisational unit: Academic Department

1 shared research output

The Hull York Medical School

Faculty of Sciences

Organisational unit: Academic Department

1 shared research output

Computer Science

Faculty of Sciences

Organisational unit: Academic Department

1 shared research output

Department of Biology, University of York York, UK.

External organisation: Unknown

4 shared research output

Univ York, Dept Biol

External organisation: External collaborations

2 shared research output

bot University of Minnesota , Department of Lab Medicine and Pathology , Minneapolis , MN , USA.

External organisation: Unknown

1 shared research output

art Technische Universität München, II. Medizinische Klinik, Klinikum rechts der Isar , Munich , Germany.

External organisation: Unknown

1 shared research output

ahd Neurogenomiks , Neurosciences Department , Faculty of Medicine and Odontology, University of Basque , Leioa , Spain.

External organisation: Unknown

1 shared research output

byh University of Vienna , Department of Chromosome Biology , Max F. Perutz Laboratories , Vienna , Austria.

External organisation: Unknown

1 shared research output

Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country, Leioa, Spain

External organisation: External collaborations

1 shared research output

dc CEA/DSV/12;BM, INSERM U1169, Gene Therapy for Neurodegenerative Diseases , Fontenay-aux-Roses Cedex , France.

External organisation: Unknown

1 shared research output

td Institute of Biomedical Investigation (INIBIC), Aging, Inflamation and Regenerative Medicine , Coruña , Spain.

External organisation: Unknown

1 shared research output

Stanford University, Stanford, CA, USA.

External organisation: Unknown

1 shared research output

pi Hebrew University of Jerusalem, Faculty of Agriculture, Food, and Environment, Biochemistry and Food Science , Rehovot , Israel.

External organisation: Unknown

1 shared research output

agb National Research Council (CNR), Institute of Translational Pharmacology (IFT) , Rome , Italy.

External organisation: Unknown

1 shared research output

bxe University of Toronto, Molecular Structure and Function, Research Institute, Hospital for Sick Children , Toronto, ON , Canada.

External organisation: Unknown

1 shared research output

MRC Laboratory of Molecular Biology, United Kingdom.

External organisation: Unknown

1 shared research output

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External organisation: External collaborations

1 shared research output

afh National Institute on Aging, National Institutes of Health, Biomedical Research Center, RNA Regulation Section, Laboratory of Genetics , Baltimore , MD , USA.

External organisation: Unknown

1 shared research output

beo University of Buenos Aires, Institute of Biochemistry and Biophysics, School of Pharmacy and Biochemistry , Buenos Aires , Argentina.

External organisation: Unknown

1 shared research output

ble University of Iowa , Department of Internal Medicine , Iowa City , IA , USA.

External organisation: Unknown

1 shared research output

sw Institut Pasteur , Department of Immunology , Paris , France.

External organisation: Unknown

1 shared research output

uo IRCCS-Istituto di Ricerche Farmacologiche Mario Negri , Department of Neuroscience , Milan , Italy.

External organisation: Unknown

1 shared research output

School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh EH14 4AS.

External organisation: Unknown

1 shared research output

Department of Electronics, University of York, Heslington, York Y010 5DD. [email protected].

External organisation: Unknown

1 shared research output

Neurology Department, Leeds Teaching Hospitals NHS Trust, Leeds LS1 3EX.

External organisation: Unknown

1 shared research output

auo Tokyo Medical University , Department of Biochemistry , Tokyo , Japan.

External organisation: Unknown

1 shared research output

Department of Computer Science, University of York, Heslington, York Y010 5GW.

External organisation: Unknown

1 shared research output

adi MRC Harwell, Mammalian Genetics Unit , Oxfordshire , UK.

External organisation: Unknown

1 shared research output

ati The Wistar Institute , Philadelphia , PA , USA.

External organisation: Unknown

1 shared research output

byx University of York , Department of Biology , Heslington, York , UK.

External organisation: Unknown

1 shared research output

Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

External organisation: External collaborations

1 shared research output

zx Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center , Torrance , CA.

External organisation: Unknown

1 shared research output

bia University of Colorado Denver, Skaggs School of Pharmacy and Pharmaceutical Sciences , Department of Pharmaceutical Sciences , Aurora , CO , USA.

External organisation: Unknown

1 shared research output

bjm University of Florida , Department of Applied Physiology and Kinesiology , Gainesville , FL , USA.

External organisation: Unknown

1 shared research output

Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA

External organisation: External collaborations

1 shared research output

bwj University of Texas, Medical Branch , Department of Pathology , Galveston , TX , USA.

External organisation: Unknown

1 shared research output

baq University College London , Department of Clinical Neurosciences , London , UK.

External organisation: Unknown

1 shared research output

bap University College Dublin, School of Chemical and Bioprocess Engineering , Dublin , Ireland.

External organisation: Unknown

1 shared research output

adf Icahn School of Medicine at Mount Sinai, Division of Hematology and Oncology , Department of Medicine , New York , NY , USA.

External organisation: Unknown

1 shared research output

byw University of York, Centre for Immunology and Infection , Department of Biology , Hull York Medical School , York , UK.

External organisation: Unknown

1 shared research output

University of York.

External organisation: Unknown

1 shared research output

dx Centro de Biologia Molecular "Severo Ochoa" (UAM/CSIC), Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) , Madrid , Spain.

External organisation: Unknown

1 shared research output

Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN.

External organisation: Unknown

1 shared research output

pf Harvard University , Department of Statistics , Cambridge , MA , USA.

External organisation: Unknown

1 shared research output

brf University of Palermo , Dipartimento di Scienze e Tecnologie Biologiche , Chimiche e Farmaceutiche (STEBICEF) , Palermo , Italy.

External organisation: Unknown

1 shared research output

atp Thomas Jefferson University , Department of Biochemistry and Molecular Biology , Philadelphia , PA , USA.

External organisation: Unknown

1 shared research output

ccw Zhejiang University, Institute of Insect Science , Hangzhou , China.

External organisation: Unknown

1 shared research output

University of York, United Kingdom;

External organisation: Unknown

1 shared research output

yn KU Leuven, Laboratory for Cell Death Research and Therapy , Department of Cellular and Molecular Medicine , Campus Gasthuisberg , Leuven , Belgium.

External organisation: Unknown

1 shared research output

Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA

External organisation: External collaborations

1 shared research output

afp National Institutes of Health, National Heart, Lung, and Blood Institute , Bethesda , MD , USA.

External organisation: Unknown

1 shared research output

be Beatson Institute for Cancer Research, University of Glasgow , Glasgow , UK.

External organisation: Unknown

1 shared research output

ape Sidra Medical and Research Centre , Doha , Qatar.

External organisation: Unknown

1 shared research output

my Georgetown University, Lombardi Comprehensive Cancer Center , Departments of Oncology and Pathology , Washington, DC , USA.

External organisation: Unknown

1 shared research output

Dept Biol

External organisation: External collaborations

1 shared research output

bog University of Michigan, Life Sciences Institute , Ann Arbor , MI , USA.

External organisation: Unknown

1 shared research output

awt Universidad de Oviedo , Departamento de Biología Funcional , Oviedo , Spain.

External organisation: Unknown

1 shared research output

bo Ben-Gurion University of the Negev and Mental Health Center , Department of Clinical Biochemistry and Pharmacology and Psychiatry Research Unit , Beer-Sheva , Israel.

External organisation: Unknown

1 shared research output

Department of Biology, University of York, Heslington, York Y010 5DD.

External organisation: Unknown

1 shared research output

tx Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) , Departamento de Biotecnología , Madrid , Spain.

External organisation: Unknown

1 shared research output

Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External organisation: External collaborations

1 shared research output

bgc University of California San Francisco , Department of Neurological Surgery , San Francisco , CA , USA.

External organisation: Unknown

1 shared research output

Lundbeck A/S

External organisation: External collaborations

1 shared research output

bqf University of Occupational and Environmental Health School of Medicine , Department of Neurology , Fukuoka , Japan.

External organisation: Unknown

1 shared research output

azx Université Paris Diderot, Sorbonne Paris Cité, Centre Epigénétique et Destin Cellulaire, UMR 7216, Centre National de la Recherche Scientifique CNRS , Paris , France.

External organisation: Unknown

1 shared research output

1. School of Life Sciences, University of Warwick, Coventry, UK.

External organisation: Unknown

1 shared research output

fv Chinese Academy of Sciences, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology , Beijing , China.

External organisation: Unknown

1 shared research output

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA

External organisation: External collaborations

1 shared research output

gx Cleveland Clinic , Department of Cancer Biology , Cleveland , OH , USA.

External organisation: Unknown

1 shared research output

atb The Scripps Research Institute , Department of Immunology and Microbial Science , La Jolla , CA , USA.

External organisation: Unknown

1 shared research output

bk Beijing Jishuitan Hospital , Department of Molecular Orthopedics , Beijing Institute of Traumatology and Orthopedics , Beijing , China.

External organisation: Unknown

1 shared research output