Chris Elliott – Network — York Research Database

Accepting PhD Students

PhD projects

The most common genetic cause of Parkinson’s disease (PD) is a mutation in the LRRK2 gene, G2019S. We have developed a new fly model, which exploits the homology of between fly and human. The proboscis extension response (PER) shows a marked decline in performance with G2019S expression, but not with other mutations in LRRK2. This loss of function is most marked when G2019S is expressed in the dopaminergic neurons. It can be rescued by drug application. We will use the extensive fly genetic toolbox to test the function of G2019S as a dominant negative kinase mutation, and to screen candidate genes which slow degeneration. We will support this by using drug application (L-DOPA, kinase inhibitors, glycolytic upregulation). This will provide a new view of LRRK2 neurophysiology in the whole organism, in a way that has not been possible in mouse models.

Alex Wade

alex.wadeyork.acuk

Psychology - Professor, Theme Lead-York Biomedical Research Inst

Person: Academic

8 shared research output

John Clifford Sparrow

jcs1york.acuk

Biology - Professor, Former employee

Person: Academic

8 shared research output

Sean Sweeney

sean.sweeneyyork.acuk

Biology - Professor

Person: Academic

8 shared research output

Sangeeta Chawla

sangeeta.chawlayork.acuk

Biology - Senior Lecturer

Person: Academic

6 shared research output

Ryan John Hatcher West

rw531york.acuk

Biology - Postdoctoral Research Associate, Former employee

Person: Research

5 shared research output

Farinaz Afsari

fa576york.acuk

Biology - Postdoctoral Research Associate, Former employee

Person: Research

3 shared research output

Marc Mason Himmelberg

Psychology - Former employee

Person: PhD

2 shared research output

Samantha Jane Hindle

sjh506york.acuk

Biology - Research Associate, Former employee

Person: Research

2 shared research output

Christopher Ugbode

cu525york.acuk

Biology - Centre for Future Health Research Fellow, Former employee

Person: Research

2 shared research output

Jack Munns

Biology - Former employee

Person: PhD

2 shared research output

Gareth John Owen Evans

gareth.evansyork.acuk

Biology - Senior Lecturer

Person: Academic

2 shared research output

Michael Adam Lones

mal503york.acuk

Electronic Engineering - Lecturer, Former employee

Person: Academic

1 shared research output

Laurence George Wilson

laurence.wilsonyork.acuk

Physics - Senior Lecturer

Person: Academic

1 shared research output

Richard John Maguire

rjm503york.acuk

Biology - Research Associate, Former employee

Person: Research

1 shared research output

Daniel Hart Baker

db900york.acuk

Psychology - Professor, Former employee

Person: Academic

1 shared research output

Betsy Pownall

betsy.pownallyork.acuk

Biology - Professor

Person: Academic

1 shared research output

Paul Christopher Michael Fogg

paul.foggyork.acuk

Biology - Sir Henry Dale Senior Research Fellow

Person: Research

1 shared research output

Stephen Leslie Smith

stephen.smithyork.acuk

Physics - Head of School of PET

Person: Academic

1 shared research output

Jeremy Charles Mottram

jeremy.mottramyork.acuk

Biology - Professor in Pathogen Biology, Director of the YBRI

Person: Academic

1 shared research output

A Vehovszky

External person

15 shared research output

C. Adam Middleton

External person

7 shared research output

G Kemenes

External person

7 shared research output

Alison Fellgett

Department of Biology, University of York York, UK.

External person

4 shared research output

H Szabo

External person

4 shared research output

L Hiripi

External person

3 shared research output

P R Benjamin

External person

3 shared research output

M Alania

External person

2 shared research output

Adam Middleton

External person

2 shared research output

D A Sakharov

External person

2 shared research output

Robin Hiesinger

External person

2 shared research output

Kevin R Leonard

External person

2 shared research output

Holly L. Brunger

External person

2 shared research output

Amy Cording

External person

2 shared research output

Friederike Kohrs

External person

2 shared research output

Belinda Bullard

External person

2 shared research output

Amy Stewart

External person

2 shared research output

M Yeoman

External person

2 shared research output

S Pitt

External person

2 shared research output

M S Yeoman

External person

2 shared research output

Daniel J Klionsky

External person

1 shared research output

Laurence wilson

External person

1 shared research output

Wei Li

External person

1 shared research output

A J Susswein

External person

1 shared research output

Iain M. Robinson

External person

1 shared research output

Henriette Szabo

External person

1 shared research output

Emmanuel T Akporiaye

External person

1 shared research output

Lies Vanden Broeck

External person

1 shared research output

Zhe Han

External person

1 shared research output

H U Kleindienst

External person

1 shared research output

Matt Oswald

External person

1 shared research output

S. T. Sweeney

External person

1 shared research output

Slimane Ait-Si-Ali

External person

1 shared research output

Jennifer Adcott

External person

1 shared research output

A Szucs

External person

1 shared research output

D R Skingsley

External person

1 shared research output

Keita Morohashi

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

Jan Aasly

External person

1 shared research output

Takahiko Akematsu

External person

1 shared research output

Anna Memou

Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

External person

1 shared research output

John S O'Neill

External person

1 shared research output

Cheng-Ting Chien

External person

1 shared research output

Sharon G Adler

External person

1 shared research output

Edoardo M Airoldi

External person

1 shared research output

Wei Li

External person

1 shared research output

Nihal Altan-Bonnet

External person

1 shared research output

Galila Agam

External person

1 shared research output

Tomasz Dobrzycki

External person

1 shared research output

Frieder Schöck

External person

1 shared research output

Iban Ubarretxena-Belandia

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Biofisika Institute (CSIC, UPV/EHU), University of the Basque Country, Leioa, Spain

External person

1 shared research output

N Zumstein

External person

1 shared research output

Maria Agnello

External person

1 shared research output

Kotb Abdelmohsen

External person

1 shared research output

Ying Wang

External person

1 shared research output

Nina Pan

Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

Iraide Alloza

External person

1 shared research output

Bart Dermaut

External person

1 shared research output

Ben Sutcliffe

External person

1 shared research output

Francesca Pei

External person

1 shared research output

Garrick Smith

Lundbeck A/S

External person

1 shared research output

Silvia Alvarez

External person

1 shared research output

Gunnar Bronstad

External person

1 shared research output

Heather Mortiboys

External person

1 shared research output

Linda Partridge

External person

1 shared research output

J. Hirsh

External person

1 shared research output

Christopher E Shaw

External person

1 shared research output

Giuseppina Amadoro

External person

1 shared research output

Nina Kreisköther

External person

1 shared research output

Anthony M Norcia

External person

1 shared research output

Chris Albanese

External person

1 shared research output

Elizabeth Emery

External person

1 shared research output

Shabab B. Hannan

External person

1 shared research output

Yi-Ci Ke

External person

1 shared research output

S. L. Hardie

External person

1 shared research output

Erika Bereczki

External person

1 shared research output

Jessika C. Bridi

External person

1 shared research output

Oliver Bandmann

External person

1 shared research output

Hui Zhang

Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA

External person

1 shared research output

M Ohtani

External person

1 shared research output

E E Voronezhskaya

External person

1 shared research output

Guillermo M Albaiceta

External person

1 shared research output

Rajesh Agarwal

External person

1 shared research output

Dag Aarsland

External person

1 shared research output

Sandro Alves

External person

1 shared research output

Chin-Hsien Lin

External person

1 shared research output

T Andrew

External person

1 shared research output

Rebecca L L McIntosh

External person

1 shared research output

Matthew L Albert

External person

1 shared research output

Patricia V Aguilar

External person

1 shared research output

Hardy Rideout

Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

External person

1 shared research output

Peter J Adhihetty

External person

1 shared research output

Camille Lyle

External person

1 shared research output

K Elekes

External person

1 shared research output

Laura Briggs

Univ York, University of Hull, University of York - UK, Hull York Med Sch, Dept Biol

External person

1 shared research output

Maria Sevdali

External person

1 shared research output

Laszlo Hiripi

External person

1 shared research output

Emma C Lord

External person

1 shared research output

Emad S Alnemri

External person

1 shared research output

Covadonga Alonso

External person

1 shared research output

Zoe N Ludlow

External person

1 shared research output

Akihisa Abe

External person

1 shared research output

Emmanouela Leandrou

Division of Basic Neurosciences, Biomedical Research Foundation of the Academy of Athens, Athens, Greece

External person

1 shared research output

Ammar Al-Chalabi

External person

1 shared research output

Katie Norville

External person

1 shared research output

Manish K Aghi

External person

1 shared research output

Jennifer Harvey

External person

1 shared research output

Hiroaki Adachi

External person

1 shared research output

Md Joynal Abedin

External person

1 shared research output

S Waddington

External person

1 shared research output

L Hernadi

External person

1 shared research output

Xiao-Jia Wang

External person

1 shared research output

Christopher M Adams

External person

1 shared research output

Dickon M Humphrey

External person

1 shared research output

David Jaciuch

External person

1 shared research output

Ming-Ming Zhou

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

Chen Yao

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA

External person

1 shared research output

Adam Schaffner

Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

Hana Algül

External person

1 shared research output

J. A. Hill

External person

1 shared research output

Abraham Acevedo Arozena

External person

1 shared research output

Benjamin Kottler

External person

1 shared research output

Diana Ivanoiu

External person

1 shared research output

Michael H Hastings

External person

1 shared research output

Yoshitsugu Adachi

External person

1 shared research output

Morten Hentzer

Lundbeck A/S

External person

1 shared research output

Rose Tomlins

External person

1 shared research output

O Forman

External person

1 shared research output

Yacob Gomez-Llorente

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

Hagai Abeliovich

External person

1 shared research output

Khosrow Adeli

External person

1 shared research output

Danielle C Diaper

External person

1 shared research output

J F Derry

External person

1 shared research output

Olivia Nippe

External person

1 shared research output

A. Vehovszky

External person

1 shared research output

Meg Stark

External person

1 shared research output

Peter D Adams

External person

1 shared research output

Meg Stark

External person

1 shared research output

Jun-yi Zhu

External person

1 shared research output

Natalia Vereshchagina

Oxford University

External person

1 shared research output

Kenneth Christensen

Lundbeck A/S

External person

1 shared research output

Lee-Yan Sheen

External person

1 shared research output

Agnes Vehovszky

External person

1 shared research output

Saffron K Smith

External person

1 shared research output

Alexander Alexandrovich

External person

1 shared research output

Julio Aguirre-Ghiso

External person

1 shared research output

Á. Vehovszky

External person

1 shared research output

Jesus Aldudo

External person

1 shared research output

Frank Hirth

External person

1 shared research output

Nicolina Clemente

Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA

External person

1 shared research output

Yulong Fu

External person

1 shared research output

Hrvoje Augustin

External person

1 shared research output

Alan Stepto

External person

1 shared research output

Xianting Li

Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

En-Peng Ho

External person

1 shared research output

Mohamed Al-Rubeai

External person

1 shared research output

Julia A Hill

External person

1 shared research output

Pedro M. Domingos

External person

1 shared research output

Katherine Parry

External person

1 shared research output

Frank Hirth

External person

1 shared research output

Maylin Almonte-Beceril

External person

1 shared research output

Diego Albani

External person

1 shared research output

Upendra Nongthomba

External person

1 shared research output

Ann-Christin Krahl

External person

1 shared research output

Shu G. Chen

Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA

External person

1 shared research output

Tobias M. Rasse

External person

1 shared research output

Dario C Altieri

External person

1 shared research output

Griff F J Chatwin

External person

1 shared research output

Patrizia Agostinis

External person

1 shared research output

Alexandru Almasan

External person

1 shared research output

Lianteng Zhi

Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA

External person

1 shared research output

Chunyu Wang

Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York 12180, USA

External person

1 shared research output

Mehrdad Alirezaei

External person

1 shared research output

H J Agricola

External person

1 shared research output

Lydia Alvarez-Erviti

External person

1 shared research output

Laszlo Hernadi

External person

1 shared research output

Shaun Calvert

External person

1 shared research output

Xiao-Jia Wang

External person

1 shared research output

Goncalo M. Pocas

External person

1 shared research output

Patrick Callaerts

External person

1 shared research output

L Karpati

External person

1 shared research output

Charles A. C. Williams

External person

1 shared research output

Xiaoluan Hua

Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

U Nongthomba

External person

1 shared research output

Nicolas Shiaelis

External person

1 shared research output

Thomas R. Jahn

External person

1 shared research output

Nina M. Dräger

External person

1 shared research output

Zhenyu Yue

Department of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029

External person

1 shared research output

Yu-En Lin

External person

1 shared research output

Olivia Nippe

University of York.

External person

1 shared research output