Daniel Paape

Search results

• 2020

  Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

  Paape, D., Prendergast, C. T., Price, H. P., Doehl, J. S. P. & Smith, D. F., 14 Mar 2020, In: Parasites & vectors. 13, 16 p., 132.

  Research output: Contribution to journal › Article › peer-review

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• Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

  Bell, A. S., Yu, Z., Hutton, J. A., Wright, M. H., Brannigan, J. A., Paape, D., Roberts, S. M., Sutherell, C. L., Ritzefeld, M., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 23 Jul 2020, In: JOURNAL OF MEDICINAL CHEMISTRY. 63, 14, p. 7740-7765 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

  Saldivia Concepcion, M. A., Fang, E., Ma, X., Myburgh, E., Brambilla Carnielli Trindade, J., Bower-Lepts, C., Brown, E., Ritchie, R., Lakshminarayana, S. B., Chen, Y.-L., Patra, D., Ornelas, E., Koh, H. X. Y., Williams, S., Supek, F., Paape, D., McCulloch, R., Kaiser, M., Barrett, M. P. & Jiricek, J. & 3 others, Diagana, T. T., Mottram, J. C. & Rao, S. P. S., Oct 2020, In: Nature Microbiology. 5, p. 1207-1216

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

  Wright, M. H., Paape, D., Price, H. P., Smith, D. F. & Tate, E. W., 10 Jun 2016, In: BMC Infectious Diseases. 2, 6, p. 427-441 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

  Rackham, M. D., Yu, Z., Brannigan, J. A., Heal, W. P., Paape, D., Barker, K. V., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 17 Aug 2015, In: MedChemComm. 6, 10, p. 1761-1766 6 p.

  Research output: Contribution to journal › Article › peer-review

• Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani

  Wright, M. H., Paape, D., Storck, E. M., Serwa, R. A., Smith, D. F. & Tate, E. W., 19 Mar 2015, In: Chemistry & Biology. 22, 3, p. 342-54 13 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Structure-based design of potent and selective leishmania N-myristoyltransferase inhibitors

  Hutton, J. A., Goncalves, V., Brannigan, J. A., Paape, D., Wright, M. H., Waugh, T. M., Roberts, S. M., Bell, A. S., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 19 Sept 2014, In: JOURNAL OF MEDICINAL CHEMISTRY. 57, 20, p. 8664-8670 7 p.

  Research output: Contribution to journal › Article › peer-review

• Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

  Paape, D., Bell, A. S., Heal, W. P., Hutton, J. A., Leatherbarrow, R. J., Tate, E. W. & Smith, D. F., 18 Dec 2014, In: PLOS NEGLECTED TROPICAL DISEASES. 8, 12, p. e3363

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2013

  The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

  Price, H. P., Paape, D., Hodgkinson, M. R., Farrant, K., Doehl, J., Stark, M. & Smith, D. F., Nov 2013, In: Molecular Microbiology. n/a, n/a, p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review