Deborah Frances Smith

Search results

• 2020

  Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

  Bell, A. S., Yu, Z., Hutton, J. A., Wright, M. H., Brannigan, J. A., Paape, D., Roberts, S. M., Sutherell, C. L., Ritzefeld, M., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 23 Jul 2020, In: JOURNAL OF MEDICINAL CHEMISTRY. 63, 14, p. 7740-7765 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  A third generation vaccine for human visceral leishmaniasis and post kala azar dermal leishmaniasis: First-in-human trial of ChAd63-KH

  Osman, M., Mistry, A., Keding, A., Gabe, R., Cook, E., Forrester, S., Wiggins, R., Di Marco, S., Colloca, S., Siani, L., Cortese, R., Smith, D. F., Aebischer, T., Kaye, P. M. & Lacey, C. J., 12 May 2017, In: PLOS NEGLECTED TROPICAL DISEASES. 11, 5, 24 p., e0005527.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Leishmania HASP and SHERP Genes are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

  Doehl, J. S. P., Sádlová, J., Aslan, H., Pružinová, K., Metangmo, S., Votýpka, J., Kamhawi, S., Volf, P. & Smith, D. F., 17 Jan 2017, In: PLOS PATHOGENS. 13, 1, p. 1-35 35 p., e1006130.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

  Wright, M. H., Paape, D., Price, H. P., Smith, D. F. & Tate, E. W., 10 Jun 2016, In: BMC Infectious Diseases. 2, 6, p. 427-441 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

  Rackham, M. D., Yu, Z., Brannigan, J. A., Heal, W. P., Paape, D., Barker, K. V., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 17 Aug 2015, In: MedChemComm. 6, 10, p. 1761-1766 6 p.

  Research output: Contribution to journal › Article › peer-review

• Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani

  Wright, M. H., Paape, D., Storck, E. M., Serwa, R. A., Smith, D. F. & Tate, E. W., 19 Mar 2015, In: Chemistry & Biology. 22, 3, p. 342-54 13 p.

  Research output: Contribution to journal › Article › peer-review

• Hybridization in Parasites: Consequences for Adaptive Evolution, Pathogenesis, and Public Health in a Changing World

  King, K. C., Stelkens, R. B., Webster, J. P., Smith, D. F. & Brockhurst, M. A., 3 Sept 2015, In: PLOS PATHOGENS. 11, 9, p. 1-12 12 p., e1005098.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

  Brannigan, J. A., Roberts, S. M., Bell, A. S., Hutton, J. A., Hodgkinson, M. R., Tate, E. W., Leatherbarrow, R. J., Smith, D. F. & Wilkinson, A. J., Jul 2014, In: IUCrJ. 1, 4, p. 250-260 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population

  Rogers, M. B., Downing, T., Smith, B. A., Imamura, H., Sanders, M., Svobodova, M., Volf, P., Berriman, M., Cotton, J. A. & Smith, D. F., 16 Jan 2014, In: PLoS Genetics. 10, 1, e1004092.

  Research output: Contribution to journal › Article › peer-review

• Structure-based design of potent and selective leishmania N-myristoyltransferase inhibitors

  Hutton, J. A., Goncalves, V., Brannigan, J. A., Paape, D., Wright, M. H., Waugh, T. M., Roberts, S. M., Bell, A. S., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 19 Sept 2014, In: JOURNAL OF MEDICINAL CHEMISTRY. 57, 20, p. 8664-8670 7 p.

  Research output: Contribution to journal › Article › peer-review

• Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes

  Paape, D., Bell, A. S., Heal, W. P., Hutton, J. A., Leatherbarrow, R. J., Tate, E. W. & Smith, D. F., 18 Dec 2014, In: PLOS NEGLECTED TROPICAL DISEASES. 8, 12, p. e3363

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2013

  Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei

  Hemsworth, G. R., Price, H. P., Smith, D. F. & Wilson, K. S., Feb 2013, In: Protein Science. 22, 2, p. 196-203 8 p.

  Research output: Contribution to journal › Article › peer-review

• The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

  Price, H. P., Paape, D., Hodgkinson, M. R., Farrant, K., Doehl, J., Stark, M. & Smith, D. F., Nov 2013, In: Molecular Microbiology. n/a, n/a, p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

  Price, H. P., Hodgkinson, M. R., Wright, M. H., Tate, E. W., Smith, B. A., Carrington, M., Stark, M. & Smith, D. F., Jul 2012, In: Biochimica et biophysica acta-Molecular cell research. 1823, 7, p. 1178-1191 14 p.

  Research output: Contribution to journal › Article › peer-review

• Functional Analysis of Leishmania Cyclopropane Fatty Acid Synthetase

  Oyola, S. O., Evans, K. J., Smith, T. K., Smith, B. A., Hilley, J. D., Mottram, J. C., Kaye, P. M. & Smith, D. F., 10 Dec 2012, In: PLoS ONE. 7, 12, 15 p., e51300.

  Research output: Contribution to journal › Article › peer-review

• GeneDB-an annotation database for pathogens

  Logan-Klumpler, F. J., De Silva, N., Boehme, U., Rogers, M. B., Velarde, G., McQuillan, J. A., Carver, T., Aslett, M., Olsen, C., Subramanian, S., Phan, I., Farris, C., Mitra, S., Ramasamy, G., Wang, H., Tivey, A., Jackson, A., Houston, R., Parkhill, J. & Holden, M. & 8 others, Harb, O. S., Brunk, B. P., Myler, P. J., Roos, D., Carrington, M., Smith, D. F., Hertz-Fowler, C. & Berriman, M., Jan 2012, In: Nucleic Acids Research. 40, D1, p. D98-D108 11 p.

  Research output: Contribution to journal › Article › peer-review

• Identification of Drosophila gene products required for phagocytosis of Leishmania donovani

  Peltan, A., Briggs, L., Matthews, G., Sweeney, S. T. & Smith, D. F., 13 Dec 2012, In: PLoS ONE. 7, 12, 12 p., e51831.

  Research output: Contribution to journal › Article › peer-review

• Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

  Bell, A. S., Mills, J. E., Williams, G. P., Brannigan, J. A., Wilkinson, A. J., Parkinson, T., Leatherbarrow, R. J., Tate, E. W., Holder, A. A. & Smith, D. F., Apr 2012, In: PLOS NEGLECTED TROPICAL DISEASES. 6, 4, 9 p., e1625.

  Research output: Contribution to journal › Article › peer-review

• The Orthologue of Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1) in Trypanosoma brucei Is an Immunogenic Self-Assembling Molecule

  Price, H. P., Hodgkinson, M. R., Curwen, R. S., MacLean, L. M., Brannigan, J. A., Carrington, M., Smith, B. A., Ashford, D. A., Stark, M. & Smith, D. F., 20 Feb 2012, In: PLoS ONE. 7, 2, 14 p., e31842.

  Research output: Contribution to journal › Article › peer-review

• Therapeutic Vaccination With Recombinant Adenovirus Reduces Splenic Parasite Burden in Experimental Visceral Leishmaniasis

  Maroof, A., Brown, N., Smith, B., Hodgkinson, M. R., Maxwell, A., Losch, F. O., Fritz, U., Walden, P., Lacey, C. N. J., Smith, D. F., Aebischer, T. & Kaye, P. M., 1 Mar 2012, In: The Journal of Infectious Diseases. 205, 5, p. 853-863 11 p.

  Research output: Contribution to journal › Article › peer-review

• Trafficking and release of Leishmania metacyclic HASPB on macrophage invasion

  MacLean, L. M., O'Toole, P. J., Stark, M., Marrison, J., Seelenmeyer, C., Nickel, W. & Smith, D. F., May 2012, In: Cellular Microbiology. 14, 5, p. 740-761 22 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania

  Rogers, M. B., Hilley, J. D., Dickens, N. J., Wilkes, J., Bates, P. A., Depledge, D. P., Harris, D., Her, Y., Herzyk, P., Imamura, H., Otto, T. D., Sanders, M., Seeger, K., Dujardin, J.-C., Berriman, M., Smith, D. F., Hertz-Fowler, C. & Mottram, J. C., 2011, In: Genome Research. 21, 12, p. 2129-2142 14 p.

  Research output: Contribution to journal › Article › peer-review

• Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress

  Ramos, C. S., Yokoyama-Yasunaka, J. K. U., Guerra-Giraldez, C., Price, H. P., Mortara, R. A., Smith, D. F. & Uliana, S. R. B., Jan 2011, In: Experimental parasitology. 127, 1, p. 228-237 10 p.

  Research output: Contribution to journal › Article › peer-review

• Structural Basis of Molecular Recognition of the Leishmania Small Hydrophilic Endoplasmic Reticulum-associated Protein (SHERP) at Membrane Surfaces

  Moore, B., Miles, A. J., Guerra-Giraldez, C., Simpson, P., Iwata, M., Wallace, B. A., Matthews, S. J., Smith, D. F. & Brown, K. A., 18 Mar 2011, In: Journal of Biological Chemistry. 286, 11, p. 9246-9256 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8+ T Cells

  Beattie, L., Peltan, A., Maroof, A., Kirby, A., Brown, N., Coles, M., Smith, D. F. & Kaye, P. M., 12 Mar 2010, In: PLOS PATHOGENS. 6, 3, 17 p., e1000805.

  Research output: Contribution to journal › Article › peer-review

• Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition

  Depledge, D. P., MacLean, L. M., Hodgkinson, M. R., Smith, B. A., Jackson, A. P., Ma, S., Uliana, S. R. B. & Smith, D. F., 28 Sept 2010, In: PLOS NEGLECTED TROPICAL DISEASES. 4, 9, e829.

  Research output: Contribution to journal › Article › peer-review

• Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

  Price, H. P., Guether, M. L. S., Ferguson, M. A. J. & Smith, D. F., Jan 2010, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 169, 1, p. 55-58 4 p.

  Research output: Contribution to journal › Article › peer-review

• N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

  Brannigan, J. A., Smith, B. A., Yu, Z., Brzozowski, A. M., Hodgkinson, M. R., Maroof, A., Price, H. P., Meier, F., Leatherbarrow, R. J., Tate, E. W., Smith, D. F. & Wilkinson, A. J., 5 Mar 2010, In: Journal of Molecular Biology. 396, 4, p. 985-999 15 p.

  Research output: Contribution to journal › Article › peer-review

• N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

  Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F. & Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In: Nature. 464, 7289, p. 728-732 5 p.

  Research output: Contribution to journal › Article › peer-review

• The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei

  Price, H. P., Peltan, A., Stark, M. & Smith, D. F., Oct 2010, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 173, 2, p. 123-131 9 p.

  Research output: Contribution to journal › Article › peer-review

• The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi

  Sadlova, J., Price, H. P., Smith, B. A., Votypka, J., Volf, P. & Smith, D. F., Dec 2010, In: Cellular Microbiology. 12, 12, p. 1765-1779 15 p.

  Research output: Contribution to journal › Article › peer-review

• TriTrypDB: a functional genomic resource for the Trypanosomatidae

  Aslett, M., Aurrecoechea, C., Berriman, M., Brestelli, J., Brunk, B. P., Carrington, M., Depledge, D. P., Fischer, S., Gajria, B., Gao, X., Gardner, M. J., Gingle, A., Grant, G., Harb, O. S., Heiges, M., Hertz-Fowler, C., Houston, R., Innamorato, F., Iodice, J. & Kissinger, J. C. & 24 others, Kraemer, E., Li, W., Logan, F. J., Miller, J. A., Mitra, S., Myler, P. J., Nayak, V., Pennington, C., Phan, I., Pinney, D. F., Ramasamy, G., Rogers, M. B., Roos, D. S., Ross, C., Sivam, D., Smith, D. F., Srinivasamoorthy, G., Stoeckert, C. J., Subramanian, S., Thibodeau, R., Tivey, A., Treatman, C., Velarde, G. & Wang, H., Jan 2010, In: Nucleic Acids Research. 38, Database issue, p. D457-62

  Research output: Contribution to journal › Article › peer-review

• Validation of a new method for immobilising kinetoplastid parasites for live cell imaging

  Price, H. P., MacLean, L., Marrison, J., O'Toole, P. J. & Smith, D. F., Jan 2010, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 169, 1, p. 66-69 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Comparative Expression Profiling of Leishmania: Modulation in Gene Expression between Species and in Different Host Genetic Backgrounds

  Depledge, D. P., Evans, K. J., Ivens, A. C., Aziz, N., Maroof, A., Kaye, P. M. & Smith, D. F., Jul 2009, In: PLOS NEGLECTED TROPICAL DISEASES. 3, 7, e476.

  Research output: Contribution to journal › Article › peer-review
• 2008

  N-myristoyltransferase: a prospective drug target for protozoan parasites

  Bowyer, P. W., Tate, E. W., Leatherbarrow, R. J., Holder, A. A., Smith, D. F. & Brown, K. A., 14 Mar 2008, In: ChemMedChem. 3, 3, p. 402-408 7 p.

  Research output: Contribution to journal › Article › peer-review

• Transgenic Leishmania and the immune response to infection

  Beattie, L., Evans, K. J., Kaye, P. M. & Smith, D. F., Apr 2008, In: Parasite immunology. 30, 4, p. 255-266 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Comparative genomic analysis of three Leishmania species that cause diverse human disease

  Peacock, C. S., Seeger, K., Harris, D., Murphy, L., Ruiz, J. C., Quail, M. A., Peters, N., Adlem, E., Tivey, A., Aslett, M., Kerhornou, A., Ivens, A., Fraser, A., Rajandream, M. A., Carver, T., Norbertczak, H., Chillingworth, T., Hance, Z., Jagels, K. & Moule, S. & 22 others, Ormond, D., Rutter, S., Squares, R., Whitehead, S., Rabbinowitsch, E., Arrowsmith, C., White, B., Thurston, S., Bringaud, F., Baldauf, S. L., Faulconbridge, A., Jeffares, D., Depledge, D. P., Oyola, S. O., Hilley, J. D., Brito, L. O., Tosi, L. R. O., Barrell, B., Cruz, A. K., Mottram, J. C., Smith, D. F. & Berriman, M., Jun 2007, In: Nature genetics. 39, 7, p. 839-847 9 p.

  Research output: Contribution to journal › Article › peer-review

• Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis

  Moreno, J., Nieto, J., Masina, S., Canavate, C., Cruz, I., Chicharro, C., Carrillo, E., Napp, S., Reymond, C., Kaye, P. M., Smith, D. F., Fasel, N. & Alvar, J., 20 Jul 2007, In: Vaccine. 25, 29, p. 5290-5300 11 p.

  Research output: Contribution to journal › Article › peer-review

• Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania

  Mills, E., Price, H. P., Johner, A., Emerson, J. E. & Smith, D. F., Mar 2007, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 152, 1, p. 22-34 13 p.

  Research output: Contribution to journal › Article › peer-review

• Leishmania: trafficking and function of acylated proteins.

  Smith, D. F., 2007, In: Journal of Eukaryotic Microbiology. 54, 2, p. 33S-33S 1 p.

  Research output: Contribution to journal › Article › peer-review

• RepSeq-A database of amino acid repeats present in lower eukaryotic pathogens

  Lower, R. P. J., Smith, D. F. & Depledge, D. P., 2007, In: BMC Bioinformatics. 8, p. 122

  Research output: Contribution to journal › Article › peer-review

  File

• TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei

  Price, H. P., Stark, M., Smith, B. & Smith, D. F., Oct 2007, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 155, 2, p. 123-127 5 p.

  Research output: Contribution to journal › Article › peer-review

• Trypanosoma brucei ARF1 plays a central role in endocytosis and Golgi-lysosome trafficking

  Price, H. P., Stark, M. & Smith, D. F., 1 Mar 2007, In: Molecular Biology of the Cell. 18, 3, p. 864-873 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Adoptive immunotherapy against experimental visceral leishmaniasis with CD8+ T cells requires the presence of cognate antigen

  Polley, R., Stager, S., Prickett, S., Maroof, A., Zubairi, S., Smith, D. F. & Kaye, P. M., Jan 2006, In: Infection and Immunity. 74, 1, p. 773-776 4 p.

  Research output: Contribution to journal › Article › peer-review

• Antigen-experienced T cells limit the priming of naive T cells during infection with Leishmania major

  Gray, P. M., Reiner, S. L., Smith, D. F., Kaye, P. & Scott, P., 15 Jul 2006, In: Journal of Immunology. 177, 2, p. 925-933 9 p.

  Research output: Contribution to journal › Article › peer-review

• Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

  Panethymitaki, C., Bowyer, P. W., Price, H. P., Leatherbarrow, R. J., Brown, K. A. & Smith, D. F., 1 Jun 2006, In: Biochemical journal. 396, 2, p. 277-285 9 p.

  Research output: Contribution to journal › Article › peer-review

• In vivo recognition of ovalbumin expressed by transgenic Leishmania is determined by its subcellular localization

  Prickett, S. P., Gray, P. M., Colpitts, S. L., Scott, P., Kaye, P. M. & Smith, D. F., 15 Apr 2006, In: Journal of Immunology. 176, 8, p. 4826-4833 8 p.

  Research output: Contribution to journal › Article › peer-review

• The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase

  Denny, P. W., Shams-Eldin, H., Price, H. P., Smith, D. F. & Schwarz, R. T., 22 Sept 2006, In: Journal of Biological Chemistry. 281, 38, p. 28200-28209 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  An evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma brucei

  Morgan, G. W., Denny, P. W., Vaughan, S., Goulding, D., Jeffries, T. R., Smith, D. F., Gull, K. & Field, M. C., May 2005, In: Molecular and Cellular Biology. 25, 9, p. 3774-83 10 p.

  Research output: Contribution to journal › Article › peer-review

• ARL1 has an essential role in Tryponosoma brucei

  Price, H. P., Goulding, D. & Smith, D. F., Aug 2005, In: Biochemical Society transactions. 33, p. 643-645 3 p.

  Research output: Contribution to journal › Article › peer-review