Elmarie Myburgh

Search results

• 2024

  TORC1 is an essential regulator of nutrient-controlled proliferation and differentiation in Leishmania

  Myburgh, E., Geoghegan, V., Alves-Ferreira, E. V., Nievas, Y. R., Grewal, J. S., Brown, E., McLuskey, K. & Mottram, J. C., 12 Mar 2024, In: EMBO Reports. 25, 3, p. 1075-1105 31 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2023

  Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

  Rao, S. P. S., Gould, M. K., Noeske, J., Saldivia, M., Jumani, R. S., Ng, P. S., René, O., Chen, Y.-L., Kaiser, M., Ritchie, R., Francisco, A. F., Johnson, N., Patra, D., Cheung, H., Deniston, C., Schenk, A. D., Cortopassi, W. A., Schmidt, R. S., Wiedemar, N. & Thomas, B. & 22 others, Palkar, R., Ghafar, N. A., Manoharan, V., Luu, C., Gable, J. E., Wan, K. F., Myburgh, E., Mottram, J. C., Barnes, W., Walker, J., Wartchow, C., Aziz, N., Osborne, C., Wagner, J., Sarko, C., Kelly, J. M., Manjunatha, U. H., Mäser, P., Jiricek, J., Lakshminarayana, S. B., Barrett, M. P. & Diagana, T. T., 29 Jun 2023, In: Science (New York, N.Y.). 380, 6652, p. 1349-1356 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic Leishmania donovani infection

  Oca, M. M. D., Dey, S., Bocxlaer, K. V., Ashwin, H., Brown, N., Myburgh, E., Dey, N. S., Rani, G. F., Muscutt, E., Osman, M., Perez-Mazliah, D., James, S., Gilbert, L., Chatterjee, M. & Kaye, P. M., 3 Jan 2023, bioRxiv, at Cold Spring Harbor Laboratory, 44 p.

  Research output: Working paper

  Open Access
• 2021

  Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

  McNae, I. W., Kinkead, J., Malik, D., Yen, L.-H., Walker, M. K., Swain, C., Webster, S. P., Gray, N., Fernandes, P. M., Myburgh, E., Blackburn, E. A., Ritchie, R., Austin, C., Wear, M. A., Highton, A. J., Keats, A. J., Vong, A., Dornan, J., Mottram, J. C. & Michels, P. A. M. & 2 others, Pettit, S. & Walkinshaw, M. D., 16 Feb 2021, In: Nature Communications. 12, 1, 10 p., 1052.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

  Rao, S. P. S., Lakshminarayana, S. B., Jiricek, J., Kaiser, M., Ritchie, R., Myburgh, E., Supek, F., Tuntland, T., Nagle, A., Molteni, V., Mäser, P., Mottram, J. C., Barrett, M. P. & Diagana, T. T., 17 Feb 2020, In: Tropical medicine and infectious disease. 5, 1, 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• In Vivo Bioluminescence Imaging to Assess Compound Efficacy Against Trypanosoma brucei

  Ritchie, R., Barrett, M. P., Mottram, J. C. & Myburgh, E., 2020, In: Methods in Molecular Biology. 2116, p. 801-817 17 p.

  Research output: Contribution to journal › Article › peer-review

• Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

  Saldivia Concepcion, M. A., Fang, E., Ma, X., Myburgh, E., Brambilla Carnielli Trindade, J., Bower-Lepts, C., Brown, E., Ritchie, R., Lakshminarayana, S. B., Chen, Y.-L., Patra, D., Ornelas, E., Koh, H. X. Y., Williams, S., Supek, F., Paape, D., McCulloch, R., Kaiser, M., Barrett, M. P. & Jiricek, J. & 3 others, Diagana, T. T., Mottram, J. C. & Rao, S. P. S., Oct 2020, In: Nature Microbiology. 5, p. 1207-1216

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  DiCre-Based Inducible Disruption of Leishmania Genes

  Duncan, S. M., Myburgh, E., Alves-Ferreira, E. V. & Mottram, J. C., 2019, Leishmania: Methods and Protocols. Clos, J. (ed.). Springer, p. 211-224 (Methods in Molecular Biology; vol. 1971).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2018

  TLR2 signaling in skin non-hematopoietic cells induces early neutrophil recruitment in response to Leishmania major infection

  Ronet, C., Passelli, K., Charmoy, M., Scarpellino, L., Myburgh, E., Hauyon La Torre, Y., Turco, S., Mottram, J. C., Fasel, N., Luther, S. A., Beverley, S. M., Launois, P. & Tacchini-Cottier, F., 27 Dec 2018, In: Journal of investigative dermatology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells

  Goundry, A., Romano, A., Lima, A. P. C. A., Mottram, J. C. & Myburgh, E., 16 Nov 2017, In: The FASEB Journal.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The mouse cortical meninges are the site of immune responses to many different pathogens, and are accessible to intravital imaging

  Coles, J. A., Stewart-Hutchinson, P. J., Myburgh, E. & Brewer, J. M., 15 Aug 2017, In: Methods. 127, p. 53-61 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

• Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain

  Coles, J. A., Myburgh, E., Brewer, J. M. & McMenamin, P. G., 25 May 2017, (E-pub ahead of print) In: Progress in neurobiology. 156, p. 107-148 42 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File
• 2016

  Attempts to Image the Early Inflammatory Response during Infection with the Lymphatic Filarial Nematode Brugia pahangi in a Mouse Model

  Myburgh, E., Ritchie, R., Goundry, A., O'Neill, K., Marchesi, F. & Devaney, E., 16 Dec 2016, In: PLoS ONE. 11, 12, e0168602.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in Leishmania mexicana cell cycle regulation

  Duncan, S. M., Myburgh, E., Philipon, C., Brown, E., Meissner, M., Brewer, J. & Mottram, J. C., 16 Mar 2016, (E-pub ahead of print) In: Molecular Microbiology. 100, 6, p. 931-944 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• PNT1 is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.

  Grewal, J., McLuskey, K., Das, D., Myburgh, E., Wilkes, J., Brown, E., Lemgruber, L., Gould, M. K., Burchmore, R. J., Coombs, G. H., Schnaufer, A. & Mottram, J. C., 29 Apr 2016, In: Journal of Biological Chemistry. 291, 18, p. 9492-9500 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

  Khare, S., Nagle, A. S., Biggart, A., Lai, Y. H., Liang, F., Davis, L. C., Barnes, S. W., Mathison, C. J. N., Myburgh, E., Gao, M.-Y., Gillespie, J. R., Liu, X., Tan, J. L., Stinson, M., Rivera, I. C., Ballard, J., Yeh, V., Groessl, T., Federe, G. & Koh, H. X. Y. & 15 others, Venable, J. D., Bursulaya, B., Shapiro, M., Mishra, P. K., Spraggon, G., Brock, A., Mottram, J. C., Buckner, F. S., Rao, S. P. S., Wen, B. G., Walker, J. R., Tuntland, T., Molteni, V., Glynne, R. J. & Supek, F., 8 Sept 2016, In: Nature. 537, 7619, p. 229-233 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes

  Myburgh, E., Coles, J., Ritchie, R., Hamilton, A., Rodgers, J., Mottram, J. C., Barrett, M. & Brewer, J., 2015, In: PLoS Neglected Tropical Diseases. 9, 4, 29 p., e0003714.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Highly sensitive in vivo imaging of Trypanosoma brucei expressing "red-shifted" luciferase

  McLatchie, A., Burrell-Saward, H., Myburgh, E., Lewis, M., Ward, T., Mottram, J. C., Croft, S., Kelly, J. & Taylor, M., 2013, In: PLoS Neglected Tropical Diseases. 7, 11, 12 p., e2571.

  Research output: Contribution to journal › Article › peer-review

• Imaging African trypanosomes

  MacLean, L., Myburgh, E., Rodgers, J. & Price, H. P., 25 Jun 2013, In: Parasite immunology. 35, 9-10, p. 283-94 12 p.

  Research output: Contribution to journal › Review article › peer-review

• In vivo imaging models for rapid drug screening studies in CNS involved trypanosomiasis

  Myburgh, E., Coles, J., Ritchie, R., Kennedy, P., McLatchie, A., Rodgers, J., Taylor, M., Barrett, M., Brewer, J. & Mottram, J. C., 2013, In: PLoS Neglected Tropical Diseases. 7, 8, 12 p., e2384.

  Research output: Contribution to journal › Article › peer-review
• 2011

  IL-4Rα-responsive smooth muscle cells contribute to initiation of TH2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections

  Horsnell, W. G. C., Vira, A., Kirstein, F., Mearns, H., Hoving, J. C., Cutler, A. J., Dewals, B., Myburgh, E., Kimberg, M., Arendse, B., White, N., Lopata, A., Burger, P. E. & Brombacher, F., Jan 2011, In: Mucosal Immunology. 4, 1, p. 83-92 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Imaging of the host/parasite interplay in cutaneous leishmaniasis

  Millington, O. R., Myburgh, E., Mottram, J. C. & Alexander, J., Nov 2010, In: Experimental parasitology. 126, 3, p. 310-7 8 p.

  Research output: Contribution to journal › Review article › peer-review
• 2008

  Interleukin-4-promoted T helper 2 responses enhance Nippostrongylus brasiliensis-induced pulmonary pathology

  Mearns, H., Horsnell, W. G. C., Hoving, J. C., Dewals, B., Cutler, A. J., Kirstein, F., Myburgh, E., Arendse, B. & Brombacher, F., Dec 2008, In: Infection and Immunity. 76, 12, p. 5535-42 8 p.

  Research output: Contribution to journal › Article › peer-review

• Murine IL-4 is able to signal via chimeric human IL-4Ralpha/mouse gamma-chain receptor

  Myburgh, E., Horsnell, W. G. C., Cutler, A. J., Arendse, B., Kubo, M. & Brombacher, F., Mar 2008, In: Molecular immunology. 45, 5, p. 1327-36 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice

  Horsnell, W. G. C., Cutler, A. J., Hoving, C. J., Mearns, H., Myburgh, E., Arendse, B., Finkelman, F. D., Owens, G. K., Erle, D. & Brombacher, F., Jan 2007, In: PLOS PATHOGENS. 3, 1, p. e1

  Research output: Contribution to journal › Article › peer-review
• 2006

  Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice

  Hölscher, C., Arendse, B., Schwegmann, A., Myburgh, E. & Brombacher, F., 15 Jan 2006, In: Journal of Immunology. 176, 2, p. 1115-21 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation

  Seki, N., Miyazaki, M., Suzuki, W., Hayashi, K., Arima, K., Myburgh, E., Izuhara, K., Brombacher, F. & Kubo, M., 15 May 2004, In: Journal of Immunology. 172, 10, p. 6158-66 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2001

  A protective and agonistic function of IL-12p40 in mycobacterial infection

  Hölscher, C., Atkinson, R. A., Arendse, B., Brown, N., Myburgh, E., Alber, G. & Brombacher, F., 15 Dec 2001, In: Journal of Immunology. 167, 12, p. 6957-66 10 p.

  Research output: Contribution to journal › Article › peer-review