Fiona MacGregor Frame

Search results

• 2024

  Raman spectroscopy reveals oxidative stress-induced metabolic vulnerabilities in early-stage AR-negative prostate-cancer versus normal-prostate cell lines

  Cameron, M., Frame, F. M., Maitland, N. J. & Hancock, Y., 25 Oct 2024, (E-pub ahead of print) In: Scientific Reports.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2023

  ST6GAL1-mediated aberrant sialylation promotes prostate cancer progression

  Scott, E., Archer Goode, E., Garnham, R., Hodgson, K., Orozco-Moreno, M., Turner, H., Livermore, K., Putri Nangkana, K., Frame, F. M., Bermudez, A., Jose Garcia Marques, F., McClurg, U. L., Wilson, L., Thomas, H., Buskin, A., Hepburn, A., Duxfield, A., Bastian, K., Pye, H. & Arredondo, H. M. & 22 others, Hysenaj, G., Heavey, S., Stopka-Farooqui, U., Haider, A., Freeman, A., Singh, S., Johnston, E. W., Punwani, S., Knight, B., McCullagh, P., McGrath, J., Crundwell, M., Harries, L., Heer, R., Maitland, N. J., Whitaker, H., Pitteri, S., Troyer, D. A., Wang, N., Elliott, D. J., Drake, R. R. & Munkley, J., 30 Aug 2023, In: Journal of Pathology. 261, 1, p. 71-84 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

  Jennifer Munkley, 1 Feb 2023, (E-pub ahead of print) In: Oncogene. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  ETS transcription factor ELF3 (ESE-1) is a cell cycle regulator in benign and malignant prostate

  Archer, L. K., Frame, F. M., Walker, H. F., Droop, A. P., McDonald, G. L. K., Kucko, S., Berney, D. M., Mann, V. M., Simms, M. S. & Maitland, N. J., 6 May 2022, In: FEBS open bio.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer

  Ibrahim, A. I. M., Batlle, E., Sneha, S., Jiménez, R., Pequerul, R., Parés, X., Rüngeler, T., Jha, V., Tuccinardi, T., Sadiq, M., Frame, F., Maitland, N. J., Farrés, J. & Pors, K., 10 Mar 2022, In: JOURNAL OF MEDICINAL CHEMISTRY. 65, 5, p. 3833-3848 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2020

  Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target

  Quattrini, L., Sadiq, M., Petrarolo, G., Maitland, N. J., Frame, F. M., Pors, K. & La Motta, C., 4 Dec 2020, In: Biomedicines. 8, 12, 569.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Overexpression of Placental Growth Factor in Stromal Cells from Benign Prostatic Hyperplasia: Another Piece in the Puzzle?

  Devlin, C., Frame, F. M., Archer, L., Mann, V. M., Walker, H., Simms, M. S., Berney, D. M., Collins, A. & Maitland, N. J., 14 Sept 2020, (E-pub ahead of print) In: European Urology Open Science. 21, p. 29-32 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  Assessing the Advantages, Limitations and Potential of Human Primary Prostate Epithelial Cells as a Pre-clinical Model for Prostate Cancer Research

  Frame, F. M., Noble, A. R., O'Toole, P., Marrison, J., Godden, T., O'Brien, A. & Maitland, N. J., 2 Oct 2019, (E-pub ahead of print) In: Advances in experimental medicine and biology. 1164, p. 109-118 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Effects on prostate cancer cells of targeting RNA polymerase III

  Petrie, J. L., Swan, C., Ingram, R. M., Frame, F. M., Collins, A. T., Dumay-Odelot, H., Teichmann, M., Maitland, N. J. & White, R. J., 7 May 2019, In: Nucleic Acids Research. 47, 8, p. 3937-3956 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments

  Packer, J. R., Hirst, A. M., Droop, A. P., Adamson, R., Simms, M. S., Mann, V. M., Frame, F. M., O'Connell, D. & Maitland, N. J., 17 Sept 2019, In: FEBS Letters. 18 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2018

  Phenotype-independent DNA methylation changes in prostate cancer

  Pellacani, D., Droop, A. P., Frame, F. M., Simms, M. S., Mann, V. M., Collins, A. T., Eaves, C. J. & Maitland, N. J., 15 Oct 2018, (E-pub ahead of print) In: British journal of cancer. 11 p., GG-2018-5107R.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

  Butler, D. E., Marlein, C., Walker, H. F., Frame, F. M., Mann, V. M., Simms, M. S., Davies, B. R., Collins, A. T. & Maitland, N. J., 23 May 2017, In: Oncotarget. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  An epigenetic reprogramming strategy to re-sensitize radioresistant prostate cancer cells

  Peitzsch, C., Cojoc, M., Hein, L., Kurth, I., Mӓbert, K., Trautmann, F., Klink, B., Schrock, E., Wirth, M. P., Krause, M., Stakhovsky, E. A., Telegeev, G. D., Novotny, V., Toma, M. I., Muders, M., Baretton, G. B., Frame, F. M., Maitland, N. J., Baumann, M. & Dubrovska, A., 1 May 2016, In: Cancer research. 76, 9, p. 2637-2651 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Harvesting Human Prostate Tissue Material and Culturing Primary Prostate Epithelial Cells

  Frame, F. M., Pellacani, D., Collins, A. T. & Maitland, N. J., 1 Jun 2016, In: Methods in Molecular Biology. 1443, p. 181-201 21 p.

  Research output: Contribution to journal › Article › peer-review

• Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future

  Hirst, A. M., Frame, F. M., Arya, M., Maitland, N. J. & O'Connell, D., 2016, In: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Mechanisms of growth inhibition of primary prostate epithelial cells following gamma irradiation or photodynamic therapy include senescence, necrosis, and autophagy, but not apoptosis

  Frame, F. M., Savoie, H., Bryden, F., Giuntini, F., Mann, V. M., Simms, M. S., Boyle, R. W. & Maitland, N. J., Jan 2016, In: Cancer Medicine. 5, 1, p. 61-73 13 p.

  Research output: Contribution to journal › Article › peer-review

• Telomerase Activity and Telomere Length in Human Benign Prostatic Hyperplasia Stem-like Cells and Their Progeny Implies the Existence of Distinct Basal and Luminal Cell Lineages

  Rane, J. K., Greener, S., Frame, F. M., Mann, V. M., Simms, M. S., Collins, A. T., Berney, D. M. & Maitland, N. J., 1 Apr 2016, In: European Urology.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2015

  Low-temperature plasma treatment induces DNA damage leading to necrotic cell death in primary prostate epithelial cells

  Hirst, A. M., Simms, M. S., Mann, V. M., Maitland, N. J., O'connell, D. & Frame, F. M., 28 Apr 2015, In: British journal of cancer. 112, 9, p. 1536-1545 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation

  Pellacani, D., Kestoras, D., Droop, A. P., Frame, F. M., Berry, P. A., Lawrence, M. G., Stower, M. J., Simms, M. S., Mann, V. M., Collins, A. T., Risbridger, G. P. & Maitland, N. J., May 2014, In: Cell death and differentiation. 21, 5, p. 761-773 13 p.

  Research output: Contribution to journal › Article › peer-review

• Low Temperature Plasma: A Novel Focal Therapy for Localized Prostate Cancer?

  Hirst, A. M., Frame, F. M., Maitland, N. J. & O'Connell, D., 13 Mar 2014, In: BioMed Research International. 2014, 878319.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Low temperature plasma causes double-strand break DNA damage in primary epithelial cells cultured from a human prostate Tumor

  Hirst, A. M., Frame, F. M., Maitland, N. J. & O'Connell, D., 1 Oct 2014, In: IEEE transactions on plasma science. 42, 10, p. 2740-2741 2 p., 6894576.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Differential cytotoxic activity of a novel palladium-based compound on prostate cell lines, primary prostate epithelial cells and prostate stem cells

  Ulukaya, E., Frame, F. M., Cevatemre, B., Pellacani, D., Walker, H., Mann, V. M., Simms, M. S., Stower, M. J., Yilmaz, V. T. & Maitland, N. J., 10 May 2013, In: PLoS ONE. 8, 5, p. e64278 e64278.

  Research output: Contribution to journal › Article › peer-review

• HDAC inhibitor confers radiosensitivity to prostate stem-like cells

  Frame, F. M., Pellacani, D., Collins, A. T., Simms, M. S., Mann, V. M., Jones, G., Meuth, M., Bristow, R. G. & Maitland, N. J., 10 Dec 2013, In: British journal of cancer. 109, 12, p. 3023-3033

  Research output: Contribution to journal › Article › peer-review
• 2011

  Cancer stem cells, models of study and implications of therapy resistance mechanisms

  Frame, F. M. & Maitland, N. J., 2011, In: Advances in experimental medicine and biology. 720, p. 105-18 14 p.

  Research output: Contribution to journal › Article › peer-review

• Prostate cancer stem cells: do they have a Basal or luminal phenotype?

  Maitland, N. J., Frame, F. M., Polson, E. S., Lewis, J. L. & Collins, A. T., Feb 2011, In: Hormones & cancer. 2, 1, p. 47-61 15 p.

  Research output: Contribution to journal › Article › peer-review

• Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer

  Pellacani, D., Packer, R. J., Frame, F. M., Oldridge, E. E., Berry, P. A., Labarthe, M.-C., Stower, M. J., Simms, M. S., Collins, A. T. & Maitland, N. J., 29 Jul 2011, In: MOLECULAR CANCER THERAPEUTICS. 10, 94, p. 1-14

  Research output: Contribution to journal › Article › peer-review
• 2010

  Development and limitations of lentivirus vectors as tools for tracking differentiation in prostate epithelial cells

  Frame, F. M., Hager, S., Pellacani, D., Stower, M. J., Walker, H. F., Burns, J. E., Collins, A. T. & Maitland, N. J., 15 Nov 2010, In: Experimental cell research. 316, 19, p. 3161-71 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  An internal polyadenylation signal substantially increases expression levels of lentivirus-delivered transgenes but has the potential to reduce viral titer in a promoter-dependent manner

  Hager, S., Frame, F. M., Collins, A. T., Burns, J. E. & Maitland, N. J., 1 Aug 2008, In: HUMAN GENE THERAPY. 19, 8, p. 840-850 11 p.

  Research output: Contribution to journal › Article › peer-review

• Transcriptional control by the R-transactivator protein of Alcelaphine Herpesvirus-1

  Frame, F. M. & Dalziel, R. G., Mar 2008, In: Veterinary research communications. 32, 3, p. 215-223 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  A lentivirus vector system to track prostate cancer stem cell differentiation

  Frame, F., Hager, S., Collins, A. T. & Maitland, N. J., Sept 2007, In: BJU International. 100, p. 24-24 1 p.

  Research output: Contribution to journal › Article › peer-review