Gavin James Wright

Search results

• 2024

  A panel of recombinant Leishmania donovani cell surface and secreted proteins identifies LdBPK_323600.1 as a serological marker of symptomatic infection

  Roberts, A. J., Ong, H. B., Clare, S., Brandt, C., Harcourt, K., Takele, Y., Ghosh, P., Toepp, A., Waugh, M., Matano, D., Färnert, A., Adams, E., Moreno, J., Mbuchi, M., Petersen, C., Mondal, D., Kropf, P. & Wright, G. J., 8 May 2024, In: MBio. 15, 5, e0085924.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions

  Segireddy, R. R., Belda, H., Yang, A. S. P., Dundas, K., Knoeckel, J., Galaway, F., Wood, L., Quinkert, D., Knuepfer, E., Treeck, M., Wright, G. J. & Douglas, A. D., 16 May 2024, In: MALARIA JOURNAL. 23, 151.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain

  Powell, G. T., Faro, A., Zhao, Y., Stickney, H., Novellasdemunt, L., Henriques, P., Gestri, G., Redhouse White, E., Ren, J., Lu, W., Young, R. M., Hawkins, T. A., Cavodeassi, F., Schwarz, Q., Dreosti, E., Raible, D. W., Li, V. S. W., Wright, G. J., Jones, E. Y. & Wilson, S. W., 3 May 2024, In: Science (New York, N.Y.). 384, 6695, p. 573-579 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Complement receptor 1 is the human erythrocyte receptor for Plasmodium vivax erythrocyte binding protein

  Lee, S-K., Crosnier, C., Valenzuela-Leon, P. C., Dizon, B. L. P., Atkinson, J. P., Mu, J., Wright, G. J., Calvo, E., Gunalan, K. & Miller, L. H., 30 Jan 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 5, 7 p., e2316304121.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

  Elofsson, A., Han, L., Bianchi, E., Wright, G. J. & Jovine, L., 26 Apr 2024, In: eLife. 13, 18 p., RP93131.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

  Wang, L. T., Cooper, A. J. R., Farrell, B., Miura, K., Diouf, A., Müller-Sienerth, N., Crosnier, C., Purser, L., Kirtley, P. J., Maciuszek, M., Barrett, J. R., McHugh, K., Ogwang, R., Tucker, C., Li, S., Doumbo, S., Doumtabe, D., Pyo, C-W., Skinner, J., Nielsen, C. M., & 17 othersSilk, S. E., Kayentao, K., Ongoiba, A., Zhao, M., Nguyen, D. C., Lee, F. E-H., Minassian, A. M., Geraghty, D. E., Traore, B., Seder, R. A., Wilder, B. K., Crompton, P. D., Wright, G. J., Long, C. A., Draper, S. J., Higgins, M. K. & Tan, J., 25 Jul 2024, (E-pub ahead of print) In: Cell. 187, 30 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1

  Bianchi, E., Jiménez-Movilla, M., Cots-Rodríguez, P., Viola, C. & Wright, G. J., 21 Feb 2024, In: Science Advances. 10, 8, eadk6352.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Mammalian fertilization: Does sperm IZUMO1 mediate fusion as well as adhesion?

  Bianchi, E. & Wright, G. J., 19 Jan 2023, In: Journal of Cell Biology. 222, 2, 2 p., e202301035.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites

  Hart, M. N., Mohring, F., DonVito, S. M., Thomas, J. A., Muller-Sienerth, N., Wright, G. J., Knuepfer, E., Saibil, H. R. & Moon, R. W., 1 Aug 2023, In: Nature Communications. 14, 4619.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Spatial multiomics map of trophoblast development in early pregnancy

  Arutyunyan, A., Roberts, K., Troulé, K., Wong, F. C. K., Sheridan, M. A., Kats, I., Garcia-Alonso, L., Velten, B., Hoo, R., Ruiz-Morales, E. R., Sancho-Serra, C., Shilts, J., Handfield, L-F., Marconato, L., Tuck, E., Gardner, L., Mazzeo, C. I., Li, Q., Kelava, I., Wright, G. J., & 7 othersPrigmore, E., Teichmann, S. A., Bayraktar, O. A., Moffett, A., Stegle, O., Turco, M. Y. & Vento-Tormo, R., 6 Apr 2023, In: Nature. 616, 7955, p. 143-151 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Special multiomics map of trophoblast development in early pregnancy

  Wright, G. J., 29 Mar 2023, In: Nature. 616, p. 143-151 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  A physical wiring diagram for the human immune system

  Shilts, J., Severin, Y., Galaway, F., Muller-Sienerth, N., Chong, Z-S., Pritchard, S., Teichmann, S., Vento-Tormo, R., Snijder, B. & Wright, G. J., 11 Aug 2022, In: Nature. p. 397–404

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Author Correction: Pooled extracellular receptor-ligand interaction screening using CRISPR activation

  Chong, Z-S., Ohnishi, S., Yusa, K. & Wright, G. J., 21 Oct 2022, In: Genome biology. 23, 224.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Innovative vaccine approaches—a Keystone Symposia report

  Cable, J., Rappuoli, R., Klemm, E. J., Kang, G., Mutreja, A., Wright, G. J., Pizza, M., Castro, S. A., Hoffmann, J. P., Alter, G., Carfi, A., Pollard, A. J., Krammer, F., Gupta, R. K., Wagner, C. E., Machado, V., Modjarrad, K., Corey, L., Gilbert, P. B., Dougan, G., & 14 othersLurie, N., Bjorkman, P. J., Chiu, C., Nemes, E., Gordon, S. B., Steer, A. C., Rudel, T., Blish, C. A., Sandberg, J. T., Brennan, K., Klugman, K. P., Stuart, L. M., Madhi, S. A. & Karp, C. L., May 2022, In: Annals of the New York Academy of Sciences. 1511, 1, p. 59-86

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• In silico Docking Analysis for Blocking JUNO‐IZUMO1 Interaction Identifies Two Small Molecules that Block in vitro Fertilization

  Stepanenko, N., Wolk, O., Bianchi, E., Wright, G. J., Schachter-Safrai, N., Makedonski, K., Ouro, A., Ben-Meir, A., Buganim, Y. & Goldblum, A., 5 Apr 2022, (E-pub ahead of print) In: Frontiers in cell and developmental biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

  Shilts, J., Crozier, T. W. M., Teixeira-Silva, A., Gabaev, I., Gerber, P. P., Greenwood, E. J. D., Watson, S. J., Ortmann, B. M., Gawden-Bone, C. M., Pauzaite, T., Hoffmann, M., Nathan, J. A., Pohlmann, S., Matheson, N. J., Lehner, P. J. & Wright, G. J., 14 Dec 2022, (Accepted/In press) In: PLoS Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Systematic identification of genes encoding cell surface and secreted proteins that are essential for in vitro growth and infection in Leishmania donovani

  Roberts, A. J., Ong, H. B., Clare, S., Brandt, C., Harcourt, K., Franssen, S. U., Cotton, J. A., Müller-Sienerth, N. & Wright, G. J., 24 Feb 2022, In: PLOS PATHOGENS. 18, 2, 18 p., e1010364.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Leishmania donovani Ortholog of the Glycosylphosphatidylinositol Anchor Biosynthesis Cofactor PBN1 Is Essential for Host Infection

  Roberts, A., Nagar, R., Brandt, C., Harcourt, K., Clare, S., Ferguson, M. A. J. & Wright, G. J., Jun 2022, In: MBio. 13, 3, 15 p., e00433-22.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface

  Romero-Ramirez, A., Casas-Sanchez, A., Autheman, D., Duffy, C. W., Brandt, C., Clare, S., Harcourt, K., Rogerio Andre, M., Jose Garcia de Almeida Castilho Neto, K., Teixeira, M. M. G., Machado, R. Z., Coombes, J., Flynn, R. J., Wright, G. J. & Jackson, A., 21 Sept 2022, (E-pub ahead of print) In: PLoS Neglected Tropical Diseases. 16, 9, 30 p., e0010791.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

  Autheman, D., Crosnier, C., Clare, S., Goulding, D. A., Brandt, C., Harcourt, K., Tolley, C., Galaway, F., Khushu, M., Ong, H., Romero-Ramirez, A., Duffy, C. W., Jackson, A. P. & Wright, G. J., 1 Jul 2021, In: Nature. 595, p. 96–100 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

  Anisul, M., Shilts, J., Schwartzentruber, J., Hayhurst, J., Buniello, A., Mohammed, E. S. E., Zheng, J., Holmes, M., Ochoa, D., Carmona, M., Maranville, J., Gaunt, T. R., Emilsson, V., Gudnason, V., McDonagh, E. M., Wright, G. J., Ghoussaini, M. & Dunham, I., 17 Aug 2021, In: eLife. 10, 22 p., e69719.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit

  Bianchi, E., Sun, Y., Almansa-Ordonez, A., Woods, M., Goulding, D., Martinez-Martin, N. & Wright, G. J., 23 Feb 2021, In: Nature Communications. 12, 12 p., 1251.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

  Shilts, J., Crozier, T. W. M., Greenwood, E. J. D., Lehner, P. J. & Wright, G. J., 11 Jan 2021, In: Scientific Reports. 11, 10 p., 413.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Systematic Identification of Plasmodium Falciparum Sporozoite Membrane Protein Interactions Reveals an Essential Role for the p24 Complex in Host Infection

  Knöckel, J., Dundas, K., Yang, A. S. P., Galaway, F., Metcalf, T., Gemert, G-J. V., Sauerwein, R. W., Rayner, J. C., Billker, O. & Wright, G. J., 27 Feb 2021, In: Molecular and Cellular Proteomics. 20, 100038.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance.

  Müller-Sienerth, N., Shilts, J., Kadir, K. A., Yman, V., Homann, M. V., Asghar, M., Ngasala, B., Singh, B., Färnert, A. & Wright, G. J., 17 Jan 2020, In: MALARIA JOURNAL. 19, 15 p., 31.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens.

  Sharma, S. & Wright, G. J., 6 Jun 2020, In: Journal of Visualized Experiments. 160, 15 p., e60803.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• CEN-tools: an integrative platform to identify the contexts of essential genes

  Sharma, S., Dincer, C., Weidemüller, P., Wright, G. J. & Petsalaki, E., 16 Oct 2020, In: Molecular systems biology. 16, 10, p. e9698

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Establishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening

  Ong, H. B., Clare, S., Roberts, A. J., Wilson, M. E. & Wright, G. J., 13 Mar 2020, In: Scientific Reports. 10, 1, 4689.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Find and fuse: Unsolved mysteries in sperm– egg recognition

  Bianchi, E. & Wright, G. J., 13 Nov 2020, (E-pub ahead of print) In: PLoS Biology. 18, 11, 11 p., e3000953.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Investigating cellular recognition using crispr/cas9 genetic screening.

  Chong, Z-S., Wright, G. J. & Sharma, S., 1 Aug 2020, In: TRENDS IN CELL BIOLOGY. 30, 8, p. 619-627 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Rapid and sensitive large-scale screening of low affinity extracellular receptor protein interactions by using reaction induced inhibition of Gaussia luciferase.

  Galaway, F. & Wright, G. J., 29 Jun 2020, In: Scientific Reports. 10, 1, 9 p., 10522.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivo

  Awuah-Mensah, G., McDonald, J., Steketee, P. C., Autheman, D., Whipple, S., D'Archivio, S., Brandt, C., Clare, S., Harcourt, K., Wright, G. J., Morrison, L. J., Gadelha, C. & Wickstead, B., 7 Dec 2020, (Accepted/In press) In: PLOS PATHOGENS.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Screening of a library of recombinant Schistosoma mansoni proteins with sera from murine and human controlled infections identifies early serological markers.

  Crosnier, C., Hokke, C. H., Protasio, A. V., Brandt, C., Rinaldi, G., Langenberg, M. C. C., Clare, S., Janse, J. J., Wilson, S., Berriman, M., Roestenberg, M. & Wright, G. J., 10 Jun 2020, In: The Journal of Infectious Diseases. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Systematic identification of P. falciparum sporozoite membrane protein interactions reveals an essential role for the p24 complex in host infection

  Knöcke, J., Dundas, K., Yang, A. S. P., Galaway, F., Metcalf, T., van Gemert, G-J., Sauerwein, R. W., Rayner, J. C., Billker, O. & Wright, G. J., 22 Dec 2020, (Accepted/In press) In: Molecular and Cellular Proteomics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site.

  Campeotto, I., Galaway, F., Mehmood, S., Barfod, L. K., Quinkert, D., Kotraiah, V., Phares, T. W., Wright, K. E., Snijders, A. P., Draper, S. J., Higgins, M. K. & Wright, G. J., 8 Sept 2020, In: MBio. 11, 5, 12 p., e01566-20.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• TMEM95 is a sperm membrane protein essential for mammalian fertilization.

  Lamas-Toranzo, I., Hamze, J. G., Bianchi, E., Fernández-Fuertes, B., Pérez-Cerezales, S., Laguna-Barraza, R., Fernández-González, R., Lonergan, P., Gutiérrez-Adán, A., Wright, G. J., Jiménez-Movilla, M. & Bermejo-Álvarez, P., 2 Jun 2020, In: eLife. 9, 18 p., e53913.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  Adaptation of Plasmodium falciparum to humans involved the loss of an ape-specific erythrocyte invasion ligand.

  Proto, W. R., Siegel, S. V., Dankwa, S., Liu, W., Kemp, A., Marsden, S., Zenonos, Z. A., Unwin, S., Sharp, P. M., Wright, G. J., Hahn, B. H., Duraisingh, M. T. & Rayner, J. C., 4 Oct 2019, In: Nature Communications. 10, 1, 12 p., 4512.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates.

  Douglas, A. D., Baldeviano, G. C., Jin, J., Miura, K., Diouf, A., Zenonos, Z. A., Ventocilla, J. A., Silk, S. E., Marshall, J. M., Alanine, D. G. W., Wang, C., Edwards, N. J., Leiva, K. P., Gomez-Puerta, L. A., Lucas, C. M., Wright, G. J., Long, C. A., Royal, J. M. & Draper, S. J., 26 Apr 2019, In: Nature Communications. 10, 1, 8 p., 1953.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• A library of recombinant Babesia microti cell surface and secreted proteins for diagnostics discovery and reverse vaccinology.

  Elton, C. M., Rodriguez, M., Ben Mamoun, C., Lobo, C. A. & Wright, G. J., Feb 2019, In: International Journal for Parasitology. 49, 2, p. 115-125 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Antibody Reactivity to Merozoite Antigens in Ghanaian Adults Correlates With Growth Inhibitory Activity Against Plasmodium falciparum in Culture.

  Mensah-Brown, H. E., Aspeling-Jones, H., Delimini, R. K., Asante, K. P., Amlabu, E., Bah, S. Y., Beeson, J. G., Wright, G. J., Conway, D. J. & Awandare, G. A., Jul 2019, In: Open forum infectious diseases. 6, 7, 10 p., ofz254.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Approaches to identify extracellular receptor-ligand interactions.

  Wood, L. & Wright, G. J., Jun 2019, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 56, p. 28-36 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Detection of cell surface ligands for human synovial γδ T cells.

  Collins, C., Lui, Y., Santos, A. M., Ballif, B. A., Gogerly-Moragoda, A. M., Brouwer, H., Ross, R., Balagurunathan, K., Sharma, S., Wright, G. J., Davis, S. & Budd, R. C., 1 Nov 2019, In: Journal of Immunology. 203, 9, p. 2369-2376 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B.

  Vögtle, T., Sharma, S., Mori, J., Nagy, Z., Semeniak, D., Scandola, C., Geer, M. J., Smith, C. W., Lane, J., Pollack, S., Lassila, R., Jouppila, A., Barr, A. J., Ogg, D. J., Howard, T. D., McMiken, H. J., Warwicker, J., Geh, C., Rowlinson, R., Abbott, W. M., & 8 othersEckly, A., Schulze, H., Wright, G. J., Mazharian, A., Fütterer, K., Rajesh, S., Douglas, M. R. & Senis, Y. A., 22 Aug 2019, In: eLife. 8, 43 p., e46840.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• High-Content Imaging for Large-Scale Detection of Low-Affinity Extracellular Protein Interactions.

  Wood, L. & Wright, G. J., Dec 2019, In: SLAS Discovery. 24, 10, p. 987-999 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

  Alanine, D. G. W., Quinkert, D., Kumarasingha, R., Mehmood, S., Donnellan, F. R., Minkah, N. K., Dadonaite, B., Diouf, A., Galaway, F., Silk, S. E., Jamwal, A., Marshall, J. M., Miura, K., Foquet, L., Elias, S. C., Labbé, G. M., Douglas, A. D., Jin, J., Payne, R. O., Illingworth, J. J., & 12 othersPattinson, D. J., Pulido, D., Williams, B. G., de Jongh, W. A., Wright, G. J., Kappe, S. H. I., Robinson, C. V., Long, C. A., Crabb, B. S., Gilson, P. R., Higgins, M. K. & Draper, S. J., 27 Jun 2019, In: Cell. 178, 1, p. 216-228

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Important Extracellular Interactions between Plasmodium Sporozoites and Host Cells Required for Infection.

  Dundas, K., Shears, M. J., Sinnis, P. & Wright, G. J., 1 Feb 2019, In: Trends in parasitology. 35, 2, p. 129-139 11 p.

  Research output: Contribution to journal › Article › peer-review

• Resurrection of the ancestral RH5 invasion ligand provides a molecular explanation for the origin of P. falciparum malaria in humans.

  Galaway, F., Yu, R., Constantinou, A., Prugnolle, F. & Wright, G. J., 15 Oct 2019, In: PLoS Biol. 17, 10, 16 p., e3000490.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Systematic screening of 96 Schistosoma mansoni cell-surface and secreted antigens does not identify any strongly protective vaccine candidates in a mouse model of infection.

  Crosnier, C., Brandt, C., Rinaldi, G., McCarthy, C., Barker, C., Clare, S., Berriman, M. & Wright, G. J., 16 Oct 2019, In: Wellcome Open Research. 4, 21 p., 159.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Alpha-v-containing integrins are host receptors for the Plasmodium falciparum sporozoite surface protein, TRAP.

  Dundas, K., Shears, M. J., Sun, Y., Hopp, C. S., Crosnier, C., Metcalf, T., Girling, G., Sinnis, P., Billker, O. & Wright, G. J., 24 Apr 2018, In: Proceedings of the National Academy of Sciences USA. 115, 17, p. 4477-4482 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Genome-scale identification of cellular pathways required for cell surface recognition.

  Sharma, S., Bartholdson, S. J., Couch, A. C. M., Yusa, K. & Wright, G. J., Sept 2018, In: Genome Research. 28, 9, p. 1372-1382 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File