Research output per year
Research output per year
Personal profile
Research interests
Structure, Function and Application of Novel Biocatalysts
- Organic Chemistry - Synthesis and analysis of biotransformation substrates and product standards.
- Microbiology - Screening for new microbial transformations; optimisation of biocatalyst production.
- Molecular biology - Cloning, expression and manipulation of novel genes of interest.
- Structural biology - Investigation and tailoring of enzyme structure and function
We are currently studying a variety of novel enzymatic systems including:
- Carbon-carbon bond lyases and hydrolases
- Enzymatic transformation of substrates containing silicon
- Cytochromes P450 and Flavin-dependent oxidases
- Comparative structural biology of enzyme superfamilies (Dehydrogenases, Oxidases)
Close collaboration between the YSBL group and Chemistry Department at the University of York ensures that facilities are available for all aspects of research into this area of chemical biology, from organic synthesis and analysis through to protein structure studies.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A refined picture of the native Amine Dehydrogenase family revealed by extensive biodiversity screening
Grogan, G. J., Elisee, E., Ducrot, L., Meheust, R., Bastard, K., Fossey-Jouenne, A., Pelletier, E., Petit, J.-L., Stam, M., de Berardinis, V., Zaparucha, A., Vallenet, D. & Vergne-Vaxelaire, C., 10 Jun 2024, In: Nature Communications. 15, 15 p., 4933.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Broad Spectrum Enantioselective Amide Bond Synthetase from Streptoalloteichus hindustanus
Tang, Q., Petchey, M., Rowlinson, B., Burden, T. J., Fairlamb, I. J. S. & Grogan, G., 19 Jan 2024, In: ACS Catalysis. 14, 2, p. 1021-1029 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Complementary specificity of unspecific peroxygenases enables access to diverse products from terpene oxygenation
Melling, B., Mielke, T., Whitwood, A. C., O'Riordan, T. J. C., Mulholland, N., Cartwright, J., Unsworth, W. P. & Grogan, G., 15 Feb 2024, In: CHEM: Catalysis. 4, 2, 14 p., 100889.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Discovery and reconstitution of securinine alkaloid biosynthesis
Lichman, B. R. (Principal investigator), Grogan, G. J. (Co-investigator), O'Toole, P. J. (Co-investigator) & Unsworth, W. P. (Co-investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
3/06/24 → 2/06/27
Project: Research project (funded) › Research
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Multifunctional Peroxygenase Catalysis for Synthetic Chemistry
Grogan, G. J. (Principal investigator) & Unsworth, W. P. (Co-investigator)
21/08/23 → 20/08/26
Project: Research project (funded) › Research
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Prosperity Partnership - Biobased and Biodegradable Polymers for a Sustainable Future
Chong, J. (Co-investigator), Farmer, T. J. (Co-investigator), Grogan, G. J. (Co-investigator), MacQuarrie, D. J. (Co-investigator), Matharu, A. S. (Co-investigator) & North, M. (Co-investigator)
31/03/23 → 30/03/28
Project: Research project (funded) › Research
Activities
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Synthesis of Amide Pharmaceuticals Using Amide Bond Synthetases Biocat 2024 Hamburg Germany 29-08-24
Grogan, G. J. (Invited speaker)
29 Aug 2024Activity: Talk or presentation › Invited talk
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Synthesis of Amide Pharmaceuticals Using Amide Bond Synthetases GRC Biocatalysis SNHU NH, USA 11/07/24
Grogan, G. J. (Invited speaker)
11 Jul 2024Activity: Talk or presentation › Invited talk
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Unspecific Peroxygenases: Expression, Application and Catalytic Promiscuity. IPRD meeting, University of Leeds
Grogan, G. J. (Invited speaker)
18 Apr 2024Activity: Talk or presentation › Invited talk
Datasets
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Sequence and HMM libraries
Elisée, E. (Creator), Ducrot, L. (Creator), Méheust, R. (Creator), Bastard, K. (Creator), Fossey-Jouenne, A. (Creator), Pelletier, E. (Creator), Petit, J. L. (Creator), Stam, M. (Creator), Grogan, G. (Creator), Berardinis, V. D. (Creator), Zaparucha, A. (Creator), Vallenet, D. (Creator) & Vergne-Vaxelaire, C. (Creator), Zenodo, 12 Sept 2023
Dataset
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Data underlying the chapter and publication: Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia
Fossey-Jouenne, A. (Creator), Ducrot, L. (Creator), Jongkind, E. (Creator), Elisée, E. (Creator), Zaparucha, A. (Creator), Grogan, G. (Creator), Paul, C. (Creator) & Vergne-Vaxelaire, C. (Creator), 4TU.ResearchData, 2 Aug 2024
DOI: 10.4121/60aff897-18b0-4dda-ad79-4a92597b90f9
Dataset
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Data underlying the chapter: Discovery and synthetic applications of a NAD(P)H-dependent reductive aminase from Rhodococcus erythropolis
Jongkind, E. (Creator), Domenech, J. (Creator), Govers, A. (Creator), van den Broek, M. (Creator), Daran, J.-M. (Creator), Grogan, G. (Creator) & Paul, C. (Creator), 4TU.ResearchData, 2 Aug 2024
DOI: 10.4121/6fda9cb1-beb8-4985-a210-a9625eca8899
Dataset