Gideon James Grogan

Search results

• 2024

  A refined picture of the native Amine Dehydrogenase family revealed by extensive biodiversity screening

  Grogan, G. J., Elisee, E., Ducrot, L., Meheust, R., Bastard, K., Fossey-Jouenne, A., Pelletier, E., Petit, J-L., Stam, M., de Berardinis, V., Zaparucha, A., Vallenet, D. & Vergne-Vaxelaire, C., 10 Jun 2024, In: Nature Communications. 15, 15 p., 4933.

  Research output: Contribution to journal › Article › peer-review

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• Broad Spectrum Enantioselective Amide Bond Synthetase from Streptoalloteichus hindustanus

  Tang, Q., Petchey, M., Rowlinson, B., Burden, T. J., Fairlamb, I. J. S. & Grogan, G., 19 Jan 2024, In: ACS Catalysis. 14, 2, p. 1021-1029 9 p.

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• Complementary specificity of unspecific peroxygenases enables access to diverse products from terpene oxygenation

  Melling, B., Mielke, T., Whitwood, A. C., O'Riordan, T. J. C., Mulholland, N., Cartwright, J., Unsworth, W. P. & Grogan, G., 15 Feb 2024, In: CHEM: Catalysis. 4, 2, 14 p., 100889.

  Research output: Contribution to journal › Article › peer-review

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• Gram-Scale Enzymatic Synthesis of 2ʹ-Deoxyribonucleoside Analogues Using Nucleoside Transglycosylase-2

  Grogan, G. J., Salihovic, A., Ascham, A., Taladriz-Sender, A., Bryson, S., Withers, J., McKean, I., Hoskisson, P. & Burley, G., 27 Aug 2024, (E-pub ahead of print) In: Chemical Science.

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• Preparative Scale Achmatowicz and aza-Achmatowicz Rearrangements Catalyzed by Agrocybe aegerita Unspecific Peroxygenase

  Pogranyi, B., Mielke, T., Diaz-Rodriguez, A., Cartwright, J., Unsworth, W. P. & Grogan, G. J., 15 Jul 2024, (E-pub ahead of print) In: Organic and Biomolecular Chemistry. 7 p.

  Research output: Contribution to journal › Article › peer-review

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• Redox-reversible siderophore-based catalyst anchoring within cross-linked artificial metalloenzyme aggregates enables enantioselectivity switching

  Miller, A. H., Thompson, S., Blagova, L., Wilson, K. S., Grogan, G. J. & Duhme-Klair, A-K., 29 Apr 2024, (E-pub ahead of print) In: Chemical communications. 4 p.

  Research output: Contribution to journal › Article › peer-review

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• Selective Oxidations of Toluenes and Benzyl Alcohols by an Unspecific Peroxygenase (UPO)

  Grogan, G. J., Pogranyi, B., Mielke, T., Cartwright, J. & Unsworth, W. P., 24 May 2024, (E-pub ahead of print) In: ChemCatChem.

  Research output: Contribution to journal › Article › peer-review

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• SilE-R and SilE-S - DABB Proteins Catalyzing Enantiospecific Hydrolysis of Organosilyl Ethers

  Pick, L., Oehme, V., Hartmann, J., Wenzlaff, J., Tang, Q., Grogan, G. J. & Ansorge-Schumacher, M., 16 May 2024, (E-pub ahead of print) In: Angewandte Chemie International Edition. 12 p.

  Research output: Contribution to journal › Article › peer-review

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• Unspecific Peroxygenase (UPO) can be Tuned for Oxygenation or Halogenation Activity by Controlling the Reaction pH

  Barber, V., Mielke, T., Diaz-Rodriguez, A., Cartwright, J., Unsworth, W. P. & Grogan, G. J., 17 May 2024, (E-pub ahead of print) In: Chemistry : A European Journal. 6 p., e2024017.

  Research output: Contribution to journal › Article › peer-review

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• 2023

  A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate

  Grogan, G. J., Gilio, A., Thorpe, T., Heyam, A., Petchey, M., Pogranyi, B., France, S. P., Howard, R., Karmilowicz, M., Lewis, R. & Turner, N., 3 Feb 2023, In: ACS Catalysis. 13, p. 1669–1677 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Divergent Cascade Ring Expansion Reactions of Acryloyl Imides

  Grogan, G. J., Orukotan, W., Palate, K., Pogranyi, B., Epton, R., Duff, L., Whitwood, A. C., Lynam, J. M., Unsworth, W. P. & Bobinski, P., 21 Nov 2023, (Accepted/In press) In: Chemistry : A European Journal. e202303270.

  Research output: Contribution to journal › Article › peer-review

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• Engineering of a Reductive Aminase to Enable the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor

  Grogan, G. J., Gilio, A., Steflik, J., Burns, M., Kumar, R., Lewis, R. & Martinez, C., 18 Jul 2023, (E-pub ahead of print) In: ACS Catalysis. 11 p.

  Research output: Contribution to journal › Article › peer-review

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• Native amine dehydrogenases can catalyze the direct reduction of carbonyl compounds to alcohols in the absence of ammonia

  Grogan, G. J., Fossey-Jouenne, A., Ducrot, L., Jongkind, E., Elisee, E., Zaparucha, A., Paul, C. & Vergne-Vaxelaire, C., 16 Jan 2023, In: Frontiers in Catalysis.

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• Structure and Mutation of Deoxypodophyllotoxin Synthase (DPS) from Podophyllum hexandrum

  Ingold, Z., Grogan, G. J. & Lichman, B. R., 24 May 2023, In: Frontiers in Catalysis. 3, 10 p., 1178345.

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• Structure of the Imine Reductase from Ajellomyces dermatitidis in Three Crystal Forms

  Sharma, M., Williams, A., Gonzalez-Martinez, D., Cuetos, A. & Grogan, G. J., 31 Jul 2023, (E-pub ahead of print) In: Acta Crystallographica Section F: Structural Biology Communications. 7 p.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  Advanced Insights into Catalytic and Structural Features of the Zinc-Dependent Alcohol Dehydrogenase from Thauera aromatica

  Stark, F., Loderer, C., Petchey, M., Grogan, G. J. & Ansorge-Schumacher, M., 14 Jun 2022, (E-pub ahead of print) In: Chembiochem. 12 p., e202200149.

  Research output: Contribution to journal › Article › peer-review

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• Biocatalytic activation of diazirines for carbene-transfer reactions

  Pogrányi, B., Unsworth, W. P. & Grogan, G., 14 Jul 2022, In: Chem. 8, 7, p. 1801-1804 4 p.

  Research output: Contribution to journal › Comment/debate › peer-review

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• Chromoselective Photocatalysis Enables Stereocomplementary Biocatalytic Pathways

  Schmermund, L., Reischauer, S., Bierbaumer, S., Winkler, C., Diaz-Rodriguez, A., Edwards, L., Kara, S., Mielke, T., Cartwright, J. L., Grogan, G. J., Pieber, B. & Kroutil, W., 22 Mar 2022, In: Angewandte Chemie International Edition. 60, 13

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• Comparing the catalytic and structural characteristics of a ‘short’ unspecific peroxygenase (UPO) expressed in P. pastoris and E. coli

  Robinson, W., Mielke, T., Melling, B., Cuetos, A., Parkin, A., Unsworth, W. P., Cartwright, J. & Grogan, G. J., 30 Nov 2022, (E-pub ahead of print) In: Chembiochem. 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Expanding the Substrate Scope of Native Amine Dehydrogenases through In Silico Structural Exploration and Targeted Protein Engineering

  Grogan, G. J., Ducrot, L., Bennett, M., Andre_Leroux, G., Elisee, E., Marynberg, S., Fossey-Jouenne, A., Zaparucha, A. & Vergne-Vaxelaire, C., 29 Sept 2022, (E-pub ahead of print) In: ChemCatChem.

  Research output: Contribution to journal › Article › peer-review

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• Multifunctional biocatalyst for conjugate reduction and reductive amination

  Thorpe, T., Marshall, J., Harawa, V., Ruscoe, R., Cuetos, A., Finnigan, J., Angelastro, A., Heath, R., Parmeggianni, F., Charnock, S. J., Howard, R., Kumar, R., Daniels, D., Grogan, G. J. & Turner, N., 2022, In: Nature. 604, p. 86-91

  Research output: Contribution to journal › Article › peer-review

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• Oxalate Oxidase for In Situ H2O2-generation in Unspecific Peroxygenase-Catalysed Drug Oxyfunctionalisations

  Grogan, G. J., Romero, E., Johansson, M., Cartwright, J. & Hayes, M. A., 2 Aug 2022, (E-pub ahead of print) In: Angewandte Chemie International Edition. 7 p., e202207831.

  Research output: Contribution to journal › Article › peer-review

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• Preparative-Scale Biocatalytic Oxygenation of N-Heterocycles with a Lyophilized Peroxygenase Catalyst

  Grogan, G. J., Pogranyi, B., Mielke, T., Diaz-Rodriguez, A., Cartwright, J. & Unsworth, W. P., 1 Dec 2022, (E-pub ahead of print) In: Angewandte Chemie International Edition. 62, 5, e202214759.

  Research output: Contribution to journal › Article › peer-review

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• Reductive Aminations by Imine Reductases: From Milligrams to Tons

  Grogan, G. J., Gilio, A., Thorpe, T. & Turner, N., 7 Apr 2022, (E-pub ahead of print) In: Chemical Science. 13, 17, p. 4697-4713

  Research output: Contribution to journal › Article › peer-review

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• Structure and Mutation of the Native Amine Dehydrogenase MATOUAmDH2

  Bennett, M., Ducrot, L., Vergne-Vaxelaire, C. & Grogan, G. J., 18 May 2022, In: Chembiochem. 23, 10, 6 p., e202200136.

  Research output: Contribution to journal › Article › peer-review

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• Synthesis of Stereoenriched Piperidines via Chemo- Enzymatic Dearomatization of Activated Pyridines

  Grogan, G. J., Harawa, V., Thorpe, T., Marshall, J., Sangster, J., Gilio, A., Pirvu, L., Heath, R., Angelastro, A., Finnigan, J., Charnock, S. J., Nafie, J., Whitehead, R. & Turner, N., 9 Nov 2022, In: Journal of the American Chemical Society. 8 p.

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• The Reactivity of α-Fluoroketones with PLP Dependent Enzymes: Transaminases as Hydrodefluorinases

  Garcia-Ramos, M., Cuetos, A., Kroutil, W., Grogan, G. J. & Lavandera, I., 17 Sept 2022, In: ChemCatChem. 13, 18, p. 3967-3972

  Research output: Contribution to journal › Article › peer-review

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• 2021

  Biocatalytic Aromaticity-Breaking Epoxidation of Naphthalene

  Grogan, G. J., Whitwood, A. C., Zhang, W., Li, H., Younes, S., Gomez de Santos, P., Tieves, F., Pabst, M., Alcalde, M. & Hollmann, F., 12 Feb 2021, (E-pub ahead of print) In: ACS Catalysis. 11, p. 2644-2649 6 p.

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• Biocatalytic reductive amination by native Amine Dehydrogenases to access short chiral alkyl amines and amino alcohols

  Ducrot, L., Bennett, M., Caparco, A., Champion, J., Bommarius, A., Zaparucha, A., Grogan, G. J. & Vergne-Vaxelaire, C., 26 Nov 2021, In: Frontiers in Catalysis. 1, 14 p., 781284.

  Research output: Contribution to journal › Article › peer-review

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• Hemoprotein Catalyzed Oxygenations: P450s, UPOs and Progress Toward Scalable Reactions

  Grogan, G. J., 26 Jul 2021, In: JACS Au. 1, 9, p. 1312-1329

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• Inverting the stereoselectivity of an NADH-dependent imine reductase variant

  Stockinger, P., Borlinghaus, N., Sharma, M., Aberle, B., Grogan, G. J., Pleiss, J. & Nestl, B., 8 Oct 2021, (E-pub ahead of print) In: ChemCatChem.

  Research output: Contribution to journal › Article › peer-review

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• Substrate anchoring and flexibility reduction in CYP153AM.aq leads to highly improved activity towards octanoic acid

  Grogan, G. J., Rowlinson, B., Sharma, M., Zukic, E., Hauer, B., Rapp, L., Marques, S. & Damborsky, J., 24 Feb 2021, (E-pub ahead of print) In: ACS Catalysis. 11, p. 3182-3189 8 p.

  Research output: Contribution to journal › Article › peer-review

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• 2020

  Artificial Imine Reductases: Developments and Future Directions

  Booth, R., Grogan, G. J., Wilson, K. S. & Duhme-Klair, A-K., 16 Oct 2020, In: RSC Chemical Biology. p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases

  Mangas-Sanchez, J., Sharma, M., Cosgrove, S., Ramsden, J. I., Marshall, J., Thorpe, T., Palmer, R., Grogan, G. J. & Turner, N., 30 Apr 2020, (Accepted/In press) In: Chemical Science. 6 p.

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• Asymmetric Synthesis of Primary and Secondary β-Fluoro-arylamines using Reductive Aminases from Fungi

  Grogan, G. J., Sharma, M., Cuetos, A., Lavandera, I., Gotor-Fernández, V., Gonzalez-Martinez, D. & Garcia-Ramos, M., 10 Feb 2020, (E-pub ahead of print) In: ChemCatChem.

  Research output: Contribution to journal › Article › peer-review

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• Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System

  Grogan, G. J., Rowlinson, B., Petchey, M., Fairlamb, I. J. S. & Lloyd, R., 30 Mar 2020, In: ACS Catalysis. 10, p. 4659-4663 5 p.

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• Inverted binding of non-natural substrates in strictosidine synthase leads to a switch of stereochemical outcome in enzyme-catalyzed Pictet-Spengler reactions

  Eger, E., Adam, S., Sharma, M., Yang, S., Breukelaar, W., Grogan, G. J., Houk, K. & Kroutil, W., 15 Jan 2020, In: Journal of the American Chemical Society. p. 1-9 9 p.

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• Mutational Analysis of Linalool Dehydratase-Isomerase (LinD) Suggests Alcohol and Alkene Transformations are Catalyzed Using Non-Covalent Mechanisms

  Grogan, G. J., Cuetos, A., Danesh-Azari, H-R., Dowle, A., Zukic, E., Iglesias, J. & Osuna, S., 15 Sept 2020, In: ACS Catalysis. p. 1-11 11 p.

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• NAD(P)H-Dependent Enzymes for Reductive Amination: Active Site Description and Carbonyl-Containing Compound Spectrum.

  Ducrot, L., Bennett, M., Grogan, G. J. & Vergne-Vaxelaire, C., 1 Oct 2020, (E-pub ahead of print) In: Advanced Synthesis and Catalysis. 25 p.

  Research output: Contribution to journal › Article › peer-review

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• 2019

  A family of Native Amine Dehydrogenases for the Asymmetric Reductive Amination of Ketones

  Grogan, G. J., Frese, A., Turkenburg, J., Beloti, L., Mayol, O., Bastard, K., Petit, J-L., Debard, A., Pellouin, V., Mariage, A., Perret, A., de Berardinis, V., Zaparucha, A. & Vergne-Vaxelaire, C., 1 Apr 2019, In: Nature Catalysis. 2, 4, p. 324-333 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Enzyme-catalyzed Synthesis of Secondary and Tertiary Amides

  Petchey, M. & Grogan, G. J., 4 Sept 2019, In: Advanced Synthesis and Catalysis. 361, 17, p. 3895-3914 20 p.

  Research output: Contribution to journal › Review article › peer-review

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• Identification and characterization of cytochrome P450 1232A24 and 1232F1 from Arthrobacter sp. and their role in the metabolic pathway of papaverine

  Klenk, J. M., Fischer, M-P., Dubiel, P., Sharma, M., Rowlinson, B., Grogan, G. & Hauer, B., 13 Feb 2019, (E-pub ahead of print) In: The Journal of Biochemistry.

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• S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation

  Grogan, G. J., McKean, I., Sadler, J., Cuetos, A., Frese, A., Humphreys, L., Hoskisson, P. & Burley, G., 2 Dec 2019, In: Angewandte Chemie International Edition. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

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• The Right Light – De Novo Design of a Robust Modular Photochemical Reactor for Optimum Batch and Flow Chemistry

  Grogan, G. J., Bonfield, H., Mercer, K., Diaz-Rodriguez, A., Cook, G., McKay, B., Slade, P., Taylor, G., Ooi, W. X., Williams, J., Roberts, J., Murphy, J., Schmermund, L., Kroutil, W., Mielke, T., Cartwright, J. & Edwards, L., 15 Aug 2019, (E-pub ahead of print) In: Chemphotochem.

  Research output: Contribution to journal › Article › peer-review

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• Two Enantiocomplementary Ephedrine Dehydrogenases from Arthrobacter sp. TS-15 with Broad Substrate Specificity

  Grogan, G. J., Shanati, T., Lockie, C., Beloti, L. & Ansorge-Schumacher, M., 5 Jul 2019, In: ACS Catalysis. 9, 7, 10 p., 6202–6211.

  Research output: Contribution to journal › Article › peer-review

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• 2018

  A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases (RedAms)

  Sharma, M., Mangas-Sanchez, J., France, S., Aleku, G., Montgomery, S. L., Ramsden, J., Turner, N. & Grogan, G. J., 26 Oct 2018, (E-pub ahead of print) In: ACS Catalysis. 2018, 8, p. 11534–11541 8 p.

  Research output: Contribution to journal › Article › peer-review

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• An Aminocaprolactam Racemase from Ochrobactrum anthropi with Promiscuous Amino Acid Ester Racemase Activity

  Grogan, G. J., Frese, A., Barrass, S., Sutton, P. & Adams, J., 10 Jul 2018, (E-pub ahead of print) In: Chembiochem. p. 1-5 5 p.

  Research output: Contribution to journal › Article › peer-review

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• Biocatalytic Conversion of Cyclic Ketones Bearing α-Quaternary Stereocenters into Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles

  Morrill, C., Jensen, C. N., Just-Baringo, X., Grogan, G., Turner, N. & Procter, D. J., 26 Mar 2018, In: Angewandte Chemie International Edition. 57, 14, p. 3692-3696 5 p.

  Research output: Contribution to journal › Article › peer-review

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• Biocatalyzed C-C bond formation for the production of alkaloids

  Grogan, G. J., Patil, M. & Yun, H., 23 Aug 2018, (E-pub ahead of print) In: ChemCatChem. 10, 24 p.

  Research output: Contribution to journal › Article › peer-review

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• Characterization and structure-guided engineering of the novel versatile terpene monooxygenase CYP109Q5 from Chondromyces apiculatus DSM436

  Klenk, J., Dubiel, P., Sharma, M., Grogan, G. J. & Hauer, B., 27 Dec 2018, (E-pub ahead of print) In: Microbial Biotechnology. 15 p.

  Research output: Contribution to journal › Article › peer-review

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