Gideon John Davies, FRS, FMedSci

Search results

• 2016

  The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases

  Frandsen, K. E. H., Simmons, T. J., Dupree, P., Poulsen, J-C. N., Hemsworth, G. R., Ciano, L., Johnston, E. M., Tovborg, M., Johansen, K. S., von Freiesleben, P., Marmuse, L., Fort, S., Cottaz, S., Driguez, H., Henrissat, B., Lenfant, N., Tuna, F., Baldansuren, A., Davies, G. J., Lo Leggio, L., & 1 othersWalton, P. H., 1 Apr 2016, In: NATURE CHEMICAL BIOLOGY. 12, 4, p. 298–303 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β-D-glucosidases

  Agirre, J., Ariza, A., Offen, W. A., Turkenburg, J. P., Roberts, S. M., McNicholas, S., Harris, P. V., McBrayer, B., Dohnalek, J., Cowtan, K. D., Davies, G. J. & Wilson, K. S., 1 Feb 2016, In: Acta crystallographica. Section D, Structural biology. 72, 2, p. 254-265 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

  Speciale, G., Jin, Y., Davies, G. J., Williams, S. J. & Goddard-Borger, E. D., Apr 2016, In: NATURE CHEMICAL BIOLOGY. 12, p. 215–217 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors

  Bergeron-Brlek, M., Goodwin-Tindall, J., Cekic, N., Roth, C., Zandberg, W. F., Shan, X., Varghese, V., Chan, S., Davies, G. J., Vocadlo, D. J. & Britton, R., 14 Dec 2015, In: Angewandte Chemie International Edition. 6 p.

  Research output: Contribution to journal › Article › peer-review

• Carbohydrate anomalies in the PDB

  Agirre, J., Davies, G., Wilson, K. & Cowtan, K., 2015, In: NATURE CHEMICAL BIOLOGY. 11, 5, p. 303 1 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

• Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

  Thompson, A. J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R. J., Chandler, E., Temple, M. J., Stepper, J., Gilbert, H. J., Rovira, C., Williams, S. J. & Davies, G. J., 27 Apr 2015, In: Angewandte Chemie International Edition. 54, 18, p. 5378-5382 5 p.

  Research output: Contribution to journal › Article › peer-review

• Exploiting the hydrophobic terrain in fucosidases with aryl-substituted pyrrolidine iminosugars

  Hottin, A., Wright, D. W., Davies, G. J. & Behr, J-B., 19 Jan 2015, In: Chembiochem. 16, 2, p. 277-283 7 p.

  Research output: Contribution to journal › Article › peer-review

• Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

  Cuskin, F., Lowe, E. C., Temple, M. J., Zhu, Y., Cameron, E. A., Pudlo, N. A., Porter, N. T., Urs, K., Thompson, A. J., Cartmell, A., Rogowski, A., Hamilton, B. S., Chen, R., Tolbert, T. J., Piens, K., Bracke, D., Vervecken, W., Hakki, Z., Speciale, G., Munōz-Munōz, J. L., & 12 othersDay, A., Peña, M. J., McLean, R., Suits, M. D. L., Boraston, A. B., Atherly, T., Ziemer, C. J., Williams, S. J., Davies, G. J., Abbott, D. W., Martens, E. C. & Gilbert, H. J., 8 Jan 2015, In: Nature. 517, 7533, p. 165-169 5 p.

  Research output: Contribution to journal › Article › peer-review

• In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-L-fucosidases

  Jiang, J., Kallemeijn, W. W., Wright, D. W., Van Den Nieuwendijk, A. M. C. H., Rohde, V. C., Folch, E. C., Van Den Elst, H., Florea, B. I., Scheij, S., Donker-Koopman, W. E., Verhoek, M., Li, N., Schürmann, M., Mink, D., Boot, R. G., Codée, J. D. C., Van Der Marel, G. A., Davies, G. J., Aerts, J. M. F. G. & Overkleeft, H. S., 1 May 2015, In: Chemical Science. 6, 5, p. 2782-2789 8 p.

  Research output: Contribution to journal › Article › peer-review

• Lytic Polysaccharide Monooxygenases in Biomass Conversion

  Hemsworth, G. R., Johnston, E. M., Davies, G. J. & Walton, P. H., Dec 2015, In: TRENDS IN BIOTECHNOLOGY. 33, 12, p. 747-761 15 p.

  Research output: Contribution to journal › Review article › peer-review

• Privateer: software for the conformational validation of carbohydrate structures

  Agirre, J., Iglesias-Fernández, J., Rovira, C., Davies, G. J., Wilson, K. S. & Cowtan, K. D., 4 Nov 2015, In: Nature Structural & Molecular Biology. 22, 11, p. 833-834 2 p.

  Research output: Contribution to journal › Letter › peer-review

  Open Access

  File

• Structural and Functional Characterization of a Novel Family GH115 4-O-Methyl-α-Glucuronidase with Specificity for Decorated Arabinogalactans

  Aalbers, F., Turkenburg, J. P., Davies, G. J., Dijkhuizen, L. & Lammerts Van Bueren, A., 4 Dec 2015, In: Journal of Molecular Biology. 427, 24, p. 3935-3946 12 p.

  Research output: Contribution to journal › Article › peer-review

• Structural and kinetic dissection of the endo-α-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp

  Hakki, Z., Thompson, A. J., Bellmaine, S., Speciale, G., Davies, G. J. & Williams, S. J., 26 Jan 2015, In: Chemistry : A European Journal. 21, 5, p. 1966-1977 12 p.

  Research output: Contribution to journal › Article › peer-review

• Structural characterization of human heparanase reveals insights into substrate recognition

  Wu, L., Viola, C. M., Brzozowski, A. M. & Davies, G. J., 16 Nov 2015, In: Nature Structural & Molecular Biology. 22, 12, p. 1016-1022 7 p.

  Research output: Contribution to journal › Article › peer-review

• Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

  Lo Leggio, L., Simmons, T. J., Poulsen, J. C. N., Frandsen, K. E. H., Hemsworth, G. R., Stringer, M. A., Von Freiesleben, P., Tovborg, M., Johansen, K. S., De Maria, L., Harris, P. V., Soong, C. L., Dupree, P., Tryfona, T., Lenfant, N., Henrissat, B., Davies, G. J. & Walton, P. H., 22 Jan 2015, In: Nature Communications. 6, 9 p., 5961.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structure–function characterization reveals new catalytic diversity in the galactose oxidase and glyoxal oxidase family

  Yin, D. T., Urresti, S., Lafond, M., Johnston, E. M., Derikvand, F., Ciano, L., Berrin, J. G., Henrissat, B., Walton, P. H., Davies, G. J. & Brumer, H., 18 Dec 2015, In: Nature Communications. 6, 13 p., 10197.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Structure of the GH76 -mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron

  Thompson, A. J., Cuskin, F., Spears, R. J., Dabin, J., Turkenburg, J. P., Gilbert, H. J. & Davies, G. J., 1 Jan 2015, In: Acta Crystallographica. Section D, Biological Crystallography. D71, p. 408-415 8 p.

  Research output: Contribution to journal › Article › peer-review

• The GH130 family of mannoside phosphorylases contains glycoside hydrolases that target β-1,2-mannosidic linkages in Candida mannan

  Cuskin, F., Baslé, A., Ladevèze, S., Day, A. M., Gilbert, H. J., Davies, G. J., Potocki-Véronèse, G. & Lowe, E. C., 9 Oct 2015, In: Journal of Biological Chemistry. 290, 41, p. 25023-25033 11 p.

  Research output: Contribution to journal › Article › peer-review

• The three-dimensional structure of the cellobiohydrolase Cel7A from Aspergillus fumigatus at 1.5Å resolution

  Moroz, O. V., Maranta, M., Shaghasi, T., Harris, P. V., Wilson, K. S. & Davies, G. J., 1 Jan 2015, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 71, p. 114-120 7 p.

  Research output: Contribution to journal › Article › peer-review

• Three-dimensional structure of a variant 'Termamyl-like' Geobacillus stearothermophilus α-amylase at 1.9Å resolution

  Offen, W. A., Viksoe-Nielsen, A., Borchert, T. V., Wilson, K. S. & Davies, G. J., Jan 2015, In: Acta Crystallographica Section F:Structural Biology Communications. 71, 1, p. 66-70 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  A complex gene locus enables xyloglucan utilization in the model saprophyte Cellvibrio japonicus

  Larsbrink, J., Thompson, A. J., Lundqvist, M., Gardner, J. G., Davies, G. J. & Brumer, H., 1 Oct 2014, In: Molecular Microbiology. 94, 2, p. 418-433 16 p.

  Research output: Contribution to journal › Article › peer-review

• A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

  Larsbrink, J., Rogers, T. E., Hemsworth, G. R., McKee, L. S., Tauzin, A. S., Spadiut, O., Klinter, S., Pudlo, N. A., Urs, K., Koropatkin, N. M., Creagh, A. L., Haynes, C. A., Kelly, A. G., Cederholm, S. N., Davies, G. J., Martens, E. C. & Brumer, H., 27 Feb 2014, In: Nature. 506, 7489, p. 498-502 5 p.

  Research output: Contribution to journal › Article › peer-review

• Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate

  Williams, R. J., Iglesias-Fernández, J., Stepper, J., Jackson, A., Thompson, A. J., Lowe, E. C., White, J. M., Gilbert, H. J., Rovira, C., Davies, G. J. & Williams, S. J., 20 Jan 2014, In: Angewandte Chemie International Edition. 53, 4, p. 1087-1091 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Discovery and characterization of a new family of lytic polysaccharide monooxygenases

  Hemsworth, G. R., Henrissat, B., Davies, G. J. & Walton, P. H., Feb 2014, In: NATURE CHEMICAL BIOLOGY. 10, 2, p. 122-126 5 p.

  Research output: Contribution to journal › Article › peer-review

• Discovery of selective small-molecule activators of a bacterial glycoside hydrolase

  Darby, J. F., Landström, J., Roth, C., He, Y., Davies, G. J. & Hubbard, R. E., 1 Dec 2014, In: Angewandte Chemie International Edition. 53, 49, p. 13419-13423

  Research output: Contribution to journal › Article › peer-review

• Dissecting conformational contributions to glycosidase catalysis and inhibition

  Speciale, G., Thompson, A. J., Davies, G. J. & Williams, S. J., Oct 2014, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 28, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Spectroscopic and computational insight into the activation of O ₂by the mononuclear Cu center in polysaccharide monooxygenases

  Kjaergaard, C. H., Qayyum, M. F., Wong, S. D., Xu, F., Hemsworth, G. R., Walton, D. J., Young, N. A., Davies, G. J., Walton, P. H., Johansen, K. S., Hodgson, K. O., Hedman, B. & Solomon, E. I., 17 Jun 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8797-8802 6 p.

  Research output: Contribution to journal › Article › peer-review

• Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway

  Kim, R. Q., Offen, W. A., Davies, G. J. & Stubbs, K. A., Jan 2014, In: Acta Crystallographica. Section D, Biological Crystallography. 70, 1, p. 177-185 9 p.

  Research output: Contribution to journal › Article › peer-review

• Structure and activity of the streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition

  Thi, N. N., Offen, W. A., Shareck, F., Davies, G. J. & Doucet, N., 25 Mar 2014, In: Biochemistry. 53, 11, p. 1789-1800 12 p.

  Research output: Contribution to journal › Article › peer-review

• Three-dimensional structure of a Streptomyces sviceus GNAT acetyltransferase with similarity to the C-terminal domain of the human GH84 O-GlcNAcase

  He, Y., Roth, C., Turkenburg, J. P. & Davies, G. J., 1 Jan 2014, In: Acta Crystallographica. Section D, Biological Crystallography. 70, 1, p. 186-195 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Cracking the code, slowly: The state of carbohydrate-active enzymes in 2013

  Davies, G. J. & Henrissat, B., 1 Oct 2013, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 23, 5, p. 649-651

  Research output: Contribution to journal › Article › peer-review

• Exploring a multivalent approach to α-L-fucosidase inhibition

  Moreno-Clavijo, E., Carmona, A. T., Moreno-Vargas, A. J., Molina, L., Wright, D. W., Davies, G. J. & Robina, I., 10 Oct 2013, In: European Journal of Organic Chemistry. 32, p. 7328-7336 9 p.

  Research output: Contribution to journal › Article › peer-review

• Identifying the catalytic acid/base in GH29 α-l-fucosidase subfamilies

  Shaikh, F. A., Lammerts Van Bueren, A., Davies, G. J. & Withers, S. G., 27 Aug 2013, In: Biochemistry. 52, 34, p. 5857-5864 8 p.

  Research output: Contribution to journal › Article › peer-review

• Recent insights into copper-containing lytic polysaccharide mono-oxygenases

  Hemsworth, G. R., Davies, G. J. & Walton, P. H., 1 Oct 2013, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 23, 5, p. 660-668

  Research output: Contribution to journal › Article › peer-review

• Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-β-glucosidase SPy1599

  Stepper, J., Dabin, J., Eklof, J. M., Thongpoo, P., Kongsaeree, P., Taylor, E. J., Turkenburg, J. P., Brumer, H. & Davies, G. J., Jan 2013, In: Acta Crystallographica. Section D, Biological Crystallography. 69, Pt 1, p. 16-23 8 p.

  Research output: Contribution to journal › Article › peer-review

• The copper active site of CBM33 polysaccharide oxygenases

  Hemsworth, G. R., Taylor, E. J., Kim, R. Q., Gregory, R. C., Lewis, S. J., Turkenburg, J. P., Parkin, A., Davies, G. J. & Walton, P. H., 24 Apr 2013, In: Journal of the American Chemical Society. 135, 16, p. 6069-6077 9 p.

  Research output: Contribution to journal › Article › peer-review

• Three dimensional structure of a bacterial α-l-fucosidase with a 5-membered iminocyclitol inhibitor

  Wright, D. W., Moreno-Vargas, A. J., Carmona, A. T., Robina, I. & Davies, G. J., 15 Aug 2013, In: Bioorganic & Medicinal Chemistry. 21, 16, p. 4751-4754

  Research output: Contribution to journal › Article › peer-review

• α-L-fucosidase inhibition by pyrrolidine-ferrocene hybrids: Rationalization of ligand-binding properties by structural studies

  Hottin, A., Wright, D. W., Steenackers, A., Delannoy, P., Dubar, F., Biot, C., Davies, G. J. & Behr, J-B., 15 Jul 2013, In: Chemistry - A European Journal. 19, 29, p. 9526-9533

  Research output: Contribution to journal › Article › peer-review
• 2012

  Biosynthesis of the tunicamycin antibiotics proceeds via unique exo-glycal intermediates

  Wyszynski, F. J., Lee, S. S., Yabe, T., Wang, H., Gomez-Escribano, J. P., Bibb, M. J., Lee, S. J., Davies, G. J. & Davis, B. G., Jul 2012, In: Nature Chemistry. 4, 7, p. 539-546 8 p.

  Research output: Contribution to journal › Article › peer-review

• Conformational Analyses of the Reaction Coordinate of Glycosidases

  Davies, G. J., Planas, A. & Rovira, C., 21 Feb 2012, In: ACCOUNTS OF CHEMICAL RESEARCH. 45, 2, p. 308-316 9 p.

  Research output: Contribution to journal › Literature review › peer-review

• Fleetamine (3-O-alpha-D-glucopyranosyl-swainsonine): the synthesis of a hypothetical inhibitor of endo-alpha-mannosidase

  Quach, T., Tsegay, S., Thompson, A. J., Kukushkin, N. V., Alonzi, D. S., Butters, T. D., Davies, G. J. & Williams, S. J., 15 Jul 2012, In: TETRAHEDRON-ASYMMETRY. 23, 13, p. 992-997 6 p.

  Research output: Contribution to journal › Article › peer-review

• Genome analyses highlight the different biological roles of cellulases

  Medie, F. M., Davies, G. J., Drancourt, M. & Henrissat, B., Mar 2012, In: Nature reviews. Microbiology. 10, 3, p. 227-U 8 p.

  Research output: Contribution to journal › Literature review › peer-review

• GLYCOBIOLOGY The case of the missing base

  Withers, S. G. & Davies, G. J., 28 Dec 2012, In: NATURE CHEMICAL BIOLOGY. 8, 12, p. 952-953 2 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity

  Cuskin, F., Flint, J. E., Gloster, T. M., Morland, C., Basle, A., Henrissat, B., Coutinho, P. M., Strazzulli, A., Solovyova, A. S., Davies, G. J. & Gilbert, H. J., 18 Dec 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 51, p. 20889-20894 6 p.

  Research output: Contribution to journal › Article › peer-review

• Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups INTRACELLULAR beta-O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF beta-O-LINKED beta-N-ACETYLGLUCOSAMINIDASE

  Macauley, M. S., Chan, J., Zandberg, W. F., He, Y., Whitworth, G. E., Stubbs, K. A., Yuzwa, S. A., Bennet, A. J., Varki, A., Davies, G. J. & Vocadlo, D. J., 17 Aug 2012, In: Journal of Biological Chemistry. 287, 34, p. 28882-28897 16 p.

  Research output: Contribution to journal › Article › peer-review

• Recent structural and mechanistic insights into post-translational enzymatic glycosylation

  Hurtado-Guerrero, R. & Davies, G. J., Dec 2012, In: Current Opinion in Chemical Biology. 16, 5-6, p. 479-87 9 p.

  Research output: Contribution to journal › Article › peer-review

• Structural and mechanistic insight into N-glycan processing by endo-alpha-mannosidase

  Thompson, A. J., Williams, R. J., Hakki, Z., Alonzi, D. S., Wennekes, T., Gloster, T. M., Songsrirote, K., Thomas-Oates, J. E., Wrodnigg, T. M., Spreitz, J., Stuetz, A. E., Butters, T. D., Williams, S. J. & Davies, G. J., 17 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 781-786 6 p.

  Research output: Contribution to journal › Article › peer-review

• Structural Enzymology of Cellvibrio japonicus Agd31B Protein Reveals α-Transglucosylase Activity in Glycoside Hydrolase Family 31

  Larsbrink, J., Izumi, A., Hemsworth, G. R., Davies, G. J. & Brumer, H., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43288-43299 12 p.

  Research output: Contribution to journal › Article › peer-review

• Structure of the catalytic core module of the Chaetomium thermophilum family GH6 cellobiohydrolase Cel6A

  Thompson, A. J., Heu, T., Shaghasi, T., Benyamino, R., Jones, A., Friis, E. P., Wilson, K. S. & Davies, G. J., Aug 2012, In: Acta Crystallographica. Section D, Biological Crystallography. 68, 8, p. 875-882 8 p.

  Research output: Contribution to journal › Article › peer-review

• THE CRYSTALLIZATION AND STRUCTURAL ANALYSIS OF CELLULASES (AND OTHER GLYCOSIDE HYDROLASES): STRATEGIES AND TACTICS

  Roberts, S. M. & Davies, G. J., 2012, CELLULASES. Gilbert, HJ. (ed.). SAN DIEGO: Elsevier, p. 141-168 28 p. (Methods in Enzymology; vol. 510).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter