Glyn Robert Hemsworth

Search results

• 2024

  Structural Dissection of Two Redox Proteins from the Shipworm Symbiont Teredinibacter turnerae

  Rajagopal, B. S., Yates, N., Smith, J., Paradisi, A., Tetard-Jones, C., Willats, W. G. T., Marcus, S., Knox, J. P., ́Firdaus-Raih, M., Henrissat, B., Davies, G. J., Walton, P. H., Parkin, A. & Hemsworth, G. R., 1 Mar 2024, In: IUCrJ. 11, 2, p. 260-274 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2023

  Recovering Biological Electron Transfer Reaction Parameters from Multiple Protein Film Voltammetric Techniques Informed by Bayesian Inference

  Lloyd-Laney, H. O., Yates, N., Hewson, A., Robinson, M., Hemsworth, G. R., Branch, J., Bond, A. M., Gavaghan, D. J. & Parkin, A., 15 Apr 2023, In: JOURNAL OF ELECTROANALYTICAL CHEMISTRY. 935, 10 p., 117264.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  Selectivity and stability of N-terminal targeting protein modification chemistries

  Barber, L. J., Yates, N. D. J., Fascione, M. A., Parkin, A., Hemsworth, G. R., Genever, P. G. & Spicer, C. D., 17 Nov 2022, (E-pub ahead of print) In: RSC Chemical Biology. 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2021

  C-type cytochrome-initiated reduction of bacterial lytic polysaccharide monooxygenases

  Branch, J., Rajagopal, B. S., Paradisi, A., Yates, N., Lindley, P. J., Smith, J., Hollingsworth, K., Turnbull, W. B., Henrissat, B., Parkin, A., Berry, A. & Hemsworth, G. R., 28 Jul 2021, In: The Biochemical journal. 478, 14, p. 2927-2944

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2020

  Insights from semi-oriented EPR spectroscopy studies into the interaction of lytic polysaccharide monooxygenases with cellulose

  Ciano, L., Paradisi, A., Hemsworth, G. R., Tovborg, M., Davies, G. J. & Walton, P. H., 3 Mar 2020, In: Dalton Transactions. 49, p. 3413-3422 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  A cell-surface GH9 endo-glucanase coordinates with surface glycan binding proteins to mediate xyloglucan uptake in the gut symbiont Bacteroides ovatus

  Foley, M. H., Dejean, G., Hemsworth, G. R., Martens, E. C., Davies, G. J., Brumer, H. & Koropatkin, N. M., 19 Jan 2019, In: Journal of Molecular Biology.

  Research output: Contribution to journal › Article › peer-review

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• Discovery, activity and characterisation of an AA10 lytic polysaccharide oxygenase from the shipworm symbiont Teredinibacter turnerae

  Fowler, C. A., Sabbadin, F., Ciano, L., Hemsworth, G. R., Elias, L., Bruce, N., McQueen-Mason, S., Davies, G. J. & Walton, P., 30 Sept 2019, In: Biotechnology for biofuels. 11 p., 232 .

  Research output: Contribution to journal › Article › peer-review

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• 2018

  An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion

  Sabbadin, F., Hemsworth, G. R., Ciano, L., Henrissat, B., Dupree, P., Tryfona, T., Marques, R. D. S., Sweeney, S. T., Besser, K., Elias, L., Pesante, G., Li, Y., Dowle, A. A., Bates, R., Gomez, L. D., Simister, R., Davies, G. J., Walton, P. H., Bruce, N. C. & McQueen-Mason, S. J., 22 Feb 2018, In: Nature Communications. 9, 1, 12 p., 756.

  Research output: Contribution to journal › Article › peer-review

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• Structure and function of a glycoside hydrolase family 8 endoxylanase from Teredinibacter turnerae

  Fowler, C. A., Hemsworth, G. R., Cuskin, F., Hart, S., Turkenburg, J., Gilbert, H. J., Walton, P. H. & Davies, G. J., 5 Oct 2018, In: Acta crystallographica. Section D, Structural biology. 74, Pt 10, p. 946-955 10 p.

  Research output: Contribution to journal › Article › peer-review

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• 2017

  Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides

  Tamura, K., Hemsworth, G. R., Déjean, G., Rogers, T. E., Pudlo, N. A., Urs, K., Jain, N., Davies, G. J., Martens, E. C. & Brumer, H., 10 Oct 2017, In: Cell reports. 21, 2, p. 417-430 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Structural and functional insight into human O-GlcNAcase

  Roth, C., Chan, O. Y., Offen, W. A., Hemsworth, G. R., Willems, L. I., King, D. T., Varghese, V., Britton, R., Vocadlo, D. J. & Davies, G. J., 1 Jun 2017, In: NATURE CHEMICAL BIOLOGY. 13, 6, p. 610-612 3 p.

  Research output: Contribution to journal › Article › peer-review

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• 2016

  Activity, stability and 3-D structure of the Cu(II) form of a chitin-active lytic polysaccharide monooxygenase from Bacillus amyloliquefaciens

  Gregory, R. C., Hemsworth, G. R., Turkenburg, J. P., Hart, S. J., Walton, P. H. & Davies, G. J., 7 Sept 2016, In: Dalton Transactions. 45, 42, p. 16904-16912 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Heterogeneity in the histidine-brace copper coordination sphere in auxiliary activity family 10 (AA10) lytic polysaccharide monooxygenases

  Chaplin, A. K., Wilson, M. T., Hough, M. A., Svistunenko, D. A., Hemsworth, G. R., Walton, P. H., Vijgenboom, E. & Worrall, J. A. R., 10 Jun 2016, In: Journal of Biological Chemistry. 291, 24, p. 12838-12850 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Learning from microbial strategies for polysaccharide degradation

  Hemsworth, G. R., Déjean, G., Davies, G. J. & Brumer, H., 9 Feb 2016, In: Biochemical Society transactions. 44, 1, p. 94-108 15 p.

  Research output: Contribution to journal › Article › peer-review

• Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut

  Hemsworth, G. R., Thompson, A. J., Stepper, J., Sobala, Ł. F., Coyle, T., Larsbrink, J., Spadiut, O., Goddard-Borger, E. D., Stubbs, K. A., Brumer, H. & Davies, G. J., 29 Jul 2016, In: Open Biology. 6, 7, 14 p., 160142.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The molecular basis of polysaccharide cleavage by lytic polysaccharide monooxygenases

  Frandsen, K. E. H., Simmons, T. J., Dupree, P., Poulsen, J-C. N., Hemsworth, G. R., Ciano, L., Johnston, E. M., Tovborg, M., Johansen, K. S., von Freiesleben, P., Marmuse, L., Fort, S., Cottaz, S., Driguez, H., Henrissat, B., Lenfant, N., Tuna, F., Baldansuren, A., Davies, G. J., Lo Leggio, L., & 1 othersWalton, P. H., 1 Apr 2016, In: NATURE CHEMICAL BIOLOGY. 12, 4, p. 298–303 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase

  Lo Leggio, L., Simmons, T. J., Poulsen, J. C. N., Frandsen, K. E. H., Hemsworth, G. R., Stringer, M. A., Von Freiesleben, P., Tovborg, M., Johansen, K. S., De Maria, L., Harris, P. V., Soong, C. L., Dupree, P., Tryfona, T., Lenfant, N., Henrissat, B., Davies, G. J. & Walton, P. H., 22 Jan 2015, In: Nature Communications. 6, 9 p., 5961.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2014

  A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes

  Larsbrink, J., Rogers, T. E., Hemsworth, G. R., McKee, L. S., Tauzin, A. S., Spadiut, O., Klinter, S., Pudlo, N. A., Urs, K., Koropatkin, N. M., Creagh, A. L., Haynes, C. A., Kelly, A. G., Cederholm, S. N., Davies, G. J., Martens, E. C. & Brumer, H., 27 Feb 2014, In: Nature. 506, 7489, p. 498-502 5 p.

  Research output: Contribution to journal › Article › peer-review

• Discovery and characterization of a new family of lytic polysaccharide monooxygenases

  Hemsworth, G. R., Henrissat, B., Davies, G. J. & Walton, P. H., Feb 2014, In: NATURE CHEMICAL BIOLOGY. 10, 2, p. 122-126 5 p.

  Research output: Contribution to journal › Article › peer-review

• Spectroscopic and computational insight into the activation of O ₂by the mononuclear Cu center in polysaccharide monooxygenases

  Kjaergaard, C. H., Qayyum, M. F., Wong, S. D., Xu, F., Hemsworth, G. R., Walton, D. J., Young, N. A., Davies, G. J., Walton, P. H., Johansen, K. S., Hodgson, K. O., Hedman, B. & Solomon, E. I., 17 Jun 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8797-8802 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei

  Hemsworth, G. R., Price, H. P., Smith, D. F. & Wilson, K. S., Feb 2013, In: Protein Science. 22, 2, p. 196-203 8 p.

  Research output: Contribution to journal › Article › peer-review

• On the catalytic mechanism of dimeric dUTPases

  Hemsworth, G. R., González-Pacanowska, D. & Wilson, K. S., 15 Nov 2013, In: Biochemical journal. 456, 1, p. 81-8 8 p.

  Research output: Contribution to journal › Article › peer-review

• Recent insights into copper-containing lytic polysaccharide mono-oxygenases

  Hemsworth, G. R., Davies, G. J. & Walton, P. H., 1 Oct 2013, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 23, 5, p. 660-668

  Research output: Contribution to journal › Article › peer-review

• The copper active site of CBM33 polysaccharide oxygenases

  Hemsworth, G. R., Taylor, E. J., Kim, R. Q., Gregory, R. C., Lewis, S. J., Turkenburg, J. P., Parkin, A., Davies, G. J. & Walton, P. H., 24 Apr 2013, In: Journal of the American Chemical Society. 135, 16, p. 6069-6077 9 p.

  Research output: Contribution to journal › Article › peer-review

• The structure of Escherichia coli ExoIX: implications for DNA binding and catalysis in flap endonucleases

  Anstey-Gilbert, C. S., Hemsworth, G. R., Flemming, C. S., Hodskinson, M. R. G., Zhang, J., Sedelnikova, S. E., Stillman, T. J., Sayers, J. R. & Artymiuk, P. J., Sept 2013, In: Nucleic Acids Research. 41, 17, p. 8357-8367 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Structural Enzymology of Cellvibrio japonicus Agd31B Protein Reveals α-Transglucosylase Activity in Glycoside Hydrolase Family 31

  Larsbrink, J., Izumi, A., Hemsworth, G. R., Davies, G. J. & Brumer, H., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43288-43299 12 p.

  Research output: Contribution to journal › Article › peer-review

• Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody

  Carpenter, B., Hemsworth, G. R., Wu, Z., Maamra, M., Strasburger, C. J., Ross, R. J. & Artymiuk, P. J., 7 Mar 2012, In: Structure. 20, 3, p. 487-97 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  The Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and Deoxyuridine

  Hemsworth, G. R., Moroz, O. V., Fogg, M. J., Scott, B., Bosch-Navarrete, C., Gonzalez-Pacanowska, D. & Wilson, K. S., 6 May 2011, In: Journal of Biological Chemistry. 286, 18, p. 16470-16481 12 p.

  Research output: Contribution to journal › Article › peer-review