Hanna Klein

Search results

• 2023

  Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

  FitzGerald, E. A., Vagrys, D., Opassi, G., Klein, H. F., Hamilton, D. J., Talibov, V. O., Abramsson, M., Moberg, A., Lindgren, M. T., Holmgren, C., Davis, B., O'Brien, P., Wijtmans, M., Hubbard, R. E., de Esch, I. J. P. & Danielson, U. H., 14 Sept 2023, In: SLAS Discovery. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2022

  Escape from planarity in fragment-based drug discovery: A synthetic strategy analysis of synthetic 3D fragment libraries

  Klein, H. F., Hamilton, D. J., de Esch, I. J. P., Wijtmans, M. & O'Brien, P., Sept 2022, In: Drug discovery today. 27, 9, p. 2484-2496

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

• Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library

  Hamilton, D. J., Beemsterboer, M., Carter, C. M., Elsayed, J., Huiberts, R. E. M., Klein, H. F., O'Brien, P., de Esch, I. J. P. & Wijtmans, M., 4 May 2022, In: ChemMedChem. 17, 9, 9 p., e202200113.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2021

  Escape from planarity in fragment-based drug discovery: A physicochemical and 3D property analysis of synthetic 3D fragment libraries

  Hamilton, D. J., Dekker, T., Klein, H. F., Janssen, G. V., Wijtmans, M., O'Brien, P. & de Esch, I. J. P., 9 Dec 2021, In: Drug Discovery Today: Technologies. 38, p. 77-90 14 p.

  Research output: Contribution to journal › Review article › peer-review
• 2020

  Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

  Douangamath, A., Fearon, D., Gehrtz, P., Krojer, T., Lukacik, P., Owen, C. D., Resnick, E., Strain-Damerell, C., Aimon, A., Ábrányi-Balogh, P., Brandão-Neto, J., Carbery, A., Davison, G., Dias, A., Downes, T. D., Dunnett, L., Fairhead, M., Firth, J. D., Jones, S. P., Keeley, A., & 14 othersKeserü, G. M., Klein, H. F., Martin, M. P., Noble, M. E. M., O’Brien, P., Powell, A., Reddi, R. N., Skyner, R., Snee, M., Waring, M. J., Wild, C., London, N., von Delft, F. & Walsh, M. A., 7 Oct 2020, In: Nature Communications. 11, 1, 5047.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Design and Synthesis of 56 Shape Diverse 3-D Fragments

  O'Brien, P., Downes, T. D., Jones, S. P., Klein, H. F., Wheldon, M. C., Atobe, M., Bond, P. S., Firth, J. D., Chan, N. S., Waddelove, L., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A. J-A. & Wrigley, G. L., 21 Apr 2020, (E-pub ahead of print) In: Chemistry : A European Journal. 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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