Research output per year
Research output per year
Search results
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2023
Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors
FitzGerald, E. A., Vagrys, D., Opassi, G., Klein, H. F., Hamilton, D. J., Talibov, V. O., Abramsson, M., Moberg, A., Lindgren, M. T., Holmgren, C., Davis, B., O'Brien, P., Wijtmans, M., Hubbard, R. E., de Esch, I. J. P. & Danielson, U. H., 14 Sept 2023, In: SLAS Discovery. 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library
Hamilton, D. J., Beemsterboer, M., Carter, C. M., Elsayed, J., Huiberts, R. E. M., Klein, H. F., O'Brien, P., de Esch, I. J. P. & Wijtmans, M., 4 May 2022, In: ChemMedChem. 17, 9, 9 p., e202200113.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Douangamath, A., Fearon, D., Gehrtz, P., Krojer, T., Lukacik, P., Owen, C. D., Resnick, E., Strain-Damerell, C., Aimon, A., Ábrányi-Balogh, P., Brandão-Neto, J., Carbery, A., Davison, G., Dias, A., Downes, T. D., Dunnett, L., Fairhead, M., Firth, J. D., Jones, S. P. & Keeley, A. & 14 others, , 7 Oct 2020, In: Nature Communications. 11, 1, 5047.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Design and Synthesis of 56 Shape Diverse 3-D Fragments
O'Brien, P., Downes, T. D., Jones, S. P., Klein, H. F., Wheldon, M. C., Atobe, M., Bond, P. S., Firth, J. D., Chan, N. S., Waddelove, L., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A.J.-A. & Wrigley, G. L., 21 Apr 2020, (E-pub ahead of print) In: Chemistry : A European Journal. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile