Helen Philippa Price

Search results

• 2024

  Evaluation of the Leishmania Inositol Phosphorylceramide Synthase as a Drug Target Using a Chemical and Genetic Approach

  Alpizar-Sosa, E. A., Zimbres, F. M., Mantilla, B. S., Dickie, E. A., Wei, W., Burle-Caldas, G. A., Filipe, L. N. S., Van Bocxlaer, K., Price, H. P., Ibarra-Meneses, A. V., Beaudry, F., Fernandez-Prada, C., Whitfield, P. D., Barrett, M. P. & Denny, P. W., 18 Jul 2024, (E-pub ahead of print) In: ACS Infectious Diseases. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Household carbon monoxide (CO) concentrations in a large African city: An unquantified public health burden?

  Orina, F., Amukoye, E., Bowyer, C., Chakaya, J., Das, D., Devereux, G., Dobson, R., Dragosits, U., Gray, C., Kiplimo, R., Lesosky, M., Loh, M., Meme, H., Mortimer, K., Ndombi, A., Pearson, C., Price, H., Twigg, M., West, S. & Semple, S., 15 Jun 2024, In: Environmental Pollution. 351, 124054, 8 p., 124054.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2020

  Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

  Paape, D., Prendergast, C. T., Price, H. P., Doehl, J. S. P. & Smith, D. F., 14 Mar 2020, In: Parasites & vectors. 13, 16 p., 132.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  Exploring the Leishmania Hydrophilic Acylated Surface Protein B (HASPB) Export Pathway by Live Cell Imaging Methods

  O'Toole, P. J., Price, H. P. & MacLean, L. M., 26 Sept 2016, In: Methods in Molecular Biology. 1459, p. 191-203 13 p.

  Research output: Contribution to journal › Article › peer-review

• Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei

  Wright, M. H., Paape, D., Price, H. P., Smith, D. F. & Tate, E. W., 10 Jun 2016, In: BMC Infectious Diseases. 2, 6, p. 427-441 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2013

  Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei

  Hemsworth, G. R., Price, H. P., Smith, D. F. & Wilson, K. S., Feb 2013, In: Protein Science. 22, 2, p. 196-203 8 p.

  Research output: Contribution to journal › Article › peer-review

• The Leishmania major BBSome subunit BBS1 is essential for parasite virulence in the mammalian host

  Price, H. P., Paape, D., Hodgkinson, M. R., Farrant, K., Doehl, J., Stark, M. & Smith, D. F., Nov 2013, In: Molecular Microbiology. n/a, n/a, p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei

  Price, H. P., Hodgkinson, M. R., Wright, M. H., Tate, E. W., Smith, B. A., Carrington, M., Stark, M. & Smith, D. F., Jul 2012, In: Biochimica et biophysica acta-Molecular cell research. 1823, 7, p. 1178-1191 14 p.

  Research output: Contribution to journal › Article › peer-review

• The Orthologue of Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1) in Trypanosoma brucei Is an Immunogenic Self-Assembling Molecule

  Price, H. P., Hodgkinson, M. R., Curwen, R. S., MacLean, L. M., Brannigan, J. A., Carrington, M., Smith, B. A., Ashford, D. A., Stark, M. & Smith, D. F., 20 Feb 2012, In: PLoS ONE. 7, 2, 14 p., e31842.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress

  Ramos, C. S., Yokoyama-Yasunaka, J. K. U., Guerra-Giraldez, C., Price, H. P., Mortara, R. A., Smith, D. F. & Uliana, S. R. B., Jan 2011, In: Experimental parasitology. 127, 1, p. 228-237 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects

  Price, H. P., Guether, M. L. S., Ferguson, M. A. J. & Smith, D. F., Jan 2010, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 169, 1, p. 55-58 4 p.

  Research output: Contribution to journal › Article › peer-review

• N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

  Brannigan, J. A., Smith, B. A., Yu, Z., Brzozowski, A. M., Hodgkinson, M. R., Maroof, A., Price, H. P., Meier, F., Leatherbarrow, R. J., Tate, E. W., Smith, D. F. & Wilkinson, A. J., 5 Mar 2010, In: Journal of Molecular Biology. 396, 4, p. 985-999 15 p.

  Research output: Contribution to journal › Article › peer-review

• N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

  Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F., Brenk, R., & 6 othersGilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In: Nature. 464, 7289, p. 728-732 5 p.

  Research output: Contribution to journal › Article › peer-review

• The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei

  Price, H. P., Peltan, A., Stark, M. & Smith, D. F., Oct 2010, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 173, 2, p. 123-131 9 p.

  Research output: Contribution to journal › Article › peer-review

• The stage-regulated HASPB and SHERP proteins are essential for differentiation of the protozoan parasite Leishmania major in its sand fly vector, Phlebotomus papatasi

  Sadlova, J., Price, H. P., Smith, B. A., Votypka, J., Volf, P. & Smith, D. F., Dec 2010, In: Cellular Microbiology. 12, 12, p. 1765-1779 15 p.

  Research output: Contribution to journal › Article › peer-review

• Validation of a new method for immobilising kinetoplastid parasites for live cell imaging

  Price, H. P., MacLean, L., Marrison, J., O'Toole, P. J. & Smith, D. F., Jan 2010, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 169, 1, p. 66-69 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania

  Mills, E., Price, H. P., Johner, A., Emerson, J. E. & Smith, D. F., Mar 2007, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 152, 1, p. 22-34 13 p.

  Research output: Contribution to journal › Article › peer-review

• TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei

  Price, H. P., Stark, M., Smith, B. & Smith, D. F., Oct 2007, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 155, 2, p. 123-127 5 p.

  Research output: Contribution to journal › Article › peer-review

• Trypanosoma brucei ARF1 plays a central role in endocytosis and Golgi-lysosome trafficking

  Price, H. P., Stark, M. & Smith, D. F., 1 Mar 2007, In: Molecular Biology of the Cell. 18, 3, p. 864-873 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

  Panethymitaki, C., Bowyer, P. W., Price, H. P., Leatherbarrow, R. J., Brown, K. A. & Smith, D. F., 1 Jun 2006, In: Biochemical journal. 396, 2, p. 277-285 9 p.

  Research output: Contribution to journal › Article › peer-review

• The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase

  Denny, P. W., Shams-Eldin, H., Price, H. P., Smith, D. F. & Schwarz, R. T., 22 Sept 2006, In: Journal of Biological Chemistry. 281, 38, p. 28200-28209 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  ARL1 has an essential role in Tryponosoma brucei

  Price, H. P., Goulding, D. & Smith, D. F., Aug 2005, In: Biochemical Society transactions. 33, p. 643-645 3 p.

  Research output: Contribution to journal › Article › peer-review

• Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes

  Price, H. P., Panethymitaki, C., Goulding, D. & Smith, D. F., 15 Feb 2005, In: Journal of Cell Science. 118, Pt 4, p. 831-41 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major

  Antoniazi, S., Price, H. P., Kropf, P., Freudenberg, M. A., Galanos, C., Smith, D. F. & Müller, I., Sept 2004, In: Infection and Immunity. 72, 9, p. 5168-74 7 p.

  Research output: Contribution to journal › Article › peer-review

• Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major

  Kropf, P., Freudenberg, M. A., Modolell, M., Price, H. P., Herath, S., Antoniazi, S., Galanos, C., Smith, D. F. & Müller, I., Apr 2004, In: Infection and Immunity. 72, 4, p. 1920-8 9 p.

  Research output: Contribution to journal › Article › peer-review

• 2003

  Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites

  Price, H. P., Menon, M. R., Panethymitaki, C., Goulding, D., McKean, P. G. & Smith, D. F., 28 Feb 2003, In: Journal of Biological Chemistry. 278, 9, p. 7206-7214 9 p.

  Research output: Contribution to journal › Article › peer-review