Research output per year
Research output per year
- 17 results
Search results
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2024
Deciphering complexity in Pd–catalyzed cross-couplings
Clarke, G. E., Firth, J. D., Ledingham, L. A., Horbaczewskyj, C. S., Bourne, R. A., Bray, J. T. W., Martin, P. L., Eastwood, J. B., Campbell, R., Pagett, A., MacQuarrie, D. J., Slattery, J. M., Lynam, J. M., Whitwood, A. C., Milani, J., Hart, S., Wilson, J. & Fairlamb, I. J. S., 10 May 2024, In: Nature Communications. 15, 1, 15 p., 3968.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2023
α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping
Seling, N., Atobe, M., Kasten, K., Firth, J. D., Karadakov, P. B., Goldberg, F. W. & O'Brien, P., 7 Dec 2023, (E-pub ahead of print) In: Angewandte Chemie International Edition. 7 p., e202314423.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2022
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates
Jones, S. P., Firth, J. D., Wheldon, M. C., Atobe, M., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Lucas, S. C. C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A. J. A., Wrigley, G. L. & O'Brien, P., 1 Dec 2022, In: RSC Medicinal Chemistry. 13, 12, p. 1614-1620Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2021
Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine
Kwong, A., Firth, J. D., Farmer, T. J. & O'Brien, P., 12 Feb 2021, In: Tetrahedron. 81, 6 p., 131899.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Synthesis and functionalisation of a bifunctional normorphan 3D building block for medicinal chemistry
Gomez-Angel, A. R., Donald, J. R., Firth, J. D., De Fusco, C., Ian Storer, R., Cox, D. J. & O'Brien, P., 12 Mar 2021, In: Tetrahedron. 83, 9 p., 131961.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease
Douangamath, A., Fearon, D., Gehrtz, P., Krojer, T., Lukacik, P., Owen, C. D., Resnick, E., Strain-Damerell, C., Aimon, A., Ábrányi-Balogh, P., Brandão-Neto, J., Carbery, A., Davison, G., Dias, A., Downes, T. D., Dunnett, L., Fairhead, M., Firth, J. D., Jones, S. P. & Keeley, A. & 14 others, , 7 Oct 2020, In: Nature Communications. 11, 1, 5047.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Design and Synthesis of 56 Shape Diverse 3-D Fragments
O'Brien, P., Downes, T. D., Jones, S. P., Klein, H. F., Wheldon, M. C., Atobe, M., Bond, P. S., Firth, J. D., Chan, N. S., Waddelove, L., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A.J.-A. & Wrigley, G. L., 21 Apr 2020, (E-pub ahead of print) In: Chemistry : A European Journal. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Fragment-derived modulators of an industrial β-glucosidase
Makraki, E., Darby, J. F., Carneiro, M. G., Firth, J. D., Heyam, A., Ab, E., O'Brien, P., Siegal, G. & Hubbard, R. E., 26 Nov 2020, In: The Biochemical journal. 477, 22, p. 4383-4395 13 p.Research output: Contribution to journal › Article › peer-review
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Light‐ and Manganese‐Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time‐Scale Revealed by Time‐Resolved Spectroscopic Analysis
Firth, J., Hammarback, A., Burden, T., Eastwood, J., Donald, J. R., Horbaczewskyj, C., McRobie, M., Tramaseur, A., Clark, I. P., Towrie, M., Robinson, A., Robinson, A., Krieger, J.-P., Lynam, J. M. & Fairlamb, I. J. S., 1 Nov 2020, (E-pub ahead of print) In: Chemistry : A European Journal. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
A synthetic and spectroscopic investigation of the asymmetric α-lithiation-trapping of six-membered N-Boc heterocycles using Alexakis diamines
Firth, J., Gelardi, G., Rayner, P. J., Stead, D. & O'Brien, P. A., 20 Jun 2018, In: Heterocycles. 97, 2, p. 1288-1303Research output: Contribution to journal › Article › peer-review
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Gram-Scale Synthesis of the (-)-Sparteine Surrogate and (-)-Sparteine
Firth, J. D., Canipa, S. J., O'Brien, P. & Ferris, L., 2 Jan 2018, In: Angewandte Chemie International Edition. 57, 1, p. 223-226 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
General Procedures for the Lithiation/Trapping of N-Boc Piperazines
Firth, J. D., O'Brien, P. & Ferris, L., 2 Jun 2017, In: The Journal of organic chemistry. 82, 13, p. 7023-7031 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Increase of enzyme activity through specific covalent modification with fragments
Darby, J. F., Atobe, M., Firth, J. D., Bond, P., Davies, G. J., O'Brien, P. A. & Hubbard, R. E., 1 Nov 2017, In: Chemical Science. 8, 11, p. 7772-7779 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2016
Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent
Firth, J. D., O'Brien, P. & Ferris, L., 20 Jan 2016, In: Journal of the American Chemical Society. 138, 2, p. 651-659 9 p.Research output: Contribution to journal › Article › peer-review
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2015
Cross-coupling knows no limits: Assessing the synthetic potential of the palladium-catalysed cross-coupling of organolithiums
Firth, J. D. & O'Brien, P., Feb 2015, In: ChemCatChem. 7, 3, p. 395-397 3 p.Research output: Contribution to journal › Article › peer-review
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2014
Revisiting the sparteine surrogate: Development of a resolution route to the (-)-sparteine surrogate
Firth, J. D., O'Brien, P. & Ferris, L., 14 Dec 2014, In: Organic and Biomolecular Chemistry. 12, 46, p. 9357-9365 9 p.Research output: Contribution to journal › Article › peer-review
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2012
An Experimental and in Situ IR Spectroscopic Study of the Lithiation-Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters
Sheikh, N. S., Leonori, D., Barker, G., Firth, J. D., Campos, K. R., Meijer, A. J. H. M., O'Brien, P. & Coldham, I., 21 Mar 2012, In: Journal of the American Chemical Society. 134, 11, p. 5300-5308 9 p.Research output: Contribution to journal › Article › peer-review