James Philip Hewitson

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• 2022

  CD317-Positive Immune Stromal Cells in Human "Mesenchymal Stem Cell" Populations

  Kay, A. G., Fox, J. M., Hewitson, J. P., Stone, A., Robertson, S., James, S., Wang, X., Kapasa, E., Yang, X. & Genever, P., 4 May 2022, (Accepted/In press) In: Frontiers in immunology.

  Research output: Contribution to journal › Article › peer-review

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• 2021

  Bone marrow remodeling supports hematopoiesis in response to immune thrombocytopenia progression in mice

  Herd, O. J., Rani, G. F., Hewitson, J. P., Hogg, K., Stone, A. P., Cooper, N., Kent, D. G., Genever, P. G. & Hitchcock, I. S., 14 Dec 2021, In: Blood Advances. 5, 23, p. 4877-4889 13 p.

  Research output: Contribution to journal › Article › peer-review

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• 2020

  Malat1 Suppresses Immunity to Infection through Promoting Expression of Maf and IL-10 in Th Cells

  Hewitson, J. P., West, K. A., James, K. R., Rani, G. F., Dey, N., Romano, A., Brown, N., Teichmann, S. A., Kaye, P. M. & Lagos, D., 22 Apr 2020, (E-pub ahead of print) In: Journal of Immunology. 12 p.

  Research output: Contribution to journal › Article › peer-review

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• 2019

  Macrophage migration inhibitory factor (MIF) is essential for Type 2 effector cell immunity to an intestinal helminth parasite

  Filbey, K. J., Varyani, F., Harcus, Y., Hewitson, J. P., Smyth, D. J., McSorley, H. J., Ivens, A., Nylén, S., Rottenberg, M., Loser, S. & Maizels, R. M., 23 Sept 2019, (Accepted/In press) In: Frontiers in immunology.

  Research output: Contribution to journal › Article › peer-review

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• miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity

  Hewitson, J. P., Shah, K. M., Brown, N., Grevitt, P., Hain, S., Newling, K., Sharp, T. V., Kaye, P. & Lagos, D., 1 May 2019, In: EMBO Reports. 20, 4, e46620.

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• 2018

  TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus

  Smyth, D. J., Harcus, Y., White, M. P. J., Gregory, W. F., Nahler, J., Stephens, I., Toke-Bjolgerud, E., Hewitson, J. P., Ivens, A., McSorley, H. J. & Maizels, R. M., 1 Apr 2018, In: International Journal for Parasitology. 48, 5, p. 379-385

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• 2017

  A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

  Johnston, C. J. C., Smyth, D. J., Kodali, R. B., White, M. P. J., Harcus, Y., Filbey, K. J., Hewitson, J. P., Hinck, C. S., Ivens, A., Kemter, A. M., Kildemoes, A. O., Le Bihan, T., Soares, D. C., Anderton, S. M., Brenn, T., Wigmore, S. J., Woodcock, H. V., Chambers, R. C., Hinck, A. P., McSorley, H. J., & 1 othersMaizels, R. M., 23 Nov 2017, In: Nature Communications. 8, 13 p., 1741.

  Research output: Contribution to journal › Article › peer-review

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• HpARI protein secreted by a helminth parasite suppresses interleukin-33

  Osbourne, M., Soares, D. C., Vacca, F., Cohen, E. S., Scott, I. C., Gregory, W. F., Smyth, D. J., Toivakka, M., Kemter, A. M., le Bihan, T., Wear, M., Hoving, D., Filbey, K. J., Hewitson, J. P., Henderson, H., Gonzalez-Ciscar, A., Errington, C., Vermeren, S., Astier, A. L., Wallace, W. A., & 4 othersSchwarze, J., Ivens, A. C., Maizels, R. M. & McSorley, H. J., 17 Oct 2017, In: Immunity. 47, 4, p. 739-751.e5 13 p.

  Research output: Contribution to journal › Article › peer-review

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• Macrophage origin limits functional plasticity in helminth-bacterial co-infection

  Rückerl, D., Campbell, S. M., Duncan, S., Sutherland, T. E., Jenkins, S. J., Hewitson, J. P., Barr, T. A., Jackson-Jones, L. H., Maizels, R. M. & Allen, J. E., 23 Mar 2017, In: PLOS PATHOGENS. 13, 3, 19 p., e1006233.

  Research output: Contribution to journal › Article › peer-review

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• 2016

  Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut

  Obieglo, K., Feng, X., Bollampalli, V. P., Dellacasa-Lindberg, I., Classon, C., Österblad, M., Helmby, H., Hewitson, J. P., Maizels, R. M., Gigliotti Rothfuchs, A. & Nylén, S., 27 Jan 2016, (E-pub ahead of print) In: Journal of Immunology. 196, 5, p. 2262-2271 10 p.

  Research output: Contribution to journal › Article › peer-review

• Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths

  Smith, K. A., Filbey, K. J., Reynolds, L. A., Hewitson, J. P., Harcus, Y., Boon, L., Sparwasser, T., Hämmerling, G. & Maizels, R. M., Mar 2016, In: Mucosal Immunology. 9, 2, p. 428-443 16 p.

  Research output: Contribution to journal › Article › peer-review

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• Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

  Maizels, R. M. & Hewitson, J. P., 23 Nov 2016, In: Microbiology spectrum. 4, 6, 10 p.

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• Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus

  Hewitson, J. P., Nguyen, D. L., van Diepen, A., Smit, C. H., Koeleman, C. A., McSorley, H. J., Murray, J., Maizels, R. M. & Hokke, C. H., Mar 2016, In: International Journal for Parasitology. 46, 3, p. 157-70 14 p.

  Research output: Contribution to journal › Article › peer-review

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• S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells

  Warner, M. J., Bridge, K. S., Hewitson, J. P., Hodgkinson, M. R., Heyam, A., Massa, B. C., Haslam, J. C., Chatzifrangkeskou, M., Evans, G. J. O., Plevin, M. J., Sharp, T. V. & Lagos, D., 16 Nov 2016, In: Nucleic Acids Research. 44, 20, p. 9942-9955 14 p.

  Research output: Contribution to journal › Article › peer-review

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• 2015

  Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection

  Hewitson, J. P., Filbey, K. J., Esser-von Bieren, J., Camberis, M., Schwartz, C., Murray, J., Reynolds, L. A., Blair, N., Robertson, E., Harcus, Y., Boon, L., Huang, S. C-C., Yang, L., Tu, Y., Miller, M. J., Voehringer, D., Le Gros, G., Harris, N. & Maizels, R. M., Mar 2015, In: PLOS PATHOGENS. 11, 3, p. e1004676

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2' phenotype in response to Th2 immunologic challenge

  Mylonas, K. J., Jenkins, S. J., Castellan, R. F. P., Ruckerl, D., McGregor, K., Phythian-Adams, A. T., Hewitson, J. P., Campbell, S. M., MacDonald, A. S., Allen, J. E. & Gray, G. A., Jul 2015, In: Immunobiology. 220, 7, p. 924-33 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites

  Reynolds, L. A., Smith, K. A., Filbey, K. J., Harcus, Y., Hewitson, J. P., Redpath, S. A., Valdez, Y., Yebra, M. J., Finlay, B. B. & Maizels, R. M., 1 Jul 2014, In: Gut Microbes. 5, 4, p. 522-32 11 p.

  Research output: Contribution to journal › Article › peer-review

• Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

  Filbey, K. J., Grainger, J. R., Smith, K. A., Boon, L., van Rooijen, N., Harcus, Y., Jenkins, S., Hewitson, J. P. & Maizels, R. M., 5 Feb 2014, In: Immunology and cell biology. 92, 5, p. 436-48 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus

  Reynolds, L. A., Harcus, Y., Smith, K. A., Webb, L. M., Hewitson, J. P., Ross, E. A., Brown, S., Uematsu, S., Akira, S., Gray, D., Gray, M., MacDonald, A. S., Cunningham, A. F. & Maizels, R. M., 15 Sept 2014, In: Journal of Immunology. 193, 6, p. 2984-93 10 p.

  Research output: Contribution to journal › Article › peer-review

• The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo

  Hewitson, J. P., Rückerl, D., Harcus, Y., Murray, J., Webb, L. M., Babayan, S. A., Allen, J. E., Kurniawan, A. & Maizels, R. M., Feb 2014, In: PLOS PATHOGENS. 10, 2, p. e1003930

  Research output: Contribution to journal › Article › peer-review

• Vaccination against helminth parasite infections

  Hewitson, J. P. & Maizels, R. M., Apr 2014, In: Expert Review of Vaccines. 13, 4, p. 473-87 15 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1

  Jenkins, S. J., Ruckerl, D., Thomas, G. D., Hewitson, J. P., Duncan, S., Brombacher, F., Maizels, R. M., Hume, D. A. & Allen, J. E., 21 Oct 2013, In: The Journal of experimental medicine. 210, 11, p. 2477-91 15 p.

  Research output: Contribution to journal › Article › peer-review

• Immunomodulation by helminth parasites: defining mechanisms and mediators

  McSorley, H. J., Hewitson, J. P. & Maizels, R. M., Mar 2013, In: International Journal for Parasitology. 43, 3-4, p. 301-10 10 p.

  Research output: Contribution to journal › Article › peer-review

• Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity

  Hewitson, J. P., Ivens, A. C., Harcus, Y., Filbey, K. J., McSorley, H. J., Murray, J., Bridgett, S., Ashford, D., Dowle, A. A. & Maizels, R. M., Aug 2013, In: PLOS PATHOGENS. 9, 8, p. e1003492

  Research output: Contribution to journal › Article › peer-review
• 2012

  Antibodies and IL-3 support helminth-induced basophil expansion

  Herbst, T., Esser, J., Prati, M., Kulagin, M., Stettler, R., Zaiss, M. M., Hewitson, J. P., Merky, P., Verbeek, J. S., Bourquin, C., Camberis, M., Prout, M., Maizels, R. M., Le Gros, G. & Harris, N. L., 11 Sept 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14954-9 6 p.

  Research output: Contribution to journal › Article › peer-review

• Immune modulation and modulators in Heligmosomoides polygyrus infection

  Maizels, R. M., Hewitson, J. P., Murray, J., Harcus, Y. M., Dayer, B., Filbey, K. J., Grainger, J. R., McSorley, H. J., Reynolds, L. A. & Smith, K. A., Sept 2012, In: Experimental parasitology. 132, 1, p. 76-89 14 p.

  Research output: Contribution to journal › Article › peer-review

• Susceptibility and immunity to helminth parasites

  Maizels, R. M., Hewitson, J. P. & Smith, K. A., Aug 2012, In: Current opinion in immunology. 24, 4, p. 459-66 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Heligmosomoides polygyrus: one species still

  Maizels, R. M., Hewitson, J. P. & Gause, W. C., Mar 2011, In: Trends in parasitology. 27, 3, p. 100-1 2 p.

  Research output: Contribution to journal › Article › peer-review

• Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes

  Hewitson, J. P., Filbey, K. J., Grainger, J. R., Dowle, A. A., Pearson, M., Murray, J., Harcus, Y. & Maizels, R. M., 1 Nov 2011, In: Journal of Immunology. 187, 9, p. 4764-77 14 p.

  Research output: Contribution to journal › Article › peer-review

• Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins

  Hewitson, J. P., Harcus, Y., Murray, J., van Agtmaal, M., Filbey, K. J., Grainger, J. R., Bridgett, S., Blaxter, M. L., Ashton, P. D., Ashford, D. A., Curwen, R. S., Wilson, R. A., Dowle, A. A. & Maizels, R. M., 24 Aug 2011, In: JOURNAL OF PROTEOMICS. 74, 9, p. 1573-94 22 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway

  Grainger, J. R., Smith, K. A., Hewitson, J. P., McSorley, H. J., Harcus, Y., Filbey, K. J., Finney, C. A. M., Greenwood, E. J. D., Knox, D. P., Wilson, M. S., Belkaid, Y., Rudensky, A. Y. & Maizels, R. M., 25 Oct 2010, In: The Journal of experimental medicine. 207, 11, p. 2331-41 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity

  Hewitson, J. P., Grainger, J. R. & Maizels, R. M., Sept 2009, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 167, 1, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products

  Hewitson, J. P., Harcus, Y. M., Curwen, R. S., Dowle, A. A., Atmadja, A. K., Ashton, P. D., Wilson, A. & Maizels, R. M., Jul 2008, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 160, 1, p. 8-21 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni

  Hewitson, J. P., Hamblin, P. A. & Mountford, A. P., Jul 2007, In: Infection and Immunity. 75, 7, p. 3539-3547 9 p.

  Research output: Contribution to journal › Article › peer-review

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• 2006

  CD40/CD154 interactions are required for the optimal maturation of skin-derived APCs and the induction of helminth-specific IFN-gamma but not IL-4

  Hewitson, J. P., Jenkins, G. R., Hamblin, P. A. & Mountford, A. P., 1 Sept 2006, In: Journal of Immunology. 177, 5, p. 3209-3217 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  Immunity induced by the radiation-attenuated schistosome vaccine

  Hewitson, J. P., Hamblin, P. A. & Mountford, A. P., 6 Sept 2005, In: Parasite immunology. 27, 7-8, p. 271-280 10 p.

  Research output: Contribution to journal › Article › peer-review

• Modulation of the host's immune response by schistosome larvae

  Hewitson, J. P., Jenkins, G. R. & Mountford, A. P., 24 Sept 2005, In: Parasite immunology. 27, 10-11, p. 385-393 9 p.

  Research output: Contribution to journal › Article › peer-review

• Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways

  Jenkins, S. J., Hewitson, J. P., Ferret-Bernard, S. & Mountford, A. P., Nov 2005, In: International immunology. 17, 11, p. 1409-1418 10 p.

  Research output: Contribution to journal › Article › peer-review