Jean Wilkinson

Search results

• 2020

  Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile

  Whittingham, J. L., Hanai, S., Brannigan, J. A., Ferreira, W. T., Dodson, E. J., Turkenburg, J. P., Cartwright, J., Cutting, S. M. & Wilkinson, A. J., 1 Jun 2020, In: Acta crystallographica. Section F, Structural biology communications. 76, p. 241-249 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi

  Okoko, T., Blagova, E. V., Whittingham, J. L., Dover, L. G. & Wilkinson, A. J., Aug 2015, In: Veterinary Microbiology. 179, 1-2, p. 42-52 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Structure of the virulence-associated protein VapD from the intracellular pathogen Rhodococcus equi

  Whittingham, J. L., Blagova, E. V., Finn, C. E., Luo, H., Miranda-CasoLuengo, R., Turkenburg, J. P., Leech, A. P., Walton, P. H., Murzin, A. G., Meijer, W. G. & Wilkinson, A. J., Aug 2014, In: Acta Crystallographica. Section D, Biological Crystallography. 70, 8, p. 2139-2151 13 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Neisseria meningitidis and Neisseria gonorrhoeae are differently adapted in regulation of denitrification: single nucleotide polymorphisms that enable species-specific tuning of the aerobic-anaerobic switch

  Edwards, J., Quinn, D., Rowbottom, K.-A., Whittingham, J. L., Thomson, M. J. & Moir, J. W. B., 1 Jul 2012, In: Biochemical journal. 445, 1, p. 69-79 11 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis and evaluation of α-thymidine analogues as novel antimalarials

  Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H., 27 Dec 2012, In: JOURNAL OF MEDICINAL CHEMISTRY. 55, 24, p. 10948-10957 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

  Baragana, B., McCarthy, O., Sanchez, P., Bosch-Navarrete, C., Kaiser, M., Brun, R., Whittingham, J. L., Roberts, S. M., Zhou, X.-X., Wilson, K. S., Johansson, N. G., Gonzalez-Pacanowska, D. & Gilbert, I. H., 1 Apr 2011, In: Bioorganic and Medicinal Chemistry. 19, 7, p. 2378-2391 14 p.

  Research output: Contribution to journal › Article › peer-review

• Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

  Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H., 4 Oct 2011, In: ChemMedChem. 6, 10, p. 1816-1831 16 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Binding to DNA Protects Neisseria meningitidis Fumarate and Nitrate Reductase Regulator (FNR) from Oxygen

  Edwards, J., Cole, L. J., Green, J. B., Thomson, M. J., Wood, A. J., Whittingham, J. L. & Moir, J. W. B., 8 Jan 2010, In: Journal of Biological Chemistry. 285, 2, p. 1105-1112 8 p., 057810.

  Research output: Contribution to journal › Article › peer-review

• Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

  Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D., 15 Jun 2010, In: Biochemical journal. 428, 3, p. 499-509 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Structural characterization of a beta-diketone hydrolase from the cyanobacterium Anabaena sp PCC 7120 in native and product-bound forms, a coenzyme A-independent member of the crotonase suprafamily

  Bennett, J. P., Whittingham, J. L., Brzozowski, A. M., Leonard, P. M. & Grogan, G., 9 Jan 2007, In: Biochemistry. 46, 1, p. 137-144 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  I222 crystal form of despentapeptide (B26-B30) insulin provides new insights into the properties of monomeric insulin

  Whittingham, J. L., Zhang, Y. S., Zakova, L., Dodson, E. J., Turkenburg, J. P., Brange, J. & Dodson, G. G., May 2006, In: Acta crystallographica section d-Biological crystallography. 62, p. 505-511 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  dUTPase as a platform for antimalarial drug design: Structural basis for the selectivity of a class of nucleoside inhibitors

  Whittingham, J. L., Leal, I., Nguyen, C., Kasinathan, G., Bell, E., Jones, A. F., Berry, C., Benito, A., Turkenburg, J. P., Dodson, E. J., Perez, L. M. R., Wilkinson, T., Johansson, N. G., Brun, R., Gilbert, I. H., Pacanowska, D. G. & Wilson, K. S., 8 Feb 2005, In: Structure. 13, 2, p. 329-338 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  Crystallographic and solution studies of N-lithocholyl insulin: A new generation of prolonged-acting human insulins

  Whittingham, J. L., Jonassen, I., Havelund, S., Roberts, S. M., Dodson, E. J., Verma, C. S., Wilkinson, A. J. & Dodson, G. G., 25 May 2004, In: Biochemistry. 43, 20, p. 5987-5995 9 p.

  Research output: Contribution to journal › Article › peer-review

• Toward the insulin-IGF-I intermediate structures: Functional and structural properties of the [Tyr(B25)NMePhe(B26)] insulin mutant

  Zakova, L., Brynda, J., Au-Alvarez, O., Dodson, E. J., Dodson, G. G., Whittingham, J. L. & Brzozowski, A. M., 28 Dec 2004, In: Biochemistry. 43, 51, p. 16293-16300 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2003

  The 2-A crystal structure of 6-oxo camphor hydrolase - New structural diversity in the crotonase superfamily

  Whittingham, J. L., Turkenburg, J. P., Verma, C. S., Walsh, M. A. & Grogan, G., 17 Jan 2003, In: Journal of Biological Chemistry. 278, 3, p. 1744-1750 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2002

  Crystallization and preliminary crystallographic investigation of a low-pH native insulin monomer with flexible behaviour

  Zhang, Y. S., Whittingham, J. L., Turkenburg, J. P., Dodson, E. J., Brange, J. & Dodson, G. G., Jan 2002, In: Acta crystallographica section d-Biological crystallography. 58, p. 186-187 2 p.

  Research output: Contribution to journal › Article › peer-review

• Insulin at pH2: Structural analysis of the conditions promoting insulin fibre formation

  Whittingham, J. L., Chance, K., Wilson, A., Finch, J., Brange, J., Scott, D. J. & Dodson, G. G., 26 Apr 2002, In: Journal of Molecular Biology. 318, 2, p. 479-490 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2001

  Sulfatide promotes the folding of proinsulin, preserves insulin crystals, and mediates its monomerization

  Osterbye, T., Jorgensen, K. H., Fredman, P., Tranum-Jensen, J., Kaas, A., Brange, J., Whittingham, J. L. & Buschard, K., Jun 2001, In: GLYCOBIOLOGY. 11, 6, p. 473-479 7 p.

  Research output: Contribution to journal › Article › peer-review

• 1999

  Structural consequences of the B5 histidine -> tyrosine mutation in human insulin characterized by x-ray crystallography and conformational analysis

  Tang, L., Whittingham, J. L., Verma, C. S., Caves, L. S. D. & Dodson, G. G., 14 Sept 1999, In: Biochemistry. 38, 37, p. 12041-12051 11 p.

  Research output: Contribution to journal › Article › peer-review

• 1998

  Interactions of phenol and m-cresol in the insulin hexamer, and their effect on the association properties of B28 Pro -> Asp insulin analogues

  Whittingham, J. L., Edwards, D. J., Antson, A. A., Clarkson, J. M. & Dodson, C. G., 18 Aug 1998, In: Biochemistry. 37, 33, p. 11516-11523 8 p.

  Research output: Contribution to journal › Article › peer-review
• 1997

  Crystal structure of a prolonged-acting insulin with albumin-binding properties

  Whittingham, J. L., Havelund, S. & Jonassen, I., 11 Mar 1997, In: Biochemistry. 36, 10, p. 2826-2831 6 p.

  Research output: Contribution to journal › Article › peer-review

• Insulin structure and diabetes treatment

  Brange, J., Whittingham, J., Edwards, D., YouShang, Z., Wollmer, A., Brandenburg, D., Dodson, G. & Finch, J., 10 Apr 1997, In: CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE. 72, 7, p. 470-476 7 p.

  Research output: Contribution to journal › Article › peer-review

• 1995

  X-ray crystallographic studies on hexameric insulins in the presence of helix-stabilizing agents, thiocyanate, methylparaben, and phenol.

  Whittingham, J. L., Chaudhuri, S., Dodson, E. J., Moody, P. C. E. & Dodson, G. G., 28 Nov 1995, In: Biochemistry. 34, 47, p. 15553-15563 11 p.

  Research output: Contribution to journal › Article › peer-review
• 1993

  Insulin Assembly: Its Modification by Protein Engineering and Ligand Binding

  DODSON, E. J., DODSON, G. G., HUBBARD, R. E., MOODY, P. C. E., TURKENBURG, J., WHITTINGHAM, J., XIAO, B., BRANGE, J., KAARSHOLM, N. & THOGERSEN, H., 15 Oct 1993, In: Philosophical Transactions: Mathematical, Physical and Engineering Sciences. 345, 1674, p. 153-164 12 p.

  Research output: Contribution to journal › Article › peer-review