Jeremy Charles Mottram

Search results

• 2024

  Formation of functional E3 ligase complexes with UBC2 and UEV1 of Leishmania mexicana

  Burge, R. J., Jameson, K. H., Geoghegan, V., Dowle, A. A., Mottram, J. C. & Wilkinson, A. J., Jun 2024, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 258, 11 p., 111619.

  Research output: Contribution to journal › Article › peer-review

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• 2023

  AAK1-like: a putative pseudokinase with potential roles in cargo uptake in bloodstream form Trypanosoma brucei parasites

  Black, J. A., Klinger, C., Lemgruber, L., Dacks, J. B., Mottram, J. C. & McCulloch, R., 7 Aug 2023, (E-pub ahead of print) In: Journal of Eukaryotic Microbiology. 20 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Autophagy in protists and their hosts: When, how and why?

  Mottram, J. C., 9 Mar 2023, In: Autophagy. 2, 1, p. 2149211 109 p.

  Research output: Contribution to journal › Article › peer-review

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• Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery

  Russell, C., Carter, J., Borgia, J. M., Bush, J., Calderón, F., Gabarró, R., Conway, S., Mottram, J. C., Wilkinson, A. J. & Jones, N., 31 Oct 2023, (E-pub ahead of print) In: ACS Infectious Diseases. 18 p.

  Research output: Contribution to journal › Article › peer-review

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• Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections

  Rao, S. P. S., Gould, M. K., Noeske, J., Saldivia, M., Jumani, R. S., Ng, P. S., René, O., Chen, Y.-L., Kaiser, M., Ritchie, R., Francisco, A. F., Johnson, N., Patra, D., Cheung, H., Deniston, C., Schenk, A. D., Cortopassi, W. A., Schmidt, R. S., Wiedemar, N. & Thomas, B. & 22 others, Palkar, R., Ghafar, N. A., Manoharan, V., Luu, C., Gable, J. E., Wan, K. F., Myburgh, E., Mottram, J. C., Barnes, W., Walker, J., Wartchow, C., Aziz, N., Osborne, C., Wagner, J., Sarko, C., Kelly, J. M., Manjunatha, U. H., Mäser, P., Jiricek, J., Lakshminarayana, S. B., Barrett, M. P. & Diagana, T. T., 29 Jun 2023, In: Science (New York, N.Y.). 380, 6652, p. 1349-1356 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase

  Mottram, J. C., 23 Feb 2023, In: Wellcome Open Research. 7, 10 p., 294.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  3’Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine

  Carnielli, J. B. T., Dave, A., Romano, A., Forrester, S. J., de Faria, P. R., Monti-Rocha, R., Costa, C. H. N., Dietze, R., Graham, I. A. & Mottram, J. C., 29 Nov 2022, In: EBioMedicine. 86, 18 p., 104378.

  Research output: Contribution to journal › Article › peer-review

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• Bromodomain factor 5 is an essential regulator of transcription in Leishmania

  Jones, N. G., Geoghegan, V., Moore, G., Carnielli, J. B. T., Newling, K., Calderón, F., Gabarró, R., Martín, J., Prinjha, R. K., Rioja, I., Wilkinson, A. J. & Mottram, J. C., 13 Jul 2022, In: Nature Communications. 13, 1, 18 p., 4071.

  Research output: Contribution to journal › Article › peer-review

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• CLK1/CLK2 driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics

  Geoghegan, V., Carnielli, J. B. T., Jones, N., Saldivia, M., Antoniou, S., Hughes, C., Neish, R., Dowle, A. & Mottram, J. C., 28 Nov 2022, In: Communications Biology.

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• Distinguishing functions of trypanosomatid protein kinases

  Cayla, M., Nievas, Y. R., Matthews, K. R. & Mottram, J. C., 1 Nov 2022, In: Trends in parasitology. 38, 11, p. 950-961 12 p.

  Research output: Contribution to journal › Article › peer-review

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• In vitro Di-ubiquitin Formation Assay and E3 Cooperation Assay

  Burge, R. J., Jameson, K. H., Wilkinson, A. J. & Mottram, J. C., 5 Nov 2022, In: Bio-protocol. 12, 21, 8 p., e4547.

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• Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis

  Grace, C. A., Sousa Carvalho, K. S., Sousa Lima, M. I., Silva, V. C., Reis-Cunha, J. L., Brune, M. J., Forrester, S., de Maria Pedrozo, C., de Azevedo, S., Costa, D. L., Speed, D., Mottram, J. C., Jeffares, D. C. & Costa, C. H. N., Dec 2022, In: MBio. 13, 6, p. e0206822 13 p.

  Research output: Contribution to journal › Article › peer-review

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• Tag thy neighbour: nanometre-scale insights into kinetoplastid parasites with proximity dependent biotinylation

  Geoghegan, V., Mottram, J. C. & Jones, N., 6 May 2022, In: Frontiers in cellular and infection microbiology.

  Research output: Contribution to journal › Article › peer-review

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• Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum

  Forrester, S. J., Goundry, A. L., Torres Dias, B., Leal-Calvo, T., Ozório Moraes, M., Kaye, P., Mottram, J. C. & Lima, A. P. C. A., 6 Apr 2022, In: Microbiology spectrum. 10, 2, 19 p., 00679.

  Research output: Contribution to journal › Article › peer-review

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• TLR2, TLR4 and Protein kinase R (PKR) induced Type I Interferon sustains infection of Leishmania donovani in macrophages

  Torres Dias, B., Goundry, A., Vivarini, A. C., Costa, T. F. R., Mottram, J. C., Gazos Lopes, U. & Lima, A. P. C. A., 28 Jan 2022, In: Frontiers in immunology. 13, 18 p., 801182.

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• Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis

  Rath, C. T., Vivarini, A. C., Vitorino dos Santos, J., Medina, J. M., Saliba, A. M., Mottram, J. C., Lima, A. P. C. A., Calegari-Silva, T. C., Pereira, R. M. & Lopes, U. G., 22 Aug 2022, (E-pub ahead of print) In: Infection and Immunity.

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• Trypanosoma brucei rhodesiense INHIBITOR OF CYSTEINE PEPTIDASE (ICP) IS REQUIRED FOR VIRULENCE IN MICE AND TO ATTENUATE THE INFLAMMATORY RESPONSE

  Costa, T. F. R., Goundry, A., Morrot, A., Grab, D., Mottram, J. C. & Lima, A. P. C. A., 22 Dec 2022, (Accepted/In press) In: International Journal of Molecular Sciences.

  Research output: Contribution to journal › Article › peer-review

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• 2021

  17-AAG-induced activation of the autophagic pathway in Leishmania is associated with parasite death

  Petersen, A. L. D. O. A., Cull, B., Simões Dias, B. R., Palma, L. C., da Silva Luz , Y., de Menezes, J. P. B., Mottram, J. C. & Veras, P. S. T., 19 May 2021, (E-pub ahead of print) In: Microorganisms. 9, 5, 1089.

  Research output: Contribution to journal › Article › peer-review

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• A CLK1-KKT2 signaling pathway regulating kinetochore assembly in Trypanosoma brucei

  Saldivia, M., Wollman, A. J. M., Carnielli, J. B. T., Jones, N. G., Leake, M. C., Bower-Lepts, C., Rao, S. P. S. & Mottram, J. C., 15 Jun 2021, In: MBio. 12, 3, 15 p., e00687-21.

  Research output: Contribution to journal › Article › peer-review

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• Candidates for Balancing Selection in Leishmania donovani Complex Parasites

  Grace, C. A., Forrester, S. J., Costa Silva, V., Carvalho, K. S. S., Kilford, H., Chew, Y. P., James, S., Costa, D. L., Mottram, J. C., Costa, C. H. N. & Jeffares, D., 2 Dec 2021, In: Molecular Biology and Evolution. 13, 12, 15 p., evab265.

  Research output: Contribution to journal › Article › peer-review

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• Divergent cytochrome c maturation system in kinetoplastid protists

  Belbelazi, A., Neish, R., Carr, M., Mottram, J. C. & Ginger, M. L., 4 May 2021, In: MBio. 12, 3, 7 p., e00166-21.

  Research output: Contribution to journal › Article › peer-review

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• Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice

  McNae, I. W., Kinkead, J., Malik, D., Yen, L.-H., Walker, M. K., Swain, C., Webster, S. P., Gray, N., Fernandes, P. M., Myburgh, E., Blackburn, E. A., Ritchie, R., Austin, C., Wear, M. A., Highton, A. J., Keats, A. J., Vong, A., Dornan, J., Mottram, J. C. & Michels, P. A. M. & 2 others, Pettit, S. & Walkinshaw, M. D., 16 Feb 2021, In: Nature Communications. 12, 1, 10 p., 1052.

  Research output: Contribution to journal › Article › peer-review

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• Importance of Angomonas deanei KAP4 for kDNA arrangement, cell division and maintenance of the host-bacterium relationship

  Gonçalves, C. S., Catta-Preta, C. M. C., Repolês, B., Mottram, J. C., de Souza, W., Machado, C. R. & Motta, M. C. M., 28 Apr 2021, In: Scientific Reports. 11, 9210.

  Research output: Contribution to journal › Article › peer-review

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• Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival

  Baker, N., Catta-Preta, C. M. C., Neish, R., Sadlova, J., Powell, B., Alves-Ferreira, E. V. C., Geoghegan, V., Carnielli, J. B. T., Newling, K., Hughes, C., Vojtkova, B., Anand, J., Mihut, A., Walrad, P. B., Wilson, L. G., Pitchford, J. W., Volf, P. & Mottram, J. C., 23 Feb 2021, In: Nature Communications. 12, 1, 15 p., 1244.

  Research output: Contribution to journal › Article › peer-review

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• The kinesin of the flagellum attachment zone in Leishmania is required for cell morphogenesis, cell division and virulence in the mammalian host

  Corrales, R. M., Vaselek, S., Neish, R., Berry, L., Brunet, C., Crobu, L., Kuk, N., Mateos-Langerak, J., Robinson, D. R., Volf, P., Mottram, J. C., Sterkers, Y. & Bastien, P., Jun 2021, In: PLOS PATHOGENS. 17, 6, 29 p., e1009666.

  Research output: Contribution to journal › Article › peer-review

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• 2020

  Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

  Rao, S. P. S., Lakshminarayana, S. B., Jiricek, J., Kaiser, M., Ritchie, R., Myburgh, E., Supek, F., Tuntland, T., Nagle, A., Molteni, V., Mäser, P., Mottram, J. C., Barrett, M. P. & Diagana, T. T., 17 Feb 2020, In: Tropical medicine and infectious disease. 5, 1, 14 p.

  Research output: Contribution to journal › Article › peer-review

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• Chromosomal assembly of the nuclear genome of the endosymbiontbearing trypanosomatid Angomonas deanei

  Davey, J. W., Catta-Preta, C. M. C., James, S., Forrester, S. J., Motta, M. C. M., Ashton, P. D. & Mottram, J. C., 27 Nov 2020, In: G3: Genes, Genomes, Genetics. 11, 1, 7 p., jkaa018.

  Research output: Contribution to journal › Article › peer-review

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• Essential roles for deubiquitination in Leishmania life cycle progression

  Damianou, A., Burge, R., Catta-Preta, C. M. C., Geoghegan, V. L., Nievas, R., Newling, K., Brown, E., Burchmore, R. J., Rodenko, B. & Mottram, J. C., 9 Jun 2020, (Accepted/In press) In: PLOS PATHOGENS.

  Research output: Contribution to journal › Article › peer-review

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• In Vivo Bioluminescence Imaging to Assess Compound Efficacy Against Trypanosoma brucei

  Ritchie, R., Barrett, M. P., Mottram, J. C. & Myburgh, E., 2020, In: Methods in Molecular Biology. 2116, p. 801-817 17 p.

  Research output: Contribution to journal › Article › peer-review

• Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex

  Burge, R. J., Damianou, A., Wilkinson, A. J., Rodenko, B. & Mottram, J. C., 27 Oct 2020, In: PLOS PATHOGENS. 16, 10, 30 p., e1008784.

  Research output: Contribution to journal › Article › peer-review

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• Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis

  Halliday, C., Yanase, R., Catta-Preta, C. M. C., Moreira-Leite, F., Myskova, J., Pruzinova, K., Volf, P., Mottram, J. C. & Sunter, J. D., 22 Oct 2020, (E-pub ahead of print) In: PLOS PATHOGENS.

  Research output: Contribution to journal › Article › peer-review

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• Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

  Saldivia Concepcion, M. A., Fang, E., Ma, X., Myburgh, E., Brambilla Carnielli Trindade, J., Bower-Lepts, C., Brown, E., Ritchie, R., Lakshminarayana, S. B., Chen, Y.-L., Patra, D., Ornelas, E., Koh, H. X. Y., Williams, S., Supek, F., Paape, D., McCulloch, R., Kaiser, M., Barrett, M. P. & Jiricek, J. & 3 others, Diagana, T. T., Mottram, J. C. & Rao, S. P. S., Oct 2020, In: Nature Microbiology. 5, p. 1207-1216

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• Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigen

  Black, J. A., Crouch, K., Lemgruber, L., Lapsley, C., Dickens, N. J., Tosi, L. R. O., Mottram, J. C. & McCulloch, R., 21 Jan 2020, In: Cell reports. 30, 3, p. 836-851 e5.

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• 2019

  Evaluation of Clan CD C11 peptidase PNT1 and other Leishmania mexicana cysteine peptidases as potential drug targets

  Grewal, J., Catta Preta, C., Brown, E., Anand, J. & Mottram, J. C., 1 Nov 2019, In: BIOCHIMIE. 11 p.

  Research output: Contribution to journal › Article › peer-review

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• Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly and pathogenicity in the host

  Sunter, J. D., Yanase, R., Wang, Z., Catta Preta, C., Moreira-Leite, F., Myskova, J., Pruzinova, K., Volf, P., Mottram, J. C. & Gull, K., 26 Mar 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 13, p. 6351-6360 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Natural Resistance of Leishmania infantum to Miltefosine Contributes to the Low Efficacy in the Treatment of Visceral Leishmaniasis in Brazil

  Brambilla Carnielli Trindade, J., Monti-Rocha, R., Costa, D. L., Sesana, A. M., Pansini, L. N. N., Segatto, M., Mottram, J. C., Nery Costa, C. H., Carvalho, S. F. G. & Dietze, R., 2 Oct 2019, In: American journal of tropical medicine and hygiene. 101, 4, p. 789-794 6 p.

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• Neutrophil elastase promotes Leishmania donovani infection via interferon-β

  Torres Dias, B., Teixeira, K. L., Godinho, J. P., Faria, M. S., Calegari-Silva, T., Mukhtar, M. M., Gazos Lopes, U., Mottram, J. C. & Lima, A. P. C. A., 1 Oct 2019, In: The FASEB Journal. 33, 10, p. 10794-10807

  Research output: Contribution to journal › Article › peer-review

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• Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis

  Forrester, S., Siefert, K., Ashwin, H., Brown, N., Zelmar, A., James, S., Lagos, D., Timmis, J., Chatterjee, M., Mottram, J. C., Croft, S. L. & Kaye, P. M., 10 Dec 2019, In: Wellcome Open Research. 4, 198, 21 p., 4.

  Research output: Contribution to journal › Article › peer-review

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• 2018

  A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis

  Mottram, J. C., Jeffares, D., Brambilla Carnielli Trindade, J., Crouch, K., Forrester, S. J., Costa Silva, V., Carvalho, S. F. G., Damasceno, J. D., Brown, E., Dickens, N. J., Costa, D. L., Costa, C. H. N. & Dietze, R., 27 Sept 2018, In: EBioMedicine. 36, 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Conditional genome engineering reveals canonical and divergent roles for the Hus1 component of the 9-1-1 complex in the maintenance of the plastic genome of Leishmania.

  Damasceno, J. D., Obonaga, R., Silva, G. L. A., Reis-Cunha, J. L., Duncan, S. M., Bartholomeu, D. C., Mottram, J. C., McCulloch, R. & Tosi, L. R. O., 14 Dec 2018, In: Nucleic Acids Research. 46, 22, p. 11835-11846

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• Drug Discovery for Kinetoplastid Diseases: Future Directions

  Rao, S. P. S., Barrett, M., Dranoff, G., Faraday, C., Gimpelewicz, C. R., Hailu, A., Jones, C. L., Kelly, J. M., Lazdins-Helds, J. K., Maeser, P., Mengel, J., Mottram, J. C., Mowbray, C. E., Sacks, D. L., Scott, P., Spath, G. F., Tarleton, R. L., Spector, J. M. & Diagana, T. T., 13 Dec 2018, (E-pub ahead of print) In: ACS Infectious Diseases. 6 p.

  Research output: Contribution to journal › Article › peer-review

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• Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects

  Jones, N., Catta Preta, C., Lima, A. P. C. A. & Mottram, J. C., 13 Apr 2018, In: ACS Infectious Diseases. 4, 4, p. 467-477 11 p.

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• Leishmania genome dynamics during environmental adaptation reveals strain-specific differences in gene copy number variation, karyotype instability, and telomeric amplification

  Bussotti, G., Gouzelou, E., Cortes Boite, M., Kherachi, I., Harrat, Z., Eddaikra, N., Mottram, J. C., Antoniou, M., Christodoulou, V., Bali, A., Guerfali, F. Z., Laouini, D., Mukhtar, M., Dumetz, F., Dujardin, J.-C., Smirlis, D., Lechat, P., Pescher, P., El Hamouchi, A. & Lemrani, M. & 10 others, Chicharro, C., Llanes-Acevedo, I. P., Botana, L., Cruz, I., Moreno, J., Jeddi, F., Aoun, K., Bouratbine, A., Cupolillo, E. & Spath, G. F., 6 Nov 2018, In: MBio. 9, 6, 18 p., e01399-18.

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• New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8

  Frey, P., Chartomastsidou, R., Kiefer, W., Mottram, J. C., Kersten, C. & Schirmeister, T., 5 Aug 2018, In: European Journal of Medicinal Chemistry. 156, p. 587-597

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• Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis [version 2; referees: 4 approved]

  Ashwin, H., Seifert, K., Forrester, S., Brown, N., MacDonald, S., James, S., Lagos, D., Timmis, J., Mottram, J., Croft, S. L. & Kaye, P. M., 29 Oct 2018, In: Wellcome Open Research. 3, 33 p., 135.

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• TLR2 signaling in skin non-hematopoietic cells induces early neutrophil recruitment in response to Leishmania major infection

  Ronet, C., Passelli, K., Charmoy, M., Scarpellino, L., Myburgh, E., Hauyon La Torre, Y., Turco, S., Mottram, J. C., Fasel, N., Luther, S. A., Beverley, S. M., Launois, P. & Tacchini-Cottier, F., 27 Dec 2018, In: Journal of investigative dermatology.

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• 2017

  A DiCre recombinase-based system for inducible expression in Leishmania major

  Santos, R. E. R. S., Silva, G. L. A., Santos, E. V., Duncan, S. M., Mottram, J. C., Damasceno, J. D. & Tosi, L. R. O., 1 Sept 2017, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 216, p. 45-48 4 p.

  Research output: Contribution to journal › Article › peer-review

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• Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

  Stortz, J. A., Serafim, T. D., Alsford, S., Wilkes, J., Fernandez-Cortes, F., Hamilton, G., Briggs, E., Lemgruber, L., Horn, D., Mottram, J. C. & McCulloch, R., 24 Jul 2017, In: PLOS PATHOGENS. 13, 7, p. e1006477

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• Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells

  Goundry, A., Romano, A., Lima, A. P. C. A., Mottram, J. C. & Myburgh, E., 16 Nov 2017, In: The FASEB Journal.

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• Recent advances in Leishmania reverse genetics: Manipulating a manipulative parasite

  Duncan, S. M., Jones, N. G. & Mottram, J. C., Sept 2017, In: MOLECULAR AND BIOCHEMICAL PARASITOLOGY. 216, p. 30-38 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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