Jim Brannigan

Search results

• 2020

  Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile

  Whittingham, J. L., Hanai, S., Brannigan, J. A., Ferreira, W. T., Dodson, E. J., Turkenburg, J. P., Cartwright, J., Cutting, S. M. & Wilkinson, A. J., 1 Jun 2020, In: Acta crystallographica. Section F, Structural biology communications. 76, p. 241-249 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

  Bell, A. S., Yu, Z., Hutton, J. A., Wright, M. H., Brannigan, J. A., Paape, D., Roberts, S. M., Sutherell, C. L., Ritzefeld, M., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 23 Jul 2020, In: JOURNAL OF MEDICINAL CHEMISTRY. 63, 14, p. 7740-7765 26 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  Water networks can determine the affinity of ligand binding to proteins

  Darby, J. F., Hopkins, A., Hubbard, R. E., Roberts, S. M., Shimizu, S., Brannigan, J. A., Turkenburg, J., Thomas, G. H. & Fischer, M., 9 Oct 2019, In: Journal of the American Chemical Society. 141, 40, p. 15818-15826 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2018

  Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

  Mousnier, A., Bell, A. S., Swieboda, D. P., Morales-Sanfrutos, J., Pérez-Dorado, I., Brannigan, J. A., Newman, J., Ritzefeld, M., Hutton, J. A., Guedán, A., Asfor, A. S., Robinson, S. W., Hopkins-Navratilova, I., Wilkinson, A. J., Johnston, S. L., Leatherbarrow, R. J., Tuthill, T. J., Solari, R. & Tate, E. W., 1 Jun 2018, In: Nature Chemistry. 10, 6, p. 599-606 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

  Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S. E., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. J. & Fascione, M. A., 7 Jul 2018, In: Chemical Science. 9, 25, p. 5585-5593 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

  Goncalves, V., Brannigan, J. A., Laporte, A., Bell, A. S., Roberts, S. M., Wilkinson, A. J., Leatherbarrow, R. J. & Tate, E. W., 2017, In: MedChemComm. 8, 1, p. 191-197 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

  Rackham, M. D., Yu, Z., Brannigan, J. A., Heal, W. P., Paape, D., Barker, K. V., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 17 Aug 2015, In: MedChemComm. 6, 10, p. 1761-1766 6 p.

  Research output: Contribution to journal › Article › peer-review

• Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

  Yu, Z., Brannigan, J. A., Rangachari, K., Heal, W. P., Wilkinson, A. J., Holder, A. A., Leatherbarrow, R. J. & Tate, E. W., 17 Aug 2015, In: MedChemComm. 6, 10, p. 1767-1772 6 p.

  Research output: Contribution to journal › Article › peer-review

• Structure mediation in substrate binding and post-translational processing of penicillin acylases: Information from mutant structures of Kluyvera citrophila penicillin G acylase

  Chand, D., Varshney, N., Ramasamy, S., Panigrahi, P., Brannigan, J. A., Wilkinson, A. J. & Suresh, C. G., 1 Oct 2015, In: Protein Science. 24, 10, p. 1660-1670 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)

  Rackham, M. D., Brannigan, J. A., Rangachari, K., Meister, S., Wilkinson, A. J., Holder, A. A., Leatherbarrow, R. J. & Tate, E. W., 27 Mar 2014, In: JOURNAL OF MEDICINAL CHEMISTRY. 57, 6, p. 2773-2788 16 p.

  Research output: Contribution to journal › Article › peer-review

• Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

  Brannigan, J. A., Roberts, S. M., Bell, A. S., Hutton, J. A., Hodgkinson, M. R., Tate, E. W., Leatherbarrow, R. J., Smith, D. F. & Wilkinson, A. J., Jul 2014, In: IUCrJ. 1, 4, p. 250-260 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

  Thinon, E., Serwa, R. A., Broncel, M., Brannigan, J. A., Brassat, U., Wright, M. H., Heal, W. P., Wilkinson, A. J., Mann, D. J. & Tate, E. W., 26 Sept 2014, In: Nature Communications. 5, 4919.

  Research output: Contribution to journal › Article › peer-review

• Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

  Olaleye, T. O., Brannigan, J. A., Roberts, S. M., Leatherbarrow, R. J., Wilkinson, A. J. & Tate, E. W., 7 Nov 2014, In: Organic and Biomolecular Chemistry. 12, 41, p. 8132-8137 6 p.

  Research output: Contribution to journal › Article › peer-review

• Structure-based design of potent and selective leishmania N-myristoyltransferase inhibitors

  Hutton, J. A., Goncalves, V., Brannigan, J. A., Paape, D., Wright, M. H., Waugh, T. M., Roberts, S. M., Bell, A. S., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 19 Sept 2014, In: JOURNAL OF MEDICINAL CHEMISTRY. 57, 20, p. 8664-8670 7 p.

  Research output: Contribution to journal › Article › peer-review

• Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

  Wright, M. H., Clough, B., Rackham, M. D., Rangachari, K., Brannigan, J. A., Grainger, M., Moss, D. K., Bottrill, A. R., Heal, W. P., Broncel, M., Serwa, R. A., Brady, D., Mann, D. J., Leatherbarrow, R. J., Tewari, R., Wilkinson, A. J., Holder, A. A. & Tate, E. W., Feb 2014, In: Nature Chemistry. 6, 2, p. 112-121 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Cloning, overexpression, crystallization and preliminary X-ray crystallographic analysis of a slow-processing mutant of penicillin G acylase from Kluyvera citrophila

  Varshney, N. K., Ramasamy, S., Suresh, C. G., Brannigan, J. A. & Wilkinson, A. J., 1 Aug 2013, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 8, p. 925-929 5 p.

  Research output: Contribution to journal › Article › peer-review

• Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferase

  Rackham, M. D., Brannigan, J. A., Moss, D. K., Yu, Z., Wilkinson, A. J., Holder, A. A., Tate, E. W. & Leatherbarrow, R. J., 10 Jan 2013, In: JOURNAL OF MEDICINAL CHEMISTRY. 56, 1, p. 371-375 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  A fluorescence-based assay for N-myristoyltransferase activity

  Goncalves, V., Brannigan, J. A., Thinon, E., Olaleye, T. O., Serwa, R., Lanzarone, S., Wilkinson, A. J., Tate, E. W. & Leatherbarrow, R. J., 1 Feb 2012, In: ANALYTICAL BIOCHEMISTRY. 421, 1, p. 342-344 3 p.

  Research output: Contribution to journal › Article › peer-review

• Design and Synthesis of Inhibitors of Plasmodium falciparum N-Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

  Yu, Z., Brannigan, J. A., Moss, D. K., Brzozowski, A. M., Wilkinson, A. J., Holder, A. A., Tate, E. W. & Leatherbarrow, R. J., 25 Oct 2012, In: JOURNAL OF MEDICINAL CHEMISTRY. 55, 20, p. 8879-8890 12 p.

  Research output: Contribution to journal › Article › peer-review

• Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode

  Goncalves, V., Brannigan, J. A., Whalley, D., Ansell, K. H., Saxty, B., Holder, A. A., Wilkinson, A. J., Tate, E. W. & Leatherbarrow, R. J., 12 Apr 2012, In: JOURNAL OF MEDICINAL CHEMISTRY. 55, 7, p. 3578-82 5 p.

  Research output: Contribution to journal › Article › peer-review

• Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

  Bell, A. S., Mills, J. E., Williams, G. P., Brannigan, J. A., Wilkinson, A. J., Parkinson, T., Leatherbarrow, R. J., Tate, E. W., Holder, A. A. & Smith, D. F., Apr 2012, In: PLOS NEGLECTED TROPICAL DISEASES. 6, 4, 9 p., e1625.

  Research output: Contribution to journal › Article › peer-review

• Synthesis and evaluation of α-thymidine analogues as novel antimalarials

  Cui, H., Carrero-Lérida, J., Silva, A. P. G., Whittingham, J. L., Brannigan, J. A., Ruiz-Pérez, L. M., Wilson, K. S., González-Pacanowska, D. & Gilbert, I. H., 27 Dec 2012, In: JOURNAL OF MEDICINAL CHEMISTRY. 55, 24, p. 10948-10957 10 p.

  Research output: Contribution to journal › Article › peer-review

• The Orthologue of Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1) in Trypanosoma brucei Is an Immunogenic Self-Assembling Molecule

  Price, H. P., Hodgkinson, M. R., Curwen, R. S., MacLean, L. M., Brannigan, J. A., Carrington, M., Smith, B. A., Ashford, D. A., Stark, M. & Smith, D. F., 20 Feb 2012, In: PLoS ONE. 7, 2, 14 p., e31842.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Design, Synthesis, and Evaluation of 5 '-Diphenyl Nucleoside Analogues as Inhibitors of the Plasmodium falciparum dUTPase

  Hampton, S. E., Baragana, B., Schipani, A., Bosch-Navarrete, C., Alexander Musso-Buendia, J., Recio, E., Kaiser, M., Whittingham, J. L., Roberts, S. M., Shevtsov, M., Brannigan, J. A., Kahnberg, P., Brun, R., Wilson, K. S., Gonzalez-Pacanowska, D., Johansson, N. G. & Gilbert, I. H., 4 Oct 2011, In: ChemMedChem. 6, 10, p. 1816-1831 16 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

  Brannigan, J. A., Smith, B. A., Yu, Z., Brzozowski, A. M., Hodgkinson, M. R., Maroof, A., Price, H. P., Meier, F., Leatherbarrow, R. J., Tate, E. W., Smith, D. F. & Wilkinson, A. J., 5 Mar 2010, In: Journal of Molecular Biology. 396, 4, p. 985-999 15 p.

  Research output: Contribution to journal › Article › peer-review

• N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

  Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A. T., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L. S., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M. F. & Brenk, R. & 6 others, Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A. J., Smith, D. F. & Wyatt, P. G., 1 Apr 2010, In: Nature. 464, 7289, p. 728-732 5 p.

  Research output: Contribution to journal › Article › peer-review

• Structural basis for the efficient phosphorylation of AZT-MP (3 '-azido-3 '-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

  Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P. G., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. & Gonzalez-Pacanowska, D., 15 Jun 2010, In: Biochemical journal. 428, 3, p. 499-509 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages

  Schnick, C., Polley, S. D., Fivelman, Q. L., Ranford-Cartwright, L. C., Wilkinson, S. R., Brannigan, J. A., Wilkinson, A. J. & Baker, D. A., Jan 2009, In: Molecular Microbiology. 71, 2, p. 533-545 13 p.

  Research output: Contribution to journal › Article › peer-review

• The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei

  Dobson, S. E., Augustijn, K. D., Brannigan, J. A., Schnick, C., Janse, C. J., Dodson, E. J., Waters, A. P. & Wilkinson, A. J., Dec 2009, In: Protein Science. 18, 12, p. 2578-2591 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Bile salt hydrolase, the member of Ntn-hydrolase family: Differential modes of structural and functional transitions during denaturation

  Kumar, R. S., Suresh, C. G., Brannigan, J. A., Dodson, G. G. & Gaikwad, S. M., Feb 2007, In: Iubmb life. 59, 2, p. 118-125 8 p.

  Research output: Contribution to journal › Article › peer-review

• Detection of picomole amounts of biological substrates by para-hydrogen-enhanced NMR methods in conjunction with a suitable receptor complex

  Wood, N. J., Brannigan, J. A., Duckett, S. B., Heath, S. L. & Wagstafft, J., 12 Sept 2007, In: Journal of the American Chemical Society. 129, 36, p. 11012-+ 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis

  Au, K., Berrow, N. S., Blagova, E., Boucher, I. W., Boyle, M. P., Brannigan, J. A., Carter, L. G., Dierks, T., Folkers, G., Grenha, R., Harlos, K., Kaptein, R., Kalliomaa, A. K., Levdikov, V. M., Meier, C., Milioti, N., Moroz, O., Muller, A., Owens, R. J. & Rzechorzek, N. & 9 others, Sainsbury, S., Stuart, D. I., Walter, T. S., Waterman, D. G., Wilkinson, A. J., Wilson, K. S., Zaccai, N., Esnouf, R. M. & Fogg, M. J., Oct 2006, In: Acta Crystallographica. Section D, Biological Crystallography. 62, p. 1267-1275 9 p.

  Research output: Contribution to journal › Article › peer-review

• Crystal structure of dihydrodipicolinate synthase (BA3935) from Bacillus anthracis at 1.94 angstrom resolution

  Blagova, E., Levdikov, V., Milioti, N., Fogg, M. J., Kalliomaa, A. K., Brannigan, J. A., Wilson, K. S. & Wilkinson, A. J., 1 Jan 2006, In: Proteins - Structure Function and Genetics. 62, 1, p. 297-301 5 p.

  Research output: Contribution to journal › Article › peer-review

• Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum

  Boucher, I. W., McMillan, P. J., Gabrielsen, M., Akerman, S. E., Brannigan, J. A., Schnick, C., Brzozowski, A. M., Wilkinson, A. J. & Muller, S., Aug 2006, In: Molecular Microbiology. 61, 4, p. 948-959 12 p.

  Research output: Contribution to journal › Article › peer-review

• Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase

  Kumar, R. S., Brannigan, J. A., Prabhune, A. A., Pundle, A. V., Dodson, G. G., Dodson, E. J. & Suresh, C. G., 27 Oct 2006, In: Journal of Biological Chemistry. 281, 43, p. 32516-32525 10 p.

  Research output: Contribution to journal › Article › peer-review

• Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli

  Grenha, R., Rzechorzek, N. J., Brannigan, J. A., de Jong, R. N., Ab, E., Diercks, T., Truffault, V., Ladds, J. C., Fogg, M. J., Bongiorni, C., Perego, M., Kaptein, R., Wilson, K. S., Folkers, G. E. & Wilkinson, A. J., 8 Dec 2006, In: Journal of Biological Chemistry. 281, 49, p. 37993-38003 11 p.

  Research output: Contribution to journal › Article › peer-review

• The crystal structure of superoxide dismutase from Plasmodium falciparum

  Boucher, I. W., Brzozowski, A. M., Brannigan, J. A., Schnick, C., Smith, D. J., Kyes, S. A. & Wilkinson, A. J., 4 Oct 2006, In: BMC Structural Biology. 6, 20, p. - 10 p.

  Research output: Contribution to journal › Article › peer-review

  File
• 2005

  An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein

  Muller, A., Thomas, G. H., Horler, R., Brannigan, J. A., Blagova, E., Levdikov, V., Fogg, M. J., Wilson, K. S. & Wilkinson, A. J., Jul 2005, In: Molecular Microbiology. 57, 1, p. 143-155 13 p.

  Research output: Contribution to journal › Article › peer-review

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• Cloning, preparation and preliminary crystallographic studies of penicillin V acylase autoproteolytic processing mutants

  Chandra, P. M., Brannigan, J. A., Prabhune, A., Pundle, A., Turkenburg, J. P., Dodson, G. G. & Suresh, C. G., Jan 2005, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 61, 1, p. 124-127 4 p.

  Research output: Contribution to journal › Article › peer-review

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• Cloning, purification, crystallization and preliminary structural studies of penicillin V acylase from Bacillus subtilis

  Rathinaswamy, P., Pundle, A. V., Prabhune, A. A., SivaRaman, H., Brannigan, J. A., Dodson, G. G. & Suresh, C. G., Jul 2005, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 61, p. 680-683 4 p.

  Research output: Contribution to journal › Article › peer-review

• Crystal structure of PurE (BA0288) from Bacillus anthracis at 1.8 angstrom resolution

  Boyle, M. P., Kalliomaa, A. K., Levdikov, V., Blagova, E., Fogg, M. J., Brannigan, J. A., Wilson, K. S. & Wilkinson, A. J., 15 Nov 2005, In: Proteins - Structure Function and Genetics. 61, 3, p. 674-676 3 p.

  Research output: Contribution to journal › Article › peer-review

• SPINE in York

  Levdikov, V. M., Blagova, E. V., Brannigan, J. A., Fogg, M. J., Moroz, O. V., Boyle, M., Grenha, R., Muller, A., Wade, J., Wilkinson, A. J. & Wilson, K. S., Jul 2005, In: FEBS Journal. 272, p. 513-513 1 p.

  Research output: Contribution to journal › Article › peer-review

• Structure and kinetics of a monomeric glucosamine 6-phosphate deaminase

  Vincent, F., Davies, G. J. & Brannigan, J. A., 20 May 2005, In: Journal of Biological Chemistry. 280, 20, p. 19649-19655 7 p.

  Research output: Contribution to journal › Article › peer-review

• Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis

  Grenha, R., Levdikov, V. M., Fogg, M. J., Blagova, E. V., Brannigan, J. A., Wilkinson, A. J. & Wilson, K. S., May 2005, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 61, 5, p. 459-462 4 p.

  Research output: Contribution to journal › Article › peer-review

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• Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine

  Schnick, C., Robien, M. A., Brzozowski, A. M., Dodson, E. J., Murshudov, G. N., Anderson, L., Luft, J. R., Mehlin, C., Hol, W. G. J., Brannigan, J. A. & Wilkinson, A. J., Sept 2005, In: Acta Crystallographica. Section D, Biological Crystallography. 61, p. 1245-1254 10 p.

  Research output: Contribution to journal › Article › peer-review

• Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre

  Boucher, I. W., Kalliomaa, A. K., Levdikov, V. M., Blagova, E. V., Fogg, M. J., Brannigan, J. A., Wilson, K. S. & Wilkinson, A. J., Jul 2005, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 61, p. 621-624 4 p.

  Research output: Contribution to journal › Article › peer-review

• The structure of bypass of forespore C, an intercompartmental signaling factor during sporulation in Bacillus

  Patterson, H. M., Brannigan, J. A., Cutting, S. M., Wilson, K. S., Wilkinson, T., AB, E., Diercks, T., de Jong, R. N., Truffault, V., Folkers, G. E. & Kaptein, R., 28 Oct 2005, In: Journal of Biological Chemistry. 280, 43, p. 36214-36220 7 p.

  Research output: Contribution to journal › Article › peer-review

• The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide

  Levdikov, V. M., Blagova, E. V., Brannigan, J. A., Wright, L., Vagin, A. A. & Wilkinson, A. J., 28 Jan 2005, In: Journal of Molecular Biology. 345, 4, p. 879-892 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  alpha-helix E of Spo0A is required for sigma(A)- but not for sigma(H)-dependent promoter activation in Bacillus subtilis

  Kumar, A., Brannigan, J. A. & Moran, C. P., Feb 2004, In: Journal of Bacteriology. 186, 4, p. 1078-1083 6 p.

  Research output: Contribution to journal › Article › peer-review

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• Crystallization of the oligopeptide-binding protein AppA from Bacillus subtilis

  Wright, L., Blagova, E., Levdikov, V. M., Brannigan, J. A., Pattenden, R. J., Chambers, J. & Wilkinson, A. J., Jan 2004, In: Acta Crystallographica. Section D, Biological Crystallography. 60, 1, p. 175-177 3 p.

  Research output: Contribution to journal › Article › peer-review

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