Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool

Miller, D. C., Reuillon, T., Molyneux, L., Blackburn, T. J., Cook, S., Edwards, N., Endicott, J. A., Golding, B. T., Griffin, R. J., Hardcastle, I. R., Heptinstall, A. B., Lochhead, P., Martin, M. P., Martin, N., Myers, S. M., Newell, D. R., Noble, R., Rigoreau, L. J. M., Thomas, H. & Tucker, J. A. & 6 others, Wang, L.-Z., Waring, M. J., Wong, A.-C., Wedge, S., Noble, M. & Cano, C., 25 Apr 2022, (E-pub ahead of print) In: JOURNAL OF MEDICINAL CHEMISTRY. 65, 9, p. 6513-6540 27 p.

Research output: Contribution to journal › Article › peer-review

Advances in Kinase Drug Discovery

Tucker, J. A. & Martin, M. P., 18 Mar 2021, In: International Journal of Molecular Sciences.

Research output: Contribution to journal › Special issue › peer-review

An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)

Al-Khawaldeh, I., Alyassiri, M., Aldred, G., Basmadjian, C., Bordoni, C., Harnor, S. J., Heptinstall, A. B., Hobson, S., Jennings, C., Khalifa, S., Lebraud, H., Martin, M. P., Miller, D. C., Shrives, H., De Souza, J., Stewart, H., Temple, M. J., Thomas, H., Totobenazara, J. & Tucker, J. A. & 12 others, Tudhope, S., Wang, L.-Z., Bronowska, A., Cano, C., Endicott, J. A., Golding, B., Hardcastle, I. R., Hickson, I., Wedge, S., Willmore, E., Noble, M. E. M. & Waring, M. J., 22 Jul 2021, In: JOURNAL OF MEDICINAL CHEMISTRY. 64, 14, p. 10001–10018

Research output: Contribution to journal › Article › peer-review