Liang Wu

Search results

• 2025

  Bespoke activity-based probes reveal that the Pseudomonas aeruginosa endoglycosidase, PslG, is an endo-β-glucanase

  Ruijgrok, G., Offen, W. A., Pickles, I. B., Raju, D., Patsos, T., de Boer, C., Ofman, T., Rompa, J., van Oord, D., Dodson, E. J., Beekers, A., Voskuilen, T., Ferrari, M., Wu, L., Janssen, A. P. A., Codée, J. D. C., Howell, L., Davies, G. J. & Overkleeft, H. S., 13 Feb 2025, (Accepted/In press) In: Journal of the American Chemical Society.

  Research output: Contribution to journal › Article › peer-review

• 2024

  Exploring the variations in ambient BTEX in urban Europe and its environmental health implications

  Liu, X., Zhang, X., Dufresne, M., Wang, T., Wu, L., Lara, R., Seco¬†, R., Monge, M., Yáñez-Serrano, A. M., Gohy, M., Petit, P., Chevalier, A., Vagnot, M.-P., Fortier, Y., Baudic, A., Ghersi, V., Gille, G., Lanzi, L., Gros, V. & Simon, L. & 22 others, Hellen, H., Reimann, S., Bras, Z. L., Müller, M. J., Beddows, D., Hou, S., Shi, Z., Harrison, R. M., Bloss, W., Dernie, J., Sauvage, S., Hopke, P. K., Duan, X., An, T., Lewis, A., Hopkins, J., Liakakou, E., Mihalopoulos, N., Zhang, X., Alastuey, A., Querol, X. & Salameh, T., 31 Jul 2024, p. 1-19, 19 p. (EGUsphere).

  Research output: Working paper › Preprint

  Open Access

• Molecular basis for inhibition of heparanases and β-glucuronidases by siastatin B

  Chen, Y., van den Nieuwendijk, A. M. C. H., Wu, L., Moran, E., Skoulikopoulou, F., Riet, V. V., Overkleeft, H. S., Davies, G. J. & Armstrong, Z., 2024, In: Journal of the American Chemical Society. 146, 1, p. 125–133 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  1,6- epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

  Kok, K., Kuo, C. L., Katzy, R. E., Lelieveld, L. T., Wu, L., Roig-Zamboni, V., Van Der Marel, G. A., Codée, J. D. C., Sulzenbacher, G., Davies, G. J., Overkleeft, H. S., Aerts, J. M. F. G. & Artola, M., 2 Aug 2022, In: Journal of the American Chemical Society. 144, p. 14819–14827 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Cryo-EM structures of human fucosidase FucA1 reveal insight into substate recognition and catalysis

  Armstrong, Z., Meek, R. W., Wu, L., Blaza, J. N. & Davies, G. J., 29 Jul 2022, (E-pub ahead of print) In: Structure. 30, 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Mechanism based heparanase inhibitors reduce cancer metastasis in vivo

  Boer, C. D., Armstrong, Z., Lit, V. A. J., Barash, U., Ruijgrok, G., Boyango, I., Weitzenberg, M. M., Schröder, S. P., Sarris, A. J. C., Meeuwenoord, N. J., Bule, P., Kayal, Y., Ilan, N., Codée, J. D. C., Vlodavsky, I., Overkleeft, H. S., Davies, G. J. & Wu, L., 26 Jul 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 31, e2203167119.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections

  Chhabra, M., Wilson, J. C., Wu, L., Davies, G. J., Gandhi, N. S. & Ferro, V., 21 Feb 2022, In: Chemistry : A European Journal. 28, 11, 11 p., e202104222.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents

  Rowland, R. J., Chen, Y., Breen, I., Wu, L., Offen, W. A., Beenakker, T., Su, Q., van den Nieuwendijk, A. M. C. H., Aerts, J. M. F. G., Artola, M., Overkleeft, H. S. & Davies, G. J., 29 Oct 2021, (E-pub ahead of print) In: Chemistry : A European Journal. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  An Overview of the Structure, Mechanism and Specificity of Human Heparanase

  Wu, L. & Davies, G. J., 2020, Advances in Experimental Medicine and Biology. Springer, p. 139-167 29 p. (Advances in Experimental Medicine and Biology; vol. 1221).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Manno- epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors

  Armstrong, Z., Kuo, C. L., Lahav, D., Liu, B., Johnson, R., Beenakker, T. J. M., De Boer, C., Wong, C. S., Van Rijssel, E. R., Debets, M. F., Florea, B. I., Hissink, C., Boot, R. G., Geurink, P. P., Ovaa, H., Van Der Stelt, M., Van Der Marel, G. M., Codée, J. D. C., Aerts, J. M. F. G. & Wu, L. & 2 others, Overkleeft, H. S. & Davies, G. J., 29 Jul 2020, In: Journal of the American Chemical Society. 142, 30, p. 13021-13029 9 p.

  Research output: Contribution to journal › Article › peer-review

• Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates

  Deen, M. C., Proceviat, C., Shan, X., Wu, L., Shen, D. L., Davies, G. J. & Vocadlo, D. J., 28 Feb 2020, (E-pub ahead of print) In: ACS Chemical Biology. 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide

  Wu, L., Wimmer, N., Davies, G. J. & Ferro, V., 18 Nov 2020, In: Chemical Communications. 56, 89, p. 13780-13783 4 p.

  Research output: Contribution to journal › Article › peer-review

• Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase v

  Darby, J. F., Gilio, A. K., Piniello, B., Roth, C., Blagova, E., Hubbard, R. E., Rovira, C., Davies, G. J. & Wu, L., 7 Aug 2020, In: ACS Catalysis. 10, 15, p. 8590-8596 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  An overview of activity-based probes for glycosidases

  Wu, L., Armstrong, Z., Schröder, S. P., Boer, C. D., Artola, M., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., Dec 2019, In: Current Opinion in Chemical Biology. 53, p. 25-36

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes

  Schröder, S. P., De Boer, C., McGregor, N. G. S., Rowland, R. J., Moroz, O., Blagova, E., Reijngoud, J., Arentshorst, M., Osborn, D., Morant, M. D., Abbate, E., Stringer, M. A., Krogh, K. B. R. M., Raich, L., Rovira, C., Berrin, J. G., Van Wezel, G. P., Ram, A. F. J., Florea, B. I. & Van Der Marel, G. A. & 5 others, Codée, J. D. C., Wilson, K. S., Wu, L., Davies, G. J. & Overkleeft, H. S., 26 Jun 2019, In: ACS Central Science. 5, 6, p. 1067-1078 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action

  Bule, P., Chuzel, L., Blagova, E., Wu, L., Gray, M. A., Henrissat, B., Rapp, E., Bertozzi, C. R., Taron, C. H. & Davies, G. J., 23 Oct 2019, In: Nature Communications. 10, 4816, 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Synthetic and crystallographic insight into exploiting sp2‐hybridization in the development of α‐L‐fucosidase inhibitors

  Coyle, T., Wu, L., Debowski, A., Davies, G. & Stubbs, K. A., 21 Jan 2019, (E-pub ahead of print) In: Chembiochem. 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• α-D-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease

  Artola, M., Hedberg, C., Rowland, R. J., Raich, L., Kytidou, K., Wu, L., Schaafa, A., Ferraz, M. J., van der Marel, G. A., Codée, J. D. C., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 20 Aug 2019, (E-pub ahead of print) In: Chemical Science. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Competitive and covalent inhibitors of human lysosomal retaining exoglucosidases

  Breen, I. Z., Artola, M., Wu, L., Beenakker, T., Offen, W. A., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 22 Jan 2018, eLS.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

• Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

  Schröder, S. P., Wu, L., Artola, M., Hansen, T., Offen, W. A., Ferraz, M. J., Li, K.-Y., Aerts, J. M. F. G., Van Der Marel, G. A., Codée, J. D. C., Davies, G. J. & Overkleeft, H. S., 2018, In: Journal of the American Chemical Society. p. 1-4 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae

  Wu, L. & Davies, G. J., 6 Aug 2018, In: Acta Crystallographica Section F: Structural Biology Communications. 74, 8, p. 512-523 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

  Artola, M., Wu, L., Ferraz, M. J., Kuo, C. L., Raich, L., Breen, I. Z., Offen, W. A., Codée, J. D. C., Van Der Marel, G. A., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 26 Jul 2017, In: ACS Central Science. 3, 7, p. 784-793 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Activity-based probes for functional interrogation of retaining β-glucuronidases

  Wu, L., Jiang, J., Jin, Y., Kallemeijn, W. W., Kuo, C. L., Artola, M., Dai, W., Van Elk, C., Van Eijk, M., Van Der Marel, G. A., Codée, J. D. C., Florea, B. I., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., 1 Aug 2017, In: NATURE CHEMICAL BIOLOGY. 13, 8, p. 867-873 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase

  Lahav, D., Liu, B., van den Berg, R. J. B. H. N., van den Nieuwendijk, A. M. C. H., Wennekes, T., Ghisaidoobe, A. T., Breen, I., Ferraz, M. J., Kuo, C.-L., Wu, L., Geurink, P. P., Ovaa, H., van der Marel, G. A., van der Stelt, M., Boot, R. G., Davies, G. J., Aerts, J. M. F. G. & Overkleeft, H. S., 11 Oct 2017, In: Journal of the American Chemical Society. 139, 40, p. 14192-14197 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2)

  Charoenwattanasatien, R., Pengthaisong, S., Breen, I., Mutoh, R., Sansenya, S., Hua, Y., Tankrathok, A., Wu, L., Songsiriritthigul, C., Tanaka, H., Williams, S. J., Davies, G. J., Kurisu, G. & Cairns, J. R. K., 15 Jul 2016, In: ACS Chemical Biology. 11, 7, p. 1891-1900 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes

  Jiang, J., Kuo, C.-L., Wu, L., Franke, C., Kallemeijn, W. W., Florea, B. I., van Meel, E., van der Marel, G. A., Codée, J. D. C., Boot, R. G., Davies, G. J., Overkleeft, H. S. & Aerts, J. M. F. G., 25 May 2016, In: ACS Central Science. 2, 5, p. 351-358 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  Structural characterization of human heparanase reveals insights into substrate recognition

  Wu, L., Viola, C. M., Brzozowski, A. M. & Davies, G. J., 16 Nov 2015, In: Nature Structural & Molecular Biology. 22, 12, p. 1016-1022 7 p.

  Research output: Contribution to journal › Article › peer-review