Research output per year
Research output per year
Search results
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2025
Bespoke activity-based probes reveal that the Pseudomonas aeruginosa endoglycosidase, PslG, is an endo-β-glucanase
Ruijgrok, G., Offen, W. A., Pickles, I. B., Raju, D., Patsos, T., de Boer, C., Ofman, T., Rompa, J., van Oord, D., Dodson, E. J., Beekers, A., Voskuilen, T., Ferrari, M., Wu, L., Janssen, A. P. A., Codée, J. D. C., Howell, L., Davies, G. J. & Overkleeft, H. S., 13 Feb 2025, (Accepted/In press) In: Journal of the American Chemical Society.Research output: Contribution to journal › Article › peer-review
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2024
Molecular basis for inhibition of heparanases and β-glucuronidases by siastatin B
Chen, Y., van den Nieuwendijk, A. M. C. H., Wu, L., Moran, E., Skoulikopoulou, F., Riet, V. V., Overkleeft, H. S., Davies, G. J. & Armstrong, Z., 2024, In: Journal of the American Chemical Society. 146, 1, p. 125–133 9 p.Research output: Contribution to journal › Article › peer-review
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2022
1,6- epi-Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease
Kok, K., Kuo, C. L., Katzy, R. E., Lelieveld, L. T., Wu, L., Roig-Zamboni, V., Van Der Marel, G. A., Codée, J. D. C., Sulzenbacher, G., Davies, G. J., Overkleeft, H. S., Aerts, J. M. F. G. & Artola, M., 2 Aug 2022, In: Journal of the American Chemical Society. 144, p. 14819–14827 9 p.Research output: Contribution to journal › Article › peer-review
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Cryo-EM structures of human fucosidase FucA1 reveal insight into substate recognition and catalysis
Armstrong, Z., Meek, R. W., Wu, L., Blaza, J. N. & Davies, G. J., 29 Jul 2022, (E-pub ahead of print) In: Structure. 30, 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanism based heparanase inhibitors reduce cancer metastasis in vivo
Boer, C. D., Armstrong, Z., Lit, V. A. J., Barash, U., Ruijgrok, G., Boyango, I., Weitzenberg, M. M., Schröder, S. P., Sarris, A. J. C., Meeuwenoord, N. J., Bule, P., Kayal, Y., Ilan, N., Codée, J. D. C., Vlodavsky, I., Overkleeft, H. S., Davies, G. J. & Wu, L., 26 Jul 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 31, e2203167119.Research output: Contribution to journal › Article › peer-review
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Structural insights into pixatimod (PG545) inhibition of heparanase, a key enzyme in cancer and viral infections
Chhabra, M., Wilson, J. C., Wu, L., Davies, G. J., Gandhi, N. S. & Ferro, V., 21 Feb 2022, In: Chemistry : A European Journal. 28, 11, 11 p., e202104222.Research output: Contribution to journal › Article › peer-review
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2021
Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents
Rowland, R. J., Chen, Y., Breen, I., Wu, L., Offen, W. A., Beenakker, T., Su, Q., van den Nieuwendijk, A. M. C. H., Aerts, J. M. F. G., Artola, M., Overkleeft, H. S. & Davies, G. J., 29 Oct 2021, (E-pub ahead of print) In: Chemistry : A European Journal. 13 p.Research output: Contribution to journal › Article › peer-review
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2020
Manno- epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors
Armstrong, Z., Kuo, C. L., Lahav, D., Liu, B., Johnson, R., Beenakker, T. J. M., De Boer, C., Wong, C. S., Van Rijssel, E. R., Debets, M. F., Florea, B. I., Hissink, C., Boot, R. G., Geurink, P. P., Ovaa, H., Van Der Stelt, M., Van Der Marel, G. M., Codée, J. D. C., Aerts, J. M. F. G. & Wu, L. & 2 others, , 29 Jul 2020, In: Journal of the American Chemical Society. 142, 30, p. 13021-13029 9 p.Research output: Contribution to journal › Article › peer-review
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Selective Fluorogenic β-Glucocerebrosidase Substrates for Convenient Analysis of Enzyme Activity in Cell and Tissue Homogenates
Deen, M. C., Proceviat, C., Shan, X., Wu, L., Shen, D. L., Davies, G. J. & Vocadlo, D. J., 28 Feb 2020, (E-pub ahead of print) In: ACS Chemical Biology. 6 p.Research output: Contribution to journal › Article › peer-review
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Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide
Wu, L., Wimmer, N., Davies, G. J. & Ferro, V., 18 Nov 2020, In: Chemical Communications. 56, 89, p. 13780-13783 4 p.Research output: Contribution to journal › Article › peer-review
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Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase v
Darby, J. F., Gilio, A. K., Piniello, B., Roth, C., Blagova, E., Hubbard, R. E., Rovira, C., Davies, G. J. & Wu, L., 7 Aug 2020, In: ACS Catalysis. 10, 15, p. 8590-8596 7 p.Research output: Contribution to journal › Article › peer-review
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2019
An overview of activity-based probes for glycosidases
Wu, L., Armstrong, Z., Schröder, S. P., Boer, C. D., Artola, M., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., Dec 2019, In: Current Opinion in Chemical Biology. 53, p. 25-36Research output: Contribution to journal › Article › peer-review
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Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes
Schröder, S. P., De Boer, C., McGregor, N. G. S., Rowland, R. J., Moroz, O., Blagova, E., Reijngoud, J., Arentshorst, M., Osborn, D., Morant, M. D., Abbate, E., Stringer, M. A., Krogh, K. B. R. M., Raich, L., Rovira, C., Berrin, J. G., Van Wezel, G. P., Ram, A. F. J., Florea, B. I. & Van Der Marel, G. A. & 5 others, , 26 Jun 2019, In: ACS Central Science. 5, 6, p. 1067-1078 12 p.Research output: Contribution to journal › Article › peer-review
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Inverting family GH156 sialidases define an unusual catalytic motif for glycosidase action
Bule, P., Chuzel, L., Blagova, E., Wu, L., Gray, M. A., Henrissat, B., Rapp, E., Bertozzi, C. R., Taron, C. H. & Davies, G. J., 23 Oct 2019, In: Nature Communications. 10, 4816, 11 p.Research output: Contribution to journal › Article › peer-review
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Synthetic and crystallographic insight into exploiting sp2‐hybridization in the development of α‐L‐fucosidase inhibitors
Coyle, T., Wu, L., Debowski, A., Davies, G. & Stubbs, K. A., 21 Jan 2019, (E-pub ahead of print) In: Chembiochem. 5 p.Research output: Contribution to journal › Article › peer-review
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α-D-Gal-cyclophellitol cyclosulfamidate is a Michaelis complex analog that stabilizes therapeutic lysosomal α-galactosidase A in Fabry disease
Artola, M., Hedberg, C., Rowland, R. J., Raich, L., Kytidou, K., Wu, L., Schaafa, A., Ferraz, M. J., van der Marel, G. A., Codée, J. D. C., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 20 Aug 2019, (E-pub ahead of print) In: Chemical Science. 13 p.Research output: Contribution to journal › Article › peer-review
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2018
Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor
Schröder, S. P., Wu, L., Artola, M., Hansen, T., Offen, W. A., Ferraz, M. J., Li, K.-Y., Aerts, J. M. F. G., Van Der Marel, G. A., Codée, J. D. C., Davies, G. J. & Overkleeft, H. S., 2018, In: Journal of the American Chemical Society. p. 1-4 4 p.Research output: Contribution to journal › Article › peer-review
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Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae
Wu, L. & Davies, G. J., 6 Aug 2018, In: Acta Crystallographica Section F: Structural Biology Communications. 74, 8, p. 512-523 12 p.Research output: Contribution to journal › Article › peer-review
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2017
1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor
Artola, M., Wu, L., Ferraz, M. J., Kuo, C. L., Raich, L., Breen, I. Z., Offen, W. A., Codée, J. D. C., Van Der Marel, G. A., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 26 Jul 2017, In: ACS Central Science. 3, 7, p. 784-793 10 p.Research output: Contribution to journal › Article › peer-review
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Activity-based probes for functional interrogation of retaining β-glucuronidases
Wu, L., Jiang, J., Jin, Y., Kallemeijn, W. W., Kuo, C. L., Artola, M., Dai, W., Van Elk, C., Van Eijk, M., Van Der Marel, G. A., Codée, J. D. C., Florea, B. I., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., 1 Aug 2017, In: NATURE CHEMICAL BIOLOGY. 13, 8, p. 867-873 7 p.Research output: Contribution to journal › Article › peer-review
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A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase
Lahav, D., Liu, B., van den Berg, R. J. B. H. N., van den Nieuwendijk, A. M. C. H., Wennekes, T., Ghisaidoobe, A. T., Breen, I., Ferraz, M. J., Kuo, C.-L., Wu, L., Geurink, P. P., Ovaa, H., van der Marel, G. A., van der Stelt, M., Boot, R. G., Davies, G. J., Aerts, J. M. F. G. & Overkleeft, H. S., 11 Oct 2017, In: Journal of the American Chemical Society. 139, 40, p. 14192-14197 6 p.Research output: Contribution to journal › Article › peer-review
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2016
Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2)
Charoenwattanasatien, R., Pengthaisong, S., Breen, I., Mutoh, R., Sansenya, S., Hua, Y., Tankrathok, A., Wu, L., Songsiriritthigul, C., Tanaka, H., Williams, S. J., Davies, G. J., Kurisu, G. & Cairns, J. R. K., 15 Jul 2016, In: ACS Chemical Biology. 11, 7, p. 1891-1900 10 p.Research output: Contribution to journal › Article › peer-review
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Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes
Jiang, J., Kuo, C.-L., Wu, L., Franke, C., Kallemeijn, W. W., Florea, B. I., van Meel, E., van der Marel, G. A., Codée, J. D. C., Boot, R. G., Davies, G. J., Overkleeft, H. S. & Aerts, J. M. F. G., 25 May 2016, In: ACS Central Science. 2, 5, p. 351-358 8 p.Research output: Contribution to journal › Article › peer-review
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2015
Structural characterization of human heparanase reveals insights into substrate recognition
Wu, L., Viola, C. M., Brzozowski, A. M. & Davies, G. J., 16 Nov 2015, In: Nature Structural & Molecular Biology. 22, 12, p. 1016-1022 7 p.Research output: Contribution to journal › Article › peer-review