Martin Anthony Fascione

Search results

• 2024

  A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification

  Hutton, E., Scott, E., Robson, C., Signoret, N. Y. M. & Fascione, M. A., 26 Apr 2024, In: Frontiers in Molecular Biosciences. 11, 17 p., 1390711.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Bimodal Glycosyl Donors as an Emerging Approach Towards a General Glycosylation Strategy

  Warnes, M. E. & Fascione, M. A., 17 Apr 2024, (E-pub ahead of print) In: Chemistry : A European Journal. 11 p., e202400399.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Co-factor prosthesis facilitates biosynthesis of azido-pseudaminic acid probes for use as glycosyltransferase reporters

  Keenan, T., Chidwick, H., Best, M., Flack, E., Yates, N., Hatton, N., Warnes, M. E. & Fascione, M. A., 2 Jan 2024, (Accepted/In press) In: Chemical communications.

  Research output: Contribution to journal › Article › peer-review

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• Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH

  Tufail, A., Akkad, S., Hatton, N., Yates, N., Spears, R., Keenan, T., Parkin, A., Signoret, N. Y. M. & Fascione, M. A., 24 Jan 2024, (E-pub ahead of print) In: RSC Advances. 14, 6, p. 3723-3729 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Crossing the Solubility Rubicon: 15-Crown-5 Facilitates the Preparation of Water-Soluble Sulfo-NHS Esters in Organic Solvents

  Yates, N., Miles, C., Spicer, C., Fascione, M. A. & Parkin, A., 17 Jan 2024, In: BIOCONJUGATE CHEMISTRY. 35, 1, 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Expanding the scope of the successive ring expansion strategy for macrocycle and medium-sized ring synthesis: unreactive and reactive lactams

  Yang, Z., Arnoux, M., Hazelard, D., Hughes, O. R., Nabarro, J., Whitwood, A. C., Fascione, M. A., Spicer, C. D., Compain, P. & Unsworth, W. P., 25 Mar 2024, (E-pub ahead of print) In: Organic & biomolecular chemistry. 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug

  Porter, J., Noble, A. R., Signoret, N., Fascione, M. A. & Miller, G. J., 9 Jul 2024, In: ACS Omega. 9, 29, p. 31703-31713 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Harnessing glycofluoroforms for impedimetric biosensing

  Hewson, A., Lloyd-Laney, H., Keenan, T., Richards, S.-J., Gibson, M. I., Linclau, B., Signoret, N. Y. M., Fascione, M. A. & Parkin, A., 13 Sept 2024, In: Chemical Science. 15, 39, p. 16086-16095 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• New insight into a simple high-yielding method for the production of fully folded and functional recombinant human CCL5

  Tufail, A., Akkad, S., Noble, A. R., Fascione, M. A. & Signoret, N., 15 Oct 2024, In: Scientific reports. 14, 1, 11 p., 24188.

  Research output: Contribution to journal › Article › peer-review

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• Strain-Promoted Cycloadditions in Lipid Bilayers Triggered by Liposome Fusion

  Jumeaux, C., Spicer, C. D., Charchar, P., Howes, P. D., Holme, M. N., Ma, L., Rose, N. C., Nabarro, J., Fascione, M. A., Rashid, M. H., Yarovsky, I. & Stevens, M. M., 4 Mar 2024, (E-pub ahead of print) In: Angewandte Chemie - International Edition. 7 p., e202314786.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Structural dissection of the CMP-pseudaminic acid synthetase (PseF)

  Keenan, T., Cowan, A., Flack, E., Hatton, N., Walklett, A., Thomas, G. H., Hemsworth, G. R. & Fascione, M. A., 23 Aug 2024, (Accepted/In press) In: Structure.

  Research output: Contribution to journal › Article › peer-review

• Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

  Hollingsworth, K., Di Maio, A., Richards, S.-J., Vendeville, J.-B., Wheatley, D. E., Council, C. E., Keenan, T., Chidwick, H., Huang, K., Parmeggiani, F., Marchesi, A., Chai, W., McBerney, R., Kaminski, T., Balmforth, M., Tamasanu, A., Finnigan, J., Young, C., Warriner, S. & Webb, M. E. & 8 others, Fascione, M. A., Flitsch, S. L., Galan, M. C., Feizi, T., Gibson, M. I., Liu, Y., Turnbull, W. B. & Linclau, B., 13 Sept 2024, In: Nature Communications. 15, 14 p., 7925.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Synthesis of Colicin Ia Neoglycoproteins: Tools Towards Glyco-Engineering of Bacterial Cell Surfaces

  Hatton, N., Wilson, L. G., Baumann, C. G. & Fascione, M. A., 13 Sept 2024, In: RSC Advances. 14, p. 29106-29112 7 p.

  Research output: Contribution to journal › Article › peer-review

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• The Retaining Pse5Ac7Ac Pseudaminyltransferase KpsS1 Defines a Previously Unreported Glycosyltransferase Family (GT118)

  Walklett, A., Flack, E., Chidwick, H., Hatton, N., Keenan, T., Budhadev, D., Walton, J., Thomas, G. H. & Fascione, M. A., 1 Feb 2024, (E-pub ahead of print) In: Angewandte Chemie International Edition. 7 p., e202318523.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Towards a 'clicked' PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer

  Noble, A. R., Akkad, S., Yates, N. D. J., Jeffries, J. M., Signoret, N. & Fascione, M. A., 29 Jul 2024, In: RSC Advances. 14, 33, p. 23796-23801 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2023

  Preparation and Application of an Inexpensive α‐Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

  Yates, N. D. J., Warnes, M. E., Breetveld, R., Spicer, C. D., Signoret, N. & Fascione, M., 20 Jan 2023, (E-pub ahead of print) In: Organic Letters. 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library

  Fascione, M. A., Keenan, T., Hatton, N., Porter, J., Vendeville, J.-B., Wheatley, D., Ghirardello, M., Ahmadipour , S., Walton, J., Galan, M. C., Linclau, B. & Miller, G. J., 28 Sept 2023, (Accepted/In press) In: Chemical Science.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Site-Selective Aryl Diazonium Installation onto Protein Surfaces at Neutral pH using a Maleimide-Functionalized Triazabutadiene

  Yates, N. D. J., Hatton, N. E., Fascione, M. A. & Parkin, A., 15 Aug 2023, In: Chembiochem. 24, 16, 7 p., e202300313.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  Catalyst-free site-selective cross-aldol bioconjugations

  Yates, N., Akkad, S., Noble, A., Keenan, T., Hatton, N., Signoret, N. Y. M. & Fascione, M. A., 26 Sept 2022, (E-pub ahead of print) In: Green Chemistry. 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Cell-specific bioorthogonal tagging of glycoproteins

  Anna , A., Calle, B., Rizou, T., Lowery, S., Bridgeman, V., Mahoney, K., Marchesi, A., Bineva-Todd, G., Flynn, H., Li, Z., Yilmaz Tastan, O., Roustan, C., Soro-Barrio, P., Rafiee, M.-R., Garza-Garcia, A., Antonopoulos, A., Wood, T., Keenan, T., Both, P. & Huang, K. & 9 others, Parmeggiani, F., Snijders, A., Skehel, J., Kjaer, S., Fascione, M. A., Bertozzi, C. R., Malaker, S., Malanchi, I. & Schumann, B., 25 Oct 2022, In: Nature Communications. 13, 18 p., 6237.

  Research output: Contribution to journal › Article › peer-review

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• Selectivity and stability of N-terminal targeting protein modification chemistries

  Barber, L. J., Yates, N. D. J., Fascione, M. A., Parkin, A., Hemsworth, G. R., Genever, P. G. & Spicer, C. D., 17 Nov 2022, (E-pub ahead of print) In: RSC Chemical Biology. 9 p.

  Research output: Contribution to journal › Article › peer-review

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• 2021

  A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations

  Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N. & Fascione, M. A., 19 Nov 2021, In: ACS Chemical Biology. 16, 11, p. 2387-2400 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Reconstitution and optimisation of the biosynthesis of bacterial sugar pseudaminic acid (Pse5Ac7Ac) enables preparative enzymatic synthesis of CMP-Pse5Ac7Ac

  Chidwick, H., Flack, E., Keenan, T., Walton, J., Thomas, G. H. & Fascione, M. A., 26 Feb 2021, In: Scientific Reports. 11, 12 p., 4756.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2020

  Biocatalytic Transfer of Pseudaminic Acid (Pse5Ac7Ac) Using Promiscuous Sialyltransferases in a Chemoenzymatic Approach to Pse5Ac7Ac Containing Glycosides

  Flack, E., Chidwick, H., Guchhait, G., Keenan, T., Budhadev, D., Huang, K., Both, P., Mas Pons, J., Ledru, H., Rui, S., Stafford, G., Shaw, J., Galan, M. C., Flitsch, S. L., Thomas, G. H. & Fascione, M. A., 21 Aug 2020, (E-pub ahead of print) In: ACS Catalysis. 10, p. 9986-9993 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates

  Valverde, P., Vendeville, J.-B., Hollingsworth, K., Mattey, A. P., Keenan, T., Chidwick, H., Ledru, H., Huonnic, K., Light, M. E., Turner, N., Jimenez Barbero, J., Galan, M. C., Fascione, M. A., Flitsch, S., Turnbull, W. B. & Linclau, B., 29 Apr 2020, (E-pub ahead of print) In: Chemical Communications. 5

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

  Richards, S.-J., Keenan, T., Vendeville, J.-B., Wheatley, D. E., Chidwick, H., Budhadev, D., Council, C. E., Webster, C. S., Ledru, H., Baker, A. N., Walker, M., Galan, M. C., Linclau, B., Fascione, M. A. & Gibson, M. I., 16 Nov 2020, In: Chemical Science.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides

  Keenan, T., Parmeggiani, F., Malassis, J., Fontenelle, C., Vendeville, J.-B., Offen, W. A., Both, P., Huang, K., Marchesi, A., Heyam, A. P., Young, C., Charnock, S. J., Davies, G. J., Linclau, B., Flitsch, S. L. & Fascione, M. A., 2 Jul 2020, (E-pub ahead of print) In: Cell Chemical Biology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Rapid sodium periodate cleavage of an unnatural amino acid enables unmasking of a highly reactive α-oxo aldehyde for protein bioconjugation

  Brabham, R., Keenan, T., Husken, A., Bilsborrow, J., McBerney, R., Kumar, V., Turnbull, W. B. & Fascione, M. A., 14 May 2020, (E-pub ahead of print) In: Organic and Biomolecular Chemistry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Synthetic Approaches for Accessing Pseudaminic Acid (Pse) Bacterial Glycans

  Flack, E., Chidwick, H., Best, M., Thomas, G. H. & Fascione, M. A., 26 Feb 2020, (E-pub ahead of print) In: Chembiochem. 21, p. 1-12

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  Aldehyde-mediated protein-to-surface tethering via controlled diazonium electrode functionalization using protected hydroxylamines

  Yates, N., Dowsett, M., Bentley, P., Dickenson-Fogg, J., Pratt, A., Blanford, C., Fascione, M. A. & Parkin, A., 13 Nov 2019, (E-pub ahead of print) In: Langmuir.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus

  Yates, N. D. J., Brabham, R. L., Spears, R. J., Keenan, T., Helliwell, P. A., Pugh, D. S., Parkin, A., Hurst, G. A. & Fascione, M. A., 26 Mar 2019, In: JOURNAL OF CHEMICAL EDUCATION. 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Ionisation bias undermines the use of matrix-assisted laser desorption/ionisation for estimating peptide deamidation: Synthetic peptide studies demonstrate electrospray ionisation gives more reliable response ratios

  Simpson, J. P., Fascione, M., Bergström, E., Wilson, J., Collins, M. J., Penkman, K. E. H. & Thomas-Oates, J., 30 Jun 2019, In: Rapid Communications in Mass Spectrometry. 33, 12, p. 1049-1057 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Mechanistic and structural studies into the biosynthesis of the bacterial sugar pseudaminic acid (Pse5Ac7Ac)

  Chidwick, H. & Fascione, M. A., 23 Dec 2019, (E-pub ahead of print) In: Organic and Biomolecular Chemistry. 18, p. 799-809

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The characterisation of a galactokinase from Streptomyces coelicolor

  Keenan, T., Mills, R., Pocock, E., Budhadev, D., Parmeggiani, F., Flitsch, S. L. & Fascione, M. A., 15 Jan 2019, In: CARBOHYDRATE RESEARCH. 472, p. 132-137

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2018

  Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification

  Brabham, R. L., Spears, R. J., Walton, J., Tyagi, S., Lemke, E. & Fascione, M. A., 6 Feb 2018, In: Chemical Communications. 54, p. 1501-1504 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

  Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S. E., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. J. & Fascione, M. A., 7 Jul 2018, In: Chemical Science. 9, 25, p. 5585-5593 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Using Automated Glycan Assembly (AGA) for the Practical Synthesis of Heparan Sulfate Oligosaccharide Precursors

  Budhadev, D., Saxby, K., Walton, J., Davies, G. J., Tyler, P., Schworer, R. & Fascione, M. A., 11 Dec 2018, (E-pub ahead of print) In: Organic and Biomolecular Chemistry. 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  Molecular-recognition mediated transformation of single-chain polymer nanoparticles into crosslinked polymer films

  Mahon, C. S., J. McGurk, C., M. D. Watson, S., Fascione, M. A., Sakonsinsiri, C., Turnbull, W. B. & A. Fulton, D., 9 Oct 2017, In: Angewandte Chemie International Edition. 56, 42, p. 12913-12918 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Pyrrolysine Amber Stop Codon Suppression: Development and Applications

  Brabham, R. L. & Fascione, M. A., 30 Jul 2017, (E-pub ahead of print) In: Chembiochem.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  Compact, Polyvalent Mannose Quantum Dots as Sensitive, Ratiometric FRET Probes for Multivalent Protein–Ligand Interactions

  Guy, Y., Sakonsinsiri, C., Nehlmeier, I., Fascione, M. A., Zhang, H., Wang, W., Pohlmann, S., Turnbull, W. B. & Zhou, D., 4 Apr 2016, In: Angewandte Chemie International Edition. 55, 15, p. 4738-4742 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Mechanistic Investigations into the Application of Sulfoxides in Carbohydrate Synthesis

  Fascione, M. A., Brabham, R. & Turnbull, W. B., 2016, In: Chemistry - A European Journal. 22, 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Templating carbohydrate-functionalised polymer-scaffolded dynamic combinatorial libraries with lectins

  Mahon, C. S., Fascione, M. A., Sakonsinsiri, C., McAllister, T. E., Bruce Turnbull, W. & A. Fulton, D., 2015, In: Organic and Biomolecular Chemistry. 13, 9, p. 2756-2761 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2014

  A protein-based pentavalent inhibitor of the Cholera toxin B-subunit

  Branson, T. R., McAllister, T. E., Garcia-Hartjes, J., Fascione, M. A., Ross, J. F., Warriner, S. L., Wennekes, T., Zuilhof, H. & Turnbull, B., 4 Aug 2014, In: Angewandte Chemie International Edition. 53, 32, p. 8323-8327 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2012

  Do glycosyl sulfonium ions engage in neighbouring-group participation? A Study of oxathiane glycosyl donors and the basis for their stereoselectivity

  Fascione, M. A., Kilner, C. A., Turnbull, W. B. & Leach, A. G., 2 Jan 2012, In: Chemistry - A European Journal. 18, 1, p. 321-333

  Research output: Contribution to journal › Article › peer-review

• Efficient N-terminal labeling of proteins by use of sortase

  Williamson, D. J., Fascione, M. A., Webb, M. E. & Turnbull, W. B., 10 Sept 2012, In: Angewandte Chemie International Edition. 51, 37, p. 9377-9380

  Research output: Contribution to journal › Article › peer-review

• Mechanistic studies on a sulfoxide transfer reaction mediated by diphenyl sulfoxide/triflic anhydride

  Fascione, M. A., Adshead, S. J., Mandal, P. K., Kilner, C. A., Turnbull, W. B. & Leach, A. G., 5 Mar 2012, In: Chemistry - A European Journal. 18, 10, p. 2987-2997

  Research output: Contribution to journal › Article › peer-review

• Stereoselective glycosylations using oxathiane spiroketal glycosyl donors

  Fascione, M. A., Webb, N. J., Kilner, C. A., Warriner, S. L. & Turnbull, W. B., 1 Feb 2012, In: CARBOHYDRATE RESEARCH. 348, p. 6-13

  Research output: Contribution to journal › Article › peer-review
• 2010

  Benzyne arylation of oxathiane glycosyl donors

  Fascione, M. A. & Turnbull, W. B., 1 Jan 2010, In: Beilstein Journal of Organic Chemistry. 6

  Research output: Contribution to journal › Article › peer-review
• 2009

  A natural carbohydrate substrate for Mycobacterium tuberculosis methionine sulfoxide reductase A

  Stalford, S. A., Fascione, M. A., Turnbull, W. B., Sasindran, S. J., Dhandayuthapani, S. & Chatterjee, D., 1 Jan 2009, In: Chemical Communications. 1, p. 110-112 3 p.

  Research output: Contribution to journal › Article › peer-review

• Stereoselective glycosylation using oxathiane glycosyl donors

  Fascione, M. A., Adshead, S. J., Stalford, S. A., Kilner, C. A., Turnbull, W. B. & Leach, A. G., 1 Jan 2009, In: Chemical Communications. 39, p. 5841-5843 3 p.

  Research output: Contribution to journal › Article › peer-review