Cell biology of receptors for chemokines

My research aims to establish the role of chemokine receptors in regulating immune cells functions, and beyond.

Work in my lab focuses on how individual receptors influence cells behaviour. I am particularly interested in the cell biological mechanisms modulating receptor activity, allosteric regulation and bias agonism. Using primary human cells, we aim to identify the molecular pathways involved, as well as the molecular mechanisms implicated in these key processes.

By extending our investigations to in vivo physiological or pathological situations we aim to obtain a better understanding of the process of inflammation, response to infection and cancer processes to identify targets for new therapies.

Nathalie Signoret is a Senior lecturer in Immunology. She obtained her undergraduate and master degrees as well as her PhD in Immunology from the University of Aix- Marseille II (France).

During her PhD, she studied the role of the glycoprotein CD4 in HIV infection in the group of Prof. Quentin Sattentau at the Centre d’Immunologie de Marseille-Luminy (CIML).

Nathalie then moved to the MRC-LMCB in London for a post-doc with Prof. Mark Marsh where she developed her interest in chemokine receptor biology. She remained in the group of Prof. Marsh at the MRC-cell Biology Unit as a senior research associate until 2005, investigating the molecular mechanisms regulating CXCR4 and CCR5 surface expression and intracellular trafficking.

In 2006 Nathalie was appointed lecturer in Immunology at HYMS and established her group in york as part of the IIU, then CII.

Nathalie is a member of the Experimental Medicine and Biomedicine research group at Hull York Medical School.

(https://www.hyms.ac.uk/research/research-centres-and-groups/experimental-medicine-and-biomedicine)