Nathalie Yvonne Micheline Signoret

Search results

• 2024

  A systematic review reveals conflicting evidence for the prevalence of antibodies against the sialic acid ‘xenoautoantigen’ Neu5Gc in humans and the need for a standardised approach to quantification

  Hutton, E., Scott, E., Robson, C., Signoret, N. Y. M. & Fascione, M. A., 26 Apr 2024, In: Frontiers in Molecular Biosciences. 11, 17 p., 1390711.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Blood immune profiles reveal a CXCR3/CCR5 axis of dysregulation in early sepsis

  Kealy, D. J., Wilson, J. C., Jaconelli, T., Hogg, K., Coop, R., Fershaw, G., Todd, N., Yates, D. & Signoret, N. Y. M., 20 Sept 2024, (Accepted/In press) In: Journal of leukocyte biology.

  Research output: Contribution to journal › Article › peer-review

• Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH

  Tufail, A., Akkad, S., Hatton, N., Yates, N., Spears, R., Keenan, T., Parkin, A., Signoret, N. Y. M. & Fascione, M. A., 24 Jan 2024, (E-pub ahead of print) In: RSC Advances. 14, 6, p. 3723-3729 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Exploring a Gemcitabine-Glucose Hybrid as a Glycoconjugate Prodrug

  Porter, J., Noble, A. R., Signoret, N., Fascione, M. A. & Miller, G. J., 9 Jul 2024, In: ACS Omega. 9, 29, p. 31703-31713 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Harnessing Glycofluoroforms for Impedimetric Biosensing

  Hewson, A., Lloyd-Laney, H., Keenan, T., Richards, S-J., Gibson, M. I., Linclau, B., Signoret, N. Y. M., Fascione, M. A. & Parkin, A., 4 Sept 2024, (Accepted/In press) In: Chemical Science.

  Research output: Contribution to journal › Article › peer-review

• Towards a 'clicked' PSMA targeting gene delivery bioconjugate-polyplex for prostate cancer

  Noble, A. R., Akkad, S., Yates, N. D. J., Jeffries, J. M., Signoret, N. & Fascione, M. A., 29 Jul 2024, In: RSC Advances. 14, 33, p. 23796-23801 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2023

  Identification of a protein expression signature distinguishing early from organising diffuse alveolar damage in COVID-19 patients

  Ashwin, H., Milross, L., Wilson, J., Majo, J., Hang Lee, J. T., Calder, G., Hunter, B., James, S., Lagos, D., Signoret, N., Filby, A., Bayraktar, O. A., Fisher, A. J. & Kaye, P. M., 9 Mar 2023, (E-pub ahead of print) In: Journal of clinical pathology. 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Preparation and Application of an Inexpensive α‐Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis

  Yates, N. D. J., Warnes, M. E., Breetveld, R., Spicer, C. D., Signoret, N. & Fascione, M., 20 Jan 2023, (E-pub ahead of print) In: Organic Letters. 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  Catalyst-free site-selective cross-aldol bioconjugations

  Yates, N., Akkad, S., Noble, A., Keenan, T., Hatton, N., Signoret, N. Y. M. & Fascione, M. A., 26 Sept 2022, (E-pub ahead of print) In: Green Chemistry. 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Integrated miRNA/cytokine/chemokine profiling reveals severity-associated step changes and principal correlates of fatality in COVID-19

  Wilson, J. C., Kealy, D. J., James, S. R., Plowman, T., Newling, K., Jagger, C., Filbey, K., Mann, E., Konkel, J., Menon, M., Knight, S., Simpson, A., Collaborative Group, CIRCO., Prihartadi, A., Forshaw, G., Todd, N., Yates, D., Grainger, J., Hussell, T., Kaye, P., & 2 othersSignoret, N. Y. M. & Lagos, D., 21 Jan 2022, In: iScience. 25, 1, 23 p., 103672.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Single-molecule and super-resolved imaging deciphers membrane behavior of onco-immunogenic CCR5

  Hunter, P., Payne-Dwyer, A. L., Shaw, M., Signoret, N. & Leake, M. C., 22 Dec 2022, In: iScience. 25, 12, p. 105675

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations

  Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N. & Fascione, M. A., 19 Nov 2021, In: ACS Chemical Biology. 16, 11, p. 2387-2400 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses

  Kasprowicz, R. M. R., Rand, E., O'Toole, P. J. & Signoret, N. Y. M., 22 May 2018, In: Scientific Reports. 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells

  Fox, J. M., Kasprowicz, R., Hartley, O. & Signoret, N., Jul 2015, In: Journal of leukocyte biology. 98, 1, p. 59-71

  Research output: Contribution to journal › Article › peer-review
• 2011

  Mechanisms regulating chemokine receptor activity

  Bennett, L. D., Fox, J. M. & Signoret, N., Nov 2011, In: Immunology. 134, 3, p. 246-56 11 p.

  Research output: Contribution to journal › Article › peer-review

• TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes

  Fox, J. M., Letellier, E., Oliphant, C. J. & Signoret, N., 10 Feb 2011, In: Blood. 117, 6, p. 1851-1860 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7

  Phillips, R., Svensson, M., Aziz, N., Maroof, A., Brown, N., Beattie, L., Signoret, N. & Kaye, P. M., Mar 2010, In: PLOS PATHOGENS. 6, 3, e1000813.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Analysis of chemokine receptor endocytosis and intracellular trafficking

  Kershaw, T., Wavre-Shapton, S. T., Signoret, N. & Marsh, M., 2009, In: Methods in enzymology. 460, A, p. 357-377 21 p.

  Research output: Contribution to journal › Article › peer-review

• ANALYSIS OF CHEMOKINE RECEPTOR ENDOCYTOSIS AND INTRACELLULAR TRAFFICKING

  Kershaw, T., Wavre-Shapton, S. T., Signoret, N. & Marsh, M., 2009, CHEMOKINES, PT A. SAN DIEGO: Elsevier, p. 357-+ 22 p.

  Research output: Chapter in Book/Report/Conference proceeding › Other chapter contribution

• 2008

  IRF-7-dependent control of Leishmania donovani infection by splenic marginal zone and marginal metallophilic macrophages

  Phillips, R., Signoret, N., Svensson, M. & Kaye, P. M., Dec 2008, In: Immunology. 125, p. 44 1 p.

  Research output: Contribution to journal › Article › peer-review

• 2005

  Agonist-induced endocytosis of CC chemokine receptor 5 is clathrin dependent

  Signoret, N. Y. M., Hewlett, L., Wavre, S., Pelchen-Matthews, A., Oppermann, M. & Marsh, M., Feb 2005, In: Molecular Biology of the Cell. 16, 2, p. 902-917 15 p.

  Research output: Contribution to journal › Article › peer-review

• Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta

  Smalley, M. J., Signoret, N., Robertson, D., Tilley, A., Hann, A., Ewan, K., Ding, Y., Paterson, H. & Dale, T. C., Nov 2005, In: Journal of Cell Science. 118, 22, p. 5279-5289 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  pH-independent endocytic cycling of the chemokine receptor CCR5

  Signoret, N., Christophe, T., Marsh, M. & Oppermann, M., 24 May 2004, In: Traffic. 5, 7, p. 529-543 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2000

  Analysis of chemokine receptor endocytosis and recycling

  Signoret, N. & Marsh, M., 2000, In: Methods in Molecular Biology. 138, p. 197-207 11 p.

  Research output: Contribution to journal › Article › peer-review

• Endocytosis and recycling of the HIV coreceptor CCR5

  Signoret, N., Pelchen-Matthews, A., Mack, M., Proudfoot, A. E. & Marsh, M., 11 Dec 2000, In: Journal of Cell Biology. 151, 6, p. 1281-94 14 p.

  Research output: Contribution to journal › Article › peer-review

• 1999

  B cell antigen receptor engagement inhibits stromal cell-derived factor (SDF)-1alpha chemotaxis and promotes protein kinase C (PKC)-induced internalization of CXCR4

  Guinamard, R., Signoret, N., Ishiai, M., Marsh, M., Kurosaki, T., Ravetch, J. V. & Masamichi, I., 3 May 1999, In: Journal of Experimental Medicine. 189, 9, p. 1461-6 6 p.

  Research output: Contribution to journal › Article › peer-review

• CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection

  Klasse, P. J., Rosenkilde, M. M., Signoret, N., Pelchen-Matthews, A., Schwartz, T. W. & Marsh, M., Sept 1999, In: JOURNAL OF VIROLOGY. 73, 9, p. 7453-66 14 p.

  Research output: Contribution to journal › Article › peer-review

• Chemokine receptor trafficking and viral replication

  Pelchen-Matthews, A., Signoret, N., Klasse, P. J., Fraile-Ramos, A. & Marsh, M., Apr 1999, In: Immunological Reviews. 168, p. 33-49 17 p.

  Research output: Contribution to journal › Article › peer-review

• 1998

  Aminooxypentane-RANTES induces CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity

  Mack, M., Luckow, B., Nelson, P. J., Cihak, J., Simmons, G., Clapham, P. R., Signoret, N., Marsh, M., Stangassinger, M., Borlat, F., Wells, T. N., Schlöndorff, D. & Proudfoot, A. E., 20 Apr 1998, In: Journal of Experimental Medicine. 187, 8, p. 1215-24 10 p.

  Research output: Contribution to journal › Article › peer-review

• Differential regulation of CXCR4 and CCR5 endocytosis

  Signoret, N., Rosenkilde, M. M., Klasse, P. J., Schwartz, T. W., Malim, M. H., Hoxie, J. A. & Marsh, M., Sept 1998, In: Journal of Cell Science. 111 ( Pt 18), p. 2819-30 12 p.

  Research output: Contribution to journal › Article › peer-review

• Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells

  Pelchen-Matthews, A., da Silva, R. P., Bijlmakers, M. J., Signoret, N., Gordon, S. & Marsh, M., Nov 1998, In: European Journal of Immunology. 28, 11, p. 3639-47 9 p.

  Research output: Contribution to journal › Article › peer-review

• 1997

  Mutations within the CD4-CDR-3-like loop allow replication in an immortalized T cell line of HIV type 1 viruses chimeric for envelope glycoproteins containing non-syncytium-inducing V3 loops

  Signoret, N., de Jong, J., Goudsmit, J. & Sattentau, Q. J., 20 Jan 1997, In: AIDS research and human retroviruses. 13, 2, p. 121-3 3 p.

  Research output: Contribution to journal › Article › peer-review

• Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4

  Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P. J., Tran, T., Brass, L. F., Rosenkilde, M. M., Schwartz, T. W., Holmes, W., Dallas, W., Luther, M. A., Wells, T. N., Hoxie, J. A. & Marsh, M., 3 Nov 1997, In: Journal of Cell Biology. 139, 3, p. 651-64 14 p.

  Research output: Contribution to journal › Article › peer-review

• Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1

  Simon, J. H., Stumbles, P., Signoret, N., Somoza, C., Puklavec, M., Sattentau, Q. J., Barclay, A. N. & James, W., Feb 1997, In: JOURNAL OF VIROLOGY. 71, 2, p. 1476-84 9 p.

  Research output: Contribution to journal › Article › peer-review

• Transduction of activation signal that follows HIV-1 binding to CD4 and CD4 dimerization involves the immunoglobulin CDR3-like region in domain 1 of CD4

  Briant, L., Signoret, N., Gaubin, M., Robert-Hebmann, V., Zhang, X., Murali, R., Greene, M. I., Piatier-Tonneau, D. & Devaux, C., 1 Aug 1997, In: Journal of Biological Chemistry. 272, 31, p. 19441-50 10 p.

  Research output: Contribution to journal › Article › peer-review

• 1996

  Selective effects of electrostatic changes in the CD4 CDR-3-like loop on infection by different human immunodeficiency virus type 1 isolates

  Signoret, N., Blanc-Zouaoui, D., Kwong, P. D. & Sattentau, Q. J., 20 Jul 1996, In: AIDS research and human retroviruses. 12, 11, p. 1001-13 13 p.

  Research output: Contribution to journal › Article › peer-review

• 1995

  Class I major histocompatibility complex-restricted cytotoxic T lymphocytes specific for Epstein-Barr virus (EBV)-transformed B lymphoblastoid cell lines against which they were raised

  Hill, A. B., Lee, S. P., Haurum, J. S., Murray, N., Yao, Q. Y., Rowe, M., Signoret, N., Rickinson, A. B. & McMichael, A. J., 1 Jun 1995, In: Journal of Experimental Medicine. 181, 6, p. 2221-8 8 p.

  Research output: Contribution to journal › Article › peer-review

• 1994

  Antisense oligonucleotides in solution or encapsulated in immunoliposomes inhibit replication of HIV-1 by several different mechanisms

  Zelphati, O., Imbach, J. L., Signoret, N., Zon, G., Rayner, B. & Leserman, L., 11 Oct 1994, In: Nucleic Acids Research. 22, 20, p. 4307-14 8 p.

  Research output: Contribution to journal › Article › peer-review

• Factors involved in entry of the human immunodeficiency virus type 1 into permissive cells: lack of evidence of a role for CD26

  Lazaro, I., Naniche, D., Signoret, N., Bernard, A. M., Marguet, D., Klatzmann, D., Dragic, T., Alizon, M. & Sattentau, Q., Oct 1994, In: JOURNAL OF VIROLOGY. 68, 10, p. 6535-46 12 p.

  Research output: Contribution to journal › Article › peer-review

• 1993

  Human and simian immunodeficiency viruses: virus-receptor interactions

  Signoret, N., Poignard, P., Blanc, D. & Sattentau, Q. J., Dec 1993, In: Trends in microbiology. 1, 9, p. 328-333 6 p.

  Research output: Contribution to journal › Article › peer-review