Paul Andrew Clarke, BSc(Hons), PhD, CChem, FRSC, PGCAP

Search results

• 2022

  Amino Imidate-Catalyzed Asymmetric Michael Reactions of Ketones and Nitroalkenes

  Clarke, P. A., Sosunovych, B. & Brown, A., 24 Feb 2022, In: SynOpen. 6, p. 67-74 8 p., SO-2022-01-0005-OP.R1.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Enantioselective “Clip-Cycle” Synthesis of Di-, Tri- and Spiro- Substituted Tetrahydropyrans

  Clarke, P. A., Alomari, K., Chakravarthy, S. P., Duchadeau, B. & Ermanis, K., 13 Jan 2022, In: Organic and Biomolecular Chemistry. 20, 6, p. 1181-1185 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  Catalytic Asymmetric Total Syntheses of (R)-Bgugaine and (R)-Irnidine

  Clarke, P. A. & Maddocks, C., 8 Jan 2021, In: Tetrahedron. 78, 8, p. 1-9 9 p., 131789.

  Research output: Contribution to journal › Special issue › peer-review

  Open Access

  File
• 2020

  Asymmetric ‘Clip-Cycle’ Synthesis of Pyrrolidines and Spiropyrrolidines

  Clarke, P. A., Ermanis, K. & Maddocks, C., 16 Oct 2020, In: Organic Letters. 22, p. 8116-8121 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Catalytic Gels for a Prebiotically Relevant Asymmetric Aldol Reaction in Water: From Organocatalyst Design to Hydrogel Discovery and Back Again

  Hawkins, K., Patterson, A., Clarke, P. A. & Smith, D. K., 4 Mar 2020, In: Journal of the American Chemical Society. 142, 9, p. 4379-4389 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  Evaluation of Amino Nitriles and an Amino Imidate as Organocatalysts in Aldol Reactions

  Vagkidis, N., Brown, A. J. & Clarke, P. A., 8 Aug 2019, In: SYNTHESIS-STUTTGART. 51, 21, p. 4106-4112 7 p., SS-2019-T0330-OP.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Correction: Synthesis of highly substituted 2-spiropiperidines(Organic and Biomolecular Chemistry(2018) DOI: 10.1039/c8ob01272e)

  Griggs, S. D., Thompson, N., Tape, D. T., Fabre, M. & Clarke, P. A., 1 Jan 2018, In: Organic and Biomolecular Chemistry. 16, 36, 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

• Strategies for the Synthesis of Spiropiperidines - A Review of the Last 10 Years

  Griggs, S. D., Tape, D. T. & Clarke, P. A., 4 Jul 2018, In: Organic and Biomolecular Chemistry. 16, 36, p. 6620-6633 14 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

• Synthesis of highly substituted 2-spiropiperidines

  Clarke, P. A., Griggs, S. D., Thompson, N., Fabre, M. & Tape, D. T., 19 Sept 2018, In: Organic and Biomolecular Chemistry. 16, 36, p. 6663-6674 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2017

  A Two-Step Synthesis of 2-Spiropiperidines

  Griggs, S. D., Thompson, N., Tape, D. T., Fabre, M. & Clarke, P. A., 12 Jul 2017, In: Chemistry : A European Journal. 23, 39, p. 9262-9265 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Prebiotic Synthesis of 2-Deoxy-D-Ribose from Interstellar Building Blocks Promoted by Amino Esters or Amino Nitriles

  Clarke, P. A., Smith, D. K., Steer, A. M. & Bia, N., 25 Sept 2017, In: Chemical Communications. 53, p. 10362-10365 4 p., c7cc06083a.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Stereodivergent Formation of 2,6-cis and 2,6-trans-Tetrahydropyrans: Experimental and Computational Investigation of the Mechanism of a Thioester Oxy-Michael Cyclization

  Clarke, P. A., Ermanis, K., Hsiao, Y-T., Kaya, U. & Jeuken, A., 1 Jan 2017, In: Chemical Science. 8, p. 482-490 9 p., C6SC03478K.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine

  Rayner, P. J., Smith, J. C., Denneval, C., O'Brien, P., Clarke, P. A. & Horan, R. A. J., 25 Jan 2016, In: Chemical Communications. 52, 7, p. 1354-1357 4 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of 2,6-trans- and 3,3,6-Trisubstituted Tetrahydropyran-4-ones from Maitland-Japp Derived 2H-Dihydropyran-4-ones: A Total Synthesis of Diospongin B

  Clarke, P. A., Nasir, N. M., Sellars, P. B., Peter, A. M., Lawson, C. A. & Burroughs, J. L., 12 Jul 2016, In: Organic and Biomolecular Chemistry. 14, 28, p. 6840-6852 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  A Maitland-Japp inspired synthesis of dihydropyran-4-ones and their stereoselective conversion to functionalised tetrahydropyran-4-ones

  Clarke, P. A., Sellars, P. B. & Mad Nasir, N., 28 Apr 2015, In: Organic and Biomolecular Chemistry. 13, 16, p. 4743-4750 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2014

  Strategies for the Construction of Tetrahydropyran Rings in the Synthesis of Natural Products

  Ermanis, K., Mad Nasir, N. & Clarke, P. A., 7 Jun 2014, In: Organic and Biomolecular Chemistry. 12, 21, p. 3323-3335 13 p.

  Research output: Contribution to journal › Literature review › peer-review
• 2013

  The development of pot, atom and step economic (PASE) synthesis of functionalised tetrahydropyrans, dihydropyrans and piperidines

  Clarke, P. A. & Ermanis, K., 2013, In: Current Organic Chemistry. 17, 18, p. 2025-2037 13 p.

  Research output: Contribution to journal › Special issue › peer-review
• 2012

  Asymmetric organocatalytic formation of protected and unprotected tetroses under potentially prebiotic conditions

  Clarke, P. A., Hayes, C. J., Forintos, H., Gilks, J. A. R., Vale, M. E., Wade, W., Zbytniewski, M. & Burroughs, L. A., 28 Feb 2012, In: Organic and Biomolecular Chemistry. 10, 8, p. 1565 6 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of the C20-C32 Tetrahydropyran Core of the Phorboxazoles and the C22 Epimer via a Stereodivergent Michael Reaction

  Clarke, P. A. & Ermanis, K., 2 Nov 2012, In: Organic Letters. 14, 21, p. 5550-5553 4 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of the complete series of mono acetates of N-acetyl-D-neuraminic acid

  Clarke, P. A., Mistry, N. & Thomas, G. H., 21 Jan 2012, In: Organic & biomolecular chemistry. 10, 3, p. 529-35 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  An asymmetric Maitland-Japp reaction: a highly enantioselective synthesis of tetrahydropyran-4-ones

  Iqbal, M., Mistry, N. & Clarke, P. A., 8 Jul 2011, In: Tetrahedron. 67, 27-28, p. 4960-4966 7 p.

  Research output: Contribution to journal › Article › peer-review

• Diastereoselective synthesis of functionalized 2-methyltetrahydropyran-4-ones

  Clarke, P. A., Sellars, P. B. & Mistry, N., 13 Jul 2011, In: Tetrahedron Letters. 52, 28, p. 3654-3656 3 p.

  Research output: Contribution to journal › Article › peer-review

• Strategies for the synthesis of tetrahydropyran-containing natural products

  Clarke, P. A., 8 Jul 2011, In: Tetrahedron. 67, 27-28, p. 4959-4959 1 p.

  Research output: Contribution to journal › Editorial › peer-review

• Studies on transannulation reactions across a nine-membered ring: the synthesis of natural product-like structures

  Iqbal, M., Black, R. J. G., Winn, J., Reeder, A. T., Blake, A. J. & Clarke, P. A., 21 Jul 2011, In: Organic and Biomolecular Chemistry. 9, 14, p. 5062-5078 17 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of an austrodorane sesquiterpenoid core via a transannular Prins cyclization

  Clarke, P. A. & Winn, J., 30 Mar 2011, In: Tetrahedron Letters. 52, 13, p. 1469-1472 4 p.

  Research output: Contribution to journal › Article › peer-review

• The Asymmetric Maitland-Japp Reaction and Its Application to the Construction of the C1-C19 Bis-pyran Unit of Phorboxazole B

  Clarke, P. A., Santos, S., Mistry, N., Burroughs, L. & Humphries, A. C., 18 Feb 2011, In: Organic Letters. 13, 4, p. 624-627 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Efficient asymmetric organocatalytic formation of erythrose and threose under aqueous conditions

  Burroughs, L., Vale, M. E., Gilks, J. A. R., Forintos, H., Hayes, C. J. & Clarke, P. A., 14 Jul 2010, In: Chemical Communications. 46, 26, p. 4776-4778 3 p.

  Research output: Contribution to journal › Article › peer-review

• Interview on EPSRC Delivery plan 2011-15

  Clarke, P. A., 2010, Nature, 468, p. 1010.

  Research output: Contribution to specialist publication › Article

• Investigation of Transannelation Reactions Across a Cyclononene Ring

  Clarke, P. A., Black, R. J. G. & Iqbala, M., Mar 2010, In: Synlett. 4, p. 543-546 4 p., D23709ST.

  Research output: Contribution to journal › Article › peer-review

• Synthetic studies on the phorboxazoles: a short synthesis of an epi-C23 tetrahydropyran core

  Clarke, P. A., Hargreaves, J. M., Woollaston, D. J. & Sarmiento, R. M. R., 8 Sept 2010, In: Tetrahedron Letters. 51, 36, p. 4731-4733 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Studies on the Synthesis of the ABC Rings of (+/-)-Hexacyclinic Acid

  Clarke, P. A., Cridland, A. P., Rolla, G. A., Iqbal, M., Bainbridge, N. P., Whitwood, A. C. & Wilson, C., 16 Oct 2009, In: Journal of Organic Chemistry. 74, 20, p. 7812-7821 10 p.

  Research output: Contribution to journal › Article › peer-review

• Transannulation Reactions in the Synthesis of Natural Products

  Clarke, P. A., Reeder, A. T. & Winn, J., 2 Mar 2009, In: SYNTHESIS-STUTTGART. 5, p. 691-709 19 p.

  Research output: Contribution to journal › Literature review › peer-review
• 2008

  One-pot synthesis of functionalized piperid-4-ones: a four-component condensation

  Clarke, P. A., Zaytsev, A. V., Morgan, T. W., Whitwood, A. C. & Wilson, C., 3 Jul 2008, In: Organic Letters. 10, 13, p. 2877-2880 4 p.

  Research output: Contribution to journal › Article › peer-review

• Pot, Atom, and Step Economic (PASE) Synthesis of Highly Substituted Piperidines: A Five-Component Condensation

  Clarke, P. A., Zaytsev, A. V. & Whitwood, A. C., 3 Nov 2008, In: SYNTHESIS-STUTTGART. 21, p. 3530-3532 3 p., M10208SS.

  Research output: Contribution to journal › Article › peer-review
• 2007

  An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol

  Clarke, P. A., Rolla, G. A., Cridland, A. P. & Gill, A. A., 10 Sept 2007, In: Tetrahedron. 63, 37, p. 9124-9128 5 p.

  Research output: Contribution to journal › Article › peer-review

  File

• Combining pot, atom and step economy (PASE) in organic synthesis. Synthesis of tetrahydropyran-4-ones

  Clarke, P. A., Santos, S. & Martin, W. H. C., May 2007, In: Green Chemistry. 9, 5, p. 438-440 3 p.

  Research output: Contribution to journal › Article › peer-review

  File

• One-pot preparation of highly substituted tetrahydropyran-4-ones

  dos Santos, S. P. P. & Clarke, P. A., 25 Mar 2007, In: ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 233, p. - 1 p.

  Research output: Contribution to journal › Article › peer-review

• Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation

  Clarke, P. A., Zaytzev, A. V. & Whitwood, A. C., 23 Jul 2007, In: Tetrahedron Letters. 48, 30, p. 5209-5212 4 p.

  Research output: Contribution to journal › Article › peer-review

  File
• 2006

  Enantioselective synthesis of the bicyclo[4.3.0]nonane ring system of the pinguisane-type sesquiterpenoids via a Bronsted acid promoted transannular enol alkylation

  Clarke, P. A., Black, R. J. G. & Blake, A. J., 27 Feb 2006, In: Tetrahedron Letters. 47, 9, p. 1453-1455 3 p.

  Research output: Contribution to journal › Article › peer-review

• Strategies for the formation of tetrahydropyran rings in the synthesis of natural products

  Clarke, P. A. & Santos, S., 28 Apr 2006, In: European Journal of Organic Chemistry. 9, p. 2045-2053 9 p.

  Research output: Contribution to journal › Literature review › peer-review
• 2005

  A racemic synthesis of an AB-ring system of hexacyclinic acid

  Clarke, P. A. & Cridland, A. P., 15 Sept 2005, In: Organic Letters. 7, 19, p. 4221-4224 4 p.

  Research output: Contribution to journal › Article › peer-review

• Exploiting the Maitland-Japp reaction: a synthesis of (+/-)-centrolobine

  Clarke, P. A. & Martin, W. H. C., 6 Jun 2005, In: Tetrahedron. 61, 23, p. 5433-5438 6 p.

  Research output: Contribution to journal › Article › peer-review

• Revisiting the Maitland-Japp reaction. Concise construction of highly functionalised tetrahydropyran-4-ones

  Clarke, P. A., Martin, W. H. C., Hargreaves, J. M., Wilson, C. & Blake, A. J., 28 Feb 2005, In: Chemical Communications. 8, p. 1061-1063 3 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of the B-ring of FR182877. Investigation of the reactions of 6-fumaryl 1,3,8-nonatrienes

  Clarke, P. A., Davie, R. L. & Peace, S., 28 Feb 2005, In: Tetrahedron. 61, 9, p. 2335-2351 17 p.

  Research output: Contribution to journal › Article › peer-review

• Synthetic studies on the DEF-rings of FR182877 and hexacyclinic acid

  Clarke, P. A., Grist, M., Ebden, M., Wilson, C. & Blake, A. J., 10 Jan 2005, In: Tetrahedron. 61, 2, p. 353-363 11 p.

  Research output: Contribution to journal › Article › peer-review

• The one-pot, multi-component construction of highly substituted tetrahydropyran-4-ones using the Maitland-Japp reaction

  Clarke, P. A., Martin, W. H. C., Hargreaves, J. M., Wilson, C. & Blake, A. J., 2005, In: Organic and Biomolecular Chemistry. 3, 19, p. 3551-3563 13 p.

  Research output: Contribution to journal › Article › peer-review
• 2004

  An expedient synthesis of (+/-)-centrolobine

  Clarke, P. A. & Martin, W. H. C., 29 Nov 2004, In: Tetrahedron Letters. 45, 49, p. 9061-9063 3 p.

  Research output: Contribution to journal › Article › peer-review

• An iodocyclisation/elimination approach to a DEF-ring core of FR182877

  Clarke, P. A., Grist, M. & Ebden, M., 26 Jan 2004, In: Tetrahedron Letters. 45, 5, p. 927-929 3 p.

  Research output: Contribution to journal › Article › peer-review

• Highlights in Total Synthesis

  Clarke, P. A. & Cridland, A. P., 2004, Annual Reports on the Progress of Chemistry: Section B: Organic Chemistry, 100, p. 91-112.

  Research output: Contribution to specialist publication › Article

• Process for the Selective Derivatisation of Taxanes

  Clarke, P. A., Holton, R. A. & Zhang, Z., 16 Mar 2004, IPC No. US 6,706,896 B1

  Research output: Patent