Paul Genever

Phone(01904) 328649
Emailpaul.geneveryork.acuk

Accepting PhD Students

PhD projects

Analysis of mesenchymal stromal/stem cell sub-populations

Human mesenchymal stromal/stem cells (MSCs) are found in adult tissues such as bone marrow and are able to differentiate into osteogenic, chondrogenic and adipogenic tissues. There is intense interest in determining how MSCs may be used in future cell-based therapies, including gene therapy, immunotherapy and tissue engineering, and as in vitro models for fundamental research and drug discovery. However, little is known about MSC identity and research is often performed on heterogeneous mixtures of different MSC sub-populations. Using a process of telomerase-based immortalisation and cell cloning, we have generated several different MSC lines that represent different “types” of MSCs. For example, some MSC lines demonstrate tri-lineage, whereas other are bi-potent, uni-potent or nulli-potent. This project will examine the differentiation characteristics of these MSC lines to determine how they reflect MSC sub-populations in vivo. Self-funded.

3 results
- Title
- Start date(ascending)

MassIVE MSV000094888 - Extracellular matrices of stromal cell subtypes regulate phenotype and contribute to the stromal microenvironment in vivo
Genever, P. (Creator), MassIVE, 29 May 2024
DOI: 10.25345/c5p55dt6z
Dataset
Metadata for "Biomolecular phenotyping and heterogeneity assessment of mesenchymal stromal cells using label-free Raman spectroscopy"
Hancock, Y. (Creator), De Almeida Rocha Ponzoni, R. (Creator), Fox, J. M. (Creator) & Genever, P. (Creator), University of York, 2021
DOI: 10.15124/597ad871-7b1f-4ab3-9d5d-93a4235b15f8
Dataset
Surfaceomics (plasma membrane located protein expression) achieved through mass spectrometry on isolated plasma membranes of immortalised MSC lines
Genever, P. (Creator), MassIVE, 19 May 2022
DOI: 10.25345/c5ms3k53w
Dataset

Paul Genever

Datasets

Search results

MassIVE MSV000094888 - Extracellular matrices of stromal cell subtypes regulate phenotype and contribute to the stromal microenvironment in vivo

Metadata for "Biomolecular phenotyping and heterogeneity assessment of mesenchymal stromal cells using label-free Raman spectroscopy"

Surfaceomics (plasma membrane located protein expression) achieved through mass spectrometry on isolated plasma membranes of immortalised MSC lines