Peter Andrew O'Brien

Search results

• 2025

  Data-led Suzuki-Miyaura Reaction Optimization: Development of a Short Course for Postgraduate Synthetic Chemists

  Smith, S., Franklin, B., Horbaczewskyj, C. S., Metcalf, J., Walder, J., O'Brien, P. A. & Fairlamb, I. J. S., 9 Jan 2025, (Accepted/In press) In: JOURNAL OF CHEMICAL EDUCATION. p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

• 2023

  Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

  FitzGerald, E. A., Vagrys, D., Opassi, G., Klein, H. F., Hamilton, D. J., Talibov, V. O., Abramsson, M., Moberg, A., Lindgren, M. T., Holmgren, C., Davis, B., O'Brien, P., Wijtmans, M., Hubbard, R. E., de Esch, I. J. P. & Danielson, U. H., 14 Sept 2023, In: SLAS Discovery. 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Organogel delivery vehicles for the stabilization of organolithium reagents

  Slavik, P., Trowse, B., O'Brien, P. A. & Smith, D. K., 16 Feb 2023, (E-pub ahead of print) In: Nature Chemistry. 15, p. 319-325 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• α-Functionalisation of Cyclic Sulfides Enabled by Lithiation Trapping

  Seling, N., Atobe, M., Kasten, K., Firth, J. D., Karadakov, P. B., Goldberg, F. W. & O'Brien, P., 7 Dec 2023, (E-pub ahead of print) In: Angewandte Chemie International Edition. 7 p., e202314423.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates

  Jones, S. P., Firth, J. D., Wheldon, M. C., Atobe, M., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Lucas, S. C. C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A. J. A., Wrigley, G. L. & O'Brien, P., 1 Dec 2022, In: RSC Medicinal Chemistry. 13, 12, p. 1614-1620

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Puckering the Planar Landscape of Fragments: Design and Synthesis of a 3D Cyclobutane Fragment Library

  Hamilton, D. J., Beemsterboer, M., Carter, C. M., Elsayed, J., Huiberts, R. E. M., Klein, H. F., O'Brien, P., de Esch, I. J. P. & Wijtmans, M., 4 May 2022, In: ChemMedChem. 17, 9, 9 p., e202200113.

  Research output: Contribution to journal › Article › peer-review

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• 2021

  2,2,5,5-Tetramethyloxolane (TMO) as a Solvent for Buchwald–Hartwig Aminations

  Trowse, B., Byrne, F., Sherwood, J. R., O'Brien, P. A., Murray, J. & Farmer, T. J., 15 Dec 2021, In: ACS Sustainable Chemistry & Engineering.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

  QCRG Structural Biology Consortium, Fraser, J. S., Ahel, I. & Thompson, M. C., 14 Apr 2021, In: Science Advances. 7, 16, 23 p., eabf8711.

  Research output: Contribution to journal › Article › peer-review

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• Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine

  Kwong, A., Firth, J. D., Farmer, T. J. & O'Brien, P., 12 Feb 2021, In: Tetrahedron. 81, 6 p., 131899.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Synthesis and functionalisation of a bifunctional normorphan 3D building block for medicinal chemistry

  Gomez-Angel, A. R., Donald, J. R., Firth, J. D., De Fusco, C., Ian Storer, R., Cox, D. J. & O'Brien, P., 12 Mar 2021, In: Tetrahedron. 83, 9 p., 131961.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2020

  Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

  Douangamath, A., Fearon, D., Gehrtz, P., Krojer, T., Lukacik, P., Owen, C. D., Resnick, E., Strain-Damerell, C., Aimon, A., Ábrányi-Balogh, P., Brandão-Neto, J., Carbery, A., Davison, G., Dias, A., Downes, T. D., Dunnett, L., Fairhead, M., Firth, J. D., Jones, S. P. & Keeley, A. & 14 others, Keserü, G. M., Klein, H. F., Martin, M. P., Noble, M. E. M., O’Brien, P., Powell, A., Reddi, R. N., Skyner, R., Snee, M., Waring, M. J., Wild, C., London, N., von Delft, F. & Walsh, M. A., 7 Oct 2020, In: Nature Communications. 11, 1, 5047.

  Research output: Contribution to journal › Article › peer-review

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• Design and Synthesis of 56 Shape Diverse 3-D Fragments

  O'Brien, P., Downes, T. D., Jones, S. P., Klein, H. F., Wheldon, M. C., Atobe, M., Bond, P. S., Firth, J. D., Chan, N. S., Waddelove, L., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A.J.-A. & Wrigley, G. L., 21 Apr 2020, (E-pub ahead of print) In: Chemistry : A European Journal. 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Fragment-derived modulators of an industrial β-glucosidase

  Makraki, E., Darby, J. F., Carneiro, M. G., Firth, J. D., Heyam, A., Ab, E., O'Brien, P., Siegal, G. & Hubbard, R. E., 26 Nov 2020, In: The Biochemical journal. 477, 22, p. 4383-4395 13 p.

  Research output: Contribution to journal › Article › peer-review

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• Visible-light-induced intramolecular charge transfer in the radical spirocyclisation of indole-tethered ynones

  Ho, H. E., Pagano, A., Rossi-Ashton, J. A., Donald, J. R., Epton, R. G., Churchill, J. C., James, M. J., O'Brien, P., Taylor, R. J. K. & Unsworth, W. P., 7 Feb 2020, In: Chemical Science. 11, 5, p. 1353-1360 8 p.

  Research output: Contribution to journal › Article › peer-review

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• 2019

  Merging π-Acid and Pd Catalysis: Dearomatizing Spirocyclization/Cross-Coupling Cascade Reactions of Alkyne-Tethered Aromatics

  Ho, H. E., Stephens, T. C., Payne, T., O'Brien, P. A., Taylor, R. J. K. & Unsworth, W. P., 4 Jan 2019, In: ACS Catalysis. 9, 1, p. 504-510 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2018

  Ag(I)-Catalyzed Synthesis of Azabicyclic Alkaloid Frameworks from Ketimine-Tethered Ynones: Total Synthesis of Indolizidine 209D

  Ho, H. E., James, M. J., O'Brien, P., Unsworth, W. P. & Taylor, R. J. K., 9 Feb 2018, (E-pub ahead of print) In: Organic Letters. p. 1439-1443 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• A synthetic and spectroscopic investigation of the asymmetric α-lithiation-trapping of six-membered N-Boc heterocycles using Alexakis diamines

  Firth, J., Gelardi, G., Rayner, P. J., Stead, D. & O'Brien, P. A., 20 Jun 2018, In: Heterocycles. 97, 2, p. 1288-1303

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Gram-Scale Synthesis of the (-)-Sparteine Surrogate and (-)-Sparteine

  Firth, J. D., Canipa, S. J., O'Brien, P. & Ferris, L., 2 Jan 2018, In: Angewandte Chemie International Edition. 57, 1, p. 223-226 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  General Procedures for the Lithiation/Trapping of N-Boc Piperazines

  Firth, J. D., O'Brien, P. & Ferris, L., 2 Jun 2017, In: The Journal of organic chemistry. 82, 13, p. 7023-7031 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Increase of enzyme activity through specific covalent modification with fragments

  Darby, J. F., Atobe, M., Firth, J. D., Bond, P., Davies, G. J., O'Brien, P. A. & Hubbard, R. E., 1 Nov 2017, In: Chemical Science. 8, 11, p. 7772-7779 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  Catalyst-driven scaffold diversity: selective synthesis of spirocycles, carbazoles and quinolines from indolyl ynones

  Liddon, J. T. R., James, M. J., Clarke, A. K., O'Brien, P., Taylor, R. J. K. & Unsworth, W. P., 20 Jun 2016, In: Chemistry : A European Journal. 22, 26, p. 8777–8780 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Catalytic Dearomatization Approach to Quinolizidine Alkaloids: Five Step Total Synthesis of (±)-Lasubine II

  James, M., Grant, N. D., O'Brien, P. A., Taylor, R. J. K. & Unsworth, W. P., 16 Dec 2016, In: Organic Letters. 18, 24, p. 6256-6259 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• From Heteroaromatic acids and Imines to Azaspirocycles: Stereoselective Synthesis and 3D Shape Analysis

  Chambers, S. J., Coulthard, G., Unsworth, W. P., O'Brien, P. & Taylor, R. J. K., 2016, In: Chemistry : A European Journal (Weinheim an der Bergstrasse, Germany). 22, 19, p. 6496-6500 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine

  Rayner, P. J., Smith, J. C., Denneval, C., O'Brien, P., Clarke, P. A. & Horan, R. A. J., 25 Jan 2016, In: Chemical Communications. 52, 7, p. 1354-1357 4 p.

  Research output: Contribution to journal › Article › peer-review

• Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor

  James, M. J., O'Brien, P., Taylor, R. J. K. & Unsworth, W. P., 8 Aug 2016, In: Angewandte Chemie International Edition. 55, 33, p. 9671-9675 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Silica-Supported Silver Nitrate as a Highly Active Dearomatizing Spirocyclization Catalyst: Synergistic Alkyne Activation by Silver Nanoparticles and Silica

  Clarke, A. K., James, M. J., O'Brien, P., Taylor, R. J. K. & Unsworth, W. P., 24 Oct 2016, In: Angewandte Chemie International Edition. 55, 44, p. 13798-13802 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Synthesis of Enantiopure Piperazines via Asymmetric Lithiation-Trapping of N-Boc Piperazines: Unexpected Role of the Electrophile and Distal N-Substituent

  Firth, J. D., O'Brien, P. & Ferris, L., 20 Jan 2016, In: Journal of the American Chemical Society. 138, 2, p. 651-659 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2015

  Cross-coupling knows no limits: Assessing the synthetic potential of the palladium-catalysed cross-coupling of organolithiums

  Firth, J. D. & O'Brien, P., Feb 2015, In: ChemCatChem. 7, 3, p. 395-397 3 p.

  Research output: Contribution to journal › Article › peer-review

• Investigation of the Lithiation-Trapping of an N -Boc Bispidine-Ketal: Reactivity and Diastereoselectivity

  Stead, D., O'Brien, P. & Sanderson, A., 8 Jul 2015, In: Synlett. 26, 17, p. 2381-2384 4 p.

  Research output: Contribution to journal › Article › peer-review

• Lead-oriented synthesis: Investigation of organolithium-mediated routes to 3-D scaffolds and 3-D shape analysis of a virtual lead-like library

  Lüthy, M., Wheldon, M. C., Haji-Cheteh, C., Atobe, M., Bond, P. S., O'Brien, P., Hubbard, R. E. & Fairlamb, I. J. S., 1 Jun 2015, In: Bioorganic and Medicinal Chemistry. 23, 11, p. 2680-2694 15 p.

  Research output: Contribution to journal › Article › peer-review

• Silver(I)-Catalyzed Dearomatization of Alkyne-Tethered Indoles: Divergent Synthesis of Spirocyclic Indolenines and Carbazoles

  James, M. J., Clubley, R. E., Palate, K. Y., Procter, T. J., Wyton, A. C., O'Brien, P., Taylor, R. J. K. & Unsworth, W. P., 21 Aug 2015, In: Organic Letters. 17, 17, p. 4372-4375 4 p.

  Research output: Contribution to journal › Article › peer-review

• Silver(I)- or Copper(II)-Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds

  James, M. J., Cuthbertson, J. D., O'Brien, P., Taylor, R. J. K. & Unsworth, W. P., 22 Jun 2015, In: Angewandte Chemie International Edition. 54, 26, p. 7640-7643 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  On the synthesis of α-amino sulfoxides

  Rayner, P. J., Gelardi, G., O'Brien, P., Horan, R. A. J. & Blakemore, D. C., 7 Jun 2014, In: Organic and Biomolecular Chemistry. 12, 21, p. 3499-3512 14 p.

  Research output: Contribution to journal › Article › peer-review

• Revisiting the sparteine surrogate: Development of a resolution route to the (-)-sparteine surrogate

  Firth, J. D., O'Brien, P. & Ferris, L., 14 Dec 2014, In: Organic and Biomolecular Chemistry. 12, 46, p. 9357-9365 9 p.

  Research output: Contribution to journal › Article › peer-review

• Use of copper(II)/diamine catalysts in the desymmetrisation of meso-diols and asymmetric Henry reactions: Comparison of (-)-sparteine and (+)-sparteine surrogates

  Canipa, S. J., Stute, A. & O'Brien, P., Oct 2014, In: Tetrahedron. 70, 40, p. 7395-7403 9 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Amines bearing tertiary substituents by tandem enantioselective carbolithiation-rearrangement of vinylureas

  Tait, M., Donnard, M., Minassi, A., Lefranc, J., Bechi, B., Clayden, J., Carbone, G. & O'Brien, P., 4 Jan 2013, In: Organic Letters. 15, 1, p. 34-37

  Research output: Contribution to journal › Article › peer-review

• Asymmetric lithiation trapping of N -boc heterocycles at temperatures above -78°C

  Gelardi, G., Barker, G., O'Brien, P. & Blakemore, D. C., 1 Nov 2013, In: Organic Letters. 15, 21, p. 5424-5427 4 p.

  Research output: Contribution to journal › Article › peer-review

• Halogen-bonded liquid crystals of 4-alkoxystilbazoles with molecular iodine: a very short halogen bond and unusual mesophase stability

  McAllister, L. J., Präsang, C., Wong, J.-W., Thatcher, R. J., Whitwood, A. C., O'Brien, P., Karadakov, P. B., Bruce, D. W. & Donnio, B., 11 May 2013, In: Chemical communications. 49, 38, p. 3946-3948

  Research output: Contribution to journal › Article › peer-review

• Preparation and reactions of enantiomerically pure α-functionalized grignard reagents

  Rayner, P. J., O'Brien, P. & Horan, R. A. J., 29 May 2013, In: Journal of the American Chemical Society. 135, 21, p. 8071-8077

  Research output: Contribution to journal › Article › peer-review

• Stereocontrolled synthesis of the AB rings of samaderine C

  Burns, D. J., Mommer, S., O'Brien, P., Taylor, R. J. K., Whitwood, A. C. & Hachisu, S., 18 Jan 2013, In: Organic Letters. 15, 2, p. 394-7 4 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of P-stereogenic phospholene boranes via asymmetric deprotonation and ring-closing metathesis

  Wu, X., O'Brien, P., Secci, F., Ellwood, S. & Kelly, B., 4 Jan 2013, In: Organic Letters. 15, 1, p. 192-195 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  An Experimental and in Situ IR Spectroscopic Study of the Lithiation-Substitution of N-Boc-2-phenylpyrrolidine and -piperidine: Controlling the Formation of Quaternary Stereocenters

  Sheikh, N. S., Leonori, D., Barker, G., Firth, J. D., Campos, K. R., Meijer, A. J. H. M., O'Brien, P. & Coldham, I., 21 Mar 2012, In: Journal of the American Chemical Society. 134, 11, p. 5300-5308 9 p.

  Research output: Contribution to journal › Article › peer-review

• Catalytic asymmetric synthesis of butane diacetal-protected (4S,5S)-dihydroxycyclohexen-1-one and use in natural product synthesis

  Burns, D. J., Hachisu, S., O'Brien, P. & Taylor, R. J. K., 14 Oct 2012, In: Organic and Biomolecular Chemistry. 10, 38, p. 7666-8 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc Pyrrolidine: In Situ React IR Spectroscopic Monitoring, Scope, and Synthetic Applications

  Barker, G., McGrath, J. L., Klapars, A., Stead, D., Zhou, G., Campos, K. R. & O'Brien, P., 5 Aug 2011, In: Journal of Organic Chemistry. 76, 15, p. 5936-5953 18 p.

  Research output: Contribution to journal › Article › peer-review

• Investigation of bispidines as the stoichiometric ligand in the two-ligand catalytic asymmetric deprotonation of N-Boc pyrrolidine

  Barker, G., O'Brien, P. & Campos, K. R., 3 Apr 2011, In: ARKIVOC. 2011, 5, p. 217-229 13 p.

  Research output: Contribution to journal › Article › peer-review

• One-ligand catalytic asymmetric deprotonation of a phosphine borane: Synthesis of P-stereogenic bisphosphine ligands

  Granander, J., Secci, F., Canipa, S. J., O'Brien, P. & Kelly, B., 3 Jun 2011, In: Journal of Organic Chemistry. 76, 11, p. 4794-4799 6 p.

  Research output: Contribution to journal › Article › peer-review

• Synthesis of the azaphilones (+)-sclerotiorin and (+)-8- O -methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization

  Germain, A. R., Bruggemeyer, D. M., Zhu, J., Genet, C., O'Brien, P. & Porco, J. A., 15 Apr 2011, In: Journal of Organic Chemistry. 76, 8, p. 2577-2584 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Asymmetric Deprotonation of N-Boc Piperidine: React IR Monitoring and Mechanistic Aspects

  Stead, D., Carbone, G., O'Brien, P., Campos, K. R., Coldham, I. & Sanderson, A., 2 Jun 2010, In: Journal of the American Chemical Society. 132, 21, p. 7260-7261

  Research output: Contribution to journal › Article › peer-review

• Asymmetric Deprotonation using s-BuLi or i-PrLi and Chiral Diamines in THF: The Diamine Matters

  Carbone, G., O'Brien, P. & Hilmersson, G., 3 Nov 2010, In: Journal of the American Chemical Society. 132, 43, p. 15445-15450 6 p.

  Research output: Contribution to journal › Article › peer-review

• Asymmetric synthesis via aziridinium ions: exploring the stereospecificity of the ring opening of aziridinium ions and a formal synthesis of (-)-swainsonine

  Oxenford, S. J., Moore, S. P., Carbone, G., Barker, G., O'Brien, P., Shipton, M. R., Gilday, J. & Campos, K. R., 23 Jun 2010, In: TETRAHEDRON-ASYMMETRY. 21, 11-12, p. 1563-1568 6 p.

  Research output: Contribution to journal › Article › peer-review