Peter John Rayner

Search results

• 2024

  Metal-mediated catalytic polarisation transfer from parahydrogen to 3,5-dihalogenated pyridines

  Tickner, B. J., Dennington, M., Collins, B. G., Gater, C. A., Tanner, T. F. N., Whitwood, A. C., Rayner, P. J., Watts, D. P. & Duckett, S. B., 19 Jan 2024, In: ACS Catalysis. 14, 2, p. 994-1004 11 p.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  Real-Time High-Sensitivity Reaction Monitoring of Important Nitrogen-Cycle Synthons by 15N Hyperpolarized Nuclear Magnetic Resonance

  Rayner, P. J., Fekete, M., Gater, C. A., Ahwal, F., Turner, N., Kennerley, A. J. & Duckett, S. B., 18 May 2022, In: Journal of the American Chemical Society. 144, 19, p. 8756–8769 14 p., ja-2022-02619k.R3.

  Research output: Contribution to journal › Article › peer-review

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• SABRE hyperpolarized anticancer agents for use in 1 H MRI

  Fear, E. J., Kennerley, A. J., Rayner, P. J., Norcott, P., Roy, S. S. & Duckett, S. B., Jul 2022, In: Magnetic Resonance in Medicine. 88, 1, p. 11-27

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• 2021

  Hyperpolarisation of weakly binding N-heterocycles using Signal Amplification by Reversible Exchange

  Rayner, P. J., Gillions, J., Hannibal, V., John, R. O. & Duckett, S. B., 28 Apr 2021, In: Chemical Science. 12, 16, p. 5910-5917

  Research output: Contribution to journal › Article › peer-review

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• Steric and Electronic Effects on the 1H Hyperpolarisation of Substituted Pyridazines by Signal Amplification by Reversible Exchange

  Rayner, P. J., Burns, M., Fear, E. & Duckett, S. B., 14 Nov 2021, In: MAGNETIC RESONANCE IN CHEMISTRY. 59, 12, p. 1187-1198

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• 2020

  A Simple and Cost-efficient Technique to Generate Hyperpolarized Long-lived 15N-15N Nuclear Spin Order in a Diazine by Signal Amplification by Reversible Exchange

  Roy, S. S., Rayner, P. J., Burns, M. & Duckett, S. B., 2 Jan 2020, (E-pub ahead of print) In: The Journal of Chemical Physics. 152, 7 p., 014201.

  Research output: Contribution to journal › Article › peer-review

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• Optimisation of Pyruvate Hyperpolarisation using SABRE by Tuning the Active Magnetisation Transfer Catalyst

  Tickner, B., IALI, W., Semenova, O., Rayner, P. J., Whitwood, A. C. & Duckett, S. B., 28 Jan 2020, (E-pub ahead of print) In: Catalysis Science and Technology. 14 p., C9CY02498K.

  Research output: Contribution to journal › Article › peer-review

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• The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized 29Si Nuclear Magnetic Resonance

  Duckett, S. B., Rayner, P. J. & Richardson, P. M., 10 Feb 2020, In: Angewandte Chemie International Edition. 59, 7, p. 2710-2714 5 p., 201915098.

  Research output: Contribution to journal › Article › peer-review

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• Using SABRE hyperpolarized ¹³C NMR to interrogate organic transformations of pyruvate

  Tickner, B., Rayner, P. J. & Duckett, S. B., 8 Jun 2020, (E-pub ahead of print) In: Analytical Chemistry. p. 1-9 9 p., ac-2020-01334p.R1.

  Research output: Contribution to journal › Article › peer-review

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• 2019

  Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

  Manoharan, A., Rayner, P. J., Fekete, M., Iali, W., Norcott, P., Hugh Perry, V. & Duckett, S. B., 21 Jan 2019, In: ChemPhysChem. 20, 2, p. 285-294 10 p.

  Research output: Contribution to journal › Article › peer-review

• Pharmacokinetics of the SABRE agent 4,6-d2-Nicotinamide and also Nicotinamide in rats following oral and intravenous administration

  Linnik, I., Rayner, P. J., Stow, R., Duckett, S. & Cheetham, G. M. T., 1 Jul 2019, In: European journal of pharmaceutical sciences. 135, p. 32-37 6 p., EJPS-D-19-00374R1.

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• Rapid 13C NMR Hyperpolarization delivered from para-hydrogen enables the low concentration detection and quantification of sugars

  Richardson, P. M., Iali, W., Roy, S. S., Rayner, P. J., Halse, M. E. & Duckett, S., 7 Dec 2019, In: Chemical Science. C9SC03450A.

  Research output: Contribution to journal › Article › peer-review

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• Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

  Rayner, P. J., Tickner, B. J., Iali, W., Fekete, M., Robinson, A. D. & Duckett, S. B., 1 Jul 2019, In: Chemical Science. 10, 33, p. 7709-7717 9 p.

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• 2018

  A synthetic and spectroscopic investigation of the asymmetric α-lithiation-trapping of six-membered N-Boc heterocycles using Alexakis diamines

  Firth, J., Gelardi, G., Rayner, P. J., Stead, D. & O'Brien, P. A., 20 Jun 2018, In: Heterocycles. 97, 2, p. 1288-1303

  Research output: Contribution to journal › Article › peer-review

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• Direct and Indirect Hyperpolarisation of Amines using Parahydrogen

  Iali, W., Rayner, P. J., Alshehri, A. M. M., Holmes, J., Ruddlesden, A. J. & Duckett, S., 21 Apr 2018, In: Chemical Science. 9, 15, p. 3677-3684 8 p., C8SC00526E.

  Research output: Contribution to journal › Article › peer-review

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• Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

  Rayner, P. J., Norcott, P., Appleby, K. M., Iali, W., John, R. O., Hart, S. J., Whitwood, A. C. & Duckett, S., 12 Oct 2018, In: Nature Communications. 9, 1, 11 p., 4251.

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• Harnessing asymmetric N-heterocyclic carbene ligands to optimise SABRE hyperpolarisation

  Duckett, S., Fekete, M., Nelson-Forde, R., Rayner, P. J., Whitwood, A. C., Messerle, B. A., Wong, C. M. & Gatus, M. R. D., 3 Sept 2018, In: Catalysis Science and Technology. 9 p., CY-ART-06-2018-001214.R1.

  Research output: Contribution to journal › Article › peer-review

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• Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy

  Richardson, P. M., John, R. O., Parrott, A., Rayner, P. J., Iali, W., Nordon, A., Halse, M. E. & Duckett, S., 7 Nov 2018, In: Physical Chemistry Chemical Physics. 20, 41, p. 26362-26371 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

  Norcott, P., Burns, M. J., Rayner, P. J., Mewis, R. E. & Duckett, S. B., 25 Jan 2018, (E-pub ahead of print) In: MAGNETIC RESONANCE IN CHEMISTRY. 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Using Parahydrogen to Hyperpolarize Amines, Amides, Carboxylic Acids, Alcohols, Phosphates and Carbonates

  Iali, W., Rayner, P. J. & Duckett, S. B., 5 Jan 2018, In: Science Advances. 4, 1, 7 p., eaao6250.

  Research output: Contribution to journal › Article › peer-review

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• 2017

  Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study

  Manoharan, A., Rayner, P. J., Iali, W., Burns, M. J., Perry, V. H. & Duckett, S. B., 12 Dec 2017, (E-pub ahead of print) In: ChemMedChem. 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Achieving High ¹H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds

  Norcott, P., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 1 Dec 2017, (E-pub ahead of print) In: Chemistry : A European Journal. 23, 67, p. 16990-16997 8 p.

  Research output: Contribution to journal › Article › peer-review

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• A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

  Roy, S. S., Norcott, P., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 19 Jul 2017, In: Chemistry : A European Journal. 23, 44, p. 10496-10500 5 p.

  Research output: Contribution to journal › Article › peer-review

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• Delivering strong ¹H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange

  Rayner, P. J., Burns, M. J., Olaru, A. M., Norcott, P., Fekete, M., Green, G. G. R., Highton, L. A. R., Mewis, R. E. & Duckett, S. B., 18 Apr 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. E3188-E3194 2016-20457RR.

  Research output: Contribution to journal › Article › peer-review

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• Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE

  Roy, S. S., Stevanato, G., Rayner, P. J. & Duckett, S. B., 1 Dec 2017, In: Journal of Magnetic Resonance. 285, p. 55-60 6 p., YJMRE6177.

  Research output: Contribution to journal › Article › peer-review

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• Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability

  Fekete, M., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 11 May 2017, (E-pub ahead of print) In: MAGNETIC RESONANCE IN CHEMISTRY. p. 1-31 31 p., MRC4607.

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• 2016

  A Hyperpolarizable ¹H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage

  Roy, S. S., Norcott, P., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 12 Dec 2016, In: Angewandte Chemie International Edition. 55, 50, p. 15642-15645 4 p.

  Research output: Contribution to journal › Article › peer-review

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• Long-lived States to Sustain SABRE Hyperpolarised Magnetisation

  Singha Roy, S., Rayner, P. J., Norcott, P., Green, G. G. R. & Duckett, S., 28 Sept 2016, In: Physical chemistry chemical physics : PCCP. 18, 36, p. 24905-24911 7 p.

  Research output: Contribution to journal › Article › peer-review

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• Mechanistic interrogation of the asymmetric lithiation-trapping of N-thiopivaloyl azetidine and pyrrolidine

  Rayner, P. J., Smith, J. C., Denneval, C., O'Brien, P., Clarke, P. A. & Horan, R. A. J., 25 Jan 2016, In: Chemical Communications. 52, 7, p. 1354-1357 4 p.

  Research output: Contribution to journal › Article › peer-review

• Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water

  Rovedo, P., Knecht, S., Bäumlisberger, T., Cremer, A. L., Duckett, S. B., Mewis, R. E., Green, G. G. R., Burns, M., Rayner, P. J., Leibfritz, D., Korvink, J. G., Hennig, J., Pütz, G., Von Elverfeldt, D. & Hövener, J. B., 30 Jun 2016, In: Journal of Physical Chemistry B. 120, 25, p. 5670-5677 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei

  Olaru, A. M., Burt, A., Rayner, P. J., Hart, S. J., Whitwood, A. C., Green, G. G. R. & Duckett, S. B., 13 Dec 2016, In: Chemical Communications. 52, 100, p. 14482-14485 4 p.

  Research output: Contribution to journal › Article › peer-review

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• 2015

  Improving the hyperpolarization of (31)p nuclei by synthetic design

  Burns, M. J., Rayner, P. J., Green, G. G. R., Highton, L. A. R., Mewis, R. E. & Duckett, S. B., 26 Mar 2015, In: Journal of Physical Chemistry B. 119, 15, p. 5020-5027 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Strategies for the hyperpolarization of acetonitrile and related Ligands by SABRE

  Mewis, R. E., Green, R. A., Cockett, M. C. R., Cowley, M. J., Duckett, S. B., Green, G. G. R., John, R. O., Rayner, P. J. & Williamson, D. C., 29 Jan 2015, In: Journal of Physical Chemistry B. 119, 4, p. 1416-1424 9 p.

  Research output: Contribution to journal › Article › peer-review

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• The reaction of an iridium PNP complex with parahydrogen facilitates polarisation transfer without chemical change

  Holmes, A. J., Rayner, P. J., Cowley, M. J., Green, G. G. R., Whitwood, A. C. & Duckett, S. B., 2015, In: Dalton Transactions. 44, 3, p. 1077-1083 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  On the synthesis of α-amino sulfoxides

  Rayner, P. J., Gelardi, G., O'Brien, P., Horan, R. A. J. & Blakemore, D. C., 7 Jun 2014, In: Organic and Biomolecular Chemistry. 12, 21, p. 3499-3512 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Iridium(III) hydrido N-heterocyclic carbene-phosphine complexes as catalysts in magnetization transfer reactions

  Fekete, M., Bayfield, O., Duckett, S. B., Hart, S., Mewis, R. E., Pridmore, N., Rayner, P. J. & Whitwood, A., 2 Dec 2013, In: Inorganic Chemistry. 52, 23, p. 13453-13461 9 p.

  Research output: Contribution to journal › Article › peer-review

• Preparation and reactions of enantiomerically pure α-functionalized grignard reagents

  Rayner, P. J., O'Brien, P. & Horan, R. A. J., 29 May 2013, In: Journal of the American Chemical Society. 135, 21, p. 8071-8077

  Research output: Contribution to journal › Article › peer-review