Puvanendran Tharmanathan

Search results

• 2024

  Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute Leukaemia – a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial

  Flett, L. G., Abdelatif, R., Baz, S. A., Brady, S., Corbacho, B., Common, K., Cowling, A., Fairhurst, C. M., Fitzmaurice, E., Gandhi, S., Hilton, A., Hope, W., Howard, A., Laycock, J. L., Lillie, P., Mitchell, G., Parker, A., Peel, M., Sheard, L. & Sneddon, J. & 6 others, Taynton, T., Tharmanathan, P., Torgerson, D. J., Wang, H.-I., Allsup, D. & Barlow, G., 28 Jun 2024, In: Trials. 25, 427.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture

  Dias, J., Tharmanathan, P., Arundel, C. E., Welch, C., Wu, Q., Leighton, P., Armaou, M., Johnson, N., James, S. J., Cooke, J., Bainbridge, L., Craigen, M., Warwick, D., Brady, S., Flett, L. G., Jones, J., Knowlson, C. N., Watson, M. S., Keding, A. & Hewitt, C. E. & 1 others, Torgerson, D. J., 9 Oct 2024, In: New England Journal of Medicine .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Pain Reduction with Oral Methotrexate in Knee Osteoarthritis; a Randomized Placebo-Controlled Clinical Trial

  Kingsbury, S. R., Tharmanathan, P., Keding, A., Watt, F. E., Scott, D. L., Roddy, E., Birrell, F., Arden, N. K., Bowes, M., Arundel, C. E., Watson, M. S., Ronaldson, S. J., Hewitt, C. E., Doherty, M., Moots, R. J., O'Neill, T. W., Green, M., Patel, G., Garrood, T. & Edwards, C. J. & 4 others, Walmsley, P. J., Sheeran, T., Torgerson, D. J. & Conaghan, P. G., 30 Jul 2024, (E-pub ahead of print) In: Annals of Internal Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Study within a trial 119: The effectiveness of a thank you card to improve trial follow up; a randomised study within a trial

  Arundel, C. E., Welch, C., Tharmanathan, P. & Dias, J., 1 Feb 2024, (E-pub ahead of print) In: Research Methods in Medicine & Health Sciences. 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2023

  Cost-effectiveness of hydroxychloroquine versus placebo for hand osteoarthritis: economic evaluation of the HERO trial

  Ronaldson, S. J., Keding, A., Tharmanathan, P., Arundel, C. E., Kingsbury, S. R., Conaghan, P. G. & Torgerson, D. J., 29 Nov 2023, In: F1000research. 10, 18 p., 821.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical treatment for older adults with acute 3- or 4-part fractures of the proximal humerus: study protocol for a randomised controlled trial (PROFHER-2: PROximal Fracture of Humerus Evaluation by Randomisation – Trial Number 2)

  Rangan, A., Gwilym, S., Keding, A., Corbacho, B., Kottam, L., Arundel, C. E., Coleman, E., DiMascio, L., Hewitt, C. E., Jones, V., Kassam, J., McDaid, C. M., Mitchell, N., Mott, A. J., O'Carroll, G., Tharmanathan, P. & Torgerson, D. J., 13 Apr 2023, In: Trials. 24, 14 p., 270.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  Researchers’ experiences of pharmacy involvement: a UK cross-sectional survey

  Watson, M. S., Whittlesea, C. & Tharmanathan, P., 16 Nov 2022, In: Journal of Pharmaceutical Health Services Research. rmac049.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Staff training to improve participant recruitment into surgical randomised controlled trials: a feasibility Study Within A Trial (SWAT) across four host randomised controlled trials simultaneously

  Parker, A., Arundel, C. E., Mills, N., Rooshenas, L., Jepson, M., Donovan, J., Blazeby, J., Coleman, E., Clark, L. K., Doherty, L., Hewitt, C. E., Partha Sarathy, P., Beard, D., Bower, P., Brealey, S. D., Brocklehurst, P., Cooper, C., Croft, J., Culliford, L. & Dias, J. & 13 others, Devane, D., Eldridge, S., Emsley, R., Galvin, S., Gemperle-Mannion, E., Jayne, D., Metcalfe, A., Montgomery, A., Rangan, A., Sutton, C., Tharmanathan, P., Treweek, S. & Torgerson, D. J., 15 Jun 2022, (E-pub ahead of print) In: Research Methods in Medicine & Health Sciences. 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2021

  Dupuytren’s Interventions Surgery versus Collagenase (DISC) Trial: Study Protocol for a pragmatic, two arm parallel group, non-inferiority randomised controlled trial

  Dias, J., Arundel, C. E., Tharmanathan, P., Keding, A., Welch, C., Corbacho Martín, B., Armaou, M., Leighton, P., Bainbridge, C., Craigen, M., Flett, L. G., Gascoyne, S., Hewitt, C. E., James, E., James, S. J., Johnson, N., Jones, J., Knowlson, C. N., Radia, P. & Torgerson, D. J. & 2 others, Warwick, D. & Watson, M. S., 30 Sept 2021, In: Trials. 22, 15 p., 671.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Report for the EcoNomics of Adaptive Clinical Trials (ENACT) project: Application of a Bayesian Value-Based Sequential Model of a Clinical Trial to the CACTUS and HERO Case Studies (with Guidance Material for Clinical Trials Units)

  Forster, M., Flight, L., Corbacho Martín, B., Keding, A., Ronaldson, S. J., Tharmanathan, P., Welch, C., Brennan, A. & Chick, S., 5 Nov 2021, 107 p.

  Research output: Other contribution

• 2020

  The Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low dose computed tomography screening for lung cancer versus usual care in a targeted population at risk

  Crosbie, P., Gabe, R., Simmonds, I., Kennedy, M., Rogerson, S., Ahmed, N., Baldwin, D. S., Booton, R., Cochrane, A., Darby, M., Franks, K., Hinde, S., Janes, S., Macleod, U., Messenger, M., Moller, H., Murray, R. L., Neal, R. D., Quaife, S. & Sculpher, M. & 3 others, Tharmanathan, P., Torgerson, D. J. & Callister, M., 8 Jul 2020, (Accepted/In press) In: BMJ Open.

  Research output: Contribution to journal › Article › peer-review

• 2019

  The current role, and perceived benefits and barriers of secondary care pharmacists facilitating patient participation in Clinical Trials of Investigational Medicinal Products (CTIMPs) conducted within the NHS: A cross-sectional survey.

  Tharmanathan, P., Watson, M. S. & Bewick, B., 28 Jan 2019, In: Journal of Evaluation in Clinical Practice. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial

  Kingsbury, S. R., Tharmanathan, P., Keding, A., Ronaldson, S. J., Grainger, A., Wakefield, R. J., Arundel, C., Birrell, F., Doherty, M., Vincent, T. L., Watt, F. E., Dziedzic, K. S., O'Neill, T. W., Arden, N. K., Scott, D. L., Dickson, J., Garrood, T., Green, M., Menon, A. & Sheeran, T. & 2 others, Torgerson, D. & Conaghan, P. G., 20 Feb 2018, (E-pub ahead of print) In: Annals of Internal Medicine. 168, 6, p. 385-395 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  No difference found in time to publication by statistical significance of trial results: a methodological review

  Jefferson, L. A., Fairhurst, C. M., Cooper, E., Hewitt, C. E., Torgerson, T., Cook, E., Tharmanathan, P., Cockayne, E. S. & Torgerson, D. J., 5 Oct 2016, In: Journal of the Royal Society of Medicine. 7, 10, p. 1-8

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  A randomised controlled trial of computerised cognitive behaviour therapy for the treatment of depression in primary care: the Randomised Evaluation of the Effectiveness and Acceptability of Computerised Therapy (REEACT) trial

  Littlewood, E., Duarte, A., Hewitt, C., Knowles, S., Palmer, S., Walker, S., Andersen, P., Araya, R., Barkham, M., Bower, P., Brabyn, S., Brierley, G., Cooper, C., Gask, L., Kessler, D., Lester, H., Lovell, K., Usman, M., Parry, G. & Richards, D. A. & 5 others, Richardson, R., Tallon, D., Tharmanathan, P., White, D. & Gilbody, S. M., 19 Dec 2015, In: Health Technology Asssessment. 91, 101, p. 1-174 174 p.

  Research output: Contribution to journal › Article › peer-review

• Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial

  Gilbody, S., Littlewood, E., Hewitt, C., Brierley, G., Tharmanathan, P., Araya, R., Barkham, M., Bower, P., Cooper, C., Gask, L., Kessler, D., Lester, H., Lovell, K., Parry, G., Richards, D. A., Andersen, P., Brabyn, S., Knowles, S., Shepherd, C. & Tallon, D. & 2 others, White, D. & REEACT Team, 11 Nov 2015, In: British medical journal. 351, 13 p., h5627.

  Research output: Contribution to journal › Article › peer-review

• Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review

  Neal, R. D., Tharmanathan, P., France, B., Din, N. U., Cotton, S., Fallon-Ferguson, J., Hamilton, W., Hendry, A., Hendry, M., Lewis, R., Macleod, U., Mitchell, E. D., Pickett, M., Rai, T., Shaw, K., Stuart, N., Tørring, M. L., Wilkinson, C., Williams, B. & Williams, N. & 1 others, Emery, J., 31 Mar 2015, In: British journal of cancer. 112 , Supplement, p. S92-S107 16 p.

  Research output: Contribution to journal › Article › peer-review

• Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial

  Kingsbury, S. R., Tharmanathan, P., Arden, N. K., Batley, M., Birrell, F., Cocks, K., Doherty, M., Edwards, C. J., Garrood, T., Grainger, A. J., Green, M., Hewitt, C., Hughes, R., Moots, R., O'Neill, T. W., Roddy, E., Scott, D. L., Watt, F. E., Torgerson, D. J. & Conaghan, P. G., 4 Mar 2015, In: Trials. 16, 1

  Research output: Contribution to journal › Article › peer-review
• 2013

  Allocation concealment: a methodological review

  Clark, L., Schmidt, U., Tharmanathan, P., Adamson, J., Hewitt, C. & Torgerson, D., 7 May 2013, In: Journal of Evaluation in Clinical Practice. 19, 4, p. 708-712

  Research output: Contribution to journal › Article › peer-review

• Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial

  Kingsbury, S. R., Tharmanathan, P., Adamson, J., Arden, N. K., Birrell, F., Cockayne, S., Dickson, J., Doherty, M., Dziedzic, K. S., Grainger, A., Hewitt, C. E., O Neill, T. W., Scott, D. L., Vincent, T. L., Wakefield, R. J., Watt, F. E., Torgerson, D. J. & Conaghan, P. G., 2 Mar 2013, In: Trials. 14, 1, p. 64

  Research output: Contribution to journal › Article › peer-review

• Poor reporting quality of key Randomization and Allocation Concealment details is still prevalent among published RCTs in 2011: a review

  Clark, L., Schmidt, U., Tharmanathan, P., Adamson, J., Hewitt, C. & Torgerson, D., 7 May 2013, In: Journal of Evaluation in Clinical Practice. 19, 4, p. 703-707 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Diagnosis and treatment of failed back surgery syndrome in the UK: mapping of practice using a cross-sectional survey

  Tharmanathan, P., Adamson, J. A., Ashby, R. L. & Eldabe, S., 2012, In: British Journal of Pain. 6, 4, p. 142-152

  Research output: Contribution to journal › Article › peer-review
• 2011

  Recruiting ahead of target: what worked in the REEACT trial?

  Tharmanathan, P., Brierley, G., Littlewood, E., Andersen, P. & Gilbody, S., 2011, In: Trials. 12, Suppl 1, p. A126

  Research output: Contribution to journal › Article › peer-review

• Systematic review and mixed treatment comparison of randomized evidence for empirical, pre-emptive and directed treatment strategies for invasive mould disease

  Freemantle, N., Tharmanathan, P. & Herbrecht, R., Jan 2011, In: The Journal of antimicrobial chemotherapy. 66 Suppl 1, SUPPL. 1, p. i25-35 dkq439.

  Research output: Contribution to journal › Article › peer-review
• 2009

  The effect of venlafaxine compared with other antidepressants and placebo in the treatment of major depression: a meta-analysis

  Bauer, M., Tharmanathan, P., Volz, H.-P., Moeller, H.-J. & Freemantle, N., Apr 2009, In: European archives of psychiatry and clinical neuroscience. 259, 3, p. 172-85 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  Long-term cost-effectiveness analysis of nebivolol compared with standard care in elderly patients with heart failure: an individual patient-based simulation model

  Yao, G., Freemantle, N., Flather, M., Tharmanathan, P., Coats, A., Poole-Wilson, P. A. & SENIORS Investigators, 2008, In: Pharmacoeconomics. 26, 10, p. 879-89 11 p.

  Research output: Contribution to journal › Article › peer-review

• The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias

  Tharmanathan, P., Calvert, M., Hampton, J. & Freemantle, N., 2008, In: BMC Medical Research Methodology. 8, p. 12 12.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Cardiac resynchronisation for patients with heart failure due to left ventricular systolic dysfunction -- a systematic review and meta-analysis

  Freemantle, N., Tharmanathan, P., Calvert, M. J., Abraham, W. T., Ghosh, J. & Cleland, J. G. F., Jun 2006, In: European journal of heart failure. 8, 4, p. 433-40 8 p.

  Research output: Contribution to journal › Article › peer-review

• Striding forward or getting too big for their boots? The developing role of data monitoring committees in clinical trials

  Tharmanathan, P., Calvert, M. J. & Freemantle, N., Apr 2006, In: Journal of Clinical Pharmacy and Therapeutics. 31, 2, p. 111-8 8 p.

  Research output: Contribution to journal › Article › peer-review