Research output per year
Research output per year
Search results
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2024
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH
Tufail, A., Akkad, S., Hatton, N., Yates, N., Spears, R., Keenan, T., Parkin, A., Signoret, N. Y. M. & Fascione, M. A., 24 Jan 2024, (E-pub ahead of print) In: RSC Advances. 14, 6, p. 3723-3729 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2021
A tale of two bioconjugations: pH controlled divergent reactivity of protein a-oxo aldehydes in competing a-oxo-Mannich and catalyst-free aldol ligations
Keenan, T., Spears, R. J., Akkad, S., Mahon, C. S., Hatton, N. E., Walton, J., Noble, A., Yates, N. D., Baumann, C. G., Parkin, A., Signoret, N. & Fascione, M. A., 19 Nov 2021, In: ACS Chemical Biology. 16, 11, p. 2387-2400 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Chemical Bioconjugation of Proteins in an Undergraduate Lab: One-Pot Oxidation and Derivatization of the N-Terminus
Yates, N. D. J., Brabham, R. L., Spears, R. J., Keenan, T., Helliwell, P. A., Pugh, D. S., Parkin, A., Hurst, G. A. & Fascione, M. A., 26 Mar 2019, In: JOURNAL OF CHEMICAL EDUCATION. 5 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2018
Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif
Thompson, A. J., Spears, R. J., Zhu, Y., Suits, M. D. L., Williams, S. J., Gilbert, H. J. & Davies, G. J., 1 May 2018, In: Acta crystallographica. Section D, Structural biology. 74, 5, p. 394-404 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Palladium-unleashed proteins: gentle aldehyde decaging for site-selective protein modification
Brabham, R. L., Spears, R. J., Walton, J., Tyagi, S., Lemke, E. & Fascione, M. A., 6 Feb 2018, In: Chemical Communications. 54, p. 1501-1504 4 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations
Spears, R. J., Brabham, R. L., Budhadev, D., Keenan, T., McKenna, S. E., Walton, J., Brannigan, J. A., Brzozowski, A. M., Wilkinson, A. J., Plevin, M. J. & Fascione, M. A., 7 Jul 2018, In: Chemical Science. 9, 25, p. 5585-5593 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2015
Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism
Thompson, A. J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R. J., Chandler, E., Temple, M. J., Stepper, J., Gilbert, H. J., Rovira, C., Williams, S. J. & Davies, G. J., 27 Apr 2015, In: Angewandte Chemie International Edition. 54, 18, p. 5378-5382 5 p.Research output: Contribution to journal › Article › peer-review
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Structure of the GH76 -mannanase homolog, BT2949, from the gut symbiont Bacteroides thetaiotaomicron
Thompson, A. J., Cuskin, F., Spears, R. J., Dabin, J., Turkenburg, J. P., Gilbert, H. J. & Davies, G. J., 1 Jan 2015, In: Acta Crystallographica. Section D, Biological Crystallography. D71, p. 408-415 8 p.Research output: Contribution to journal › Article › peer-review