Sean McClarey Meaden

Search results

• 2024

  CRISPR-Cas in Pseudomonas aeruginosa provides transient population-level immunity against high phage exposures

  Meaden, S., Watson, B., Capria, L., Alseth, E., Pons, B., Biswas, A., Lenzi, L., Buckling, A., van Houte, S. & Westra, E., 10 Jan 2024, (E-pub ahead of print) In: The ISME Journal. 18, 1, 11 p., wrad039.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2023

  Antagonistic Mobile Genetic Elements Can Counteract Each Other's Effects on Microbial Community Composition

  Castledine, M., Newbury, A., Lewis, R., Hacker, C., Meaden, S. & Buckling, A., 6 Apr 2023, In: MBio. 14, 2, e0046023.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Decolonizing drug-resistant E. coli with phage and probiotics: breaking the frequency-dependent dominance of residents

  Forsyth, J. H., Barron, N. L., Scott, L., Watson, B. N. J., Chisnall, M. A. W., Meaden, S., van Houte, S. & Raymond, B., 7 Jul 2023, In: Microbiology (Reading, England). 169, 7, 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2022

  High viral abundance and low diversity are associated with increased CRISPR-Cas prevalence across microbial ecosystems

  Meaden, S., Biswas, A., Arkhipova, K., Morales, S. E., Dutilh, B. E., Westra, E. R. & Fineran, P. C., 10 Jan 2022, In: Current biology : CB. 32, 1, p. 220-227.e5

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Padloc: a web server for the identification of antiviral defence systems in microbial genomes

  Payne, L. J., Meaden, S., Mestre, M. R., Palmer, C., Toro, N., Fineran, P. C. & Jackson, S. A., 5 Jul 2022, In: Nucleic Acids Research. 50, W1, p. W541-W550

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  Bacterial defense islands limit viral attack

  Meaden, S. & Fineran, P. C., 22 Oct 2021, In: Science (New York, N.Y.). 374, 6566, p. 399-400 2 p.

  Research output: Contribution to journal › Comment/debate

• Correction: Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity

  Meaden, S., Capria, L., Alseth, E., Gandon, S., Biswas, A., Lenzi, L., van Houte, S. & Westra, E. R., Aug 2021, In: The ISME Journal. 15, 8, p. 2491 1 p.

  Research output: Contribution to journal › Article

• Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks

  Weissman, J. L., Alseth, E. O., Meaden, S., Westra, E. R. & Fuhrman, J. A., 27 Oct 2021, In: Proceedings of the Royal Society B: Biological Sciences. 288, 1961, 2021.1555.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Individual bacteria in structured environments rely on phenotypic resistance to phage

  Attrill, E. L., Claydon, R., Łapińska, U., Recker, M., Meaden, S., Brown, A. T., Westra, E. R., Harding, S. V. & Pagliara, S., 12 Oct 2021, In: PLoS Biology. 19, 10, e3001406.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Phage gene expression and host responses lead to infection-dependent costs of CRISPR immunity

  Meaden, S., Capria, L., Alseth, E., Gandon, S., Biswas, A., Lenzi, L., van Houte, S. & Westra, E. R., Feb 2021, In: The ISME Journal. 15, 2, p. 534-544 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Exploitation of the Cooperative Behaviors of Anti-CRISPR Phages

  Chevallereau, A., Meaden, S., Fradet, O., Landsberger, M., Maestri, A., Biswas, A., Gandon, S., van Houte, S. & Westra, E. R., 12 Feb 2020, In: Cell Host & Microbe. 27, 2, p. 189-198.e6

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Functional genomics reveals the toxin-antitoxin repertoire and AbiE activity in Serratia

  Hampton, H. G., Smith, L. M., Ferguson, S., Meaden, S., Jackson, S. A. & Fineran, P. C., 19 Oct 2020, In: Microbial Genomics. 6, 11

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Resource quality determines the evolution of resistance and its genetic basis

  Roberts, K. E., Meaden, S., Sharpe, S., Kay, S., Doyle, T., Wilson, D., Bartlett, L. J., Paterson, S. & Boots, M., Nov 2020, In: Molecular Ecology. 29, 21, p. 4128-4142 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The effect of phage genetic diversity on bacterial resistance evolution

  Broniewski, J. M., Meaden, S., Paterson, S., Buckling, A. & Westra, E. R., Mar 2020, In: The ISME Journal. 14, 3, p. 828-836 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2019

  Recombination between phages and CRISPR-cas loci facilitates horizontal gene transfer in staphylococci

  Varble, A., Meaden, S., Barrangou, R., Westra, E. R. & Marraffini, L. A., Jun 2019, In: Nature Microbiology. 4, 6, p. 956-963 8 p.

  Research output: Contribution to journal › Article › peer-review

• The effect of bacterial mutation rate on the evolution of CRISPR-Cas adaptive immunity

  Chevallereau, A., Meaden, S., van Houte, S., Westra, E. R. & Rollie, C., 13 May 2019, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1772, p. 20180094

  Research output: Contribution to journal › Article › peer-review

• Variability in the durability of CRISPR-Cas immunity

  Chabas, H., Nicot, A., Meaden, S., Westra, E. R., Tremblay, D. M., Pradier, L., Lion, S., Moineau, S. & Gandon, S., 13 May 2019, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 374, 1772, p. 20180097

  Research output: Contribution to journal › Article › peer-review
• 2018

  Anti-CRISPR Phages Cooperate to Overcome CRISPR-Cas Immunity

  Landsberger, M., Gandon, S., Meaden, S., Rollie, C., Chevallereau, A., Chabas, H., Buckling, A., Westra, E. R. & van Houte, S., 9 Aug 2018, In: Cell. 174, 4, p. 908-916.e12

  Research output: Contribution to journal › Article › peer-review

• Evolutionary emergence of infectious diseases in heterogeneous host populations

  Chabas, H., Lion, S., Nicot, A., Meaden, S., van Houte, S., Moineau, S., Wahl, L. M., Westra, E. R. & Gandon, S., Sept 2018, In: PLoS Biology. 16, 9, p. e2006738

  Research output: Contribution to journal › Article › peer-review
• 2017

  Adaptation of the pathogen, Pseudomonas syringae, during experimental evolution on a native vs. alternative host plant

  Meaden, S. & Koskella, B., Apr 2017, In: Molecular Ecology. 26, 7, p. 1790-1801 12 p.

  Research output: Contribution to journal › Article › peer-review

• A signature of tree health? Shifts in the microbiome and the ecological drivers of horse chestnut bleeding canker disease

  Koskella, B., Meaden, S., Crowther, W. J., Leimu, R. & Metcalf, C. J. E., Jul 2017, In: The New phytologist. 215, 2, p. 737-746 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2016

  Assessing Illumina technology for the high-throughput sequencing of bacteriophage genomes

  Rihtman, B., Meaden, S., Clokie, M. R. J., Koskella, B. & Millard, A. D., 2016, In: PeerJ. 4, p. e2055

  Research output: Contribution to journal › Article › peer-review
• 2015

  The cost of phage resistance in a plant pathogenic bacterium is context-dependent

  Meaden, S., Paszkiewicz, K. & Koskella, B., May 2015, In: Evolution: international journal of organic evolution. 69, 5, p. 1321-8 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2013

  Exploring the risks of phage application in the environment

  Meaden, S. & Koskella, B., 2013, In: Frontiers in Microbiology. 4, p. 358

  Research output: Contribution to journal › Review article › peer-review

• Understanding bacteriophage specificity in natural microbial communities

  Koskella, B. & Meaden, S., 11 Mar 2013, In: Viruses. 5, 3, p. 806-23 18 p.

  Research output: Contribution to journal › Review article › peer-review