Sean Sweeney

Search results

• 2022

  GCH1 Deficiency Activates Brain Innate Immune Response and Impairs Tyrosine Hydroxylase Homeostasis

  Larbalestier, H., Keatinge, M., Watson, L., White, E., Gowda, S., Wei, W., Koler, K., Semenova, S. A., Elkin, A. M., Rimmer, N., Sweeney, S. T., Mazzolini, J., Sieger, D., Hide, W., McDearmid, J., Panula, P., MacDonald, R. B. & Bandmann, O., 26 Jan 2022, In: Journal of neuroscience. 42, 4, p. 702-716 15 p.

  Research output: Contribution to journal › Article › peer-review

• Sampling and Analysis of Low-Molecular-Weight Volatile Metabolites in Cellular Headspace and Mouse Breath

  Redeker, K. R., Sweeney, S., Brackenbury, W. & Issitt, T., 27 Jun 2022, In: Metabolites. 12, 7, 16 p., 599.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• The Putative Drosophila TMEM184B Ortholog Tmep Ensures Proper Locomotion by Restraining Ectopic Firing at the Neuromuscular Junction

  Cho, T. S., Beigaitė, E., Klein, N. E., Sweeney, S. T. & Bhattacharya, M. R. C., Apr 2022, In: Molecular neurobiology. 59, 4, p. 2605-2619 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Volatile compounds in human breath: critical review and meta-analysis

  Issitt, T., Wiggins, L., Veysey, M., Sweeney, S., Brackenbury, W. & Redeker, K. R., 4 Feb 2022, (Accepted/In press) In: Journal of Breath Research.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2020

  Ik2/TBK1 and Hook/Dynein, an adaptor complex for early endosome transport, are genetic modifiers of FTD-associated mutant CHMP2B toxicity in Drosophila

  Lu, Y., West, R. J. H., Pons, M., Sweeney, S. & Gao, F-B., 26 Aug 2020, (E-pub ahead of print) In: Scientific Reports. 10, p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• JNK signalling regulates antioxidant responses in neurons

  Ugbode, C., Garnham, N. A., Fort Aznar, L., Evans, G. J. O., Chawla, S. & Sweeney, S., 1 Oct 2020, In: Redox Biology. 37, 11 p., 101712.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Neuroprotective Activity of Ursodeoxycholic Acid in CHMP2BIntron5 Models of Frontotemporal Dementia

  West, R. J., Ugbode, C., Fort Aznar, L. & Sweeney, S., 13 Aug 2020, In: Neurobiology of disease. 144, 105047.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Retrovirus reactivation in CHMP2BIntron5 models of Frontotemporal Dementia

  Fort Aznar, L., Ugbode, C. & Sweeney, S., 6 Jul 2020, (E-pub ahead of print) In: Human Molecular Genetics. 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2019

  IPIP27 coordinates PtdIns(4,5)P2 homeostasis for successful cytokinesis

  Carim, S. C., Ben El Kadhi, K., Yan, G., Sweeney, S., Hickson, G. R., Carreno, S. & Lowe, M., 4 Mar 2019, In: Current Biology. 29, 5, p. 775-789 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2018

  A MAPK/c-Jun-mediated switch regulates the initial adaptive and cell death responses to mitochondrial damage in a neuronal cell model

  Ryan, T. A., Roper, K., Bond, J., Bell, S. M., Sweeney, S. & Morrison, E. E., Nov 2018, In: The International Journal of Biochemistry & Cell Biology. 104, p. 73-86 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion

  Sabbadin, F., Hemsworth, G. R., Ciano, L., Henrissat, B., Dupree, P., Tryfona, T., Marques, R. D. S., Sweeney, S. T., Besser, K., Elias, L., Pesante, G., Li, Y., Dowle, A. A., Bates, R., Gomez, L. D., Simister, R., Davies, G. J., Walton, P. H., Bruce, N. C. & McQueen-Mason, S. J., 22 Feb 2018, In: Nature Communications. 9, 1, 12 p., 756.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Reactive Oxygen Species Regulate Activity-Dependent Neuronal Plasticity in Drosophila

  Oswald, M. C. W., Brooks, P. S., Zwart, M. F., Mukherjee, A., West, R. J. H., Giachello, C., Morarach, K., Baines, R. A., Sweeney, S. & Landgraf, M., 17 Dec 2018, In: eLife. 7, e39393.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Sphingolipids Regulate Neuromuscular Synapse Structure and function in Drosophila

  West, R. J. H., Briggs, L., Fjeldstad, M. P., Ribchester, R. R. & Sweeney, S., 1 Sep 2018, In: Journal of comparative neurology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The Pro-Apoptotic JNK Scaffold POSH/SH3RF1 Mediates CHMP2BIntron5-Associated Toxicity in Animal Models Frontotemporal Dementia

  West, R. J. H., Ugbode, C., Gao, F-B. & Sweeney, S., 15 Apr 2018, In: Human Molecular Genetics. 27, 8, p. 1382–1395 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila

  Rosa-Ferreira, C., Sweeney, S. & Munro, S., 31 Jul 2018, (Accepted/In press) In: Biology Open.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  A saposin deficiency model in Drosophila: Lysosomal storage, progressive neurodegeneration and sensory physiological decline

  Elliott, C. J. H. & Sweeney, S., Feb 2017, In: Neurobiology of disease. 98, p. 77-87 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• dOCRL maintains immune cell quiescence in Drosophila by regulating endosomal traffic

  del Signore, S. J., Biber, S. A., Lehmann, K. S., Heimler, S. R., Rosenfeld, B. H., Eskin, T. L., Sweeney, S. & Rodal, A., 13 Oct 2017, In: PLoS Genetics. 29 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders

  Sweeney, S., 18 Oct 2017, In: Molecular Biology of the Cell. 28, 26, p. 3728-3740 12 p., 26.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2016

  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

  Autophagy group authors, Elliott, C. J., Mottram, J. C. & Sweeney, S. T., 21 Jan 2016, In: Autophagy. 12, 1, p. 1-222 223 p.

  Research output: Contribution to journal › Article › peer-review
• 2015

  Binding partners of the kinase domains in Drosophila obscurin and their effect on the structure of the flight muscle

  Katzemich, A., West, R. J. H., Fukuzawa, A., Sweeney, S. T., Gautel, M., Sparrow, J. & Bullard, B., 15 Sep 2015, In: Journal of Cell Science. 128, p. 3386-3397

  Research output: Contribution to journal › Article › peer-review

• Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1

  Oswald, M., West, R. J. H., Lloyd-Evans, E. & Sweeney, S., 15 Dec 2015, In: Human Molecular Genetics. 24, 24, p. 6899-6909 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Mitochondrial retrograde signaling regulates neuronal function

  Cagin, U., Duncan, O. F., Gatt, A. P., Dionne, M. S., Sweeney, S. T. & Bateman, J. M., 3 Nov 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. E6000-E6009

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia

  West, R. J. H., Lu, Y., Marie, B., Gao, F-B. & Sweeney, S., 30 Mar 2015, In: Journal of Cell Biology. 208, 7, p. 931-947 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2014

  Class IIa histone deacetylases are conserved regulators of circadian function

  Fogg, P. C. M., O'Neill, J. S., Dobrzycki, T., Calvert, S., Lord, E. C., McIntosh, R. L. L., Elliott, C. J. H., Sweeney, S. T., Hastings, M. H. & Chawla, S., 5 Dec 2014, In: The Journal of biological chemistry. 289, p. 34341-34348 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2013

  Dopaminergic expression of the Parkinsonian gene LRRK2-G2019S leads to non-autonomous visual neurodegeneration, accelerated by increased neural demands for energy

  Hindle, S., Afsari, F., Stark, M., Middleton, C. A., Evans, G. J. O., Sweeney, S. T. & Elliott, C. J. H., Jun 2013, In: Human Molecular Genetics. 22, 11, p. 2129-2140 12 p.

  Research output: Contribution to journal › Article › peer-review

• Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation

  Lu, Y., Zhang, Z., Sun, D., Sweeney, S. T. & Gao, F-B., 24 Oct 2013, In: Molecular Cell. n/a, 2, p. n/a 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Identification of Drosophila gene products required for phagocytosis of Leishmania donovani

  Peltan, A., Briggs, L., Matthews, G., Sweeney, S. T. & Smith, D. F., 13 Dec 2012, In: PLoS ONE. 7, 12, 12 p., e51831.

  Research output: Contribution to journal › Article › peer-review

• Oxidative stress and autophagy: Mediators of synapse growth?

  West, R. J. H. & Sweeney, S. T., 2012, In: Autophagy. 8, 2

  Research output: Contribution to journal › Article › peer-review

• Oxidative stress in synapse development and function

  Milton, V. J. & Sweeney, S. T., Jan 2012, In: Developmental neurobiology. 72, 1, p. 100-10 11 p.

  Research output: Contribution to journal › Article › peer-review

• parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress

  Vincent, A., Briggs, L., Chatwin, G. F. J., Emery, E., Tomlins, R., Oswald, M., Middleton, C. A., Evans, G. J. O., Sweeney, S. T. & Elliott, C. J. H., 2012, In: Human Molecular Genetics. 21, 8, p. 1760-1769 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  A novel thermosensitive escape behavior in Drosophila larvae

  Oswald, M., Rymarczyk, B., Chatters, A. & Sweeney, S., Oct 2011, In: Fly. 5, 4, p. 304-306 3 p.

  Research output: Contribution to journal › Article › peer-review

• Invertebrate models of lysosomal storage disease: what have we learned so far?

  Hindle, S., Hebbar, S. & Sweeney, S. T., Dec 2011, In: Invertebrate neuroscience : IN. 11, 2, p. 59-71 13 p.

  Research output: Contribution to journal › Article › peer-review

• Oxidative stress induces overgrowth of the Drosophila neuromuscular junction

  Milton, V. J., Gowers, K., Jarrett, H. E., Chalak, S., Briggs, L., Robinson, I. M. & Sweeney, S. T., 18 Oct 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 42, p. 17521-17526 6 p.

  Research output: Contribution to journal › Article › peer-review

• RNAi screening of Drosophila (Sophophora) melanogaster S2 cells for ricin sensitivity and resistance

  Pawar, V., De, A., Briggs, L., Omar, M. M., Sweeney, S. T., Lord, J. M., Roberts, L. M., Spooner, R. A. & Moffat, K. G., Apr 2011, In: Journal of biomolecular screening. 16, 4, p. 436-42 7 p.

  Research output: Contribution to journal › Article › peer-review

• Teaching report: the use of Drosophila melanogaster larval thermosensitive escape behaviour as a model system to demonstrate sensory function

  Harrison, A. B., Oswald, M. & Sweeney, S. T., Dec 2011, In: Invertebrate neuroscience : IN. 11, 2, p. 109-12 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling

  Li, X., Kuromi, H., Briggs, L., Green, D. B., Rocha, J. J., Sweeney, S. & Bullock, S. L., 3 Mar 2010, In: EMBO Journal. 29, 5, p. 992-1006 15 p.

  Research output: Contribution to journal › Article › peer-review

• Postmating Change in Physiology of Male Drosophila Mediated by Serotonin (5-HT)

  Norville, K., Sweeney, S. & Elliott, C. J. H., Mar 2010, In: Journal of neurogenetics. 24, 1, p. 27-32 6 p.

  Research output: Contribution to journal › Article › peer-review

• The nuclear protein Waharan is required for endosomal-lysosomal trafficking in Drosophila

  Lone, M., Kungl, T., Koper, A., Bottenberg, W., Kammerer, R., Klein, M., Sweeney, S. T., Auburn, R. P., O'Kane, C. J. & Prokop, A., 15 Jul 2010, In: Journal of Cell Science. 123, Pt 14, p. 2369-74 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Genetic screen identifies serpin5 as a regulator of the toll pathway and CHMP2B toxicity associated with frontotemporal dementia

  Ahmad, S. T., Sweeney, S., Lee, J-A., Sweeney, N. T. & Gao, F-B., 21 Jul 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 29, p. 12168-12173 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  Modelling lysosomal storage disease in Drosophila

  Sweeney, S. T., 2008, In: SEB experimental biology series. 60, p. 115-39 25 p.

  Research output: Contribution to journal › Article

• Neuromuscular control of a single twitch muscle in wild type and mutant Drosophila, measured with an ergometer

  Harvey, J., Brunger, H., Middleton, C. A., Hill, J. A., Sevdali, M., Sweeney, S. T., Sparrow, J. C. & Elliott, C. J. H., Jun 2008, In: Invertebrate neuroscience : IN. 8, 2, p. 63-70 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Neuromuscular organization and aminergic modulation of contractions in the Drosophila ovary

  Middleton, C. A., Nongthomba, U., Parry, K., Sweeney, S. T., Sparrow, J. C. & Elliott, C. J. H., Jun 2006, In: BMC Biology. 4, 17, p. - 16 p., 17.

  Research output: Contribution to journal › Article › peer-review

  File

• Waharan, a novel Drosophila protein involved in ubiquitin-mediated regulation of NMJ size

  Lone, M., Asztalos, Z., Auburn, R., Bottenberg, W., Kammerer, R., Kane, C. O., Rocha, J., Sweeney, S., Yang, M. & Prokop, A., 2006, In: Journal of neurogenetics. 20, 3-4, p. 166-167 2 p.

  Research output: Contribution to journal › Article › peer-review

• 2004

  Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth

  Marie, B., Sweeney, S. T., Poskanzer, K. E., Roos, J., Kelly, R. B. & Davis, G. W., 22 Jul 2004, In: Neuron. 43, 2, p. 207-219 12 p.

  Research output: Contribution to journal › Article › peer-review

• In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1)

  Hardie, R. C., Gu, Y., Martin, F., Sweeney, S. T. & Raghu, P., 2004, In: Journal of Biological Chemistry. 279, 46, p. 47773-82 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2003

  Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements

  Clyne, P. J., Brotman, J. S., Sweeney, S. T. & Davis, G., 2003, In: Genetics. 165, 3, p. 1433-41 9 p.

  Research output: Contribution to journal › Article › peer-review

• Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo

  Poskanzer, K. E., Marek, K. W., Sweeney, S. T. & Davis, G. W., 2003, In: Nature. 426, 6966, p. 559-563 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2002

  Targeted expression of tetanus neurotoxin interferes with behavioral responses to sensory input in Drosophila

  Keller, A., Sweeney, S. T., Zars, T., O'Kane, C. J. & Heisenberg, M., 2002, In: Journal of neurobiology. 50, 3, p. 221-33 13 p.

  Research output: Contribution to journal › Article › peer-review

• Targeted expression of tetanus toxin: a new tool to study the neurobiology of behavior

  Martin, J-R., Keller, A. & Sweeney, S. T., 2002, In: Advances in genetics. 47, p. 1-47 47 p.

  Research output: Contribution to journal › Article › peer-review

• Unrestricted synaptic growth in spinster - A late endosomal protein implicated in TGF-ß-mediated synaptic growth regulation

  Sweeney, S. T. & Davis, G. W., 30 Oct 2002, In: Neuron. 36, 3, p. 403-416 13 p.

  Research output: Contribution to journal › Article › peer-review