Wendy Anne Offen

Search results

• 2023

  A multiplexing activity-based protein profiling platform for dissection of a native bacterial xyloglucan-degrading system

  McGregor, N. G. S., De Boer, C., Foucart, Q. P. O., Beenakker, T. J. N., Offen, W. A., Codee, J. D. C., Willems, L. I., Overkleeft, H. S. & Davies, G. J., 24 Nov 2023, (E-pub ahead of print) In: ACS Central Science. 9, 12, p. 2306-2314 9 p.

  Research output: Contribution to journal › Article › peer-review

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• The Development of a Broad-Spectrum Retaining β-Exo-Galactosidase Activity-Based Probe

  Su, Q., Kuo, E., van den Nieuwendijk, R., Codee, J. D., Beenakker, T. J. N., Marques, A., Sarris, A. J. C., Van Der Marel, G., Florea, B. I., Davies, G. J., Offen, W. A., Aerts, H., Willems, L. I., Boot, R. G. & Overkleeft, H. S., 15 Sept 2023, In: Organic & biomolecular chemistry. 21, p. 7813–7820 8 p.

  Research output: Contribution to journal › Article › peer-review

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• β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases

  Borlandelli, V., Offen, W. A., Moroz, O., Nin-Hill, A., McGregor, N., Binkhorst, L., Ishiwata, A., Armstrong, Z., Artola, M., Rovira, C., Davies, G. J. & Overkleeft, H. S., 5 Dec 2023, (E-pub ahead of print) In: ACS Chemical Biology. 18, 12, p. 2564–2573 10 p.

  Research output: Contribution to journal › Article › peer-review

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• 2022

  Synthesis of Broad-Specificity Activity-Based Probes for Exo-β-Mannosidases

  McGregor, N. G. S., Kuo, C-L., Beenakker, T. J. M., Wong, C-S., Offen, W. A., Armstrong, Z., Florea, B. I., Codée, J. D. C., Overkleeft, H. S., Aerts, J. M. F. G. & Davies, G. J., 28 Jan 2022, In: Organic and Biomolecular Chemistry. 20, p. 877-886 10 p.

  Research output: Contribution to journal › Article › peer-review

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• 2021

  Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents

  Rowland, R. J., Chen, Y., Breen, I., Wu, L., Offen, W. A., Beenakker, T., Su, Q., van den Nieuwendijk, A. M. C. H., Aerts, J. M. F. G., Artola, M., Overkleeft, H. S. & Davies, G. J., 29 Oct 2021, (E-pub ahead of print) In: Chemistry : A European Journal. 13 p.

  Research output: Contribution to journal › Article › peer-review

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• The development of non-hydrolysable oligosaccharide activity-based inactivators for endoglycanases: a case study on a-1,6 mannanases

  Schröder, S. P., Offen, W. A., Males, A., Jin, Y., Boer, C. D., Enotarpi, J., Marino, L., van der Marel, G. A., Florea, B. I., Codée, J. D. C., Overkleeft, H. S. & Davies, G. J., 21 May 2021, (E-pub ahead of print) In: Chemistry A European Journal. 6 p.

  Research output: Contribution to journal › Article › peer-review

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• 2020

  Discovery of a fungal copper radical oxidase with high catalytic efficiency towards 5-hydroxymethylfurfural and benzyl alcohols for green bioprocessing

  Mathieu, Y., Offen, W. A., Forget, S., Ciano, L., Viborg, A. H., Blagova, E., Henrissat, B., Walton, P. H., Davies, G. J. & Brumer, H., 6 Mar 2020, In: ACS Catalysis. 10, p. 3042-3058 17 p.

  Research output: Contribution to journal › Article › peer-review

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• Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine

  Weber, P., Thonhofer, M., Averill, S., Davies, G. J., Santana, A. G., Müller, P., Nasseri, S. A., Offen, W. A., Pabst, B. M., Paschke, E., Schalli, M., Torvisco, A., Tschernutter, M., Tysoe, C., Windischhofer, W., Withers, S. G., Wolfsgruber, A., Wrodnigg, T. M. & Stütz, A. E., 3 Sept 2020, In: MOLECULES. 25, 17, 25 p., 4025.

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• Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides

  Keenan, T., Parmeggiani, F., Malassis, J., Fontenelle, C., Vendeville, J-B., Offen, W. A., Both, P., Huang, K., Marchesi, A., Heyam, A. P., Young, C., Charnock, S. J., Davies, G. J., Linclau, B., Flitsch, S. L. & Fascione, M. A., 2 Jul 2020, (E-pub ahead of print) In: Cell Chemical Biology.

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• 2019

  Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation

  Cabry, M. P., Offen, W. A., Saleh, P., Li, Y., Winzer, T., Graham, I. A. & Davies, G. J., 3 May 2019, In: ACS Catalysis. 9, 5, p. 3840–3848 9 p.

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• 2018

  Functional and informatics analysis enables glycosyltransferase activity prediction

  Yang, M., Fehl, C., Lees, K. V., Lim, E-K., Offen, W. A., Davies, G. J., Bowles, D. J., Davidson, M. G., Roberts, S. J. & Davis, B. G., 12 Nov 2018, (E-pub ahead of print) In: NATURE CHEMICAL BIOLOGY. 14, p. 1109-1117 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

  Schröder, S. P., Wu, L., Artola, M., Hansen, T., Offen, W. A., Ferraz, M. J., Li, K-Y., Aerts, J. M. F. G., Van Der Marel, G. A., Codée, J. D. C., Davies, G. J. & Overkleeft, H. S., 2018, In: Journal of the American Chemical Society. p. 1-4 4 p.

  Research output: Contribution to journal › Article › peer-review

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• In vitro and in vivo characterization of three Cellvibrio japonicus Glycoside Hydrolase Family 5 members reveals potent xyloglucan backbone-cleaving functions

  Attia, M. A., Nelson, C. E., Offen, W. A., Jain, N., Davies, G. J., Gardner, J. G. & Brumer, H., 17 Feb 2018, In: Biotechnology for biofuels. 11, 1, 45.

  Research output: Contribution to journal › Article › peer-review

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• 2017

  1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

  Artola, M., Wu, L., Ferraz, M. J., Kuo, C. L., Raich, L., Breen, I. Z., Offen, W. A., Codée, J. D. C., Van Der Marel, G. A., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 26 Jul 2017, In: ACS Central Science. 3, 7, p. 784-793 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Carba-Cyclophellitols are Neutral Retaining Glucosidase Inhibitors

  Beenakker, T. J. M., Wander, D., Offen, W. A., Artola, M., Raich, L., Ferraz, M. J., Li, K-Y., Houben, J. H. P. M., Rijssel, E. R. V., Hansen, T., Marel, G. A. V. D., Codée, J. D. C., Aerts, J. M. F. G., Rovira, C., Davies, G. J. & Overkleeft, H. S., 2017, In: Journal of the American Chemical Society. 139, 19, p. 6534–6537

  Research output: Contribution to journal › Article › peer-review

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• Structural and functional insight into human O-GlcNAcase

  Roth, C., Chan, O. Y., Offen, W. A., Hemsworth, G. R., Willems, L. I., King, D. T., Varghese, V., Britton, R., Vocadlo, D. J. & Davies, G. J., 1 Jun 2017, In: NATURE CHEMICAL BIOLOGY. 13, 6, p. 610-612 3 p.

  Research output: Contribution to journal › Article › peer-review

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• Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

  Schroder, S. P., van de Sande, J. W., Kallemeijn, W. W., Kuo, C-L., Artola, M., van Rooden, E. J., Jiang, J., Beenakker, T. JM., Florea, B. I., Offen, W. A., Davies, G., Minnaard, A. J., Aerts, H., Codee, J. D., Van Der Marel, G. A. & Overkleeft, H. S., 6 Nov 2017, (E-pub ahead of print) In: Chemical Communications. p. 1-5 5 p.

  Research output: Contribution to journal › Article › peer-review

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• 2016

  Three-dimensional structures of two heavily N-glycosylated Aspergillus sp. family GH3 β-D-glucosidases

  Agirre, J., Ariza, A., Offen, W. A., Turkenburg, J. P., Roberts, S. M., McNicholas, S., Harris, P. V., McBrayer, B., Dohnalek, J., Cowtan, K. D., Davies, G. J. & Wilson, K. S., 1 Feb 2016, In: Acta crystallographica. Section D, Structural biology. 72, 2, p. 254-265 12 p.

  Research output: Contribution to journal › Article › peer-review

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• 2015

  Three-dimensional structure of a variant 'Termamyl-like' Geobacillus stearothermophilus α-amylase at 1.9Å resolution

  Offen, W. A., Viksoe-Nielsen, A., Borchert, T. V., Wilson, K. S. & Davies, G. J., Jan 2015, In: Acta Crystallographica Section F:Structural Biology Communications. 71, 1, p. 66-70 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway

  Kim, R. Q., Offen, W. A., Davies, G. J. & Stubbs, K. A., Jan 2014, In: Acta Crystallographica. Section D, Biological Crystallography. 70, 1, p. 177-185 9 p.

  Research output: Contribution to journal › Article › peer-review

• Structure and activity of the streptomyces coelicolor A3(2) β-N-acetylhexosaminidase provides further insight into GH20 family catalysis and inhibition

  Thi, N. N., Offen, W. A., Shareck, F., Davies, G. J. & Doucet, N., 25 Mar 2014, In: Biochemistry. 53, 11, p. 1789-1800 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2011

  Structure and Activity of Paenibacillus polymyxa Xyloglucanase from Glycoside Hydrolase Family 44

  Ariza, A., Eklöf, J. M., Spadiut, O., Offen, W. A., Roberts, S. M., Besenmatter, W., Friis, E. P., Skjøt, M., Wilson, K. S., Brumer, H. & Davies, G., 30 Sept 2011, In: Journal of Biological Chemistry. 286, 39, p. 33890-900 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

  Offen, W. A., Zechel, D. L., Withers, S. G., Gilbert, H. J. & Davies, G. J., 2009, In: Chemical Communications. 18, p. 2484-2486 3 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  Structural and biochemical evidence for a boat-like transition state in beta-mannosidases

  Tailford, L. E., Offen, W. A., Smith, N. L., Dumon, C., Morland, C., Gratien, J., Heck, M-P., Stick, R. V., Bleriot, Y., Vasella, A., Gilbert, H. J. & Davies, G. J., 23 May 2008, In: NATURE CHEMICAL BIOLOGY. 4, 5, p. 306-312 7 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants

  Brazier-Hicks, M., Offen, W. A., Gershater, M. C., Revett, T. J., Lim, E-K., Bowles, D. J., Davies, G. J. & Edwards, R., 18 Dec 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 51, p. 20238-20243 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Structure of a flavonoid glucosyltransferase reveals the basis for plant natural product modification

  Offen, W., Martinez-Fleites, C., Yang, M., Kiat-Lim, E., Davis, B. G., Tarling, C. A., Ford, C. M., Bowles, D. J. & Davies, G. J., 22 Mar 2006, In: EMBO Journal. 25, 6, p. 1396-1405 10 p.

  Research output: Contribution to journal › Article › peer-review
• 2003

  Multifunctional xylooligosaccharide/cephalosporin C deacetylase revealed by the hexameric structure of the Bacillus subtilis enzyme at 1.9 angstrom resolution

  Vincent, F., Charnock, S. J., Verschueren, K. H. G., Turkenburg, J. P., Scott, D. J., Offen, W. A., Roberts, S., Pell, G., Gilbert, H. J., Davies, G. J. & Brannigan, J. A., 11 Jul 2003, In: Journal of Molecular Biology. 330, 3, p. 593-606 14 p.

  Research output: Contribution to journal › Article › peer-review
• 1999

  Crystallization of the regulatory and effector domains of the key sporulation response regulator Spo0A

  Muchova, K., Lewis, R. J., Brannigan, J. A., Offen, W. A., Brown, D. P., Barak, I., Youngman, P. & Wilkinson, A. J., 3 Mar 1999, In: Acta Crystallographica. Section D, Biological Crystallography. 55, 3, p. 671-676 6 p.

  Research output: Contribution to journal › Article › peer-review

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• 1998

  An evolutionary link between sporulation and prophage induction in the structure of a repressor: Anti-repressor complex

  Lewis, R. J., Brannigan, J. A., Offen, W. A., Smith, I. & Wilkinson, A. J., 13 Nov 1998, In: Journal of Molecular Biology. 283, 5, p. 907-912 6 p.

  Research output: Contribution to journal › Article › peer-review

• 1997

  RNA cleavage without hydrolysis. Splitting the catalytic activities of binase with Asn101 and Thr101 mutations

  Okorokov, A. L., Panov, K. I., Offen, W. A., Mukhortov, V. G., Antson, A. A., Karpeisky, M. Y., Wilkinson, A. J. & Dodson, G. G., Mar 1997, In: PROTEIN ENGINEERING DESIGN. 10, 3, p. 273-278 6 p.

  Research output: Contribution to journal › Article › peer-review