Will Brackenbury

Search results

• 2025

  CellPhePy: a Python implementation of the CellPhe toolkit for automated cell phenotyping from microscopy time-lapse videos

  Wiggins, L., Lacy, S., Park, G. J., Marrison, J., Powell, B., Cimini, B., O'Toole, P. J., Wilson, J. C. & Brackenbury, W., 1 Apr 2025, (Accepted/In press) In: Journal of Microscopy.

  Research output: Contribution to journal › Article › peer-review

• Identification of robust RT-qPCR reference genes for studying changes in gene expression in response to hypoxia in breast cancer cell lines

  Mason, J., Bridge, K. S., Holding, A. N. & Brackenbury, W., 21 Jan 2025, In: BMC Genomics. 26, 12 p., 59.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2024

  23Na MRI: Inter-reader reproducibility of Normal Fibroglandular Sodium Concentration Measurements at 3 T

  Arponen, O., McLean, M., Nanaa, M., Manavaki, R., Baxter, G., Gill, A. B., Riemer, F., Kennerley, A. J., Woitek, R., Kaggie, J. D., Brackenbury, W. & Gilbert, F. J., 10 Jun 2024, In: European Radiology Experimental. 8, 12 p., 75.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis

  Leslie, T., Tripp, A., James, A., Fraser, S. P., Nelson, M., Sajjaboontawee, N., Capatina, A., Toss, M., Fadhil, W., Salvage, S., Arias Garcia, M., Beykou, M., Rakha, E., Speirs, V., Bakal, C., Poulogiannis, G., Djamgoz, M. B. A., Jackson, A. P., Matthews, H. R. & Huang, C.L.-H. & 3 others, Chawla, S., Holding, A. N. & Brackenbury, W., 16 Aug 2024, In: Oncogene. 43, p. 2578–2594 17 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Exploring the impact of variability in cell segmentation and tracking approaches

  Brackenbury, W., Wiggins, L., Wilson, J. C. & O'Toole, P. J., 16 Nov 2024, (E-pub ahead of print) In: Microscopy research and technique. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2023

  Blocking channels to metastasis: Targeting sodium transport in breast cancer

  Brackenbury, W. & Palmien, C., 10 Nov 2023, In: Breast cancer research : BCR. 25, 3 p., 140.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• GC/MS analysis of hypoxic volatile metabolic markers in the MDA-MB-231 breast cancer cell line

  Issitt, T., Reilly, M., Sweeney, S., Brackenbury, W. & Redeker, K. R., 11 May 2023, In: Frontiers in Molecular Biosciences. 10, 9 p., 1178269.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium channel-inhibiting drugs and cancer-specific survival: a population-based study of electronic primary care data

  Fairhurst, C. M., Martin, F., Watt, I., Bland, M., Doran, T. & Brackenbury, W., 3 Feb 2023, In: BMJ Open. 13, 52 p., e064376.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium regulates PLC and IP3R-mediated calcium signalling in invasive breast cancer cells

  James, A., Unthank, K. P., Jones, I., Sajjaboontawee, N., Sizer, R., Chawla, S., Evans, G. J. O. & Brackenbury, W., 5 Apr 2023, In: Physiological Reports. 11, 17, 11 p., e15663.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The CellPhe toolkit for cell phenotyping using time-lapse imaging and pattern recognition

  Wiggins, L., Lord, A., Murphy, K. L., Lacy, S. E., O'Toole, P. J., Brackenbury, W. & Wilson, J. C., 3 Apr 2023, In: Nature Communications. 14, 15 p., 1854.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Voltage-gated Sodium Channels, Sodium Transport and Progression of Solid Tumours

  Malcolm, J., Sajjaboontawee, N., Yerlikaya, S., Plunkett-Jones, L., Boxall, P. & Brackenbury, W., 23 Nov 2023, In: Current Topics in Membranes. 92, p. 71-98 28 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2022

  Harnessing the membrane potential to combat cancer progression

  Yang, M. & Brackenbury, W., 22 Mar 2022, (E-pub ahead of print) In: Bioelectricity.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Inhibition of the Na+/K+-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation

  Shandell, M. A., Capatina, A. L., Lawrence, S. M., Brackenbury, W. J. & Lagos, D., 9 Feb 2022, (E-pub ahead of print) In: The Journal of biological chemistry. 298, 3, p. 101707

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sampling and Analysis of Low-Molecular-Weight Volatile Metabolites in Cellular Headspace and Mouse Breath

  Redeker, K. R., Sweeney, S., Brackenbury, W. & Issitt, T., 27 Jun 2022, In: Metabolites. 12, 7, 16 p., 599.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium accumulation in breast cancer predicts malignancy and treatment response

  James, A. D., Leslie, T. K., Kaggie, J. D., Wiggins, L., Patten, L., Murphy O'Duinn, J., Langer, S., Labarthe, M.-C., Riemer, F., Baxter, G., McLean, M. A., Gilbert, F. J., Kennerley, A. J. & Brackenbury, W. J., 20 Jul 2022, In: British journal of cancer. 127, p. 337–349 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium channels and the ionic microenvironment of breast tumours

  Leslie, T. & Brackenbury, W., 2 Oct 2022, (E-pub ahead of print) In: Journal of Physiology. 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit

  Haworth, A. S., Hodges, S. L., Capatina, A. L., Isom, L. L., Baumann, C. G. & Brackenbury, W., Aug 2022, In: The Journal of biological chemistry. 298, 8, 18 p., 102174.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Volatile compounds in human breath: critical review and meta-analysis

  Issitt, T., Wiggins, L., Veysey, M., Sweeney, S., Brackenbury, W. & Redeker, K. R., 23 Feb 2022, In: Journal of Breath Research. 16, 2, 16 p., 024001.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Widespread association of ERα with RMRP and tRNA genes in MCF-7 cells and breast cancers

  Malcolm, J. R., Leese, N. K., Lamond-Warner, P. I., Brackenbury, W. J. & White, R. J., 5 May 2022, In: Gene. 821, 13 p., 146280.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2021

  Pharmacological and nutritional targeting of voltage-gated sodium channels in the treatment of cancers

  Lopez-Charcas, O., Pukkanasut, P., Velu, S. E., Brackenbury, W., Hales, T. G., Besson, P., Gomora, J. C. & Roger, S., 23 Apr 2021, In: iScience. 24, 26 p., 102270.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2020

  Inhibitory effect of eslicarbazepine acetate and S-licarbazepine on Nav1.5 channels

  Leslie, T., Bruckner, L., Chawla, S. & Brackenbury, W., 10 Sept 2020, (Accepted/In press) In: Frontiers in Pharmacology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Metastatic breast cancer cells induce altered microglial morphology & electrical excitability in vivo

  Simon, A. M., Yang, M., Marrison, J., James, A., Hunt, M. J., O'Toole, P. J., Kaye, P., Whittington, M. A., Chawla, S. & Brackenbury, W., 19 Mar 2020, In: Journal of Neuroinflammation. 17, 15 p., 87.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Targeting ion channels for cancer treatment: current progress and future challenges

  Capatina, A., Lagos, D. & Brackenbury, W., 1 Sept 2020, (E-pub ahead of print) In: Reviews of Physiology, Biochemistry and Pharmacology. 44 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2019

  Relationship between lecture capture usage and examination performance of undergraduate bioscience students

  Brackenbury, W., 23 Dec 2019, (E-pub ahead of print) In: Journal of Biological Education. 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium homeostasis in the tumour microenvironment

  Leslie, T. K., James, A. D., Zaccagna, F., Grist, J. T., Deen, S., Kennerley, A. J., Riemer, F., Kaggie, J. D., Gallagher, F. A., Gilbert, F. J. & Brackenbury, W. J., 23 Jul 2019, (E-pub ahead of print) In: BBA - Reviews on Cancer. 1872, 2, p. 1-16 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Voltage-dependent activation of Rac1 by Nav1.5 channels promotes cell migration

  Yang, M., James, A. D., Suman, R., Kasprowicz, R. M. R., Nelson, M., O'Toole, P. J. & Brackenbury, W. J., 15 Oct 2019, (E-pub ahead of print) In: Journal of cellular physiology. 23 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  High-Throughput, low-loss, low-cost, and label-free cell separation using electrophysiology-Activated cell enrichment

  Faraghat, S. A., Hoettges, K. F., Steinbach, M. K., van der Veen, D. R., Brackenbury, W. J., Henslee, E. A., Labeed, F. H. & Hughes, M. P., 13 Apr 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 18, p. 4591-4596 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines

  Thurber, A., Nelson, M., Frost, C., Levin, M., Brackenbury, W. J. & Kaplan, D. L., 21 Mar 2017, In: Oncotarget. 16 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Inhibition of N1-Src kinase by a specific SH3 peptide ligand reveals a role for N1-Src in neurite elongation by L1-CAM

  Keenan, S., Wetherill, S. J., Ugbode, C., Chawla, S., Brackenbury, W. J. & Evans, G. J. O., 21 Feb 2017, In: Scientific Reports. 7, p. 1-9 9 p., 43106.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2016

  Blockade of voltage-gated sodium channels inhibits invasion of endocrine resistant breast cancer cells

  Mohammed, F., Khajah, M., Yang, M., Brackenbury, W. & Luqmani, Y., Jan 2016, In: International journal of oncology. 48, 1, p. 73-83

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the CPRD primary care database

  Fairhurst, C. M., Martin, F., Watt, I. S., Doran, T., Bland, J. M. & Brackenbury, W. J., 6 Sept 2016, In: BMJ Open. 6, 9, 8 p., e011661.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo

  Nelson, M., Yang, M., Millican-Slater, R. & Brackenbury, W., 6 Oct 2015, In: Oncotarget. 6, 32, p. 32914-32929

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Sodium channel-inhibiting drugs and survival of breast, colon and prostate cancer: a population-based study

  Fairhurst, C. M., Watt, I., Martin, F., Bland, M. & Brackenbury, W., 18 Nov 2015, In: Scientific Reports. 5, p. 16758

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Therapeutic value of voltage-gated sodium channel inhibitors in breast, colorectal and prostate cancer: a systematic review

  Martin, F., Ufodiama, C., Watt, I., Bland, M. & Brackenbury, W., 12 Nov 2015, In: Frontiers in Pharmacology. 6, 273.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis.

  Nelson, M., Yang, M., Dowle, A., Thomas, J. & Brackenbury, W., 27 Jan 2015, In: Molecular Cancer. 14, 13.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2014

  Exposure to sodium channel-inhibiting drugs and cancer survival: protocol for a cohort study using the QResearch primary care database

  Fairhurst, C., Watt, I., Martin, F., Bland, M. & Brackenbury, W. J., 14 Nov 2014, In: BMJ Open. 4, 11, p. e006604

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation

  Fraser, S. P., Ozerlat-Gunduz, I., Brackenbury, W. J., Fitzgerald, E. M., Campbell, T. M., Coombes, R. C. & Djamgoz, M. B. A., 19 Mar 2014, In: Philosophical Transactions Of The Royal Society Of London Series B - Biological Sciences. 369, 1638, 12 p., 20130105.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• The sodium channel β1 subunit mediates outgrowth of neurite-like processes on breast cancer cells and promotes tumour growth and metastasis

  Nelson, M., Millican-Slater, R., Forrest, L. C. & Brackenbury, W. J., 15 Nov 2014, In: International Journal of Cancer. 135, 10, p. 2338-2351

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2013

  Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability

  Brackenbury, W. J., Yuan, Y., O'Malley, H. A., Parent, J. M. & Isom, L. L., 15 Jan 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 3, p. 1089-1094 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Therapeutic potential for phenytoin: targeting Na_v1.5 sodium channels to reduce migration and invasion in metastatic breast cancer

  Yang, M., Kozminski, D. J., Wold, L. A., Modak, R., Calhoun, J. D., Isom, L. L. & Brackenbury, W. J., Jul 2012, In: BREAST CANCER RESEARCH AND TREATMENT. 134, 2, p. 603-615 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2011

  Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo

  Lopez-Santiago, L. F., Brackenbury, W. J., Chen, C. & Isom, L. L., 1 Jul 2011, In: Journal of Biological Chemistry. 286, 26, p. 22913-23 11 p.

  Research output: Contribution to journal › Article › peer-review

• Voltage-Gated Na+ Channel beta 1B: A Secreted Cell Adhesion Molecule Involved in Human Epilepsy

  Patino, G. A., Brackenbury, W. J., Bao, Y., Lopez-Santiago, L. F., O'Malley, H. A., Chen, C., Calhoun, J. D., Lafreniere, R. G., Cossette, P., Rouleau, G. A. & Isom, L. L., 12 Oct 2011, In: Journal of neuroscience. 31, 41, p. 14577-14591 15 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth

  Brackenbury, W. J., Calhoun, J. D., Chen, C., Miyazaki, H., Nukina, N., Oyama, F., Ranscht, B. & Isom, L. L., 2 Feb 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 5, p. 2283-2288 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  A novel adhesion molecule in human breast cancer cells: Voltage-gated Na+ channel beta 1 subunit

  Chioni, A.-M., Brackenbury, W. J., Calhoun, J. D., Isom, L. L. & Djamgoz, M. B. A., May 2009, In: International Journal of Biochemistry and Cell Biology. 41, 5, p. 1216-1227 12 p.

  Research output: Contribution to journal › Article › peer-review
• 2008

  Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na⁺ channel activity

  Ding, Y., Brackenbury, W. J., Onganer, P. U., Montano, X., Porter, L. M., Bates, L. F. & Djamgoz, M. B. A., Apr 2008, In: Journal of cellular physiology. 215, 1, p. 77-81 5 p.

  Research output: Contribution to journal › Article › peer-review

  File

• Voltage-gated Na+ channel beta 1 subunit-mediated neurite outgrowth requires fyn kinase and contributes to postnatal CNS development in vivo

  Brackenbury, W. J., Davis, T. H., Chen, C., Slat, E. A., Detrow, M. J., Dickendesher, T. L., Ranscht, B. & Isom, L. L., 19 Mar 2008, In: Journal of neuroscience. 28, 12, p. 3246-3256 11 p.

  Research output: Contribution to journal › Article › peer-review
• 2007

  Nerve growth factor enhances voltage-gated Na+ channel activity and transwell migration in Mat-LyLu rat prostate cancer cell line

  Brackenbury, W. J. & Djamgoz, M. B. A., Mar 2007, In: Journal of cellular physiology. 210, 3, p. 602-608 7 p.

  Research output: Contribution to journal › Article › peer-review

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• The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells

  Brackenbury, W. J., Chioni, A.-M., Diss, J. K. J. & Djamgoz, M. B. A., Jan 2007, In: BREAST CANCER RESEARCH AND TREATMENT. 101, 2, p. 149-160 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2006

  Activity-dependent regulation of voltage-gated Na+ channel expression in Mat-LyLu rat prostate cancer cell line

  Brackenbury, W. J. & Djamgoz, M. B. A., 1 Jun 2006, In: Journal of Physiology. 573, 2, p. 343-356 14 p.

  Research output: Contribution to journal › Article › peer-review
• 2005

  Expression of Na+-dependent citrate transport in a strongly metastatic human prostate cancer PC-3M cell line: regulation by voltage-gated Na+ channel activity

  Mycielska, M. E., Palmer, C. P., Brackenbury, W. J. & Djamgoz, M. B. A., 1 Mar 2005, In: Journal of Physiology. 563, 2, p. 393-408 16 p.

  Research output: Contribution to journal › Article › peer-review