Research output per year
Research output per year
Research output
- 17 Article
- 17 results
Search results
-
2024
Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition
Ofman, T. P., Heming, J. J. A., Nin-Hill, A., Küllmer, F., Moran, E., Bennett, M., Steneker, R., Klein, A.-M., Ruijgrok, G., Kok, K., Armstrong, Z. W. B., Aerts, J. M. F. G., van der Marel, G. A., Rovira, C., Davies, G. J., Artola, M., Codée, J. D. C. & Overkleeft., H. S., 16 Apr 2024, (E-pub ahead of print) In: Chemistry - A European Journal. 10 p.Research output: Contribution to journal › Article › peer-review
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Epi-cyclophellitol cyclosulfate, a mechanism-based ER α-glucosidase II inhibitor, blocks replication of SARS-CoV-2 and other coronaviruses
Thaler, M., Ofman, T. P., Kok, K., Heming, J. J. A., Moran, E., Pickles, I., Leijs, A. A., Nieuwendijk, A. M. C. H. V. D., Berg, R. J. B. H. N. V. D., Ruijgrok, G., Armstrong, Z., Salgado-Benvindo, C., Ninaber, D. K., Snijder, E. J., Boeckel, C. A. A. V., Artola, M., Davies, G. J., Overkleeft, H. S. & Hemert, M. J. V., 9 Jul 2024, (Accepted/In press) In: ACS Central Science. 10, 8, p. 1594–1608Research output: Contribution to journal › Article › peer-review
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Molecular basis for inhibition of heparanases and β-glucuronidases by siastatin B
Chen, Y., van den Nieuwendijk, A. M. C. H., Wu, L., Moran, E., Skoulikopoulou, F., Riet, V. V., Overkleeft, H. S., Davies, G. J. & Armstrong, Z., 2024, In: Journal of the American Chemical Society. 146, 1, p. 125–133 9 p.Research output: Contribution to journal › Article › peer-review
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Precision activity-based α-amylase probes for dissection and annotation of linear and branched-chain starch degrading enzymes
Pickles, I. B., Chen, Y., Moroz, O., Brown, H. A., de Boer, C., Armstrong, Z., McGregor, N. G. S., Artola, M., Codée, J. D. C., Koropatkin, N. M., Overkleeft, H. S. & Davies, G. J., 27 Dec 2024, (E-pub ahead of print) In: Angewandte Chemie International Edition. 15 p., e202415219.Research output: Contribution to journal › Article › peer-review
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Structure-Guided Design of C3-Branched Swainsonine as Potent and Selective Human Golgi α-Mannosidase (GMII) Inhibitor
Koemans, T., Bennett, M., Ferraz, M. J., Armstrong, Z., Artola, M., Aerts, J. M. F. G., Codée, J. D. C., Overkleeft, H. S. & Davies, G. J., 20 Sept 2024, (E-pub ahead of print) In: Chemical Communications.Research output: Contribution to journal › Article › peer-review
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2023
4-O-Substituted Glucuronic Cyclophellitols are Selective Mechanism-Based Heparanase Inhibitors
Borlandelli, V., Armstrong, Z., Nin-Hill, A., Codée, J. D. C., Raich, L., Artola, M., Rovira, C., Davies, G. J. & Overkleeft, H. S., 14 Feb 2023, In: ChemMedChem. 18, 4, 7 p., e202200580.Research output: Contribution to journal › Article › peer-review
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Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum
Li, J., Sharma, M., Meek, R., Alhifthi, A., Armstrong, Z., Soler, N. M., Goddard-Borger, E. D., Blaza, J., Davies, G. J. & Williams, S. J., 25 Sept 2023, (E-pub ahead of print) In: Chemical Science. 12 p.Research output: Contribution to journal › Article › peer-review
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Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of α-Iduronidase, β-Glucuronidase and Heparanase**
Doherty, G. G., Ler, G. J. M., Wimmer, N., Bernhardt, P. V., Ashmus, R. A., Vocadlo, D. J., Armstrong, Z., Davies, G. J., Maccarana, M., Li, J. P., Kayal, Y. & Ferro, V., 14 Feb 2023, In: Chembiochem. 24, 4, 7 p., e202200619.Research output: Contribution to journal › Article › peer-review
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β-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining β-L-arabinofuranosidases
Borlandelli, V., Offen, W. A., Moroz, O., Nin-Hill, A., McGregor, N., Binkhorst, L., Ishiwata, A., Armstrong, Z., Artola, M., Rovira, C., Davies, G. J. & Overkleeft, H. S., 5 Dec 2023, (E-pub ahead of print) In: ACS Chemical Biology. 18, 12, p. 2564–2573 10 p.Research output: Contribution to journal › Article › peer-review
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2022
Cryo-EM structures of human fucosidase FucA1 reveal insight into substate recognition and catalysis
Armstrong, Z., Meek, R. W., Wu, L., Blaza, J. N. & Davies, G. J., 29 Jul 2022, (E-pub ahead of print) In: Structure. 30, 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanism based heparanase inhibitors reduce cancer metastasis in vivo
Boer, C. D., Armstrong, Z., Lit, V. A. J., Barash, U., Ruijgrok, G., Boyango, I., Weitzenberg, M. M., Schröder, S. P., Sarris, A. J. C., Meeuwenoord, N. J., Bule, P., Kayal, Y., Ilan, N., Codée, J. D. C., Vlodavsky, I., Overkleeft, H. S., Davies, G. J. & Wu, L., 26 Jul 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 31, e2203167119.Research output: Contribution to journal › Article › peer-review
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Synthesis of Broad-Specificity Activity-Based Probes for Exo-β-Mannosidases
McGregor, N. G. S., Kuo, C.-L., Beenakker, T. J. M., Wong, C.-S., Offen, W. A., Armstrong, Z., Florea, B. I., Codée, J. D. C., Overkleeft, H. S., Aerts, J. M. F. G. & Davies, G. J., 28 Jan 2022, In: Organic and Biomolecular Chemistry. 20, p. 877-886 10 p.Research output: Contribution to journal › Article › peer-review
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The structure of Phocaeicola vulgatus sialic acid acetylesterase
Scott, H., Davies, G. J. & Armstrong, Z., 1 May 2022, In: Acta Crystallographica Section D: Structural Biology. D78, p. 647-657Research output: Contribution to journal › Article › peer-review
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2021
Activity-based protein profiling of retaining α-amylases in complex biological samples
Chen, Y., Armstrong, Z., Artola, M., Florea, B. I., Kuo, C.-L., de Boer, C., Rasmussen, M. S., Hachem, M. A., van der Marel, G. A., Codée, J. D. C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 26 Jan 2021, (E-pub ahead of print) In: Journal of the American Chemical Society. 143, 5, p. 2423-2432Research output: Contribution to journal › Article › peer-review
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2020
Manno- epi-cyclophellitols Enable Activity-Based Protein Profiling of Human α-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors
Armstrong, Z., Kuo, C. L., Lahav, D., Liu, B., Johnson, R., Beenakker, T. J. M., De Boer, C., Wong, C. S., Van Rijssel, E. R., Debets, M. F., Florea, B. I., Hissink, C., Boot, R. G., Geurink, P. P., Ovaa, H., Van Der Stelt, M., Van Der Marel, G. M., Codée, J. D. C., Aerts, J. M. F. G. & Wu, L. & 2 others, , 29 Jul 2020, In: Journal of the American Chemical Society. 142, 30, p. 13021-13029 9 p.Research output: Contribution to journal › Article › peer-review
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Structure and function of Bs164 β-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164
Armstrong, Z. & Davies, G. J., 27 Mar 2020, In: The Journal of biological chemistry. 295, 13, p. 4316-4326 19 p.Research output: Contribution to journal › Article › peer-review
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2019
An overview of activity-based probes for glycosidases
Wu, L., Armstrong, Z., Schröder, S. P., Boer, C. D., Artola, M., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., Dec 2019, In: Current Opinion in Chemical Biology. 53, p. 25-36Research output: Contribution to journal › Article › peer-review
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