Cutaneous leishmaniasis (CL) is a disfiguring disease caused by infections with Leishmania parasites. At least 20,000 cases of CL occur each year in Brazil. Treatment failure is documented in about 50% of cases. CL disease develops in three forms; localized, disseminated and mucocutaneous. It is not well understood why some patients develop mild localized cutaneous disease while others suffer from severely-disfiguring mucocutaneous CL. Some studies suggest that the three forms of CL can be caused by different Leishmania braziliensis subtypes. However, the relevance of parasite subtypes to disease outcome is poorly understood. To address this, we will collect and sequence the genomes of parasites from 40 patients and record disease symptoms of each patient in collaboration with Prof. Carvalho (Bahia state, Brazil). We will then test whether particular parasite subtypes cause different CL disease outcomes. This is an urgent need, as CL cases are rising in Bahia state.
|Effective start/end date||14/02/22 → 31/07/22|