C2D2 Research 5a - Towards biosensors and nanoconstruction with a novel protein building block

Stratified and personalised medicine and the associated need for multiplexed detection are driving the development of novel biosensor arrays. A critical challenge facing these technologies is the identification of immobilisation strategies that ensure binding affinity and specificity are retained following selective integration of specific antibodies with individual biosensors within an array. This proposal will address this challenge using a novel repetitive protein scaffold discovered in the Potts group to direct the assembly of antibodies with high spatial resolution. Our technology will underpin future innovation of multiplexed biosensors capable of detecting a variety of antigens including bacteria, disease biomarkers and drugs.