CFH1 Partnership - Pharmaceutical Optimisation using a Laboratory Automated Reaction Intelligent System (POLARIS)

Scientists are dependent on lead chemical compounds with precise ‘drugable’ properties. Chemical synthesis of new drug targets requires multiple reaction steps, e.g. 4-10 steps. A key problem is in optimising each chemical reaction – it is common to dedicate 6 months to one step, creating a drug development bottleneck, arising from the way that chemical reactions are optimised one at a time.
This inefficient work pattern operates in drug discovery laboratories the world over. In this knowledge transfer project a Pharmaceutical Optimisation using a Laboratory Automated Reaction Intelligent System (POLARIS) will be developed to improve the chemical synthesis of drug targets.