Dissection of alpha mannosidases from reaction corodinate to inhibition

Research output

Research output per year 2009 2010 2012 2014 2018

• 12 Article

Research output per year

Research output per year

Search results

• 2018

  Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif

  Thompson, A. J., Spears, R. J., Zhu, Y., Suits, M. D. L., Williams, S. J., Gilbert, H. J. & Davies, G. J., 1 May 2018, In: Acta crystallographica. Section D, Structural biology. 74, 5, p. 394-404 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2017

  An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-α-mannanase inhibitor

  Belz, T., Jin, Y., Coines, J., Rovira, C., Davies, G. J. & Williams, S. J., 25 Aug 2017, In: Chemical Communications. 53, 66, p. 9238-9241 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2015

  Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

  Thompson, A. J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R. J., Chandler, E., Temple, M. J., Stepper, J., Gilbert, H. J., Rovira, C., Williams, S. J. & Davies, G. J., 27 Apr 2015, In: Angewandte Chemie International Edition. 54, 18, p. 5378-5382 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2014

  Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate

  Williams, R. J., Iglesias-Fernández, J., Stepper, J., Jackson, A., Thompson, A. J., Lowe, E. C., White, J. M., Gilbert, H. J., Rovira, C., Davies, G. J. & Williams, S. J., 20 Jan 2014, In: Angewandte Chemie International Edition. 53, 4, p. 1087-1091 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

• Dissecting conformational contributions to glycosidase catalysis and inhibition

  Speciale, G., Thompson, A. J., Davies, G. J. & Williams, S. J., Oct 2014, In: CURRENT OPINION IN STRUCTURAL BIOLOGY. 28, 1, p. 1-13 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• 2013

  Structure and activity of the Streptococcus pyogenes family GH1 6-phospho-β-glucosidase SPy1599

  Stepper, J., Dabin, J., Eklof, J. M., Thongpoo, P., Kongsaeree, P., Taylor, E. J., Turkenburg, J. P., Brumer, H. & Davies, G. J., Jan 2013, In: Acta Crystallographica. Section D, Biological Crystallography. 69, Pt 1, p. 16-23 8 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Fleetamine (3-O-alpha-D-glucopyranosyl-swainsonine): the synthesis of a hypothetical inhibitor of endo-alpha-mannosidase

  Quach, T., Tsegay, S., Thompson, A. J., Kukushkin, N. V., Alonzi, D. S., Butters, T. D., Davies, G. J. & Williams, S. J., 15 Jul 2012, In: TETRAHEDRON-ASYMMETRY. 23, 13, p. 992-997 6 p.

  Research output: Contribution to journal › Article › peer-review

• Structural and mechanistic insight into N-glycan processing by endo-alpha-mannosidase

  Thompson, A. J., Williams, R. J., Hakki, Z., Alonzi, D. S., Wennekes, T., Gloster, T. M., Songsrirote, K., Thomas-Oates, J. E., Wrodnigg, T. M., Spreitz, J., Stuetz, A. E., Butters, T. D., Williams, S. J. & Davies, G. J., 17 Jan 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 3, p. 781-786 6 p.

  Research output: Contribution to journal › Article › peer-review

• The Reaction Coordinate of a Bacterial GH47 α-Mannosidase: A Combined Quantum Mechanical and Structural Approach

  Thompson, A. J., Dabin, J., Iglesias-Fernandez, J., Ardevol, A., Dinev, Z., Williams, S. J., Bande, O., Siriwardena, A., Moreland, C., Hu, T.-C., Smith, D. K., Gilbert, H. J., Rovira, C. & Davies, G. J., 29 Oct 2012, In: Angewandte Chemie International Edition. 51, 44, p. 10997-11001 5 p.

  Research output: Contribution to journal › Article › peer-review
• 2010

  Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont

  Zhu, Y., Suits, M. D. L., Thompson, A. J., Chavan, S., Dinev, Z., Dumon, C., Smith, N., Moremen, K. W., Xiang, Y., Siriwardena, A., Williams, S. J., Gilbert, H. J. & Davies, G. J., Feb 2010, In: NATURE CHEMICAL BIOLOGY. 6, 2, p. 125-132 8 p.

  Research output: Contribution to journal › Article › peer-review

• Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 α-Mannosidase

  Suits, M. D. L., Zhu, Y., Taylor, E. J., Walton, J., Zechel, D. L., Gilbert, H. J. & Davies, G. J., 3 Feb 2010, In: PLoS ONE. 5, 2, p. - 11 p., e9006.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis

  Offen, W. A., Zechel, D. L., Withers, S. G., Gilbert, H. J. & Davies, G. J., 2009, In: Chemical Communications. 18, p. 2484-2486 3 p.

  Research output: Contribution to journal › Article › peer-review