Dissection of the Leishmania mannogen biosynthetic pathway: beta 1-2 mannan in pathogens and beyond

Davies, Gideon John (Principal investigator)

Chemistry

Project: Research project (funded) › Research

Status	Finished
Effective start/end date	20/01/20 → 19/04/23

Funding

BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL): £429,706.77

5 Article
1 Review article

Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy
Males, A., Kok, K., Nin-Hill, A., Beukel, S. V. D., Beenakker, T. J. M., van der Marel, G. A., Codée, J. D. C., Overkleeft, H. S., Rovira, C., Davies, G. J. & Artola, M., 17 Nov 2023, In: Chemical Science. 14, p. 13581-13586 6 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Human O-GlcNAcase Uses a Preactivated Boat-like Substrate Conformation for Catalysis: Evidence from X-ray Crystallography and QM/MM Metadynamics
Calvelo, M., Males, A., Alteen, M. G., Willems, L. I., Vocadlo, D. J., Davies, G. J. & Rovira, C., 10 Oct 2023, (E-pub ahead of print) In: ACS Catalysis. 13, p. 13672–13678
Research output: Contribution to journal › Article › peer-review

Open Access
File
Structure, function and mechanism of N-glycan processing enzymes: endo-α-1,2-mannanase and endo-α-1,2-mannosidase
Burchill, L., Males, A., Kaur, A., Davies, G. J. & Williams, S. J., 1 Feb 2023, In: Israel Journal of Chemistry. 63, 1-2, 13 p., e202200067.
Research output: Contribution to journal › Article › peer-review

Open Access
File