Glycosylation: Programmes for Observation, Inhibition & Structure-based Exploitation of key carbohydrate-active enzymes

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• 2020

  An epoxide intermediate in glycosidase catalysis

  Sobala, L. F., Speciale, G., Zhu, S., Raich, L., Sannikova, N., Thompson, A. J., Hakki, Z., Lu, D., Abadi, S. S. K., Lewis, A. R., Rojas-Cervellera, V., Bernardo-Seisdedos, G., Zhang, Y., Millet, O., Jiménez-Barbero, J., Bennet, A. J., Sollogoub, M., Rovira, C., Davies, G. J. & Williams, S. J., 27 May 2020, In: ACS Central Science. 6, 5, p. 760-770

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• Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling

  Jariwala, P. B., Pellock, S. J., Cloer, E. W., Artola, M., Simpson, J. B., Bhatt, A. P., Walton, W. G., Roberts, L. R., Davies, G. J., Overkleeft, H. S. & Redinbo, M. R., 17 Jan 2020, In: ACS Chemical Biology. 15, p. 217-225 9 p.

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• Structural insights into heparanase activity using a fluorogenic heparan sulfate disaccharide

  Wu, L., Wimmer, N., Davies, G. J. & Ferro, V., 18 Nov 2020, In: Chemical Communications. 56, 89, p. 13780-13783 4 p.

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• Substrate Engagement and Catalytic Mechanisms of N-Acetylglucosaminyltransferase v

  Darby, J. F., Gilio, A. K., Piniello, B., Roth, C., Blagova, E., Hubbard, R. E., Rovira, C., Davies, G. J. & Wu, L., 7 Aug 2020, In: ACS Catalysis. 10, 15, p. 8590-8596 7 p.

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• 2019

  A family of dual-activity glycosyltransferasesphosphorylases mediates mannogen turnover and virulence in Leishmania parasites

  Sernee, M. F., Ralton, J. E., Nero, T. L., Sobala, L. F., Kloehn, J., Viera-Lara, M., Cobbold, S. A., Stanton, L., Pires, D. E. V., Hanssen, E., Males, A., Ward, T., Bastidas, L. M., Peet, P. L. V. D., Parker, M. W., Ascher, D. B., Williams, S. J., Davies, G. J. & McConville, M. J., 11 Sept 2019, In: Cell Host & Microbe. 26, 3, p. 385-399 15 p.

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• An overview of activity-based probes for glycosidases

  Wu, L., Armstrong, Z., Schröder, S. P., Boer, C. D., Artola, M., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., Dec 2019, In: Current Opinion in Chemical Biology. 53, p. 25-36

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• 2018

  Exploration of Strategies for Mechanism-Based Inhibitor Design for Family GH99 endo-α-1,2-Mannanases

  Fernandes, P. Z., Petricevic, M., Sobala, L., Davies, G. J. & Williams, S. J., 23 May 2018, In: Chemistry : A European Journal. 24, 29, p. 7464-7473 10 p.

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• From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-α-mannosidase

  Lu, D., Zhu, S., Sobala, L. F., Bernardo-Seisdedos, G., Millet, O., Zhang, Y., Jiménez-Barbero, J., Davies, G. J. & Sollogoub, M., 7 Dec 2018, In: Organic Letters. 20, 23, p. 7488-7492 5 p.

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• Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor

  Schröder, S. P., Wu, L., Artola, M., Hansen, T., Offen, W. A., Ferraz, M. J., Li, K.-Y., Aerts, J. M. F. G., Van Der Marel, G. A., Codée, J. D. C., Davies, G. J. & Overkleeft, H. S., 2018, In: Journal of the American Chemical Society. p. 1-4 4 p.

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• Spiro-epoxyglycosides as Activity-Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase

  Schröder, S. P., Kallemeijn, W. W., Debets, M. F., Hansen, T., Sobala, L. F., Hakki, Z., Williams, S. J., Beenakker, T. J. M., Aerts, J. M. F. G., Van Der Marel, G. A., Codée, J. D. C., Davies, G. J. & Overkleeft, H. S., 24 May 2018, (E-pub ahead of print) In: Chemistry : A European Journal. 11 p.

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• 2017

  1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor

  Artola, M., Wu, L., Ferraz, M. J., Kuo, C. L., Raich, L., Breen, I. Z., Offen, W. A., Codée, J. D. C., Van Der Marel, G. A., Rovira, C., Aerts, J. M. F. G., Davies, G. J. & Overkleeft, H. S., 26 Jul 2017, In: ACS Central Science. 3, 7, p. 784-793 10 p.

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• Activity-based probes for functional interrogation of retaining β-glucuronidases

  Wu, L., Jiang, J., Jin, Y., Kallemeijn, W. W., Kuo, C. L., Artola, M., Dai, W., Van Elk, C., Van Eijk, M., Van Der Marel, G. A., Codée, J. D. C., Florea, B. I., Aerts, J. M. F. G., Overkleeft, H. S. & Davies, G. J., 1 Aug 2017, In: NATURE CHEMICAL BIOLOGY. 13, 8, p. 867-873 7 p.

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• An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-α-mannanase inhibitor

  Belz, T., Jin, Y., Coines, J., Rovira, C., Davies, G. J. & Williams, S. J., 25 Aug 2017, In: Chemical Communications. 53, 66, p. 9238-9241 4 p.

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• Carba-Cyclophellitols are Neutral Retaining Glucosidase Inhibitors

  Beenakker, T. J. M., Wander, D., Offen, W. A., Artola, M., Raich, L., Ferraz, M. J., Li, K.-Y., Houben, J. H. P. M., Rijssel, E. R. V., Hansen, T., Marel, G. A. V. D., Codée, J. D. C., Aerts, J. M. F. G., Rovira, C., Davies, G. J. & Overkleeft, H. S., 2017, In: Journal of the American Chemical Society. 139, 19, p. 6534–6537

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• Contribution of shape and charge to the inhibition of a family GH99 endo-α-1,2-mannanase

  Petricevic, M., Sobala, L., Fernandes, P. Z., Raich, L., Thompson, A. J., Ganeko , B.-S., Millet, O., Zhu, S., Sollogoub, M., Jiménez-Barbero, J., Rovira, C., Davies, G. J. & Williams, S. J., 2017, In: Journal of the American Chemical Society. 139, 3, p. 1089–1097 jacs.6b10075.

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• Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines

  Schroder, S. P., van de Sande, J. W., Kallemeijn, W. W., Kuo, C.-L., Artola, M., van Rooden, E. J., Jiang, J., Beenakker, T. J., Florea, B. I., Offen, W. A., Davies, G., Minnaard, A. J., Aerts, H., Codee, J. D., Van Der Marel, G. A. & Overkleeft, H. S., 6 Nov 2017, (E-pub ahead of print) In: Chemical Communications. p. 1-5 5 p.

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• 2015

  Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

  Thompson, A. J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R. J., Chandler, E., Temple, M. J., Stepper, J., Gilbert, H. J., Rovira, C., Williams, S. J. & Davies, G. J., 27 Apr 2015, In: Angewandte Chemie International Edition. 54, 18, p. 5378-5382 5 p.

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• Structural characterization of human heparanase reveals insights into substrate recognition

  Wu, L., Viola, C. M., Brzozowski, A. M. & Davies, G. J., 16 Nov 2015, In: Nature Structural & Molecular Biology. 22, 12, p. 1016-1022 7 p.

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