Hyperpolarisation using SABRE as a new tool for imaging

Research output

Research output per year 2013 2015 2016 2017 2018 2019 2020 2022

• 56 Article
• 1 Review article

Research output per year

Research output per year

Search results

• 2022

  In Situ Ternary Adduct Formation of Yttrium Polyaminocarboxylates Leads to Small Molecule Capture and Activation

  Duckett, S. B., Tickner, B., Angelovski, G. & Platas-Iglesias, C., 13 Oct 2022, In: Chemistry : A European Journal. 28, 57, e202201780.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Towards Optimising and Understanding Reversible Hyperpolarisation of Lactate Esters Relayed from Parahydrogen

  Tickner, B., Svensson, S.K.-M., Vaara, J. & Duckett, S. B., 21 Jul 2022, In: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 13, p. 6859–6866 8 p.

  Research output: Contribution to journal › Article › peer-review

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• 2021

  Exploring the hyperpolarisation of EGTA-based ligands using SABRE

  Tickner, B., Borozdina, Y., Duckett, S. B. & Angelovski, G., 22 Jan 2021, (E-pub ahead of print) In: Dalton Transactions. p. 1-15 15 p.

  Research output: Contribution to journal › Article › peer-review

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• Hyperpolarisation of weakly binding N-heterocycles using Signal Amplification by Reversible Exchange

  Rayner, P. J., Gillions, J., Hannibal, V., John, R. O. & Duckett, S. B., 28 Apr 2021, In: Chemical Science. 12, 16, p. 5910-5917

  Research output: Contribution to journal › Article › peer-review

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• Steric and Electronic Effects on the 1H Hyperpolarisation of Substituted Pyridazines by Signal Amplification by Reversible Exchange

  Rayner, P. J., Burns, M., Fear, E. & Duckett, S. B., 14 Nov 2021, In: MAGNETIC RESONANCE IN CHEMISTRY. 59, 12, p. 1187-1198

  Research output: Contribution to journal › Article › peer-review

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• 2020

  A role for low concentration reaction intermediates in the signal amplification by reversible exchange process revealed by theory and experiment

  Fekete, M., Roy, S. S. & Duckett, S. B., 18 Feb 2020, In: Physical chemistry chemical physics : PCCP. 22, 9, p. 5033-5037 5 p., CP-COM-11-2019-006386.R1.

  Research output: Contribution to journal › Article › peer-review

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• A Simple and Cost-efficient Technique to Generate Hyperpolarized Long-lived 15N-15N Nuclear Spin Order in a Diazine by Signal Amplification by Reversible Exchange

  Roy, S. S., Rayner, P. J., Burns, M. & Duckett, S. B., 2 Jan 2020, (E-pub ahead of print) In: The Journal of Chemical Physics. 152, 7 p., 014201.

  Research output: Contribution to journal › Article › peer-review

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• Optimisation of Pyruvate Hyperpolarisation using SABRE by Tuning the Active Magnetisation Transfer Catalyst

  Tickner, B., IALI, W., Semenova, O., Rayner, P. J., Whitwood, A. C. & Duckett, S. B., 28 Jan 2020, (E-pub ahead of print) In: Catalysis Science and Technology. 14 p., C9CY02498K.

  Research output: Contribution to journal › Article › peer-review

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• Remarkable Levels of 15N Polarization Delivered through SABRE Into Unlabeled Pyridine, Pyrazine or Metronidazole Enable Single Scan NMR Quantification at the mM Level

  Fekete, M., Ahwal, F. & Duckett, S. B., 8 May 2020, (E-pub ahead of print) In: Journal of Physical Chemistry B. jp-2020-02583e.

  Research output: Contribution to journal › Article › peer-review

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• Reversible hyperpolarization of ketoisocaproate using sulfoxide-containing polarization transfer catalysts

  Tickner, B., Ahwal, F., Whitwood, A. C. & Duckett, S. B., 26 Nov 2020, (E-pub ahead of print) In: ChemPhysChem. 6 p., 202000825R1 .

  Research output: Contribution to journal › Article › peer-review

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• The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized 29Si Nuclear Magnetic Resonance

  Duckett, S. B., Rayner, P. J. & Richardson, P. M., 10 Feb 2020, In: Angewandte Chemie International Edition. 59, 7, p. 2710-2714 5 p., 201915098.

  Research output: Contribution to journal › Article › peer-review

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• Using SABRE hyperpolarized ¹³C NMR to interrogate organic transformations of pyruvate

  Tickner, B., Rayner, P. J. & Duckett, S. B., 8 Jun 2020, (E-pub ahead of print) In: Analytical Chemistry. p. 1-9 9 p., ac-2020-01334p.R1.

  Research output: Contribution to journal › Article › peer-review

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• 2019

  Catalyst-Substrate Effects on Biocompatible SABRE Hyperpolarization

  Manoharan, A., Rayner, P. J., Fekete, M., Iali, W., Norcott, P., Hugh Perry, V. & Duckett, S. B., 21 Jan 2019, In: ChemPhysChem. 20, 2, p. 285-294 10 p.

  Research output: Contribution to journal › Article › peer-review

• Hyperpolarizing Pyruvate through Signal Amplification By Reversible Exchange (SABRE)

  Iali, W., Roy, S. S., Tickner, B. J., Ahwal, F., Kennerley, A. J. & Duckett, S., 17 Jun 2019, In: Angewandte Chemie International Edition. 58, 30, p. 10271-10275 5 p.

  Research output: Contribution to journal › Article › peer-review

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• Mechanistic Insight into Novel Sulfoxide Containing SABRE Polarisation Transfer Catalysts

  Tickner, B. J., Lewis, J. S., John, R. O., Whitwood, A. C. & Duckett, S., 24 Sept 2019, In: Dalton Transactions. 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Pharmacokinetics of the SABRE agent 4,6-d2-Nicotinamide and also Nicotinamide in rats following oral and intravenous administration

  Linnik, I., Rayner, P. J., Stow, R., Duckett, S. & Cheetham, G. M. T., 1 Jul 2019, In: European journal of pharmaceutical sciences. 135, p. 32-37 6 p., EJPS-D-19-00374R1.

  Research output: Contribution to journal › Article › peer-review

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• Probing the hydrogenation of vinyl sulfoxides using para-hydrogen

  Tickner, B. J., Duckett, S., Parker, R. R. & Whitwood, A. C., 14 Nov 2019, (E-pub ahead of print) In: Organometallics. 38, 22, 9b00610.

  Research output: Contribution to journal › Article › peer-review

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• Rapid 13C NMR Hyperpolarization delivered from para-hydrogen enables the low concentration detection and quantification of sugars

  Richardson, P. M., Iali, W., Roy, S. S., Rayner, P. J., Halse, M. E. & Duckett, S., 7 Dec 2019, In: Chemical Science. C9SC03450A.

  Research output: Contribution to journal › Article › peer-review

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• Reaction monitoring using SABRE-hyperpolarized benchtop (1 T) NMR spectroscopy

  Semenova, O., Richardson, P. M., Parrott, A., Nordon, A., Halse, M. E. & Duckett, S., 21 May 2019, In: Analytical Chemistry. 91, 10, p. 6695-6701 7 p., 9b00729.

  Research output: Contribution to journal › Article › peer-review

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• Relayed hyperpolarisation from para-hydrogen improves the NMR detectability of alcohols

  Rayner, P. J., Tickner, B. J., Iali, W., Fekete, M., Robinson, A. D. & Duckett, S. B., 1 Jul 2019, In: Chemical Science. 10, 33, p. 7709-7717 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Understanding substrate substituent effects to improve catalytic efficiency in the SABRE hyperpolarisation process

  Stanbury, E., Richardson, P. M. & Duckett, S., 7 Aug 2019, In: Catalysis Science and Technology. 9, p. 3914-3922 CY-ART-02-2019-000396.R1.

  Research output: Contribution to journal › Article › peer-review

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• Using coligands to gain mechanistic insight into iridium complexes hyperpolarized with parahydrogen

  Tickner, B. J., John, R. O., Roy, S. S., Hart, S. J., Whitwood, A. C. & Duckett, S., 19 Mar 2019, (E-pub ahead of print) In: Chemical Science.

  Research output: Contribution to journal › Article › peer-review

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• 2018

  Direct and Indirect Hyperpolarisation of Amines using Parahydrogen

  Iali, W., Rayner, P. J., Alshehri, A. M. M., Holmes, J., Ruddlesden, A. J. & Duckett, S., 21 Apr 2018, In: Chemical Science. 9, 15, p. 3677-3684 8 p., C8SC00526E.

  Research output: Contribution to journal › Article › peer-review

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• Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design

  Rayner, P. J., Norcott, P., Appleby, K. M., Iali, W., John, R. O., Hart, S. J., Whitwood, A. C. & Duckett, S., 12 Oct 2018, In: Nature Communications. 9, 1, 11 p., 4251.

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• Iridium α-carboxyimine complexes hyperpolarized with parahydrogen exist in nuclear singlet states before conversion into iridium carbonates

  Tickner, B. J., Iali, W., Roy, S. S., Whitwood, A. C. & Duckett, S. B., 27 Sept 2018, In: ChemPhysChem. 6 p., cphc.201800829.

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• SABRE-Relay: A Versatile Route to Hyperpolarization

  Roy, S. S., Appleby, K. M., Fear, E. J. & Duckett, S. B., 1 Mar 2018, In: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 9, 5, p. 1112-1117 6 p., jz-2017-03026f.R3.

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• Unlocking a diazirine long-lived nuclear singlet state via photochemistry: NMR detection and lifetime of an unstabilized diazo-compound

  Procacci, B., Roy, S. S., Norcott, P., Turner, N. & Duckett, S., 5 Dec 2018, In: Journal of the American Chemical Society. 140, 48, p. 16855-16864 10 p.

  Research output: Contribution to journal › Article › peer-review

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• Using 2H Labelling to Improve the NMR detectability of a Series of Pyridines by SABRE

  Norcott, P., Burns, M. J., Rayner, P. J., Mewis, R. E. & Duckett, S. B., 25 Jan 2018, (E-pub ahead of print) In: MAGNETIC RESONANCE IN CHEMISTRY. 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Using hyperpolarised NMR and DFT to rationalise the unexpected hydrogenation of quinazoline to 3,4-dihydroquinazoline

  Richards, J. E., Hooper, A. J. J., Bayfield, O. W., Cockett, M. C. R., Dear, G. J., Holmes, A. J., John, R. O., Mewis, R. E., Pridmore, N., Roberts, A. D., Whitwood, A. C. & Duckett, S. B., 18 Sept 2018, In: Chemical Communications. 54, 73, p. 10375-10378 4 p.

  Research output: Contribution to journal › Article › peer-review

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• Using Parahydrogen to Hyperpolarize Amines, Amides, Carboxylic Acids, Alcohols, Phosphates and Carbonates

  Iali, W., Rayner, P. J. & Duckett, S. B., 5 Jan 2018, In: Science Advances. 4, 1, 7 p., eaao6250.

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• 2017

  Achieving Biocompatible SABRE: An in vitro Cytotoxicity Study

  Manoharan, A., Rayner, P. J., Iali, W., Burns, M. J., Perry, V. H. & Duckett, S. B., 12 Dec 2017, (E-pub ahead of print) In: ChemMedChem. 9 p.

  Research output: Contribution to journal › Article › peer-review

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• Achieving High ¹H Nuclear Hyperpolarization Levels with Long Lifetimes in a Range of Tuberculosis Drug Scaffolds

  Norcott, P., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 1 Dec 2017, (E-pub ahead of print) In: Chemistry : A European Journal. 23, 67, p. 16990-16997 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Achieving High Levels of NMR-Hyperpolarization in Aqueous Media With Minimal Catalyst Contamination via SABRE

  Iali, W., Olaru, A. M., Green, G. G. R. & Duckett, S. B., 19 Jul 2017, In: Chemistry : A European Journal. 23, 44, p. 10491–10495 6 p., EMID:5887bf1d5bf20112.

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• A Simple Route to Strong Carbon-13 NMR Signals Detectable for Several Minutes

  Roy, S. S., Norcott, P., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 19 Jul 2017, In: Chemistry : A European Journal. 23, 44, p. 10496-10500 5 p.

  Research output: Contribution to journal › Article › peer-review

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• Delivering strong ¹H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange

  Rayner, P. J., Burns, M. J., Olaru, A. M., Norcott, P., Fekete, M., Green, G. G. R., Highton, L. A. R., Mewis, R. E. & Duckett, S. B., 18 Apr 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 16, p. E3188-E3194 2016-20457RR.

  Research output: Contribution to journal › Article › peer-review

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• Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE

  Roy, S. S., Stevanato, G., Rayner, P. J. & Duckett, S. B., 1 Dec 2017, In: Journal of Magnetic Resonance. 285, p. 55-60 6 p., YJMRE6177.

  Research output: Contribution to journal › Article › peer-review

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• Harnessing polarisation transfer to indazole and imidazole through signal amplification by reversible exchange to improve their NMR detectability

  Fekete, M., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 11 May 2017, (E-pub ahead of print) In: MAGNETIC RESONANCE IN CHEMISTRY. p. 1-31 31 p., MRC4607.

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• SABRE hyperpolarisation of vitamin B3 as a function of pH

  Olaru, A. M., Burns, M. J., Green, G. G. R. & Duckett, S. B., 1 Mar 2017, In: Chemical Science. 8, 3, p. 2257-2266 10 p.

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• Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by 1H-NMR spectrscopy

  Diaz-Rullo, F., Zamberlan, F., Mewis, R. E., Fekete, M., Broche, L., Cheyne, L., Dall’Angelo, S., Duckett, S., Dawson, D. & Zanda, M., 21 Mar 2017, (E-pub ahead of print) In: Bioorganic & Medicinal Chemistry. 13 p., BMC_2016_473_R1 .

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• 2016

  A Hyperpolarizable ¹H Magnetic Resonance Probe for Signal Detection 15 Minutes after Spin Polarization Storage

  Roy, S. S., Norcott, P., Rayner, P. J., Green, G. G. R. & Duckett, S. B., 12 Dec 2016, In: Angewandte Chemie International Edition. 55, 50, p. 15642-15645 4 p.

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• Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE

  Duckett, S., Green, G. G. R., Olaru, M. A., Singha Roy, S., Lloyd, L. S. & Coombes, S., 31 May 2016, (E-pub ahead of print) In: Chemical Communications. 4 p.

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• Iridium Cyclooctene Complex Forms a Hyperpolarization Transfer Catalyst Before Converting to a Binuclear C-H Bond Activation Product Responsible for Hydrogen Isotope Exchange

  Iali, W., Duckett, S., Green, G. G. R., Hart, S. J. & Whitwood, A. C., 9 Nov 2016, (E-pub ahead of print) In: Inorganic Chemistry. p. 1-5 5 p.

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• Long-lived States to Sustain SABRE Hyperpolarised Magnetisation

  Singha Roy, S., Rayner, P. J., Norcott, P., Green, G. G. R. & Duckett, S., 28 Sept 2016, In: Physical chemistry chemical physics : PCCP. 18, 36, p. 24905-24911 7 p.

  Research output: Contribution to journal › Article › peer-review

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• Solvent responsive catalyst improves NMR sensitivity via efficient magnetisation transfer

  Duckett, S. & Ruddlesden, A. J., 2 Jun 2016, (E-pub ahead of print) In: Chemical communications. 5 p.

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• Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei

  Olaru, A. M., Burt, A., Rayner, P. J., Hart, S. J., Whitwood, A. C., Green, G. G. R. & Duckett, S. B., 13 Dec 2016, In: Chemical Communications. 52, 100, p. 14482-14485 4 p.

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• 2015

  Catalytic Transfer of Magnetism Using a Neutral Iridium Phenoxide Complex

  Ruddlesden, A. J., Mewis, R. E., Green, G. G. R., Whitwood, A. C. & Duckett, S. B., 2015, In: Organometallics.

  Research output: Contribution to journal › Article › peer-review

• Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application

  Mewis, R. E., Fekete, M., Green, G. G. R., Whitwood, A. C. & Duckett, S. B., 2015, In: Chemical Communications. 51, p. 9857-9859 3 p.

  Research output: Contribution to journal › Article › peer-review

• Improving the hyperpolarization of (31)p nuclei by synthetic design

  Burns, M. J., Rayner, P. J., Green, G. G. R., Highton, L. A. R., Mewis, R. E. & Duckett, S. B., 26 Mar 2015, In: Journal of Physical Chemistry B. 119, 15, p. 5020-5027 8 p.

  Research output: Contribution to journal › Article › peer-review

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• Strategies for the hyperpolarization of acetonitrile and related Ligands by SABRE

  Mewis, R. E., Green, R. A., Cockett, M. C. R., Cowley, M. J., Duckett, S. B., Green, G. G. R., John, R. O., Rayner, P. J. & Williamson, D. C., 29 Jan 2015, In: Journal of Physical Chemistry B. 119, 4, p. 1416-1424 9 p.

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• Utilisation of water soluble iridium catalysts for signal amplification by reversible exchange

  Fekete, M., Gibard, C., Dear, G. J., Green, G. G. R., Hooper, A. J. J., Roberts, A. D., Cisnetti, F. & Duckett, S. B., 21 Apr 2015, In: Dalton Transactions. 44, 17, p. 7870-7880 11 p.

  Research output: Contribution to journal › Article › peer-review